Fabrice H F Pierre

Summary

Country: France

Publications

  1. doi request reprint Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved
    Nadia M Bastide
    INRA TOXALIM Research Centre in Food Toxicology, Université de Toulouse INP ENVT, Toulouse, France
    Cancer Prev Res (Phila) 4:177-84. 2011
  2. pmc Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium
    Fabrice Pierre
    UMR1089 Xenobiotiques, INRA ENVT, 23 ch Capelles, Toulouse, France
    Br J Nutr 99:1000-6. 2008
  3. ncbi request reprint Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats
    F Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques 23 chemin des Capelles, 31076 Toulouse, France
    Carcinogenesis 28:321-7. 2007
  4. ncbi request reprint Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    J Nutr 134:2711-6. 2004
  5. pmc Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    Carcinogenesis 24:1683-90. 2003
  6. pmc Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon
    Raphaëlle L Santarelli
    Universite de Toulouse, ENVT, INRA, UMR1331 Toxalim, BP 87614, 23 Ch des Capelles, F 31076, Toulouse, France IFIP Institut Français du Porc, 149 rue de Bercy, F 75595, Paris Cedex 12, France
    Int J Cancer 133:2533-41. 2013
  7. pmc Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis
    Ossama Allam
    Universite de Toulouse, UMR 1089 Xenobiotiques, INRA, ENVT, 23 Capelles, F 31076 Toulouse, France
    Br J Nutr 105:384-92. 2011
  8. pmc Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon
    Fabrice H F Pierre
    Universite de Toulouse, INRA ENVT, Toulouse, France
    Nutr Cancer 62:567-73. 2010
  9. doi request reprint 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron
    Maryse Baradat
    INRA UMR1331, TOXALIM Research Center in Food Toxicology, Universite de Toulouse, ENVT, INP, UPS, Toxalim, Toulouse, France
    Chem Res Toxicol 24:1984-93. 2011
  10. doi request reprint High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation
    Delphine Bellocq
    INRA ENVT, UMR1089 Laboratoire des Xénobiotiques, 180, Chemin de Tournefeuille, F 31931 Toulouse, France
    Mutat Res 653:34-43. 2008

Collaborators

  • Raphaëlle L Santarelli
  • Sheila Bingham
  • Amanda J Cross
  • Francoise Gueraud
  • Jacques Dupuy
  • D E Corpet
  • Virginie Forest
  • Sylviane Tache
  • Nadia M Bastide
  • Ossama Allam
  • Maryse Baradat
  • Jean Menanteau
  • Khaled Meflah
  • Cecile Canlet
  • Delphine Bellocq
  • Euphémie Bassonga
  • Maiwenn Olier
  • Isabelle Jouanin
  • Laurence Huc
  • Sabine Dalleau
  • Nathalie Naud
  • Diane Bahuaud
  • Mathilde Gieules
  • Laurent Debrauwer
  • Jérôme Molina
  • Pascal G P Martin
  • Alain Paris
  • Estelle Rathahao
  • Christophe Olivier
  • Monique Clement
  • Jean Paul Lemaitre
  • Charles Divies
  • Jean Guzzo
  • André Rousset

Detail Information

Publications18

  1. doi request reprint Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved
    Nadia M Bastide
    INRA TOXALIM Research Centre in Food Toxicology, Université de Toulouse INP ENVT, Toulouse, France
    Cancer Prev Res (Phila) 4:177-84. 2011
    ..A review of evidence supporting these hypotheses suggests that both pathways are involved in heme iron toxicity...
  2. pmc Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium
    Fabrice Pierre
    UMR1089 Xenobiotiques, INRA ENVT, 23 ch Capelles, Toulouse, France
    Br J Nutr 99:1000-6. 2008
    ..They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with the excess of a useful nutrient may be prevented by another nutrient...
  3. ncbi request reprint Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats
    F Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques 23 chemin des Capelles, 31076 Toulouse, France
    Carcinogenesis 28:321-7. 2007
    ..We propose that this mechanism could be involved in the promotion of colon carcinogenesis by haem in vivo...
  4. ncbi request reprint Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    J Nutr 134:2711-6. 2004
    ..MDF promotion was correlated with high fecal water lipoperoxides and cytotoxicity (r = 0.65, P < 0.01). This is the first study to show the promotion of experimental carcinogenesis by dietary meat and the association with heme intake...
  5. pmc Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    Carcinogenesis 24:1683-90. 2003
    ..The results suggest that myoglobin in red meat could promote colon cancer. Diets high in calcium, or in oxidation-resistant fats, may prevent the possible cancer-promoting effect of red meat...
  6. pmc Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon
    Raphaëlle L Santarelli
    Universite de Toulouse, ENVT, INRA, UMR1331 Toxalim, BP 87614, 23 Ch des Capelles, F 31076, Toulouse, France IFIP Institut Français du Porc, 149 rue de Bercy, F 75595, Paris Cedex 12, France
    Int J Cancer 133:2533-41. 2013
    ..2.3 ± 1.4, respectively, p < 0.05). This is the first experimental evidence that a widely consumed processed meat promotes colon carcinogenesis in rats. It also shows that dietary prevention of this detrimental effect is possible...
  7. pmc Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis
    Ossama Allam
    Universite de Toulouse, UMR 1089 Xenobiotiques, INRA, ENVT, 23 Capelles, F 31076 Toulouse, France
    Br J Nutr 105:384-92. 2011
    ..They support the concept that the nature of the associated anion to a protective metal ion is important for chemoprevention...
  8. pmc Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon
    Fabrice H F Pierre
    Universite de Toulouse, INRA ENVT, Toulouse, France
    Nutr Cancer 62:567-73. 2010
    ..Freeze-dried cooked ham can promote colon carcinogenesis in a rodent model. Hemin, but not hemoglobin, mimicked ham effect on early biochemical markers associated with carcinogenesis...
  9. doi request reprint 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron
    Maryse Baradat
    INRA UMR1331, TOXALIM Research Center in Food Toxicology, Universite de Toulouse, ENVT, INP, UPS, Toxalim, Toulouse, France
    Chem Res Toxicol 24:1984-93. 2011
    ..These differential biotransformation capacities would explain the differences of susceptibility between normal and Apc-mutated cells regarding secondary lipid oxidation products...
  10. doi request reprint High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation
    Delphine Bellocq
    INRA ENVT, UMR1089 Laboratoire des Xénobiotiques, 180, Chemin de Tournefeuille, F 31931 Toulouse, France
    Mutat Res 653:34-43. 2008
    ..So, the more important potency to metabolically bio-activate PhIP, as measured in Apc(Min/+) cells, can be linked to a higher probability to generate new in situ mutations...
  11. ncbi request reprint New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT 1089 Xénobiotiques, Toulouse, France
    Cancer Epidemiol Biomarkers Prev 15:2274-9. 2006
    ....
  12. ncbi request reprint How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, BP 87614, 23 Capelles, 31076 Toulouse, France
    Eur J Cancer 41:1911-22. 2005
    ..However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention...
  13. ncbi request reprint Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cells
    Virginie Forest
    INSERM U 419, IFR 26, HNRC Nantes, France
    Nutr Cancer 45:84-92. 2003
    ..This feature may contribute to explain the protective effect exerted by butyrogenic diets on colon carcinogenesis in animal models...
  14. pmc Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France
    Cancer Epidemiol Biomarkers Prev 12:391-400. 2003
    ....
  15. pmc Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence
    Raphaëlle L Santarelli
    UMR1089 INRA ENVT Xénobiotiques, Universite de Toulouse, Ecole Nationale Veterinaire, Toulouse, France
    Nutr Cancer 60:131-44. 2008
    ..Nitrosation might increase the toxicity of heme in cured products. Solving this puzzle is a challenge that would permit to reduce cancer load by changing the processes rather than by banning processed meat...
  16. ncbi request reprint Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15R alpha complex and CD4+ CD25+ T cells are the main targets
    Virginie Forest
    INSERM UMR 419, IFR 26, HNRC Nantes, Institut de Biologie, 9, quai Moncousu, 44035 Nantes Cedex 01, France
    Cancer Immunol Immunother 54:78-86. 2005
    ..Some of these modulations could contribute to the development of a better immune anticancer response in the early steps of cancer development...
  17. ncbi request reprint Apc+/Min colonic epithelial cells express TNF receptors and ICAM-1 when they are co-cultured with large intestine intra-epithelial lymphocytes
    Virginie Forest
    INSERM UMR 419, IFR 26, HNRC Nantes, 9, quai Moncousu, Nantes Cedex 01 44035, France
    Cell Immunol 223:70-6. 2003
    ..These events could participate in determining the Apc+/Min IEC immunogenicity under different in vivo conditions...
  18. ncbi request reprint Assessment of the pathogenic potential of two Listeria monocytogenes human faecal carriage isolates
    Maiwenn Olier
    Laboratoire de Microbiologie, ENSBANA, 1 Esplanade Erasme, 21000 Dijon, France
    Microbiology 148:1855-62. 2002
    ..Taken together, these data provide a starting point for the study of the behaviour of two types of human faeces carriage strains and their characterization...