B Perbal

Summary

Country: France

Publications

  1. pmc The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, Institut National de la Santé et de la Recherche Médicale U142, Hopital Saint Antoine, 75012 Paris, France
    Proc Natl Acad Sci U S A 96:869-74. 1999
  2. pmc NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D, Diderot, France
    Mol Pathol 54:57-79. 2001
  3. pmc Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells
    C Gaillard
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, 75005 Paris, France
    Mol Pathol 55:325-35. 2002
  4. pmc A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon
    M Vellard
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Proc Natl Acad Sci U S A 89:2511-5. 1992
  5. ncbi [Genetic alterations associated with pathologic differentiation of Wilms' tumors]
    G Chevalier
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Bull Cancer 84:289-303. 1997
  6. pmc Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene
    A Sureau
    Laboratoire d Oncologie Virale et Moléculaire, Unité de Formation et de Recherche de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Nucleic Acids Res 25:4513-22. 1997
  7. pmc A role for CCN3 (NOV) in calcium signalling
    C L Li
    Laboratoire d Oncologie Virale et Moléculaire LOVM, UFR de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Mol Pathol 55:250-61. 2002
  8. ncbi Regulation of nov by WT1: a potential role for nov in nephrogenesis
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Oncogene 12:1479-92. 1996
  9. ncbi Pathogenic potential of myeloblastosis-associated virus: implication of env proteins for osteopetrosis induction
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Virology 195:812-9. 1993
  10. pmc Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Universite, Paris, Diderot, France
    Mol Pathol 50:310-6. 1997

Collaborators

  • C Martinerie
  • A Lombet
  • K Scotlandi
  • B Roizman
  • Alain Berhneim
  • R E Smith
  • M Keller
  • A Bernheim
  • V Huff
  • D R Brigstock
  • V Martinez
  • H Wang
  • P Coullin
  • Jiujiang Yu
  • LESTER LAU
  • F Eitner
  • A M Bleau
  • E Le Rouzic
  • M Fukunaga-Kalabis
  • A Sureau
  • C R C van Roeyen
  • N Planque
  • C Gaillard
  • J Soret
  • G Dambrine
  • C L Li
  • M Maillard
  • V Joliot
  • B Cadot
  • S Kocialkowski
  • L Glukhova
  • G N Thomopoulos
  • S Kyurkchiev
  • B Y Su
  • N Gupta
  • D E Elder
  • I Juhasz
  • T Scholl
  • S M Telson
  • Z J Liu
  • H J Grone
  • K Balint
  • U Kunter
  • P Boor
  • T Ostendorf
  • M Herlyn
  • G Martinez
  • J Floege
  • P N Schofield
  • T Quan
  • N Lazar
  • G Fisher
  • A Ori
  • D Zambelli
  • C Guyon
  • S Dumon
  • G Chevalier
  • C Creminon
  • Y Cherel
  • M Afanassieff
  • M R Snaith
  • P Thoraval
  • B He
  • S Advani
  • C Lavialle
  • M J Terrier-Lacombe
  • T L McLeod
  • H Yeger
  • J Kingdom
  • K Sethia
  • C C Naus
  • R R Weichselbaum
  • D R Edwards
  • A F Goguel
  • R Y Ball
  • C G Zhang
  • R Tatoud
  • E Angevin
  • W Q Cai
  • F Lasserre
  • F Apiou
  • B Dutrillaux
  • W Ansorge
  • R Gattoni
  • J Stevenin
  • H Voss
  • M Popielarz
  • M Vellard
  • P Crisanti
  • J Crochet

Detail Information

Publications37

  1. pmc The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, Institut National de la Santé et de la Recherche Médicale U142, Hopital Saint Antoine, 75012 Paris, France
    Proc Natl Acad Sci U S A 96:869-74. 1999
    ..These results set the stage for a study of NOVH-fibulin 1C interactions and their potential significance in cell-adhesion signaling in normal and pathological conditions...
  2. pmc NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D, Diderot, France
    Mol Pathol 54:57-79. 2001
    ..In this model, disruption of the secondary structure of the CCN proteins induced by deletions of either terminus is expected to confer on the truncated polypeptide constitutive positive or negative activities...
  3. pmc Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells
    C Gaillard
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, 75005 Paris, France
    Mol Pathol 55:325-35. 2002
    ..In addition, to determine whether alterations in the binding of the MYB protein to MREs affects HL-60 cell proliferation and differentiation...
  4. pmc A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon
    M Vellard
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Proc Natl Acad Sci U S A 89:2511-5. 1992
    ..Furthermore, we show that PR264-specific mRNAs are expressed in normal hematopoietic cells of chicken and human origin and that the relative proportion of the PR264 transcripts is developmentally regulated in chicken...
  5. ncbi [Genetic alterations associated with pathologic differentiation of Wilms' tumors]
    G Chevalier
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Bull Cancer 84:289-303. 1997
    ..Our observations also indicate that nov could be involved in the development of Wilms' tumors, and represent a marker of their differentiation state...
  6. pmc Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene
    A Sureau
    Laboratoire d Oncologie Virale et Moléculaire, Unité de Formation et de Recherche de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Nucleic Acids Res 25:4513-22. 1997
    ..Northern blot analyses performed with several murine tissues confirmed the differential expression of the ET gene and revealed that it is predominantly expressed in the testis...
  7. pmc A role for CCN3 (NOV) in calcium signalling
    C L Li
    Laboratoire d Oncologie Virale et Moléculaire LOVM, UFR de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Mol Pathol 55:250-61. 2002
    ....
  8. ncbi Regulation of nov by WT1: a potential role for nov in nephrogenesis
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Oncogene 12:1479-92. 1996
    ..The downregulation of novH expression by WT1 might represent a key element in normal and tumoral nephrogenesis...
  9. ncbi Pathogenic potential of myeloblastosis-associated virus: implication of env proteins for osteopetrosis induction
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Virology 195:812-9. 1993
    ..These results, together with sequence comparisons between the MAV strains examined, suggest that subtle changes in the primary structure of the TM env protein's extracellular domain are likely to affect the tumorigenic potential of MAV...
  10. pmc Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Universite, Paris, Diderot, France
    Mol Pathol 50:310-6. 1997
    ....
  11. pmc Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression
    B Perbal
    UFR de Biochimie, Universite, Paris, France
    Mol Pathol 52:84-91. 1999
    ....
  12. pmc Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene
    J Soret
    Laboratoire d Oncologie Virale et Moléculaire, INSERM U142, Bâtiment Kourilsky, Hopital Saint Antoine, Paris 75571 Cedex 12, France
    Mol Cell Biol 18:4924-34. 1998
    ..These results demonstrate, for the first time, that an SR splicing factor, which represents a novel member of the SR family, is encoded by a functional retropseudogene...
  13. pmc Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor
    A Sureau
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Proc Natl Acad Sci U S A 91:932-6. 1994
    ....
  14. ncbi Physical mapping of human loci homologous to the chicken nov proto-oncogene
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Oncogene 7:2529-34. 1992
    ..1. The chromosomal assignment of nov and CTGF proximal to c-myc and c-myb respectively is of interest because chromosomal abnormalities involving these regions have been associated with different human tumors including Wilms'...
  15. ncbi Chromosomal reallocation of the chicken c-myb locus and organization of 3'-proximal coding exons
    J Soret
    Laboratoire d Oncologie Virale et Moléculaire, Centre Universitaire, Orsay, France
    FEBS Lett 263:254-60. 1990
    ..Our sequencing data also indicate that the 3'-proximal noncoding sequences represented in c-myb mRNA species are derived from non-contiguous exons...
  16. pmc The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Centre National de la Recherche Scientifique UMR 146, Institut Curie, Centre Universitaire, Orsay, France
    J Virol 70:2576-80. 1996
    ....
  17. pmc Alterations of the MDV oncogenic regions in an MDV transformed lymphoblastoid cell line
    E Le Rouzic
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, Paris, France
    Mol Pathol 55:262-72. 2002
    ..In an attempt to define the respective participation of c-myb and MDV in the transformed phenotype of T9 cells, an analysis of MDV oncogenic sequences (BamHI-H, BamHI-A, and EcoQ fragments) was performed in these cells...
  18. ncbi Contribution of MAV-1-induced nephroblastoma to the study of genes involved in human Wilms' tumor development
    B Perbal
    UFR de Biochimie, Université Paris 7 D Diderot, France
    Crit Rev Oncog 5:589-613. 1994
    ..The recent data that are discussed in this review strongly suggest that the nov protein might play a critical role in normal and pathological nephrogenesis...
  19. pmc Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells
    J Soret
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    J Virol 63:1803-7. 1989
    ..Rearrangements occur preferentially in the gag-pol region of the MAV1 proviral genome, and similar rearrangements can be detected in well-developed independent tumors...
  20. ncbi Structural analysis of the human nov proto-oncogene and expression in Wilms tumor
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Oncogene 9:2729-32. 1994
    ..Our results suggest that the regulation of IGFII expression by WT1 and increase of novH in Wilms tumors might be interrelated and represent a key element in tumor development in human...
  21. ncbi Pathogenic potential of myeloblastosis-associated viruses
    B Perbal
    UFR de Biochimie, Université Paris 7 D Diderot, France
    Infect Agents Dis 4:212-27. 1995
    ....
  22. pmc Report on the second international workshop on the CCN family of genes
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Mol Pathol 56:80-5. 2003
    ..fr) as an important medium for the exchange of scientific knowledge and resources in the CCN field. Once more, the high quality of scientific communications and individual interactions set the stage for an extremely fruitful meeting...
  23. pmc The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene
    A Sureau
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Proc Natl Acad Sci U S A 89:11683-7. 1992
    ..Moreover, expression from the PR264 promoter is transactivated, both in vitro and in cultured cells, by different c-myb products. Thus, the PR264 gene is most likely a physiological target for the c-myb family of transcription factors...
  24. ncbi Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation
    A M Bleau
    Université Paris7 D Diderot, UFR de Biochimie, Laboratoire d Oncologie Virale et Moléculaire, 2 place Jussieu, 75005 Paris, France
    J Cell Biochem 101:1475-91. 2007
    ..The use of several clones expressing various portions of CCN3 established that the CT module of CCN3 is sufficient to induce cell growth inhibition...
  25. pmc Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Mol Cell Biol 12:10-21. 1992
    ..We also showed that the expression of an amino-terminal-truncated nov product in chicken embryo fibroblasts was sufficient to induce their transformation...
  26. ncbi Downregulation of CCN3 expression as a potential mechanism for melanoma progression
    M Fukunaga-Kalabis
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 27:2552-60. 2008
    ..Whereas major matricellular proteins, such as osteopontin, tenascin or secreted protein acidic and rich in cysteine (SPARC), are strongly upregulated in melanoma cells; CCN3 is the first member of this family that is downregulated...
  27. ncbi Patterns of specific genomic alterations associated with poor prognosis in high-grade renal cell carcinomas
    L Glukhova
    , Institut Gustave Roussy, Villejuif, France
    Cancer Genet Cytogenet 130:105-10. 2001
    ..1 and is overexpressed in some Wilms tumors. It could be an interesting candidate gene, since its level of expression and release in the culture medium was found to be increased in all of the fast growing tumors analyzed...
  28. ncbi Immunocytochemical localization of NOVH protein and ultrastructural characteristics of NCI-H295R cells
    G N Thomopoulos
    Aristotle University, School of Sciences, Department of Biology, Thessaloniki, Greece
    J Submicrosc Cytol Pathol 33:251-60. 2001
    ..This localization pattern, along with the ultrastructural and biochemical findings raise interesting questions on the function(s) and the mode of secretion of NOVH protein...
  29. pmc Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues
    M Maillard
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Mol Pathol 54:275-80. 2001
    ..CONCLUSION: The overexpression of hccn3 (nov) RNA in cancer cell lines compared with other cell lines and its epithelial localisation in human prostate samples are consistent with a role for hCCN3 (NOV) in prostatic tumorigenesis...
  30. pmc The expression of ccn3 (nov) RNA and protein in the rat central nervous system is developmentally regulated
    B Y Su
    Department of Histology and Embryology, The Third Military Medical University, Chongqing 630038, China
    Mol Pathol 54:184-91. 2001
    ....
  31. pmc Report and abstracts of the 3rd International Workshop on the CCN Family of Genes. St Malo, France, 20-23 October 2004
    D Brigstock
    J Clin Pathol 58:463-78. 2005
  32. ncbi CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation
    C R C van Roeyen
    Department of Nephrology, RWTH Aachen University, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Kidney Int 73:86-94. 2008
    ..Glomerular cell proliferation negatively correlated with CCN3 expression in necrotizing GN. Our study identifies CCN3 as an endogenous inhibitor of mesangial cell growth and a modulator of PDGF-induced mitogenesis...
  33. ncbi Genomic structure and chromosomal mapping of the mouse nov gene
    M R Snaith
    Department of Genetics, University of Cambridge, United Kingdom
    Genomics 38:425-8. 1996
    ..The nov gene maps to chromosome 15, between D15 Mit 153 and D15 Mit 183, in a region of conserved synteny with human chromosome 8...
  34. pmc Proposal for a unified CCN nomenclature
    D R Brigstock
    Department of Surgery, Ohio State University, Colombus, Ohio 43205, USA
    Mol Pathol 56:127-8. 2003
    ..This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules...
  35. ncbi Assignment of the chicken NOV gene (alias CCN3) to chromosome 2q34-->q36: Conserved and compared synteny between avian, mouse and human
    P Coullin
    UMR 1599, Cytogénétique et génomique des cancers, IGR, Villejuif, France
    Cytogenet Genome Res 97:140C. 2002
  36. ncbi Expression of the human NOV gene in first trimester fetal tissues
    S Kocialkowski
    Department of Anatomy, University of Cambridge, UK
    Anat Embryol (Berl) 203:417-27. 2001
    ..The sites of expression suggest strongly that autocrine or paracrine expression of NOV is associated with the process of cell differentiation...
  37. pmc Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)
    N Gupta
    Department of Surgery, University of Chicago, Chicago IL 60637, USA
    Mol Pathol 54:293-9. 2001
    ..The antiproliferative activity of CCN3 (NOV) established in this work sets the stage for the potential use of CCN proteins in molecular oncology...