Research Topics
Genomes and GenesSpecies | Florence PedeutourSummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
A newly characterized human well-differentiated liposarcoma cell line contains amplifications of the 12q12-21 and 10p11-14 regionsFlorence Pedeutour
Institute for Research on Cancer and Aging, University of Nice Sophia Antipolis, Nice, France
Virchows Arch 461:67-78. 2012..The 10p amplicon contained 62 genes, including oncogenes such as MLLT10, previously described in chimeric fusion with MLL in leukemias, NEBL, and BMI1...
Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literatureRenaud Sabatier
Department of Medical Oncology, Institut Paoli Calmettes, 13009 Marseille, France
BMC Cancer 10:645. 2010..Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare...- HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent ampliconAntoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
Int J Cancer 122:2233-41. 2008..We also found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATS4 might play an important role together with MDM2 in WDLPS/DDLPS oncogenesis... - KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implicationsAntoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Ann Surg Oncol 17:1429-34. 2010..The question of primary resistance to anti-EGFR treatment as a result of the presence of KRAS or BRAF mutations only in metastases has been raised but not resolved... - Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusionLaurence Bianchini
Laboratoire de génétique des tumeurs solides, Faculte de Medecine, Centre Hospitalier Universitaire de Nice, Universite de Nice Sophia Antipolis, Nice, France
Virchows Arch 452:689-96. 2008..2 were disrupted by this rearrangement. Although rare, the existence of cases of DFSP negative for the COL1A1-PDGFB fusion has to be taken in consideration when performing molecular diagnosis for a tumor suspected to be a DFSP... - NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22Antoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Genes Chromosomes Cancer 47:971-7. 2008..Our findings suggest that the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas... - Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic dataLaurence Bianchini
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Genes Chromosomes Cancer 50:442-55. 2011.... - Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomasAntoine Italiano
Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
Clin Cancer Res 15:5696-703. 2009..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway... - Renal cell carcinoma and a constitutional t(11;22)(q23;q11.2): case report and review of the potential link between the constitutional t(11;22) and cancerJérôme Doyen
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Cancer Genet 205:603-7. 2012..This observation reopens the issue of a link between the constitutional t(11;22) and cancer, and the utility of cancer prevention workups for t(11;22) carriers... - EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancyAntoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Int J Cancer 125:2479-82. 2009..The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation and the high rate of KRAS mutation observed in our series also suggest that most patients with lung SC are not likely to benefit from anti-EGFR therapies... - Strength of molecular cytogenetic analyses for adjusting the diagnosis of renal cell carcinomas with both clear cells and papillary features: a study of three casesJuliette Haudebourg
Department of Pathology, Nice University Hospital, Nice, France
Virchows Arch 457:397-404. 2010..Our observations demonstrate the necessity to use immunohistochemical and cytogenetic tools in all cases of RCC showing unusual features. The combination of FISH and SNP arrays is prevailing for characterizing cases with hybrid features... 
Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?Antoine Italiano
Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Nice, France
Int J Cancer 121:308-15. 2007..Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential...- Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysisMaxime Benchetritt
Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, Nice, France
Virchows Arch 452:209-13. 2008..Immunohistochemistry, by showing that tumor cells expressed vimentin, epithelial membrane antigen, and progesterone antigens, and cytogenetic analysis, by identifying a monosomy 22, confirmed the diagnosis of CCM... - Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analysesMaxime Benchetritt
Laboratory of Clinical and Experimental Pathology, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France
Cancer Genet Cytogenet 179:150-5. 2007..Array comparative genomic hybridization showed amplifications of chromosome arms 6q, 12q, and 15q, shared by both tumors and strongly pointing to a common origin... - Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alterationFlorence Pedeutour
University of Nice Sophia Antipolis, CNRS, UMR 6543, Nice, France
Pediatr Blood Cancer 58:798-800. 2012..HMGA2 is the main target of clonal aberrations encountered in lipomas. This result supports the hypothesis that benign lipomatous tumors harboring PLAG1 or HMGA2 rearrangement could constitute a unique pathogenetic entity... - EGFR mutation status in brain metastases of non-small cell lung carcinomaFanny Burel-Vandenbos
Department of Pathology, University Hospital of Nice, Nice, France
J Neurooncol 111:1-10. 2013.... - Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy numberAntoine Italiano
Department of Medical Oncology, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
Ann Surg Oncol 15:649-54. 2008..The aim or our study was to relate the EGFR gene copy number to therapeutic results in patients with metastatic colorectal cancer (CRC) treated with a cetuximab-containing regimen... - A clinical, histologic, and molecular study of 9 cases of congenital dermatofibrosarcoma protuberansGeorges Maire
Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Arch Dermatol 143:203-10. 2007..Little is known about congenital DFSP, the frequency of which is probably underestimated because the initial lesion may pass unnoticed...