- [Functional brain mapping of pain perception]Roland Peyron
Département de Neurologie et Centre de la Douleur, CHU, F 42055 Saint Etienne, INSERM U879, UCBL Lyon 1, UJM Saint Étienne, F 42023 Saint Etienne, France
Med Sci (Paris) 27:82-7. 2011..Interestingly, these activations may correlate with the magnitude of pain relief, with the activation of the PAG, and, at least in some instances, with the involvement of endogenous opioids...
- Modulations of pain sensationsR Peyron
U1028 Inserm, Central Integration of Pain, Neuroscience Research Center, Saint Etienne, France
Neurophysiol Clin 42:293-8. 2012..These findings are discussed with regard to previous literature of pain modulations but also with regard to the concept of the "pain matrix", its inputs and the temporal dynamics of its constitutive responses...
- Central representation of the RIII flexion reflex associated with overt motor reaction: an fMRI studyR Peyron
Departement de Neurologie, CHU de St Etienne, 42055 St Etienne, France
Neurophysiol Clin 37:249-59. 2007..They should be considered as a motor component of pain-related processes activated in case of intense pain...
- Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain. A PET studyRoland Peyron
Department of Neurology, CHU Saint Etienne, France
Neuroimage 34:310-21. 2007..These hemodynamic changes are lengthened and might therefore underlie the long-lasting clinical effects that largely outlast the actual stimulation periods...
- An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic painR Peyron
Departement de Neurologie, Hopital de Bellevue, Bd Pasteur, 42055 Saint Etienne, France
Neurology 63:1838-46. 2004..To investigate cerebral activity associated with allodynia in patients with neuropathic pain...
- Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentialsR Peyron
Clinical Neurophysiology and Epileptology Department, Lyon, France
Neuroimage 17:1336-46. 2002....
- Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological studyL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Pain 83:259-73. 1999..In contrast, the hypothesis of somatosensory cortex activation by MCS could not be confirmed by our results...
- Parietal and cingulate processes in central pain. A combined positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual caseR Peyron
Neurological Department, Bellevue Hospital, 42055, Saint Etienne, France
Pain 84:77-87. 2000..This response is likely to be responsible for the strange and very unpleasant allodynic sensation elicited on the left side by a non-noxious stimulation...
- Motor cortex stimulation for pain control induces changes in the endogenous opioid systemJ Maarrawi
INSERM U879, Bron, France
Neurology 69:827-34. 2007..We studied the possible contribution of the endogenous opioid system to MCS-related pain relief...
- Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TLR Peyron
Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
Epilepsy Res 19:55-62. 1994..This metabolic response in the hypometabolic focus, observed in the absence of any epileptic discharge during FDG accumulation and PET data acquisition, suggests that GABAA receptors are up-regulated or, at least, preserved in TLE...
- Allodynia after lateral-medullary (Wallenberg) infarct. A PET studyR Peyron
Neurological Department, Bellevue Hospital, Saint Etienne, France
Brain 121:345-56. 1998....
- Haemodynamic brain responses to acute pain in humans: sensory and attentional networksR Peyron
Departement de Neurologie and Centre de la douleur, Hopital de Bellevue, Saint Etienne, France
Brain 122:1765-80. 1999..Attentional processes could possibly explain part of the variability observed in previous PET reports and should therefore be considered in further studies on pain in both normal subjects and patients with chronic pain...
- Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortexL Mazzola
INSERM U 879 Central Integration of Pain, Lyon, St Etienne, France
Pain 146:99-104. 2009..These data suggest that, in spite of large and often bilateral receptive fields, pain representation shows some degree of somatotopic organization in the human insula...
- Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humansL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Arch Med Res 31:248-57. 2000..The combination of clinical electrophysiology and functional neuroimaging provides insight into the mechanisms of action of neuromodulation procedures, guides clinical decision, and contributes to optimize patient selection...
- Cognitive effects of precentral cortical stimulation for pain control: an ERP studyC Montes
Equipe d'Accueil, EA1880 UCB, Lyon, France
Neurophysiol Clin 32:313-25. 2002....
- Positron emission tomography during motor cortex stimulation for pain controlL Garcia-Larrea
CERMEP Positron Emission Tomography Center, Lyon, France
Stereotact Funct Neurosurg 68:141-8. 1997..Such effects may be obtained only if thalamic activation reaches a 'threshold' level, below which the analgesic cascade would not be successfully triggered...
- Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET studyR Peyron
Department of Neurology, Bellevue Hospital, Etienne, France
Pain 62:275-86. 1995..Painful dysesthesiae during stimulation have to be distinguished from other innocuous sensory side effects, since they may compromise PGS efficacy...
- [Central post-stroke pain]S Demasles
Centre stéphanois de la douleur et service de neurologie, Hopital de Bellevue, 42055 Saint Etienne Cedex 02, France
Rev Neurol (Paris) 164:825-31. 2008..The thalamus plays a prominent role in this disorder of central control of pain...
- The role of parietal opercular and insular cortex in pain sensation in humans: data from PET activation studies and intracortical recordings of CO2 laser evoked potentials (LEPs)F Mauguiere
Functional Neurology and Epileptology Department, Neurological Hospital, Lyon, France
Electroencephalogr Clin Neurophysiol Suppl 49:255-60. 1999
- Pain relief by rTMS: differential effect of current flow but no specific action on pain subtypesN Andre-Obadia
INSERM U879, University Claude Bernard Lyon 1, France
Neurology 71:833-40. 2008..To assess, against placebo, the pain-relieving effects of high-rate repetitive transcranial magnetic stimulation (rTMS) on neuropathic pain...
- Episodic ataxia type 2: unusual aspects in clinical and genetic presentation. Special emphasis in childhoodP Bertholon
Service ORL, Pavillon 50, Hopital Bellevue, Bvd Pasteur, CHU Saint Etienne, France
J Neurol Neurosurg Psychiatry 80:1289-92. 2009..To describe aspects in clinical and genetic presentation in five patients with episodic ataxia type 2 (EA2)...
- In-patient versus out-patient withdrawal programmes for medication overuse headache: a 2-year randomized trialC Créac'h
North University Hospital, France
Cephalalgia 31:1189-98. 2011..Medication-overuse headache (MOH) management usually includes a medication withdrawal. The choice of withdrawal modalities remains a matter of debate...
- How a clock can change your pain? The illusion of duration and pain perceptionFlorence B Pomares
Department of Neurology, CHU, 42055 Saint Etienne, France
Pain 152:230-4. 2011..This study suggests that the perceived duration of a noxious stimulation may influence the perceived intensity of pain. The perceived duration of the length of a noxious stimulation influences (decreases) the intensity of perceived pain...
- Positional cluster-like headache. A case report of a neurovascular compression between the third cervical root and the vertebral arteryChristelle Créac'h
Universite Lyon 1, France
Cephalalgia 30:1509-13. 2010..The excellent outcome after microvascular cervical decompression suggests a causal relationship between the cluster-like headache and the vertebral constraint on the C3 root...
- [Positron emission tomography to study central pain integration]B Laurent
Service de Neurologie de Saint Etienne et Centre stéphanois de la douleur, Lyon, France
Rev Neurol (Paris) 156:341-51. 2000..To advance our knowledge of the mechanisms generating both abnormal pain and analgesia (drugs and surgical techniques) in patients is the main motivation of such anexciting challenge...
- Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activationR Peyron
Centre d Exploration et de Recherches Médicales par Emission de Positons, Lyon, France
Epilepsy Res 19:45-54. 1994....
- Functional imaging of brain responses to pain. A review and meta-analysis (2000)R Peyron
Departement de Neurologie, Hopital de Bellevue, boulevard Pasteur, 42055 Saint Etienne, France
Neurophysiol Clin 30:263-88. 2000..The precise biochemical nature of these mechanisms remains to be investigated...
- Transcranial magnetic stimulation for pain control. Double-blind study of different frequencies against placebo, and correlation with motor cortex stimulation efficacyNathalie Andre-Obadia
University Hospital Lyon Sud, Lyon, France
Clin Neurophysiol 117:1536-44. 2006..To assess, using a double-blind procedure, the pain-relieving effects of rTMS against placebo, and their predictive value regarding the efficacy of implanted motor cortex stimulation (MCS)...
- Motor cortex stimulation for refractory neuropathic pain: four year outcome and predictors of efficacyChristophe Nuti
Department of Neurosurgery, CHU Saint Etienne, Bd Pasteur, 42055 Saint Etienne Cedex 2, France
Pain 118:43-52. 2005..744; p<0.0001). These results confirm that MCS can be a satisfactory and durable alternative to medical treatments in patients with refractory pain, and suggest that the efficacy of MCS may be predicted in the first month of therapy...
- Operculo-insular pain (parasylvian pain): a distinct central pain syndromeLuis Garcia-Larrea
Central Integration of Pain Unit, U879 INSERM and University Claude Bernard, Lyon 1, Neurological Hospital, Lyon, France
Brain 133:2528-39. 2010..Parasylvian pain may be extremely difficult to treat; the magnitude of pain-temperature sensory disturbances may be prognostic for its development, hence the importance of early sensory assessment with quantitative methods...
- Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan studyBogdan Galusca
Endocrinology Department, CHU Saint Etienne, France
Biol Psychiatry 64:1009-13. 2008..4-(2-methoxyphenyl)-1-[2-(N-2-pyridinyl)-p-fluorobenzamido]-ethylpiperazine ([(18)F]MPPF) is a selective 5-HT(1A) receptor antagonist with an affinity close to that of endogenous 5-HT...
- Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked painLuis Garcia-Larrea
INSERM and Laboratoire de neurophysiologie humaine du CERMEP, Lyon, France
Brain 125:2766-81. 2002..In selected contexts (pain sine materia, non-organic anaesthesia), normal or enhanced LEPs may support a psychogenic participation in the syndrome...
- [Introduction to pain pathophysiology. Applications to visceral pain]Patrice Queneau
, CHU de Saint-Etienne
Gastroenterol Clin Biol 27:S59-67. 2003
- Motor cortex stimulation for neuropathic pain: From phenomenology to mechanismsLuis Garcia-Larrea
Central Integration of Pain Inserm U 879, F 69677, France
Neuroimage 37:S71-9. 2007..This, along with the delayed and long-lasting activation of several brain structures, is consistent with the clinical effects of MCS, which may also last for hours or days after MCS discontinuation...
- On the relation between sensory deafferentation, pain and thalamic activity in Wallenberg's syndrome: a PET-scan study before and after motor cortex stimulationLuis Garcia-Larrea
INSERM E342, Central Integration of Human Pain, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France Université Claude Bernard Lyon1, France
Eur J Pain 10:677-88. 2006..Restoration of thalamic activity in neuropathic pain might represent one important condition to obtain successful relief by analgesic procedures, including cortical neurostimulation...
- Differential brain opioid receptor availability in central and peripheral neuropathic painJoseph Maarrawi
INSERM EMI 342 Central Integration of pain, 59 Bd Pinel, 69394 Lyon and St Etienne, France
Pain 127:183-94. 2007..Central and peripheral forms of NP may differ in distribution of brain opioid system changes and this in turn might underlie their different sensitivity to opiates...