Mathias Pessiglione

Summary

Country: France

Publications

  1. pmc How the brain translates money into force: a neuroimaging study of subliminal motivation
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
    Science 316:904-6. 2007
  2. pmc Subliminal instrumental conditioning demonstrated in the human brain
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 59:561-7. 2008
  3. ncbi An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution
    Mathias Pessiglione
    Hopital de la Salpetriere, Paris, France
    J Cogn Neurosci 17:1886-96. 2005
  4. ncbi Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits
    Mathias Pessiglione
    Laboratoire de neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale Unité 679, Hopital de la Salpetriere, 75651 Paris, France
    J Neurosci 25:1523-31. 2005
  5. ncbi Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:437-46. 2004
  6. doi Brain hemispheres selectively track the expected value of contralateral options
    Stefano Palminteri
    Institut du Cerveau et de la Moëlle èpinière CR ICM, INSERM UMR 975, Paris, France
    J Neurosci 29:13465-72. 2009
  7. pmc Neural mechanisms underlying motivation of mental versus physical effort
    Liane Schmidt
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France
    PLoS Biol 10:e1001266. 2012
  8. ncbi Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism. I. Effects of task complexity
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:426-36. 2004
  9. doi Splitting motivation: unilateral effects of subliminal incentives
    Liane Schmidt
    institut du cerveau et de la moelle épinière, Paris, France
    Psychol Sci 21:977-83. 2010
  10. pmc A critical role for the hippocampus in the valuation of imagined outcomes
    Maël Lebreton
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France Service de neuroradiologie, Hopital Pitie Salpetriere, Centre de NeuroImagerie de Recherche CENIR, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie UPMC Paris 6, Paris, France
    PLoS Biol 11:e1001684. 2013

Collaborators

Detail Information

Publications28

  1. pmc How the brain translates money into force: a neuroimaging study of subliminal motivation
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
    Science 316:904-6. 2007
    ..Our findings thus reveal this region as a key node in brain circuitry that enables expected rewards to energize behavior, without the need for the subjects;awareness...
  2. pmc Subliminal instrumental conditioning demonstrated in the human brain
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 59:561-7. 2008
    ..We conclude that, even without conscious processing of contextual cues, our brain can learn their reward value and use them to provide a bias on decision making...
  3. ncbi An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution
    Mathias Pessiglione
    Hopital de la Salpetriere, Paris, France
    J Cogn Neurosci 17:1886-96. 2005
    ..We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior...
  4. ncbi Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits
    Mathias Pessiglione
    Laboratoire de neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale Unité 679, Hopital de la Salpetriere, 75651 Paris, France
    J Neurosci 25:1523-31. 2005
    ..Thus the major dysfunction after dopamine depletion appeared to be the loss of functional segregation within cortico-BG circuits, which could also be at the heart of parkinsonian pathophysiology...
  5. ncbi Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:437-46. 2004
    ..Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD...
  6. doi Brain hemispheres selectively track the expected value of contralateral options
    Stefano Palminteri
    Institut du Cerveau et de la Moëlle èpinière CR ICM, INSERM UMR 975, Paris, France
    J Neurosci 29:13465-72. 2009
    ..We therefore suggest that expected values are represented in a distributed manner that respects the topography of the brain systems elicited by the available options...
  7. pmc Neural mechanisms underlying motivation of mental versus physical effort
    Liane Schmidt
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France
    PLoS Biol 10:e1001266. 2012
    ..Thus, we suggest that the interaction between a common motivational system and the different task-specific systems underpinning behavioral performance might occur within the basal ganglia...
  8. ncbi Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism. I. Effects of task complexity
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:426-36. 2004
    ..We therefore suggest that everyday cognitive difficulties may exacerbate hypokinesia (lack of initiation, abnormal slowness) and executive disorders (hesitations, freezing) in the early stages of human PD...
  9. doi Splitting motivation: unilateral effects of subliminal incentives
    Liane Schmidt
    institut du cerveau et de la moelle épinière, Paris, France
    Psychol Sci 21:977-83. 2010
    ..These results show that in the absence of conscious control, one brain hemisphere, and hence one side of the body, can be motivated independently of the other...
  10. pmc A critical role for the hippocampus in the valuation of imagined outcomes
    Maël Lebreton
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France Service de neuroradiologie, Hopital Pitie Salpetriere, Centre de NeuroImagerie de Recherche CENIR, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie UPMC Paris 6, Paris, France
    PLoS Biol 11:e1001684. 2013
    ..We conclude that hippocampus-mediated simulation plays a critical role in providing the motivation to pursue goals that are not present to our senses. ..
  11. pmc Learning affective values for faces is expressed in amygdala and fusiform gyrus
    Predrag Petrovic
    Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, WC1N 3BG, UK
    Soc Cogn Affect Neurosci 3:109-18. 2008
    ..We conclude that amygdala and fusiform encode affective value in a manner that closely approximates a standard computational solution to learning...
  12. doi Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder
    Stefano Palminteri
    Institut National de la Santé et de la Recherche Médicale Unité 975, Centre National de la Recherche Scientifique Unité 7225, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Biol Psychiatry 72:244-50. 2012
    ..An influential theory has suggested that dopamine and serotonin represent opponent systems respectively driving reward and punishment learning...
  13. doi Reinforcement learning and Gilles de la Tourette syndrome: dissociation of clinical phenotypes and pharmacological treatments
    Yulia Worbe
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Hopital Pitie Salpetriere, Paris, France
    Arch Gen Psychiatry 68:1257-66. 2011
    ..The heterogeneity of clinical phenotypes may relate to the dysfunction of distinct frontal cortex-basal ganglia circuits...
  14. doi Get aroused and be stronger: emotional facilitation of physical effort in the human brain
    Liane Schmidt
    Institut du Cerveau et de la Moëlle épinière ICM, INSERM UMRS 975, Paris, France
    J Neurosci 29:9450-7. 2009
    ..We suggest that this region, by driving the motor cortex, constitutes a brain pathway that allows emotional arousal to facilitate physical effort...
  15. doi Dopamine-dependent reinforcement of motor skill learning: evidence from Gilles de la Tourette syndrome
    Stefano Palminteri
    institut du cerveau et de la moelle épinière, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Brain 134:2287-301. 2011
    ..These results support the hypothesis that overactive dopamine transmission leads to excessive reinforcement of motor sequences, which might explain the formation of tics in Gilles de la Tourette syndrome...
  16. doi An automatic valuation system in the human brain: evidence from functional neuroimaging
    Maël Lebreton
    Institut du Cerveau et de la Moëlle èpinière CR ICM, INSERM UMR 975, Paris, France
    Neuron 64:431-9. 2009
    ..These regions may therefore constitute a brain system that automatically engages in valuating the various components of our environment so as to influence our future choices...
  17. doi Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity
    Cédric Lemogne
    CNRS USR 3246, Pitie Salpetriere Hospital, Paris, France
    Hum Brain Mapp 32:1856-67. 2011
    ..Additionally, they suggest that measuring life stress exposure is a critical step when imaging genetics...
  18. ncbi Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys
    Caroline Jan
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Eur J Neurosci 18:2082-6. 2003
    ..The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP-treated monkeys...
  19. doi Better get back to work: a role for motor beta desynchronization in incentive motivation
    Florent Meyniel
    Motivation, Brain, and Behavior Laboratory, Centre de NeuroImagerie de Recherche, and Institut du Cerveau et de la Moelle Épinière, Hopital de la Pitie Salpetriere, F 75013 Paris, France, and Centre National de la Recherche Scientifique Unité Mixte de Recherche UMR 7225, Institut National de la Santé et de la Recherche Médicale UMR 975, Universite Pierre et Marie Curie Paris 6, F 75005 Paris, France
    J Neurosci 34:1-9. 2014
    ..We conclude that MBS reduction could represent a neural mechanism that speeds the initiation of effort production when the effort is more rewarded. ..
  20. pmc Why don't you try harder? An investigation of effort production in major depression
    Marie Laure Cléry-Melin
    Motivation, Brain and Behavior lab, institut du cerveau et de la moelle épinière, Hopital de la Pitie Salpetriere, Paris, France
    PLoS ONE 6:e23178. 2011
    ..We suggest that incentive motivation impairment is a core deficit of major depression, which may render everyday tasks abnormally effortful for patients...
  21. ncbi Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's disease
    Mathias Pessiglione
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 126:1392-408. 2003
    ..Similar behavioural disorders might therefore occur in the presymptomatic stage of human Parkinson's disease...
  22. doi Imaging social motivation: distinct brain mechanisms drive effort production during collaboration versus competition
    Raphaël Le Bouc
    Équipe Motivation, Cerveau et Comportement, Centre de NeuroImagerie de Recherche, institut du cerveau et de la moelle épinière, Hopital de la Pitie Salpetriere, F 75013, Paris, France, and Institut National de la Santé et de la Recherche Médicale Unité 975, Centre National de la Recherche Scientifique Unité 7225, Universite Pierre et Marie Curie Paris 6, F 75005 Paris, France
    J Neurosci 33:15894-902. 2013
    ..More generally, our findings suggest that the individual propensity to invest energy in collaborative work might have an identifiable counterpart in the brain functional architecture. ..
  23. doi Hemispheric dissociation of reward processing in humans: insights from deep brain stimulation
    Stefano Palminteri
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Hopital de la Pitie Salpetriere, Paris, France INSERM UMR 975, CNRS UMR 7225, Université Pierre et Marie Curie UPMC Paris 6, Hopital de la Pitie Salpetriere, Paris, France
    Cortex 49:2834-44. 2013
    ..As these findings proved independent from therapeutic effects on parkinsonian motor symptoms, they might provide insight into DBS impact on non-motor disorders, such as apathy or hypomania. ..
  24. ncbi How the brain decides when to work and when to rest: dissociation of implicit-reactive from explicit-predictive computational processes
    Florent Meyniel
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Groupe Hospitalier Pitie Salpetriere, Université Pierre et Marie Curie UPMC Paris 6, Paris, France
    PLoS Comput Biol 10:e1003584. 2014
    ..In contrast, cost-evidence bounds and dissipation rate might be adjusted in anticipation, depending on explicit task difficulty. ..
  25. doi Disconnecting force from money: effects of basal ganglia damage on incentive motivation
    Liane Schmidt
    Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
    Brain 131:1303-10. 2008
    ..We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards...
  26. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
    ..We conclude that dopamine-dependent modulation of striatal activity can account for how the human brain uses reward prediction errors to improve future decisions...
  27. doi Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis
    Sabrina Boulet
    Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Dynamique des Réseaux Neuronaux du Mouvement, Grenoble F 38043 Cedex 09, France
    J Neurosci 28:9575-84. 2008
    ....
  28. ncbi A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery
    Stéphanie Mounayar
    Institut National de la Sante et de la Recherche Medicale, Unité 679, Paris F 75013, France
    Brain 130:2898-914. 2007
    ..The immunohistological results suggest that both dopamine and serotonin could be implicated in the compensatory mechanisms...