Research Topics
Species | Fabrice H F PierreSummaryCountry: France Publications
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Publications
Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involvedNadia M Bastide
INRA TOXALIM Research Centre in Food Toxicology, Université de Toulouse INP ENVT, Toulouse, France
Cancer Prev Res (Phila) 4:177-84. 2011..A review of evidence supporting these hypotheses suggests that both pathways are involved in heme iron toxicity...
Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed ratsF Pierre
Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques 23 chemin des Capelles, 31076 Toulouse, France
Carcinogenesis 28:321-7. 2007..We propose that this mechanism could be involved in the promotion of colon carcinogenesis by haem in vivo...
Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in ratsFabrice Pierre
Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
Carcinogenesis 24:1683-90. 2003..The results suggest that myoglobin in red meat could promote colon cancer. Diets high in calcium, or in oxidation-resistant fats, may prevent the possible cancer-promoting effect of red meat...- Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calciumFabrice Pierre
UMR1089 Xenobiotiques, INRA ENVT, 23 ch Capelles, Toulouse, France
Br J Nutr 99:1000-6. 2008..They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with the excess of a useful nutrient may be prevented by another nutrient... - Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colonsFabrice Pierre
Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
J Nutr 134:2711-6. 2004..MDF promotion was correlated with high fecal water lipoperoxides and cytotoxicity (r = 0.65, P < 0.01). This is the first study to show the promotion of experimental carcinogenesis by dietary meat and the association with heme intake... - Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesisOssama Allam
Universite de Toulouse, UMR 1089 Xenobiotiques, INRA, ENVT, 23 Capelles, F 31076 Toulouse, France
Br J Nutr 105:384-92. 2011..They support the concept that the nature of the associated anion to a protective metal ion is important for chemoprevention... - Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colonFabrice H F Pierre
Universite de Toulouse, INRA ENVT, Toulouse, France
Nutr Cancer 62:567-73. 2010..Freeze-dried cooked ham can promote colon carcinogenesis in a rodent model. Hemin, but not hemoglobin, mimicked ham effect on early biochemical markers associated with carcinogenesis... - 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme ironMaryse Baradat
INRA UMR1331, TOXALIM Research Center in Food Toxicology, Universite de Toulouse, ENVT, INP, UPS, Toxalim, Toulouse, France
Chem Res Toxicol 24:1984-93. 2011..These differential biotransformation capacities would explain the differences of susceptibility between normal and Apc-mutated cells regarding secondary lipid oxidation products... - How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and menDenis E Corpet
UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, BP 87614, 23 Capelles, 31076 Toulouse, France
Eur J Cancer 41:1911-22. 2005..However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention... - New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acidFabrice Pierre
, , Toulouse, France
Cancer Epidemiol Biomarkers Prev 15:2274-9. 2006..CONCLUSION: Urinary DHN-MA is a useful noninvasive biomarker for determining the risk of preneoplastic lesions associated with heme iron consumption and should be further investigated as a potential biomarker of colon cancer risk... - Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model systemDenis E Corpet
UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France
Cancer Epidemiol Biomarkers Prev 12:391-400. 2003.... - High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutationDelphine Bellocq
INRA ENVT, UMR1089 Laboratoire des Xénobiotiques, 180, Chemin de Tournefeuille, F 31931 Toulouse, France
Mutat Res 653:34-43. 2008..So, the more important potency to metabolically bio-activate PhIP, as measured in Apc(Min/+) cells, can be linked to a higher probability to generate new in situ mutations... - Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cellsVirginie Forest
INSERM U.419, IFR 26, HNRC Nantes, France
Nutr Cancer 45:84-92. 2003..This feature may contribute to explain the protective effect exerted by butyrogenic diets on colon carcinogenesis in animal models... - Processed meat and colorectal cancer: a review of epidemiologic and experimental evidenceRaphaëlle L Santarelli
UMR1089 INRA ENVT Xénobiotiques, Universite de Toulouse, Ecole Nationale Veterinaire, Toulouse, France
Nutr Cancer 60:131-44. 2008..Nitrosation might increase the toxicity of heme in cured products. Solving this puzzle is a challenge that would permit to reduce cancer load by changing the processes rather than by banning processed meat... - Apc+/Min colonic epithelial cells express TNF receptors and ICAM-1 when they are co-cultured with large intestine intra-epithelial lymphocytesVirginie Forest
INSERM UMR. 419, IFR 26, HNRC Nantes, 9, quai Moncousu, Nantes-Cedex 01 44035, France
Cell Immunol 223:70-6. 2003..These events could participate in determining the Apc+/Min IEC immunogenicity under different in vivo conditions... - Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15R alpha complex and CD4+ CD25+ T cells are the main targetsVirginie Forest
INSERM UMR 419, IFR 26, HNRC Nantes, Institut de Biologie, 9, quai Moncousu, 44035 Nantes Cedex 01, France
Cancer Immunol Immunother 54:78-86. 2005..Some of these modulations could contribute to the development of a better immune anticancer response in the early steps of cancer development... - Assessment of the pathogenic potential of two Listeria monocytogenes human faecal carriage isolatesMaiwenn Olier
Laboratoire de Microbiologie, ENSBANA, 1 Esplanade Erasme, 21000 Dijon, France
Microbiology 148:1855-62. 2002..Taken together, these data provide a starting point for the study of the behaviour of two types of human faeces carriage strains and their characterization...