Florence Pedeutour

Summary

Country: France

Publications

  1. doi request reprint A newly characterized human well-differentiated liposarcoma cell line contains amplifications of the 12q12-21 and 10p11-14 regions
    Florence Pedeutour
    Institute for Research on Cancer and Aging, University of Nice Sophia Antipolis, Nice, France
    Virchows Arch 461:67-78. 2012
  2. pmc Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature
    Renaud Sabatier
    Department of Medical Oncology, Institut Paoli Calmettes, 13009 Marseille, France
    BMC Cancer 10:645. 2010
  3. doi request reprint HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
  4. doi request reprint KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Ann Surg Oncol 17:1429-34. 2010
  5. doi request reprint Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
  6. doi request reprint Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion
    Laurence Bianchini
    Laboratoire de génétique des tumeurs solides, Faculte de Medecine, Centre Hospitalier Universitaire de Nice, Universite de Nice Sophia Antipolis, Nice, France
    Virchows Arch 452:689-96. 2008
  7. doi request reprint NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 47:971-7. 2008
  8. doi request reprint Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 50:442-55. 2011
  9. doi request reprint Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Institute for Research on Cancer and Aging of Nice IRCAN, CNRS UMR 7284 INSERM U1081, University of Nice Sophia Antipolis, Nice, France
    Genes Chromosomes Cancer 52:580-90. 2013
  10. doi request reprint Renal cell carcinoma and a constitutional t(11;22)(q23;q11.2): case report and review of the potential link between the constitutional t(11;22) and cancer
    Jérôme Doyen
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Cancer Genet 205:603-7. 2012

Collaborators

Detail Information

Publications20

  1. doi request reprint A newly characterized human well-differentiated liposarcoma cell line contains amplifications of the 12q12-21 and 10p11-14 regions
    Florence Pedeutour
    Institute for Research on Cancer and Aging, University of Nice Sophia Antipolis, Nice, France
    Virchows Arch 461:67-78. 2012
    ..The 10p amplicon contained 62 genes, including oncogenes such as MLLT10, previously described in chimeric fusion with MLL in leukemias, NEBL, and BMI1...
  2. pmc Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature
    Renaud Sabatier
    Department of Medical Oncology, Institut Paoli Calmettes, 13009 Marseille, France
    BMC Cancer 10:645. 2010
    ..Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare...
  3. doi request reprint HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..We also found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATS4 might play an important role together with MDM2 in WDLPS/DDLPS oncogenesis...
  4. doi request reprint KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Ann Surg Oncol 17:1429-34. 2010
    ..The question of primary resistance to anti-EGFR treatment as a result of the presence of KRAS or BRAF mutations only in metastases has been raised but not resolved...
  5. doi request reprint Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
    ..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway...
  6. doi request reprint Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion
    Laurence Bianchini
    Laboratoire de génétique des tumeurs solides, Faculte de Medecine, Centre Hospitalier Universitaire de Nice, Universite de Nice Sophia Antipolis, Nice, France
    Virchows Arch 452:689-96. 2008
    ..2 were disrupted by this rearrangement. Although rare, the existence of cases of DFSP negative for the COL1A1-PDGFB fusion has to be taken in consideration when performing molecular diagnosis for a tumor suspected to be a DFSP...
  7. doi request reprint NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 47:971-7. 2008
    ..Our findings suggest that the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas...
  8. doi request reprint Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 50:442-55. 2011
    ....
  9. doi request reprint Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Institute for Research on Cancer and Aging of Nice IRCAN, CNRS UMR 7284 INSERM U1081, University of Nice Sophia Antipolis, Nice, France
    Genes Chromosomes Cancer 52:580-90. 2013
    ....
  10. doi request reprint Renal cell carcinoma and a constitutional t(11;22)(q23;q11.2): case report and review of the potential link between the constitutional t(11;22) and cancer
    Jérôme Doyen
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Cancer Genet 205:603-7. 2012
    ..This observation reopens the issue of a link between the constitutional t(11;22) and cancer, and the utility of cancer prevention workups for t(11;22) carriers...
  11. doi request reprint EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Int J Cancer 125:2479-82. 2009
    ..The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation and the high rate of KRAS mutation observed in our series also suggest that most patients with lung SC are not likely to benefit from anti-EGFR therapies...
  12. doi request reprint Strength of molecular cytogenetic analyses for adjusting the diagnosis of renal cell carcinomas with both clear cells and papillary features: a study of three cases
    Juliette Haudebourg
    Department of Pathology, Nice University Hospital, Nice, France
    Virchows Arch 457:397-404. 2010
    ..Our observations demonstrate the necessity to use immunohistochemical and cytogenetic tools in all cases of RCC showing unusual features. The combination of FISH and SNP arrays is prevailing for characterizing cases with hybrid features...
  13. ncbi request reprint Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?
    Antoine Italiano
    Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Nice, France
    Int J Cancer 121:308-15. 2007
    ..Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential...
  14. doi request reprint EGFR mutation status in brain metastases of non-small cell lung carcinoma
    Fanny Burel-Vandenbos
    Department of Pathology, University Hospital of Nice, Nice, France
    J Neurooncol 111:1-10. 2013
    ....
  15. doi request reprint Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis
    Maxime Benchetritt
    Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, Nice, France
    Virchows Arch 452:209-13. 2008
    ..Immunohistochemistry, by showing that tumor cells expressed vimentin, epithelial membrane antigen, and progesterone antigens, and cytogenetic analysis, by identifying a monosomy 22, confirmed the diagnosis of CCM...
  16. ncbi request reprint Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses
    Maxime Benchetritt
    Laboratory of Clinical and Experimental Pathology, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France
    Cancer Genet Cytogenet 179:150-5. 2007
    ..Array comparative genomic hybridization showed amplifications of chromosome arms 6q, 12q, and 15q, shared by both tumors and strongly pointing to a common origin...
  17. doi request reprint Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alteration
    Florence Pedeutour
    University of Nice Sophia Antipolis, CNRS, UMR 6543, Nice, France
    Pediatr Blood Cancer 58:798-800. 2012
    ..HMGA2 is the main target of clonal aberrations encountered in lipomas. This result supports the hypothesis that benign lipomatous tumors harboring PLAG1 or HMGA2 rearrangement could constitute a unique pathogenetic entity...
  18. ncbi request reprint Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number
    Antoine Italiano
    Department of Medical Oncology, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
    Ann Surg Oncol 15:649-54. 2008
    ..The aim or our study was to relate the EGFR gene copy number to therapeutic results in patients with metastatic colorectal cancer (CRC) treated with a cetuximab-containing regimen...
  19. doi request reprint Immunohistological features in adenomatoid odontogenic tumor: review of the literature and first expression and mutational analysis of β-catenin in this unusual lesion of the jaws
    Jean Claude Harnet
    Faculty of Dentistry, Nice Sophia Antipolis University, Nice, France
    J Oral Maxillofac Surg 71:706-13. 2013
    ....
  20. ncbi request reprint A clinical, histologic, and molecular study of 9 cases of congenital dermatofibrosarcoma protuberans
    Georges Maire
    Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Arch Dermatol 143:203-10. 2007
    ..Little is known about congenital DFSP, the frequency of which is probably underestimated because the initial lesion may pass unnoticed...