J M Pawlotsky

Summary

Country: France

Publications

  1. ncbi What technique should be used for routine detection and quantification of HBV DNA in clinical samples?
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 65:245-53. 1997
  2. pmc Serological determination of hepatitis C virus genotype: comparison with a standardized genotyping assay
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Clin Microbiol 35:1734-9. 1997
  3. ncbi GB virus C (GBV-C) infection in patients with chronic hepatitis C. Influence on liver disease and on hepatitis virus behaviour: effect of interferon alfa therapy
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Med Virol 54:26-37. 1998
  4. pmc Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol 72:2795-805. 1998
  5. ncbi Quantification of hepatitis C virus RNA in serum by branched DNA-based signal amplification assays
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 79:227-35. 1999
  6. ncbi Routine detection and quantification of hepatitis B virus DNA in clinical laboratories: performance of three commercial assays
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 85:11-21. 2000
  7. ncbi [The G virus: the orphan virus]
    J M Pawlotsky
    Service de Bacteriologie Virologie, Hopital Henri Mondor, Universite Paris XII, Creteil
    Presse Med 28:1882-3. 1999
  8. ncbi Diagnostic tests for hepatitis C
    J M Pawlotsky
    Department of Bacteriology and Virology and INSERM U99, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Hepatol 31:71-9. 1999
  9. ncbi Standardization of hepatitis C virus RNA quantification
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    Hepatology 32:654-9. 2000
  10. pmc Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    L Castera
    Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Universite Paris XII, Creteil, France
    Gut 52:288-92. 2003

Detail Information

Publications23

  1. ncbi What technique should be used for routine detection and quantification of HBV DNA in clinical samples?
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 65:245-53. 1997
    ..This study emphasizes the need for more sensitive, university standardised quantitative HBV DNA assays and for the definition of clinically relevant cutoffs with these assays...
  2. pmc Serological determination of hepatitis C virus genotype: comparison with a standardized genotyping assay
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Clin Microbiol 35:1734-9. 1997
    ..Subtyping of 1a and 1b is still not possible with the existing peptides, but discriminating between subtypes may not be necessary for routine use...
  3. ncbi GB virus C (GBV-C) infection in patients with chronic hepatitis C. Influence on liver disease and on hepatitis virus behaviour: effect of interferon alfa therapy
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Med Virol 54:26-37. 1998
    ..GBV-C is sensitive to 3 mega units of interferon alfa administered three times per week in two-thirds of the patients, but relapse is constant with this dosage after treatment withdrawal...
  4. pmc Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol 72:2795-805. 1998
    ....
  5. ncbi Quantification of hepatitis C virus RNA in serum by branched DNA-based signal amplification assays
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 79:227-35. 1999
    ..0 is not influenced by the HCV genotype. The relationship between values obtained with assays 1.0 and 2.0 on clinical specimens is not linear, indicating that HCV RNA titers cannot reliably be calculated from the results of version 1.0...
  6. ncbi Routine detection and quantification of hepatitis B virus DNA in clinical laboratories: performance of three commercial assays
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Virol Methods 85:11-21. 2000
    ..Given their respective performance, these three assays should be used in complementary fashion in the management of HBV-infected patients...
  7. ncbi [The G virus: the orphan virus]
    J M Pawlotsky
    Service de Bacteriologie Virologie, Hopital Henri Mondor, Universite Paris XII, Creteil
    Presse Med 28:1882-3. 1999
    ..To date, this virus has not been associated with acute or chronic hepatitis and as such hepatitis G virus is a misnomer. This orphelin virus is thus still looking for the right name and perhaps an induced pathology...
  8. ncbi Diagnostic tests for hepatitis C
    J M Pawlotsky
    Department of Bacteriology and Virology and INSERM U99, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Hepatol 31:71-9. 1999
    ....
  9. ncbi Standardization of hepatitis C virus RNA quantification
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    Hepatology 32:654-9. 2000
    ....
  10. pmc Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    L Castera
    Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Universite Paris XII, Creteil, France
    Gut 52:288-92. 2003
    ..The aim of the present study was to evaluate in patients with CHC and paired liver biopsies the relationship between the evolution of steatosis and that of fibrosis between the two biopsies...
  11. pmc Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, 94010 Creteil, France
    J Virol 73:6490-9. 1999
    ..These changes are associated with profound alterations of the natural outcome of HCV-related liver disease, raising the hypothesis of a causal relationship...
  12. doi Liver stiffness diminishes with antiviral response in chronic hepatitis C
    C Hezode
    Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Universite Paris Est, Creteil, France INSERM U955, Creteil, France
    Aliment Pharmacol Ther 34:656-63. 2011
    ..Transient elastography measures liver stiffness, which correlates with the hepatic fibrosis stage and has excellent accuracy for the diagnosis of cirrhosis in patients with chronic hepatitis C...
  13. pmc Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
    L Castera
    Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Gut 53:420-4. 2004
    ..To investigate this hypothesis, we studied the relationship between steatosis evolution and HCV clearance after antiviral treatment in patients with chronic hepatitis C and paired liver biopsies...
  14. pmc Impact of smoking on histological liver lesions in chronic hepatitis C
    C Hezode
    Department of Hepatology Gastroenterology, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Gut 52:126-9. 2003
    ..Total lifetime tobacco consumption was recorded as the number of cigarette packs smoked per year (packs-years). Liver biopsy specimens were graded for histological activity and fibrosis according to the METAVIR scoring system...
  15. ncbi Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections
    C Hezode
    Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Universite Paris XII, 94010 Creteil Cedex, France
    J Viral Hepat 11:455-8. 2004
    ..These findings suggest that steatosis is a cytopathic lesion induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se or at the usual in vivo expression levels...
  16. ncbi Low HCV replication levels in end-stage hepatitis C virus-related liver disease
    C Duvoux
    Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Hepatol 31:593-7. 1999
    ..To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched DNA (bDNA) assay...
  17. ncbi Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis: a prospective study
    C Hezode
    Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Aliment Pharmacol Ther 17:1031-7. 2003
    ..To evaluate the effects of minimal to moderate alcohol consumption on the severity of histological lesions in patients with chronic hepatitis C...
  18. doi Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    Christophe Hezode
    Assistance Publique Hopitaux de Paris, Henri Mondor Hospital, University of Paris 12 and INSERM Unité 955, Creteil, France
    N Engl J Med 360:1839-50. 2009
    ..Telaprevir is a specific inhibitor of the HCV serine protease and could be of value in HCV treatment...
  19. ncbi Hepatitis C virus population dynamics during infection
    J M Pawlotsky
    Service de Virologie, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Curr Top Microbiol Immunol 299:261-84. 2006
    ..HCV quasispecies variability also has therapeutic implications, as the continuous generation and selection of fitter or truly resistant variants can allow the virus to escape control by antiviral drugs...
  20. doi [Virologic techniques for the diagnosis and monitoring of hepatitis B]
    J M Pawlotsky
    Centre National de Référence des Hépatites B, C et delta, Laboratoire de Virologie, INSERM U841, Hopital Henri Mondor, Universite Paris 12, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Gastroenterol Clin Biol 32:S56-63. 2008
    ....
  21. ncbi Detection of genomic viral RNA in nerve and muscle of patients with HCV neuropathy
    F J Authier
    Groupe Nerf Muscle, Departement de Pathologie, Hopital Henri Mondor, Creteil, France
    Neurology 60:808-12. 2003
    ..MC may contain viral RNA, and tissues showing vasculitis may contain intracellular HCV. Local HCV replication remains to be evidenced...
  22. pmc Multicenter performance evaluation of a new TaqMan PCR assay for monitoring human immunodeficiency virus RNA load
    L Perrin
    Clinical Virology, University of Geneve, Switzerland, and Department of Bacteriology and Virology, Hopital Henri Mondor, Creteil, France
    J Clin Microbiol 44:4371-5. 2006
    ..These data indicate that the HPS-CTMHIV assay may be one of the tests of choice for monitoring viral load throughout the course of HIV infection and during highly active antiretroviral therapy...
  23. doi Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events
    M R Higgs
    Institut National de la Sante et de la Recherche Medicale INSERM, U955, Institut Mondor de Recherche Biomedicale, Creteil, France
    Oncogene 32:4683-93. 2013
    ..Together, these data provide a novel insight into the mechanisms involved in HCV-associated HCCs, strongly suggesting that c-Myc has a crucial contributory role in this process. ..