C Pasquier

Summary

Country: France

Publications

  1. ncbi request reprint Multicenter quality control of the detection of HIV-1 genome in semen before medically assisted procreation
    Christophe Pasquier
    Laboratoire de Virologie, laboratoire de Spermiologie et CECOS Midi Pyrénées, Toulouse University Hospital, Toulouse, France
    J Med Virol 78:877-82. 2006
  2. ncbi request reprint Genetic diversity of HCV genotype 2 strains in south western France
    Fabienne Thomas
    Service de Virologie, Hopital Purpan, CHU Toulouse, Toulouse Cedex, France
    J Med Virol 79:26-34. 2007
  3. doi request reprint Antiviral effect of maraviroc in semen: a case report
    Christophe Pasquier
    Laboratory of Virology, INSERM U1043, IFB, CHU de Toulouse, Université Paul Sabatier Toulouse 3, Toulouse, France
    Antivir Ther 17:933-6. 2012
  4. ncbi request reprint [Human T lymphotropic virus: from molecular epidemiology to disease]
    C Pasquier
    Faculté des Sciences Pharmaceutiques de Toulouse, France
    Med Trop (Mars) 64:511-6. 2004
  5. ncbi request reprint Virological exploration of individuals with discordant HIV screening tests
    C Pasquier
    Laboratoire de Virologie, Variabilité Virale, EA2046 IFR30, Place du Dr Baylac, Hopital Purpan, TSA 40031, F 31 059 Toulouse Cedex, France
    J Clin Virol 30:218-23. 2004
  6. ncbi request reprint Distribution and heterogeneity of hepatitis C genotypes in hepatitis patients in Cameroon
    Christophe Pasquier
    Laboratoire de Virologie, Variabilité Virale, Hopital Purpan, TSA, Toulouse, France
    J Med Virol 77:390-8. 2005
  7. doi request reprint Multicenter assessment of HIV-1 RNA quantitation in semen in the CREAThE network
    Christophe Pasquier
    Laboratory of Virology, CHU de Toulouse, Institut Fédératif de Biologie INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, France
    J Med Virol 84:183-7. 2012
  8. doi request reprint [Management of an HTLV-1 infected man in assisted reproductive technology]
    C Pasquier
    INSERM U1043, Laboratoire de Virologie, CHU de Toulouse, Toulouse, France
    Bull Soc Pathol Exot 104:203-4. 2011
  9. pmc Determining seminal plasma human immunodeficiency virus type 1 load in the context of efficient highly active antiretroviral therapy
    Christophe Pasquier
    Service de Virologie, CHU de Toulouse, Institut Fédératif de Biologie, TSA40031, 330 avenue de Grande Bretagne, Toulouse F 31059, France
    J Clin Microbiol 47:2883-7. 2009
  10. ncbi request reprint Intermittent detection of hepatitis C virus (HCV) in semen from men with human immunodeficiency virus type 1 (HIV-1) and HCV
    Christophe Pasquier
    Laboratoire de Virologie, UFR des Sciences Pharmaceutiques et Faculté de Médecine de Toulouse Purpan, Hopital Purpan, Toulouse, France
    J Med Virol 69:344-9. 2003

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Multicenter quality control of the detection of HIV-1 genome in semen before medically assisted procreation
    Christophe Pasquier
    Laboratoire de Virologie, laboratoire de Spermiologie et CECOS Midi Pyrénées, Toulouse University Hospital, Toulouse, France
    J Med Virol 78:877-82. 2006
    ..This first quality control highlights the need for technical improvements of the assays to detect and quantify HIV in semen fractions and for regular evaluation of their performance...
  2. ncbi request reprint Genetic diversity of HCV genotype 2 strains in south western France
    Fabienne Thomas
    Service de Virologie, Hopital Purpan, CHU Toulouse, Toulouse Cedex, France
    J Med Virol 79:26-34. 2007
    ..56.5 years, P < 0.01). This study shows substantial genetic diversity of HCV-2 subtypes in the south of France and the spread of 2a strains via intravenous drug users...
  3. doi request reprint Antiviral effect of maraviroc in semen: a case report
    Christophe Pasquier
    Laboratory of Virology, INSERM U1043, IFB, CHU de Toulouse, Université Paul Sabatier Toulouse 3, Toulouse, France
    Antivir Ther 17:933-6. 2012
    ..Adding maraviroc to HAART stopped the seminal shedding. We discuss the mechanisms involved and the effect on sexual transmission...
  4. ncbi request reprint [Human T lymphotropic virus: from molecular epidemiology to disease]
    C Pasquier
    Faculté des Sciences Pharmaceutiques de Toulouse, France
    Med Trop (Mars) 64:511-6. 2004
    ..Determinant factors for development of adult T cell leukemia (ATL) and tropical spastic paraparesis (TSP) are complex and treatment outcomes have been disappointing...
  5. ncbi request reprint Virological exploration of individuals with discordant HIV screening tests
    C Pasquier
    Laboratoire de Virologie, Variabilité Virale, EA2046 IFR30, Place du Dr Baylac, Hopital Purpan, TSA 40031, F 31 059 Toulouse Cedex, France
    J Clin Virol 30:218-23. 2004
    ..To compliment follow-up of HIV screening, early testing for HIV RNA could be useful to identify or eliminate a recent infection...
  6. ncbi request reprint Distribution and heterogeneity of hepatitis C genotypes in hepatitis patients in Cameroon
    Christophe Pasquier
    Laboratoire de Virologie, Variabilité Virale, Hopital Purpan, TSA, Toulouse, France
    J Med Virol 77:390-8. 2005
    ..HCV Genotypes 1 and 4 are very heterogeneous in Cameroon, perhaps due to ancient infections. The homogeneity of HCV Genotype 2 indicates its more recent introduction from western Africa...
  7. doi request reprint Multicenter assessment of HIV-1 RNA quantitation in semen in the CREAThE network
    Christophe Pasquier
    Laboratory of Virology, CHU de Toulouse, Institut Fédératif de Biologie INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, France
    J Med Virol 84:183-7. 2012
    ..Its use as a marker of global HAART efficiency in the HIV reservoir needs further study. Standardized assays are required for detection and measurement of HIV-1 RNA in semen samples...
  8. doi request reprint [Management of an HTLV-1 infected man in assisted reproductive technology]
    C Pasquier
    INSERM U1043, Laboratoire de Virologie, CHU de Toulouse, Toulouse, France
    Bull Soc Pathol Exot 104:203-4. 2011
    ..The sperm processing (centrifugation on density gradient) performed for semen of HIV-infected men was applied. Detection of HTLV-1 provirus DNA was negative before and after sperm processing, allowing ART...
  9. pmc Determining seminal plasma human immunodeficiency virus type 1 load in the context of efficient highly active antiretroviral therapy
    Christophe Pasquier
    Service de Virologie, CHU de Toulouse, Institut Fédératif de Biologie, TSA40031, 330 avenue de Grande Bretagne, Toulouse F 31059, France
    J Clin Microbiol 47:2883-7. 2009
    ..This highlights the residual risk of HIV-1 transmission during unprotected intercourse and raises the question of the possible consequences of ineffective highly active antiretroviral therapy in the genital tract...
  10. ncbi request reprint Intermittent detection of hepatitis C virus (HCV) in semen from men with human immunodeficiency virus type 1 (HIV-1) and HCV
    Christophe Pasquier
    Laboratoire de Virologie, UFR des Sciences Pharmaceutiques et Faculté de Médecine de Toulouse Purpan, Hopital Purpan, Toulouse, France
    J Med Virol 69:344-9. 2003
    ..The intermittent detection of HCV RNA in semen samples support the systematic search for HCV RNA in semen and the use of processed spermatozoa in assisted medical procreation of infertile HCV serodiscordant couples...
  11. ncbi request reprint Validation of an automated real-time PCR protocol for detection and quantitation of HIV and HCV genomes in semen
    Christophe Pasquier
    Laboratoire de Virologie, EA2046 IFR30, Hopital Purpan, 31059 Toulouse, France
    J Virol Methods 137:156-9. 2006
    ..This automated protocol permits a convenient, standardized testing for HIV and HCV in semen. The performance is the same as that of the previous generation of automated assays but the cost and operating time are both reduced...
  12. ncbi request reprint Decay of HIV-1 DNA in patients receiving suppressive antiretroviral therapy
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, Toulouse, France
    J Acquir Immune Defic Syndr Hum Retrovirol 19:478-83. 1998
    ..The findings suggest that, in addition to potent antiretroviral regimens, new strategies must be developed to ensure eradication of the latent reservoir of provirus, and hence of the virus itself...
  13. ncbi request reprint Quantification of HIV-1 proviral DNA by a standardized colorimetric PCR-based assay
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, Toulouse, France
    J Med Virol 54:54-9. 1998
    ..The reliability of this simple and convenient colorimetric PCR-based technique indicates its suitability for assessing the effect of current antiretroviral regimens on the latent reservoirs of provirus...
  14. ncbi request reprint Mutations conferring resistance to zidovudine diminish the antiviral effect of stavudine plus didanosine
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, Toulouse Cedex, France
    J Med Virol 59:507-11. 1999
    ..Cross-resistance between nucleoside analogues deserves maximal attention to ensure optimal antiretroviral therapy and design algorithms for antiretroviral management based on genotypic antiretroviral resistance testing...
  15. ncbi request reprint Intermittent selection pressure with zidovudine plus zalcitabine treatment reduces the emergence in vivo of zidovudine resistance HIV mutations
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, Toulouse, France
    J Med Virol 57:163-8. 1999
    ..001). No mutations conferring ddC resistance or multidideoxynucleoside resistance were observed in either group. These findings may have clinical implications for long-term treatment strategies...
  16. pmc Molecular evidence for mother-to-child transmission of multiple variants by analysis of RNA and DNA sequences of human immunodeficiency virus type 1
    C Pasquier
    Laboratoire de Virologie, Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Virol 72:8493-501. 1998
    ..We have thus described a particular case of vertical human immunodeficiency virus type 1 transmission with the transmission of multiple maternal variants to the infant and a rapid, fatal outcome in the child...
  17. ncbi request reprint Molecular evidence for nosocomial transmission of hepatitis C virus in a French hemodialysis unit
    J Izopet
    Laboratoire de Virologie, CHU Purpan, Toulouse, France
    J Med Virol 58:139-44. 1999
    ..This policy needs to be evaluated by large-scale prospective studies...
  18. ncbi request reprint Prevalence of drug resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection
    C Tamalet
    Laboratoire de Virologie, Hopital Timone, Marseille, France
    J Med Virol 61:181-6. 2000
    ..Other factors, such as adherence to treatment, tolerance and pharmacokinetics parameters are probably major determinants of virological response in patients with early therapeutic intervention...
  19. doi request reprint Analytical sensitivity of three real-time PCR assays for measuring subtype B HIV-1 RNA
    K Saune
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Clin Virol 57:80-3. 2013
    ..Commercial assays of HIV virus load now need to detect virus RNA concentrations below 50 c/ml and several of them have claimed a limit of detection (LOD) of 20-45 c/ml...
  20. ncbi request reprint Using RT-PCR and bDNA assays to measure non-clade B HIV-1 subtype RNA
    C Pasquier
    Laboratoire de Virologie, Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Virol Methods 81:123-9. 1999
    ..The new primers corrected the detection and quantification defect observed previously for HIV-1 non-B subtypes and gave slightly higher RNA concentrations than those measured using the bDNA assay (+0.39 log copies/ml)...
  21. pmc Automated extraction and quantification of human cytomegalovirus DNA in whole blood by real-time PCR assay
    C Mengelle
    Laboratoire de Virologie, CHU Toulouse, Toulouse, France
    J Clin Microbiol 41:3840-5. 2003
    ..This system may be very useful for monitoring of immune-suppressed and unsuppressed patients...
  22. ncbi request reprint Detection and quantitation of HCV RNA using real-time PCR after automated sample processing
    K Sandres-Saune
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Med Virol 79:1821-6. 2007
    ..89, P < 0.001). The mean difference [CAP/CTM-CAM] was 0.17 log IU/ml and it was not influenced by the HCV genotype or by the subtype. It is concluded that the new CAP/CTM system is adequate for quantifying HCV RNA in clinical practice...
  23. doi request reprint Evaluation of the QIAsymphony™ SP and Artus™ RealTime extraction-quantification systems for measuring HIV-1 virus load
    K Sandres-Saune
    INSERM U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Clin Virol 52:349-52. 2011
    ..The new Artus HIV-1 RealTime assay can be performed after automated extraction with the Qiagen Qiasymphony robot...
  24. ncbi request reprint Longitudinal analysis of hepatitis C virus replication and liver fibrosis progression in renal transplant recipients
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, Centre Hospitalier Universitaire CHU Toulouse 31059 Toulouse Cédex, France
    J Infect Dis 181:852-8. 2000
    ..Comparison of samples revealed that liver fibrosis progression was significantly associated with slower HVR-1 quasispecies diversification, suggesting the selection of more aggressive variants in fibrosers...
  25. ncbi request reprint Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen
    J Izopet
    Laboratoire de Virologie, Hopital Purpan, CHU Toulouse, France
    AIDS 14:2247-55. 2000
    ..To investigate the changes in genotypic drug-resistance pattern, plasma HIV RNA and CD4 cell count after treatment interruption and assess the short-term antiviral effect of a new salvage regimen...
  26. ncbi request reprint Determination of HCV genotype using two antibody assays and genome typing
    K Sandres
    Service de Virologie, Hĵpital Purpan, Toulouse, France
    Eur J Clin Microbiol Infect Dis 20:666-9. 2001
    ..The Murex enzyme immunoassay serotyping method was less sensitive for identifying genotype 2 (P<0.05). The concordance with genotyping of the RIBA serotyping method was lower for genotype 2 than for the other genotypes (P<0.05)...
  27. ncbi request reprint [HIV risk and procreation, how to reduce HIV and HCV transmission risk for serodiscordant couples?]
    C Pasquier
    Laboratoire de Virologie, Hopital Purpan, CHU de Toulouse, TSA 40031, 31059 Toulouse, France
    Med Mal Infect 35:S26-7. 2005
  28. ncbi request reprint Persistence of distinct HIV-1 populations in blood monocytes and naive and memory CD4 T cells during prolonged suppressive HAART
    Pierre Delobel
    Laboratory of Virology EA2046 IFR30, Toulouse University Hospital, France
    AIDS 19:1739-50. 2005
    ..There is therefore a need to clearly understand the molecular nature of the virus populations that persist in patients with sustained suppression of plasma viraemia on highly active antiretroviral therapy (HAART)...
  29. ncbi request reprint High rate of hepatitis C virus infection and predominance of genotype 4 among elderly inhabitants of a remote village of the rain forest of South Cameroon
    Richard Njouom
    Laboratoire de Virologie, Centre Pasteur du Cameroun, Yaounde, Cameroun, France
    J Med Virol 71:219-25. 2003
    ..The results suggest a cohort effect with an old, possibly iatrogenic, group exposure rather than a continuous exposure. A more in-depth population-based epidemiological study is needed to address this issue further...
  30. ncbi request reprint Determining hepatitis C genotype by analyzing the sequence of the NS5b region
    K Sandres-Saune
    Service de Virologie, Hopital Purpan, CHU, Toulouse, France
    J Virol Methods 109:187-93. 2003
    ..But analysis of the NS5b region may be more useful for tracing the source of an HCV infection...
  31. ncbi request reprint Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France
    Florence Nicot
    Service de Virologie, Hopital Purpan, EA2046 IFR30, CHU Toulouse, 31059 Toulouse Cedex, France
    J Gen Virol 86:107-14. 2005
    ..This study of a large cohort of patients shows the great diversity of HCV-4 strains, and that these subtypes have spread differently...
  32. ncbi request reprint Assessment of HIV-1 subtyping for Cameroon strains using phylogenetic analysis of pol gene sequences
    Richard Njouom
    Laboratoire de Virologie, CHU Toulouse Purpan, Place Dr Baylac, TAS40031 31059 Cedex, Toulouse, France
    J Virol Methods 110:1-8. 2003
    ..However, it can be a useful method for HIV-1 subtyping, provided that the gene is amplifiable...
  33. ncbi request reprint Low risk of mother-to-child transmission of hepatitis C virus in Yaounde, Cameroon: the ANRS 1262 study
    Richard Njouom
    Centre Pasteur du Cameroun, Yaounde, Cameroun Laboratoire de Virologie, CHU Toulouse Purpan, Toulouse, France
    Am J Trop Med Hyg 73:460-6. 2005
    ..None of those screened at 6 weeks and 6 months of age were HCV-RNA positive. The failure to detect HCV vertical transmission suggests that the mother-to-child transmission (MTCT) is not a major route of HCV transmission in Cameroon...
  34. ncbi request reprint Intermittent human immunodeficiency type 1 virus (HIV-1) shedding in semen and efficiency of sperm processing despite high seminal HIV-1 RNA levels
    Louis Bujan
    Centre d Etudes et de Conservation des Oeufs et du Sperme Humain, Midi Pyrénées and Research Group on Human Fertility, Service d Uro Andrologie, Hôpital La Grave, Toulouse, France
    Fertil Steril 78:1321-3. 2002
    ..In an HIV-1-infected man with intermittent seminal viral excretion, sperm processing was effective in obtaining spermatozoa without detectable HIV-1 genomes...
  35. ncbi request reprint Factors of intermittent HIV-1 excretion in semen and efficiency of sperm processing in obtaining spermatozoa without HIV-1 genomes
    Louis Bujan
    CECOS Midi Pyrénées, the Research Group on Human Fertility and the Fédération de Gynécologie Obstétrique, University Hospital Paule de Viguier, Toulouse, France
    AIDS 18:757-66. 2004
    ..To study the risk factors for HIV-1 in semen according to the localization of HIV-1 in sperm cell fractions and to assess the efficiency of sperm processing in obtaining spermatozoa without HIV-1 genomes...
  36. doi request reprint Genotypic prediction of HIV-1 subtype CRF01-AE tropism
    S Raymond
    Centre Hospitalier Universitaire de Toulouse, Laboratoire de Virologie, Toulouse, France
    J Int AIDS Soc 15:18156. 2012
    ..The genotypic prediction of HIV-1 subtype CRF01-AE coreceptor usage requires an optimized genotypic tool for a safely use of CCR5 antagonists...
  37. ncbi request reprint HIV-1 subtyping using phylogenetic analysis of pol gene sequences
    C Pasquier
    Laboratoire de Virologie, , Place Baylac, Toulouse, France
    J Virol Methods 94:45-54. 2001
    ..One potential advantage over env subtyping HMA is the ability to identify some circulating recombinant forms (CRFs)...
  38. pmc Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy
    Pierre Delobel
    Laboratoire de Virologie EA2046 IFR30, Centre Hospitalier Universitaire, TSA 40031, 31059 Toulouse Cedex 9, France
    J Virol 80:10229-36. 2006
    ..X4 viruses could play a role in the depletion of naïve T cells in poor immunological responders to HAART by triggering persistent T-cell activation and bystander apoptosis via gp120-CXCR4 interactions...
  39. ncbi request reprint Full-length genome sequences of hepatitis C virus subtype 4f
    Fatma Hmaied
    Service de Virologie, CHU de Toulouse, Institut Fédératif de Biologie, F 31059 Toulouse, France
    J Gen Virol 88:2985-90. 2007
    ..It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon...
  40. pmc New natural intergenotypic (2/5) recombinant of hepatitis C virus
    Florence Legrand-Abravanel
    Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave de Grande Bretagne, TSA 40031, 31059 Toulouse Cedex 9, France
    J Virol 81:4357-62. 2007
    ..Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses...
  41. ncbi request reprint Azoospermic HIV-1 infected patients wishing to have children: proposed strategy to reduce HIV-1 transmission risk during sperm retrieval and intracytoplasmic sperm injection: Case Report
    Louis Bujan
    Universite Toulouse III Paul Sabatier, Research Group on Human Fertility, EA 3694, Toulouse, France
    Hum Reprod 22:2377-81. 2007
    ..METHODS; Sperm obtained by micro-epididymal sperm aspiration was frozen after density gradient preparation and tested for HIV-RNA and DNA. ICSI with frozen sperm was performed...
  42. ncbi request reprint Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment
    Louis Bujan
    University Toulouse III Paul Sabatier, EA 3694, Research Group on Human Fertility, and CECOS Midi Pyrénées, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne, TSA 70034, 31059 Toulouse Cedex 9, France
    J Androl 28:444-52. 2007
    ..In HIV-1 patients, further longitudinal studies are required to analyze the impact of treatment regimen on sperm parameter alterations...
  43. ncbi request reprint Quantitation of human cytomegalovirus in recipients of solid organ transplants by real-time quantitative PCR and pp65 antigenemia
    Catherine Mengelle
    Laboratoire de Virologie, Hopital Purpan, CHU Toulouse, Toulouse, France
    J Med Virol 69:225-31. 2003
    ..The real-time Light Cycler quantitative PCR assay is a rapid and labour-saving technique. This molecular method could be useful for monitoring infections and antiviral treatment in recipients of solid organ transplants...
  44. ncbi request reprint Evolution of total and integrated HIV-1 DNA and change in DNA sequences in patients with sustained plasma virus suppression
    Jacques Izopet
    Laboratoire de Virologie, Hopital Purpan, CHU Toulouse, 31059 Toulouse Cedex, France
    Virology 302:393-404. 2002
    ....
  45. ncbi request reprint Genetic heterogeneity of the NS5A gene of hepatitis C virus and early response to interferon-alpha
    Anne Boulestin
    Laboratoire de Virologie, Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Infect Dis 188:1367-70. 2003
    ..5 log (early responders) were similarly analyzed. In the 2 groups, the PKRbd evolved similarly over the first 24 h. Selection of resistant HCV variants is unlikely to explain primary resistance to IFN-alpha...
  46. ncbi request reprint HIV therapy after treatment interruption in patients with multiple failure and more than 200 CD4+ T lymphocyte count
    Acil Jaafar
    Laboratoire de Virologie, Hopital Purpan, CHU Toulouse, Toulouse Cedex, France
    J Med Virol 74:8-15. 2004
    ..Randomised trials in this population are needed to assess the clinical benefit of this strategy...
  47. ncbi request reprint Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child
    Louis Bujan
    CECOS Midi Pyrénées and Research Group on Human Fertility Hôpital Paule de Viguier, Toulouse, France
    Fertil Steril 82:857-62. 2004
    ..To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program...
  48. ncbi request reprint R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective highly active antiretroviral therapy
    Pierre Delobel
    The Laboratory of Virology, Purpan University Hospital, Toulouse, France
    J Acquir Immune Defic Syndr 38:382-92. 2005
    ..These results suggest that potent antiretroviral therapy produces the conditions necessary for the gradual emergence of X4 variants in cellular reservoirs...
  49. ncbi request reprint Good efficiency of intrauterine insemination programme for serodiscordant couples with HIV-1 infected male partner: a retrospective comparative study
    Louis Bujan
    Universite Toulouse III Paul Sabatier, EA 3694, Research Group on Human Fertility, France
    Eur J Obstet Gynecol Reprod Biol 135:76-82. 2007
    ..The aim of this study was to investigate the efficiency of sperm washing and intrauterine insemination (IUI) in these couples...
  50. ncbi request reprint Evolution of human immunodeficiency virus type 1 populations after resumption of therapy following treatment interruption and shift in resistance genotype
    Jacques Izopet
    Laboratoire de Virologie, Hopital Purpan, Centre Hospitalier Universitaire Toulouse, 31059 Toulouse Cedex, France
    J Infect Dis 185:1506-10. 2002
    ....
  51. pmc Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae
    Henri Dabernat
    Laboratoire de Microbiologie, Centre national de reference des Haemophilus influenzae, Toulouse, France
    Antimicrob Agents Chemother 46:2208-18. 2002
    ..The level of resistance remains low but opens the way to greater resistance in the future...
  52. ncbi request reprint Incidence of HCV infection in French hemodialysis units: a prospective study
    Jacques Izopet
    Laboratoire de Virologie, Variabilité virale EA2046 IFR30, Hopital Purpan, CHU Toulouse, France
    J Med Virol 77:70-6. 2005
    ..Identifying new infections is crucial because alpha-IFN treatment results in long term clearance of HCV RNA in a large proportion of patients...
  53. doi request reprint Serum concentrations of ribavirin and pegylated interferon and viral responses in patients infected with HIV and HCV
    Florence Nicot
    INSERM, U 563, Toulouse, France
    J Med Virol 80:1523-9. 2008
    ..Thus ribavirin concentrations influence treatment outcome in HIV patients infected with HCV genotype 1 or 4. Monitoring ribavirin concentrations could help adapt ribavirin concentrations and improve the sustained virological response...
  54. doi request reprint Decrease of mitochondrial DNA level in sperm from patients infected with human immunodeficiency virus-1 linked to nucleoside analogue reverse transcriptase inhibitors
    Lynda Pavili
    Universite de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine EA 3694, Human Fertility Research Group, TSA 70034, CECOS Midi Pyrénées, Hôpital Paule de Viguier, Toulouse, France
    Fertil Steril 94:2151-6. 2010
    ..To study sperm parameters in patients infected with human immunodeficiency virus (HIV)-1 and to analyze mitochondrial DNA (mtDNA) in sperm according to the HIV treatment...
  55. ncbi request reprint Genetic heterogeneity of the envelope 2 gene and eradication of hepatitis C virus after a second course of interferon-alpha
    Anne Boulestin
    Laboratoire de Virologie, Hopital Purpan, Toulouse Cedex, France
    J Med Virol 68:221-8. 2002
    ....
  56. ncbi request reprint Virological and immunological effects of salvage therapy following treatment interruption and a shift in HIV-1 resistance genotype
    Jacques Izopet
    Laboratoire de Virologie, Hopital Purpan, CHU Toulouse, Place du Dr Baylac, Toulouse, France
    J Med Virol 68:305-10. 2002
    ..Treatment interruption could be useful for optimising salvage therapy for patients previously given many failing regimens. However, controlled trials are needed to assess the clinical benefit of this strategy...
  57. ncbi request reprint Ribavirin and pegylated interferon treatment for hepatitis C was associated not only with semen alterations but also with sperm deoxyribonucleic acid fragmentation in humans
    Stephane Pecou
    Human Fertility Research Group, Université Toulouse III Paul Sabatier EA 3694, Toulouse, France
    Fertil Steril 91:933.e17-22. 2009
    ..To report the effects of ribavirin plus pegylated interferon on semen parameters and sperm DNA integrity in a man given treatment for hepatitis C...
  58. doi request reprint No evidence of occult hepatitis C virus (HCV) infection in serum of HCV antibody-positive HCV RNA-negative kidney-transplant patients
    Florence Nicot
    INSERM, U563, Toulouse, France
    Transpl Int 23:594-601. 2010
    ..No biochemical or virologic relapse was seen during follow-up. The absence of HCV relapse in formerly HCV-infected immunocompromised patients suggests the complete eradication of HCV after its elimination while on dialysis...
  59. pmc Population-based sequencing of the V3 region of env for predicting the coreceptor usage of human immunodeficiency virus type 1 quasispecies
    Pierre Delobel
    Laboratoire de Virologie EA2046 IFR30, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    J Clin Microbiol 45:1572-80. 2007
    ....
  60. pmc HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy
    Maud Mavigner
    INSERM, U563, Toulouse, France
    PLoS ONE 4:e7658. 2009
    ....
  61. ncbi request reprint Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN
    Bénédicte Puissant
    Laboratoire d Immunogenetique moleculaire, Universite Paul Sabatier, faculté de médecine Toulouse Rangueil, Toulouse, France
    AIDS 19:627-30. 2005
    ..Our results suggest a slight protective effect of Lewis b antigen on HIV infection, possibly by the competition of Lewis antigens with HIV for binding to DC-SIGN...
  62. ncbi request reprint The hepatitis C virus epidemic in Cameroon: genetic evidence for rapid transmission between 1920 and 1960
    Richard Njouom
    Laboratoire de Virologie, Centre Pasteur du Cameroun, BP 1274 Yaounde, Cameroon
    Infect Genet Evol 7:361-7. 2007
    ....
  63. ncbi request reprint Hepatitis C virus infection among pregnant women in Yaounde, Cameroon: prevalence, viremia, and genotypes
    Richard Njouom
    Laboratoire de Virologie, Centre Pasteur du Cameroun, Yaounde, Cameroon
    J Med Virol 69:384-90. 2003
    ..The percentage of HCV seropositive pregnant women who had circulating HCV RNA was similar to that observed in Europe. Several HCV genotypes were found in Cameroon...
  64. ncbi request reprint Trying to avoid the transmission of human immunodeficiency virus particles in sperm ejaculates
    Louis Bujan
    Fertil Steril 87:1241; author reply 1241-2. 2007
  65. ncbi request reprint Determining the source of nosocomial transmission in hemodialysis units in Tunisia by sequencing NS5B and E2 sequences of HCV
    Fatma Hmaied
    Laboratoire de Microbiologie, Hopital Charles Nicolle, Tunis, Tunisia
    J Med Virol 79:1089-94. 2007
    ..Phylogenetic analysis of NS5b sequences is useful for determining the HCV genotype and providing evidence of nosocomial transmission...
  66. pmc Multicenter quality control for the detection of hepatitis C virus RNA in seminal plasma specimens
    Thomas Bourlet
    Laboratoire de Bacteriologie virologie, Unite de Pharmacologie Clinique, Faculte de Medecine, University of Saint Etienne, Saint Etienne, France
    J Clin Microbiol 41:789-93. 2003
    ..These results allowed us to validate standardized techniques adapted to the performance of this test on a routine basis, especially in men infected with HCV and involved in programs of medically assisted reproduction...
  67. ncbi request reprint A cost-effective algorithm for the diagnosis of Hepatitis C virus infection and prediction of HCV viremia in Cameroon
    Richard Njouom
    Laboratoire de Virologie, Centre Pasteur du Cameroun, Yaounde, Cameroon
    J Virol Methods 133:223-6. 2006
    ..These results suggest an algorithm using ImmunoComb II HCV as a first test to screen anti-HCV positive subjects, and Hexagon HCV as a second test to discriminate between viremic and non-viremic HCV seropositive subjects...
  68. ncbi request reprint Hepatitis C virus infection in cameroon: A cohort-effect
    Eric Nerrienet
    Centre Pasteur du Cameroun, Yaounde, Cameroun
    J Med Virol 76:208-14. 2005
    ..This clearly indicates a cohort effect for which the seroprevalence trends are clearly related with the year of birth, rather than the age. The highest prevalence was observed among people born around 1940...
  69. ncbi request reprint Choice of ART programme for serodiscordant couples with an HIV infected male partner
    Louis Bujan
    Hum Reprod 21:1332-3; author reply 1333-4. 2006
  70. ncbi request reprint Reproductive options for HIV-serodiscordant couples
    Louis Bujan
    Perspect Sex Reprod Health 34:104. 2002
  71. ncbi request reprint Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte counts
    Bénédicte Puissant
    Laboratoire d Immunogenetique moleculaire, Universite Paul Sabatier, faculté de médecine Toulouse Rangueil, 31062 Toulouse Cedex 04, France
    AIDS Res Hum Retroviruses 22:153-62. 2006
    ..04) than other patients. Moreover, we showed that the CX(3)CR1- 280M allele was associated with higher peripheral CD4+ T cell counts not only in HIV+ patients but also in healthy controls (p = 0.003)...