Lalau J. Lactic acidosis induced by metformin: incidence, management and prevention. Drug Saf. 2010;33:727-40 pubmed publisher
..The implications of these contraindications are discussed. ..
Lalau J, Kajbaf F, Bennis Y, Hurtel Lemaire A, Belpaire F, De Broe M. Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4. Diabetes Care. 2018;41:547-553 pubmed publisher
..Provided that the dose is adjusted for renal function, metformin treatment appears to be safe and still pharmacologically efficacious in moderate-to-severe CKD. ..
Kajbaf F, De Broe M, Lalau J. Therapeutic Concentrations of Metformin: A Systematic Review. Clin Pharmacokinet. 2016;55:439-59 pubmed publisher