Research Topics
| Jean Francois PayenSummaryCountry: France Publications
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Detail Information
Publications
Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRIJinyuan Zhou
Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Nat Med 9:1085-90. 2003..This observation opens the possibility of using intrinsic pH contrast, as well as protein- and/or peptide-content contrast, as diagnostic tools in clinical imaging...- Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxiaC Julien
Unité Mixte INSERM UJF 594, LRC CEA 30 V, Pavillon B, BP 217, Hopital Albert Michallon, F 38043 Grenoble, France
Br J Cancer 91:374-80. 2004..A method is thus available for noninvasively demonstrating whether any particular vascular modifying strategy results in the desired outcome in terms of tumour blood volume changes... - [Brain perfusion and metabolism imaging techniques]J F Payen
Departement d Anesthesie Reanimation, Hopital Michallon, BP 217, 38043 Grenoble Cedex 09, France
Ann Fr Anesth Reanim 25:722-8. 2006..Details are provided about brain parameters given by each technique and their clinical relevance, the accessibility of the technique in the emergency setting and the optimal window to use it during the patient's evolution... - [Pain management]J F Payen
Departement d Anesthesie Reanimation, Hopital Michallon, B P 217, 38043 Grenoble, France
Ann Fr Anesth Reanim 27:633-40. 2008..Protocols/guidelines may help caregivers to rationally use sedatives and opioids and possibly reduce mechanical ventilation and ICU length of stay... - [Pupillometry in anesthesia and critical care]J F Payen
Pôle d Anesthésie Réanimation, Hopital Albert Michallon, BP 217, 38043 Grenoble Cedex 09, France
Ann Fr Anesth Reanim 31:e155-9. 2012..The pupil light reflex measurement is part of the routine monitoring for severely head-injured patients. The impact of pupillometry in this condition remains to be determined... - Corticosteroid after etomidate in critically ill patients: a randomized controlled trialJean Francois Payen
Departmentsof Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
Crit Care Med 40:29-35. 2012..To investigate the effects of moderate-dose hydrocortisone on hemodynamic status in critically ill patients throughout the period of etomidate-related adrenal insufficiency... - [Obstructive sleep-apnoea syndrome in adult and its perioperative management]J F Payen
Pôle d Anesthésie Réanimation, Hopital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Ann Fr Anesth Reanim 29:787-92. 2010..Alternatives to opioids should be promoted for postoperative pain control... - [Sedation in neurointensive care unit]J F Payen
service de réanimation neurochirurgicale, Pôle d Anesthésie Réanimation, Hopital Michallon, Grenoble Cedex 09, France
Ann Fr Anesth Reanim 28:1015-9. 2009..During this period, an elevation of intracranial pressure is usual, and should not always result in reintroducing the neurosedation... - Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit: a post Hoc analysis of the DOLOREA studyJean Francois Payen
Department of Anesthesiology and Critical Care, Grenoble University Hospital, Grenoble, France
Anesthesiology 111:1308-16. 2009..Critically ill patients frequently experience pain, but assessment rates remain below 40% in mechanically ventilated patients. Whether pain assessment affects patient outcomes is largely unknown... - [Should etomidate still be used?]J F Payen
Pôle d Anesthésie Réanimation, Hopital Michallon, BP 217, 38043 Grenoble, France
Ann Fr Anesth Reanim 27:915-9. 2008..Substitutive opotherapy with low doses of hydrocortisone should be assessed after a single dose of etomidate for critically ill patients... - Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based studyJean Francois Payen
Department of Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
Anesthesiology 106:687-95; quiz 891-2. 2007.... - [Brain oedema following blood-brain barrier disruption: mechanisms and diagnosis]J F Payen
Departement d Anesthesie Reanimation, Hopital Michallon, BP 217, 38043 Grenoble, France
Ann Fr Anesth Reanim 22:220-5. 2003..The reference method for the diagnosis of vasogenic oedema is the MRI diffusion-weighted imaging... - [Contribution of magnetic resonance spectroscopy in predicting severity and outcome in traumatic brain injury]J F Payen
Département d anesthésie réanimation 1, Hopital Michallon, BP 217, 38043 Grenoble Cedex 9, France
Ann Fr Anesth Reanim 24:522-7. 2005..However, there are methodological issues which still impede to recommend MRS as a tool for predicting neurological outcome in the clinical setting... - Transcranial Doppler to screen on admission patients with mild to moderate traumatic brain injuryPierre Bouzat
Department of Anesthesia and Critical Care, Albert Michallon Hospital, Grenoble, France
Neurosurgery 68:1603-9; discussion 1609-10. 2011..Detecting patients at risk for secondary neurological deterioration (SND) after mild to moderate traumatic brain injury is challenging... - The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a rat model of traumatic brain injurySamuel Valable
INSERM, U836, Grenoble, Cedex, France
J Cereb Blood Flow Metab 30:361-9. 2010..The findings of our study indicate that the anti edematous effect of rhEPO could be mediated through an early inhibition of ERK phosphorylation after diffuse TBI... - Detecting traumatic internal carotid artery dissection using transcranial Doppler in head-injured patientsPierre Bouzat
Department of Anesthesiology and Critical Care, Albert Michallon Hospital, 38000, Grenoble, France
Intensive Care Med 36:1514-20. 2010..We searched for criteria from transcranial Doppler (TCD) measurements on admission that could be associated with subsequent TICAD diagnosis in patients with traumatic brain injury (TBI)... - Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivativePierre Bouzat
INSERM, U836, Grenoble, F 38042, France
Crit Care Med 39:2099-105. 2011..To investigate the effects of carbamylated erythropoietin, a modified erythropoietin lacking erythropoietic activity, on brain edema and functional recovery in a model of diffuse traumatic brain injury... - Diagnostic accuracy of ultrasonography in the acute assessment of common thoracic lesions after traumaAnne Claire Hyacinthe
Pôle d Anesthésie Réanimation, Hopital Michallon, et Université Joseph Fourier, Grenoble, France
Chest 141:1177-83. 2012..The accuracy of combined clinical examination (CE) and chest radiography (CXR) (CE + CXR) vs thoracic ultrasonography in the acute assessment of pneumothorax, hemothorax, and lung contusion in chest trauma patients is unknown... - Duration of adrenal inhibition following a single dose of etomidate in critically ill patientsMarc Vinclair
Department of Anesthesiology and Critical Care, Albert Michallon Hospital, BP 217, 38043, Grenoble, France
Intensive Care Med 34:714-9. 2008..To determine the incidence and duration of adrenal inhibition induced by a single dose of etomidate in critically ill patients... - Diffusion tensor imaging of diffuse axonal injury in a rat brain trauma modelYohan Van de Looij
Grenoble Institute of Neuroscience, Research Center, INSERM U836 UJF CEA CHU, Grenoble, France
NMR Biomed 25:93-103. 2012.... - Measuring hemoglobin oxygen saturation during graded hypoxic hypoxia in rat striatumCécile Julien
INSERM UM 594, Neuroimagerie Fonctionelle et Metabolique, and Laboratoire de Spectrométrie Physique, Universite Joseph Fourier, and Département d anesthésie réanimation, Hopital Albert Michallon, Grenoble, France
Anesth Analg 102:565-70. 2006..SssO2 and LCBF measurements during graded hypoxic hypoxia indicate that changes in SstrO2 reflect primarily those in brain venous oxygenation... - Do patients still require admission to an intensive care unit after elective craniotomy for brain surgery?Ossam Rhondali
Department of Anesthesia and Critical Care, Michallon Hospital, and Joseph Fourier University, Grenoble, France
J Neurosurg Anesthesiol 23:118-23. 2011..We sought to identify predictors of postoperative complications to define perioperative conditions that would safely allow ICU bypass... - Erythropoietin protects from post-traumatic edema in the rat brainOlivier Verdonck
INSERM, U594, Grenoble, France
J Cereb Blood Flow Metab 27:1369-76. 2007..Further studies should be conducted to identify the biochemical mechanisms involved in these immediate effects and to assess the use of rhEpo as a possible therapy for post-traumatic brain edema... - Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressureGilles Francony
Department of Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
Crit Care Med 36:795-800. 2008..To compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HSS) in the treatment of patients with sustained elevated intracranial pressure (ICP)... - Focal brain ischemia in rat: acute changes in brain tissue T1 reflect acute increase in brain tissue water contentEmmanuel L Barbier
INSERM, Universite Joseph Fourier, UM 594, Neuroimagerie Fonctionnelle et Métabolique, Centre Hospitalier Universitaire Albert Michallon, 38043 Grenoble Cedex 9, France
NMR Biomed 18:499-506. 2005..3%). This suggests that there is an increase in tissue water content concomitant with cell swelling during the first hours of ischemia... - The effects of prolonged ambulation on labor with epidural analgesiaStephane Frenea
Department of Anesthesiology, Albert Michallon Hospital, BP 217, 38043 Grenoble, France
Anesth Analg 98:224-9. 2004..Whereas walking had no impact on either duration of labor or pain relief, it was associated with a reduction in both bupivacaine and oxytocin requirements... - Perfusion CT to quantify the cerebral vasospasm following subarachnoid hemorrhageVirginie Lefournier
Department of Neuroradiology, CHU Grenoble, University Joseph Fourier, BP 217, 38043 Grenoble Cedex 9, France
J Neuroradiol 37:284-91. 2010..The purpose of this study was to identify the best perfusion parameters in perfusion-CT (PCT) able to predict vasospasm diagnosed by angiography after SAH... - Intra-aortic balloon occlusion to salvage patients with life-threatening hemorrhagic shocks from pelvic fracturesThomas Martinelli
Department of Radiology and Medical Imaging, Grenoble University Hospital, Grenoble, France
J Trauma 68:942-8. 2010..The purpose of this study was to describe a blinded intra-aortic balloon occlusion (IABO) procedure in pelvic fractures (PF) for patients with critically uncontrollable hemorrhagic shock (CUHS)... - [Thromboprophylaxis in neurosurgery and head trauma]J-F Payen
, CHU de Grenoble, France
Ann Fr Anesth Reanim 24:921-7. 2005..There is no demonstrated benefit to begin a prophylaxis with LMWH before the intervention. The duration of the prophylaxis is 7 to 10 days but this has not been scientifically determined... - The interaction between magnetization transfer and blood-oxygen-level-dependent effectsJinyuan Zhou
Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
Magn Reson Med 53:356-66. 2005..The results offer a potential approach to measure absolute cerebral blood volume in vivo and to amplify the BOLD effects for fMRI studies... - Transcranial Doppler to detect on admission patients at risk for neurological deterioration following mild and moderate brain traumaPaul Jaffres
Department of Anaesthesiology and Critical Care Medicine, Albert Michallon Hospital, 38043 Grenoble, France
Intensive Care Med 31:785-90. 2005..Computed tomography and Doppler measurements could be combined to detect on admission patients at risk for secondary neurological deterioration in order to improve their initial disposition... - Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipidsPeter C M van Zijl
Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 49:440-9. 2003....