Genomes and Genes
- Acetylation is important for MyoD function in adult miceArnaud Duquet
Laboratoire Epigénétique et Cancer, CNRS FRE 2944, Institut Andre Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France
EMBO Rep 7:1140-6. 2006..Together, these results show the importance of MyoD acetylation for adult myogenesis...
- Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiencyAnna Polesskaya
Centre National de la Recherche Scientifique CNRS FRE 2944, Institut Andre Lwoff, Villejuif F 94801, France
Genes Dev 21:1125-38. 2007..Our results unravel novel mechanisms of translational regulation in skeletal muscle and suggest that Lin-28 performs the role of "translational enhancer" in embryonic and adult cells and tissues...
- [A novel role for an embryonic regulatory protein Lin-28 in adult skeletal muscle differentiation]Anna Polesskaya
Med Sci (Paris) 23:796-7. 2007
- Differential cooperation between heterochromatin protein HP1 isoforms and MyoD in myoblastsHakima Yahi
Institut Andre Lwoff, CNRS, FRE 2944, 7 rue Guy Moquet, Villejuif, France
J Biol Chem 283:23692-700. 2008..In addition, they strongly suggest that HP1 isoforms play important roles during muscle terminal differentiation in an isoform-dependent manner...
- [Micro-RNAs and muscle differentiation]Irina Naguibneva
CNRS FRE 2944 Epigénétique et Cancer, Institut Andre Lwoff, 7 rue Guy Moquet, BP8, 94801 Villejuif Cedex, France
J Soc Biol 201:367-76. 2007..Therefore, miRNAs can be involved in the establishment of a differentiated phenotype - even when they are not expressed in the corresponding fully differentiated tissue...
- A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cellsSlimane Ait-Si-Ali
UPR 9079 CNRS Labellisée Ligue Nationale Contre le Cancer, Institut Andre Lwoff, Villejuif, France
EMBO J 23:605-15. 2004..Thus, appropriately timed H3K9 methylation by Suv39h seems to be part of the control switch for exiting the cell cycle and entering differentiation...
- [Small non-coding RNAs: new targets and new therapeutic possibilities]Annick Harel-Bellan
CNRS FRE 2944, Institut Andre Lwoff, Villejuif, F 94801 and Universit6 Paris Sud, Villejuif F 94801, France
Bull Acad Natl Med 194:319-24; discussion 324-5. 2010..These small non-coding RNAs are powerful tools for exploring cellular pathways and for artificially controlling gene expression. Natural small RNAs also represent potential therapeutic targets...
- A MyoD-dependent differentiation checkpoint: ensuring genome integrityAnna Polesskaya
Ottawa Health Research Institute, 501 Smyth Road, Ontario K1H 8L6, Canada
Dev Cell 3:757-8. 2002..In a recent paper, the concept of a genotoxic stress-induced differentiation checkpoint has been proposed. The suggested function of this checkpoint is to preserve the integrity of the genome in terminally differentiated cells...
- Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regenerationAnna Polesskaya
Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
Cell 113:841-52. 2003..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
- The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiationIrina Naguibneva
UPR9079 CNRS Ligue Nationale Contre le Cancer, 7 rue Guy Moquet, 94801 Villejuif Cedex, France
Nat Cell Biol 8:278-84. 2006..Therefore, miRNAs can be involved in the establishment of a differentiated phenotype - even when they are not expressed in the corresponding fully differentiated tissue...
- Adult stem cell specification by Wnt signaling in muscle regenerationPatrick Seale
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada
Cell Cycle 2:418-9. 2003..Importantly, our study suggests that targeting the Wnt-pathway represents a promising therapeutic approach for the treatment of neuromuscular degenerative diseases...
- Structural requirements for furin-induced cleavage and activation of Shiga toxinAlma Kurmanova
W A Engelhardt Institute for Molecular Biology, The Russian Academy of Sciences, Moscow, Russia
Biochem Biophys Res Commun 357:144-9. 2007..In contrast, LoVo/neo cells lacking functional furin were unable to activate both wild type Shiga toxin and Shiga-2D toxin. In conclusion, an extended loop structure is required for furin-induced cleavage of Shiga toxin...