Christian Dina

Summary

Affiliation: Pasteur Institute
Country: France

Publications

  1. ncbi Comment on "A common genetic variant is associated with adult and childhood obesity"
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Science 315:187; author reply 187. 2007
  2. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
  3. ncbi New insights into the genetics of body weight
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Curr Opin Clin Nutr Metab Care 11:378-84. 2008
  4. ncbi Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    Nat Genet 41:157-9. 2009
  5. doi Effects of TCF7L2 polymorphisms on obesity in European populations
    Stephane Cauchi
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 16:476-82. 2008
  6. pmc Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits
    Amelie Bonnefond
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Diabetes 58:2687-97. 2009
  7. doi The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
    Helene Choquet
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 18:2495-501. 2009
  8. ncbi A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2
    David Meyre
    Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 8090, Institute of Biology of Lille, Pasteur Institute, Lille, France
    Diabetes 53:803-11. 2004
  9. pmc Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population
    Audrey Guerardel
    Institute of Biology CNRS UMR 8090, Pasteur Institute, Lille, France
    BMC Genet 6:19. 2005
  10. pmc Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8199, Institut Pasteur de Lille, Lille, France
    Diabetes 59:2662-71. 2010

Detail Information

Publications46

  1. ncbi Comment on "A common genetic variant is associated with adult and childhood obesity"
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Science 315:187; author reply 187. 2007
    ..We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity...
  2. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    ..The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses...
  3. ncbi New insights into the genetics of body weight
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Curr Opin Clin Nutr Metab Care 11:378-84. 2008
    ..In parallel, thanks to the increasing sequencing and genotyping capacities, large studies on rare mutations can now be carried out...
  4. ncbi Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    Nat Genet 41:157-9. 2009
    ..9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7))...
  5. doi Effects of TCF7L2 polymorphisms on obesity in European populations
    Stephane Cauchi
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 16:476-82. 2008
    ..Furthermore, our data suggest that the rs7903146 T allele may be possibly functional and associated with a nominal decrease in TCF7L2 expression in adipose tissue of individuals under calorie restriction...
  6. pmc Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits
    Amelie Bonnefond
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Diabetes 58:2687-97. 2009
    ..HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice...
  7. doi The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
    Helene Choquet
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 18:2495-501. 2009
    ..This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes...
  8. ncbi A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2
    David Meyre
    Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 8090, Institute of Biology of Lille, Pasteur Institute, Lille, France
    Diabetes 53:803-11. 2004
    ..01 [0.0027-0.0254]). Six independent ge-nome scans in adults have reported quantitative trait loci on 6q linked to energy or glucose homeostasis-associated phenotypes. Possible candidate genes in this region include SIM1, MCHR2, and PC-1...
  9. pmc Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population
    Audrey Guerardel
    Institute of Biology CNRS UMR 8090, Pasteur Institute, Lille, France
    BMC Genet 6:19. 2005
    ..The aim of this study was to evaluate the effect of polymorphisms within the CART gene with regards to a possible association with obesity in a Caucasian population...
  10. pmc Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8199, Institut Pasteur de Lille, Lille, France
    Diabetes 59:2662-71. 2010
    ..G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit. This study examines the contribution of two G6PC2 promoter SNPs, rs13431652 and rs573225, to the association signal...
  11. ncbi Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study
    Martine Vaxillaire
    UMR8090 and Institute of Biology, Lille 2 University, CNRS and Pasteur Institute, Lille, France
    Diabetes 57:244-54. 2008
    ..However, the relevance of these genes for disease prediction has not been extensively tested...
  12. ncbi Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
    Michael Benzinou
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 17:1916-21. 2008
    ..As CB1 is a drug target for obesity, a pharmacogenetic analysis of the endocannabinoid blockade obesity treatment may be of interest to identify best responders...
  13. ncbi TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis
    Stephane Cauchi
    CNRS, 8090, Institute of Biology, Pasteur Institute, Lille, 59000, France
    J Mol Med (Berl) 85:777-82. 2007
    ..In the near future, large-scale genome-wide association studies will fully extend the genome coverage, potentially delivering other common diabetes-susceptibility genes like TCF7L2...
  14. ncbi Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes
    Stephane Cauchi
    CNRS Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 55:2903-8. 2006
    ..These data provide evidence that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis...
  15. pmc Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
    Fanny Stutzmann
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2511-8. 2008
    ..However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown...
  16. doi A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Nabila Bouatia-Naji
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Nat Genet 41:89-94. 2009
    ..Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway...
  17. pmc Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 37:863-7. 2005
    ..These findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions...
  18. ncbi Fine mapping of a region on chromosome 8p gives evidence for a QTL contributing to individual differences in an anxiety-related personality trait: TPQ harm avoidance
    Christian Dina
    Génétique Maladies Multifactorielles Institut de Biologie de Lille, Lille, France
    Am J Med Genet B Neuropsychiatr Genet 132:104-8. 2005
    ..We hypothesize that this common genetic factor may contribute to emotional liability during early development, which constitutes a predisposing factor for major psychosis...
  19. pmc GAD2 on chromosome 10p12 is a candidate gene for human obesity
    Philippe Boutin
    Institute of Biology Centre National de la Recherche Scientifique, Pasteur Institute, Lille, France
    PLoS Biol 1:E68. 2003
    ..01, respectively). These data support the hypothesis of the orexigenic effect of GABA in humans and of a contribution of genes involved in GABA metabolism in the modulation of food intake and in the development of morbid obesity...
  20. ncbi Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes
    Mouna Barat-Houari
    Institute of Biology, Centre National de la Recherche Scientifique CNRS 80 90, Lille, France
    Diabetes 51:1640-3. 2002
    ..However, in French Caucasian morbidly obese subjects, the Isl1-47A-->G SNP may modulate the risk for type 2 diabetes and may increase body weight in diabetic morbidly obese subjects...
  21. pmc Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
    Yong Jun Liu
    School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Hum Mol Genet 17:1803-13. 2008
    ..Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO...
  22. ncbi A genome-wide association study identifies novel risk loci for type 2 diabetes
    Robert Sladek
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada
    Nature 445:881-5. 2007
    ..These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits...
  23. ncbi Common nonsynonymous variants in PCSK1 confer risk of obesity
    Michael Benzinou
    Genomic Medicine, Imperial College London, Hammersmith Hospital, London W120NN, UK
    Nat Genet 40:943-5. 2008
    ..27 x 10(-8) and P = 2.31 x 10(-12), respectively). Functional analysis showed a significant impairment of the N221D-mutant PC1/3 protein catalytic activity...
  24. ncbi Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients
    Sophie Marchal-Victorion
    INSERM U531, Institut Louis Bugnard, CHU Rangueil, Bat L3, 31403 Toulouse Cedex, France
    Pharmacogenetics 12:23-30. 2002
    ..Polymorphism or mutations in the CCK receptors may be involved in type 2 diabetes mellitus and obesity. However, further studies are necessary to precisely evaluate this role in humans...
  25. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  26. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  27. doi A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France
    Science 320:1085-8. 2008
    ..We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells...
  28. ncbi Genotype-by-nutrient interactions assessed in European obese women. A case-only study
    Jose L Santos
    Dept of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain
    Eur J Nutr 45:454-62. 2006
    ..Whereas changes in the environment appear to be responsible for the increasing prevalence of obesity, genetic factors interacting with environmental factors would contribute to explain obesity onset and severity...
  29. ncbi Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p
    Yasumichi Mori
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:1247-55. 2002
    ....
  30. ncbi Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
    Francis Vasseur
    CNRS 8090, Institut de Biologie de Lille, Institut Pasteur, and CHU Lille, France
    Hum Mol Genet 11:2607-14. 2002
    ....
  31. ncbi A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 2800 Winslow, Room 2110, Mail Code 5041, Cincinnati, OH 45229, USA
    Diabetes 51:3568-72. 2002
    ..Within the 1-LOD unit support interval, there are two strong candidates: PCSK1 and CAST. Furthermore, we have obtained a replication (LOD = 1.6) for a QTL for type 2 diabetes on chromosome 11 detected by Hanson and colleagues (1998)...
  32. ncbi A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity
    Timothy M Frayling
    Department of Diabetes and Vascular Medicine, Postgraduate School of Medicine and Health Science, University of Exeter, Exeter, U K
    Diabetes 52:872-81. 2003
    ..88 at 169-175 cM), and to chromosomes 3 (heterogeneity LOD [HLOD] score 1.27 at 124 cM) and 5 (HLOD score 1.22 at 175 cM) in 14 more strictly defined families. Our results provide evidence for further heterogeneity in MODY...
  33. ncbi A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes
    Florence Demenais
    EMI 0006, INSERM Universite d Evry, Evry, France
    Hum Mol Genet 12:1865-73. 2003
    ..This meta-analysis has led to identification of a novel region on chromosome 17 linked to type 2 diabetes; this region has not been highlighted in any published scan to date but on the basis of these data justifies further exploration...
  34. ncbi VNTR polymorphism of the insulin gene and childhood overweight in a general population
    Barbara Heude
    Institut National de la Sante et de la Recherche Medicale, Unité 258 IFR69, Faculte de Medecine Paris Sud, Villejuif, France
    Obes Res 12:499-504. 2004
    ..Our purpose was to analyze the association between this polymorphism and adiposity variability in an unselected population of children and adolescents in northern France...
  35. ncbi Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q
    Christopher G Bell
    Hammersmith Genome Centre and Department of Genomic Medicine, Hammersmith Hospital, Imperial College Faculty of Medicine, London, UK
    Diabetes 53:1857-65. 2004
    ..3-q21.3 (LOD = 2.68) and 10q24.32-26.2 (LOD = 2.47). Plausible positional candidate genes include NR1H2 and TULP2...
  36. ncbi Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians
    Emmanuelle Durand
    CNRS UMR8090, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 447 59021 Lille, France
    Diabetes 53:2483-6. 2004
    ..003 < P < 0.06). In conclusion, these data confirm an association of the SLC6A14 gene locus with obesity...
  37. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
    ..Thus, both functional and genetic analyses reveal that KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes...
  38. ncbi TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Stephane Cauchi
    Imperial College, Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:3189-92. 2006
    ..We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion...
  39. ncbi Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
    Takafumi Tsuchiya
    Departments of Medicine and Human Genetics, The University of Chicago, 5841 S Maryland Ave, MC1027, Chicago, IL 60637, USA
    Mol Genet Metab 89:174-84. 2006
    ..68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans...
  40. ncbi EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families
    Claire Cheyssac
    CNRS UMR 8090, Biology Institute and Pasteur Institute of Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille, France
    Diabetes 55:1171-6. 2006
    ..The potential role of EIF4A2 in glucose homeostasis and its putative contribution to type 2 diabetes in the presence of metabolic stress will require further investigation...
  41. ncbi Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population
    Kazuo Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:536-40. 2002
    ..Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes...
  42. ncbi Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population
    Martine Vaxillaire
    CNRS 8090, Institut de Biologie, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille, France
    Diabetes 55:856-61. 2006
    ..25 [95% CI 1.07-1.45], P = 0.0051). In conclusion, our data suggest a modest contribution of ADIPOR2 variants in diabetes risk in the French population...
  43. ncbi ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity
    Nabila Bouatia-Naji
    Centre National de la Recherche Scientifique UMR8090, Pasteur Institute of Lille, France
    Diabetes 55:545-50. 2006
    ..In summary, our study suggests that variations at the ACDC/adiponectin gene are associated with risk of severe forms of obesity. However, the mechanisms underlying these possible associations are not fully understood...
  44. ncbi A new locus for spinocerebellar ataxia (SCA21) maps to chromosome 7p21.3-p15.1
    Isabelle Vuillaume
    Unité Fonctionnelle de Neurobiologie, Laboratoire de Biochimie et Biologie Moleculaire, Hopital R Salengro, Centre Hospitalier Regional et Universitaire, Boulevard du Professeur Leclerc, 59037 Lille Cedex, France
    Ann Neurol 52:666-70. 2002
    ..3-p15.1. Analysis of key recombinants and haplotype reconstruction traced this novel spinocerebellar ataxia locus to a 24cM interval flanked by D7S2464 and D7S516...
  45. pmc AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance
    Rachel Bachner-Melman
    Department of Psychology, Mount Scopus, Hebrew University, Jerusalem, Israel
    PLoS Genet 1:e42. 2005
    ....
  46. ncbi Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21
    Ada H Zohar
    The Ruppin Institute of Higher Education, Emek Hefer 40250, Israel
    Am J Med Genet B Neuropsychiatr Genet 117:66-9. 2003
    ..We found evidence for linkage to TPQ HA at 8p21-23 (Lod score = 2.907) confirming in an independent sample the initial findings by Cloninger and his colleagues...