Research Topics
Genomes and Genes | Anna PolesskayaSummaryCountry: France Publications
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Publications
Acetylation is important for MyoD function in adult miceArnaud Duquet
Laboratoire Epigénétique et Cancer, CNRS FRE 2944, Institut Andre Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France
EMBO Rep 7:1140-6. 2006..Together, these results show the importance of MyoD acetylation for adult myogenesis...
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiencyAnna Polesskaya
Centre National de la Recherche Scientifique CNRS FRE 2944, Institut Andre Lwoff, Villejuif F 94801, France
Genes Dev 21:1125-38. 2007..Our results unravel novel mechanisms of translational regulation in skeletal muscle and suggest that Lin-28 performs the role of "translational enhancer" in embryonic and adult cells and tissues...
[A novel role for an embryonic regulatory protein Lin-28 in adult skeletal muscle differentiation]Anna Polesskaya
Med Sci (Paris) 23:796-7. 2007
Differential cooperation between heterochromatin protein HP1 isoforms and MyoD in myoblastsHakima Yahi
Institut Andre Lwoff, CNRS, FRE 2944, 7 rue Guy Moquet, Villejuif, France
J Biol Chem 283:23692-700. 2008..In addition, they strongly suggest that HP1 isoforms play important roles during muscle terminal differentiation in an isoform-dependent manner...
[Micro-RNAs and muscle differentiation]Irina Naguibneva
CNRS FRE 2944 Epigénétique et Cancer, Institut Andre Lwoff, 7 rue Guy Moquet, BP8, 94801 Villejuif Cedex, France
J Soc Biol 201:367-76. 2007..Therefore, miRNAs can be involved in the establishment of a differentiated phenotype - even when they are not expressed in the corresponding fully differentiated tissue...
A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cellsSlimane Ait-Si-Ali
UPR 9079 CNRS Labellisée Ligue Nationale Contre le Cancer, Institut Andre Lwoff, Villejuif, France
EMBO J 23:605-15. 2004..Thus, appropriately timed H3K9 methylation by Suv39h seems to be part of the control switch for exiting the cell cycle and entering differentiation...
[Small non-coding RNAs: new targets and new therapeutic possibilities]Annick Harel-Bellan
CNRS FRE 2944, Institut Andre Lwoff, Villejuif, F 94801 and Universit6 Paris Sud, Villejuif F 94801, France
Bull Acad Natl Med 194:319-24; discussion 324-5. 2010..These small non-coding RNAs are powerful tools for exploring cellular pathways and for artificially controlling gene expression. Natural small RNAs also represent potential therapeutic targets...
A MyoD-dependent differentiation checkpoint: ensuring genome integrityAnna Polesskaya
Ottawa Health Research Institute, 501 Smyth Road, Ontario K1H 8L6, Canada
Dev Cell 3:757-8. 2002..In a recent paper, the concept of a genotoxic stress-induced differentiation checkpoint has been proposed. The suggested function of this checkpoint is to preserve the integrity of the genome in terminally differentiated cells...
Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regenerationAnna Polesskaya
Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
Cell 113:841-52. 2003..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiationIrina Naguibneva
UPR9079 CNRS-Ligue Nationale Contre le Cancer, 7 rue Guy Moquet, 94801 Villejuif Cedex, France
Nat Cell Biol 8:278-84. 2006..Therefore, miRNAs can be involved in the establishment of a differentiated phenotype - even when they are not expressed in the corresponding fully differentiated tissue...
Adult stem cell specification by Wnt signaling in muscle regenerationPatrick Seale
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada
Cell Cycle 2:418-9. 2003..Importantly, our study suggests that targeting the Wnt-pathway represents a promising therapeutic approach for the treatment of neuromuscular degenerative diseases...
Structural requirements for furin-induced cleavage and activation of Shiga toxinAlma Kurmanova
W A Engelhardt Institute for Molecular Biology, The Russian Academy of Sciences, Moscow, Russia
Biochem Biophys Res Commun 357:144-9. 2007..In contrast, LoVo/neo cells lacking functional furin were unable to activate both wild type Shiga toxin and Shiga-2D toxin. In conclusion, an extended loop structure is required for furin-induced cleavage of Shiga toxin...
