D Parent-Massin

Summary

Country: France

Publications

  1. doi request reprint In vitro myelotoxicity assessment of the emerging mycotoxins Beauvericin, Enniatin b and Moniliformin on human hematopoietic progenitors
    A S Ficheux
    Laboratoire de Toxicologie Alimentaire et Cellulaire, Université Européenne de Bretagne Université de Bretagne Occidentale UEB UBO, 6 Av Victor Le Gorgeu, CS93837, 29238 Brest Cedex 3, France
    Toxicon 59:182-91. 2012
  2. doi request reprint Stem cells in myelotoxicity
    D Parent-Massin
    Laboratoire de Toxicologie Alimentaire et Cellulaire, EA 3880, Université Européene de Bretagne, Universite de Brest, 29200 Brest, France
    Toxicology 267:112-7. 2010
  3. ncbi request reprint Relevance of clonogenic assays in hematotoxicology
    D Parent-Massin
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ESMISAB ISAMOR, Plouzane, France
    Cell Biol Toxicol 17:87-94. 2001
  4. ncbi request reprint Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor
    G Le Drean
    Laboratoire de Toxicologie Alimentaire, EA 3880, Universite de Bretagne Occidentale, Technopole Brest Iroise, 29280 Plouzane, France
    Toxicol In Vitro 19:1015-24. 2005
  5. ncbi request reprint T-2 toxin inhibits the differentiation of human monocytes into dendritic cells and macrophages
    N Hymery
    Food Toxicology Laboratory, EA 3880, UFR Sciences et Techniques, 6 avenue Le Gorgeu CS 93837 29238 Brest cedex 3, Brest University, France
    Toxicol In Vitro 23:509-19. 2009
  6. ncbi request reprint Simulation of automatic measurement of cell distribution inhomogeneity in clonogenic assays
    A C Roudot
    Ecole Supérieure de Microbiologie et de Sécurité Alimentaire de Brest, Technopole Brest Iroise, F 29280 Plouzane, France
    In Vitr Mol Toxicol 13:89-98. 2000
  7. ncbi request reprint Improvement of human dendritic cell culture for immunotoxicological investigations
    N Hymery
    Laboratoire de Toxicologie Alimentaire, Universite de Bretagne Occidentale, Technopole Brest Iroise, Plouzane, France
    Cell Biol Toxicol 22:243-55. 2006
  8. ncbi request reprint Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters?
    R Froquet
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopole Brest Iroise, 29280 Plouzane, France
    Mycopathologia 156:349-56. 2003
  9. ncbi request reprint Effect of Ochratoxin A on human haematopoietic progenitors proliferation and differentiation: an in vitro study
    R Froquet
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopole Brest Iroise, 29280 Plouzane, France
    Hum Exp Toxicol 22:393-400. 2003
  10. ncbi request reprint Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK)
    R Froquet
    , , ISAMOR, , France
    Hum Exp Toxicol 20:84-9. 2001

Collaborators

  • A C Roudot
  • A Pessina
  • R Froquet
  • N Hymery
  • Y Sibiril
  • I Malerba
  • A S Ficheux
  • G Le Drean
  • F Arnold
  • P Batina
  • L Gribaldo
  • R Le Garrec
  • B Rio
  • J L Jung
  • F G Carpentier
  • K Leon
  • M Auffret
  • D Arzur
  • S Casati
  • C Diodovich
  • A F Castoldi

Detail Information

Publications17

  1. doi request reprint In vitro myelotoxicity assessment of the emerging mycotoxins Beauvericin, Enniatin b and Moniliformin on human hematopoietic progenitors
    A S Ficheux
    Laboratoire de Toxicologie Alimentaire et Cellulaire, Université Européenne de Bretagne Université de Bretagne Occidentale UEB UBO, 6 Av Victor Le Gorgeu, CS93837, 29238 Brest Cedex 3, France
    Toxicon 59:182-91. 2012
    ..These in vitro effects may be responsible for in vivo hematological troubles in case of consumption of contaminated commodities. In vivo studies have to be performed to test this hypothesis...
  2. doi request reprint Stem cells in myelotoxicity
    D Parent-Massin
    Laboratoire de Toxicologie Alimentaire et Cellulaire, EA 3880, Université Européene de Bretagne, Universite de Brest, 29200 Brest, France
    Toxicology 267:112-7. 2010
    ..Clonogenic assays have been used to detect myelotoxicity induced by chemicals, drug, food and environmental contaminants. Designs and applications are described in this review...
  3. ncbi request reprint Relevance of clonogenic assays in hematotoxicology
    D Parent-Massin
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ESMISAB ISAMOR, Plouzane, France
    Cell Biol Toxicol 17:87-94. 2001
    ..Red blood cells progenitor culture (BFU-E) has been proposed but needs international validation to be recognized...
  4. ncbi request reprint Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor
    G Le Drean
    Laboratoire de Toxicologie Alimentaire, EA 3880, Universite de Bretagne Occidentale, Technopole Brest Iroise, 29280 Plouzane, France
    Toxicol In Vitro 19:1015-24. 2005
    ..The hematological effects observed in T-2 toxin mycotoxicosis could then be assigned to hematopoiesis inhibition by apoptosis. Different mechanisms that need to be further elucidated are involved in DON myelotoxicity...
  5. ncbi request reprint T-2 toxin inhibits the differentiation of human monocytes into dendritic cells and macrophages
    N Hymery
    Food Toxicology Laboratory, EA 3880, UFR Sciences et Techniques, 6 avenue Le Gorgeu CS 93837 29238 Brest cedex 3, Brest University, France
    Toxicol In Vitro 23:509-19. 2009
    ..These results show that T-2 toxin disturbs human monocytes differentiation process into macrophages and dendritic cells. These results could significantly contribute to immunosuppressive properties of this alimentary toxin...
  6. ncbi request reprint Simulation of automatic measurement of cell distribution inhomogeneity in clonogenic assays
    A C Roudot
    Ecole Supérieure de Microbiologie et de Sécurité Alimentaire de Brest, Technopole Brest Iroise, F 29280 Plouzane, France
    In Vitr Mol Toxicol 13:89-98. 2000
    ..The comparative tests are made on computer-generated images representing different cell distributions. Combining two of these three algorithms gives fairly good results on complex images created by adding various simple distributions...
  7. ncbi request reprint Improvement of human dendritic cell culture for immunotoxicological investigations
    N Hymery
    Laboratoire de Toxicologie Alimentaire, Universite de Bretagne Occidentale, Technopole Brest Iroise, Plouzane, France
    Cell Biol Toxicol 22:243-55. 2006
    ....
  8. ncbi request reprint Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters?
    R Froquet
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopole Brest Iroise, 29280 Plouzane, France
    Mycopathologia 156:349-56. 2003
    ..Due to the differences in sensitivities between mature blood cells and haematopoietic progenitors, haematological problems associated with trichothecene intoxication could be attributed to haematopoiesis inhibition...
  9. ncbi request reprint Effect of Ochratoxin A on human haematopoietic progenitors proliferation and differentiation: an in vitro study
    R Froquet
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopole Brest Iroise, 29280 Plouzane, France
    Hum Exp Toxicol 22:393-400. 2003
    ..For the lowest concentrations haematopoietic progenitor proliferation is not affected by OTA. Comparison with other mycotoxins known to be myelotoxic shows that OTA is less myelotoxic than trichothecenes...
  10. ncbi request reprint Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK)
    R Froquet
    , , ISAMOR, , France
    Hum Exp Toxicol 20:84-9. 2001
    ..Sensitivity of human CFU-MK is compared to respective sensitivities of human red blood cell progenitors (BFU-E) and white blood cell progenitors (CF-U-GM) that were described in previous works...
  11. ncbi request reprint Improvement of megakaryocytic progenitor culture for toxicological investigations
    R Froquet
    , , ISAMOR, , 29280, , France
    Toxicol In Vitro 15:691-9. 2001
    ..The CFU-MK culture conditions defined revealed their usefulness for investigating drug cytoxicity towards megakaryocytic progenitors and disturbance of their proliferation...
  12. ncbi request reprint Haematotoxicity of trichothecenes
    D Parent-Massin
    Laboratory of Food Toxicology EA, ESMISAB, West Brittany University, Technopole Brest Iroise, 29280 Plouzane, France
    Toxicol Lett 153:75-81. 2004
    ..Deoxynivalenol (DON) is the least myelotoxic and T-2 the most. As circulating blood cells present a less important sensitivity to these toxins, haematological troubles observed in toxicosis are due to myelotoxicity of these toxins...
  13. ncbi request reprint In vitro effects of trichothecenes on human dendritic cells
    N Hymery
    Laboratoire de Toxicologie Alimentaire, EA 3880 Université de Bretagne Occidentale, Technopôle Brest Iroise 29280 Plouzané, France
    Toxicol In Vitro 20:899-909. 2006
    ..These results suggest trichothecenes have adverse effects on dendritic cells and dendritic cell maturation process...
  14. ncbi request reprint Inhibition of CFU-E/BFU-E and CFU-GM colony growth by cyclophosphamide, 5-fluorouracil and taxol: development of a high-throughput in vitro method
    I Malerba
    Laboratory of Hematotoxicology, ECVAM, Institute for Health and Consumer Protection, J R C, Ispra, Italy
    Toxicol In Vitro 18:293-300. 2004
    ....
  15. ncbi request reprint In vitro effect of lead acetate on human erythropoietic progenitors
    B Rio
    , , ESMISAB/ISAMOR, , France
    Cell Biol Toxicol 17:41-50. 2001
    ....
  16. ncbi request reprint In vitro myelotoxicity of propanil and 3,4-dichloroaniline on murine and human CFU-E/BFU-E progenitors
    I Malerba
    Laboratory of Hematotoxicology, ECVAM, Institute for Health and Consumer Protection, J R C, Ispra 21020, Italy
    Toxicol Sci 69:433-8. 2002
    ..These data confirm the evidence that the compounds investigated interfere with erythroid colony formation at different stages of the differentiation pathway and have different effects according to the dose...
  17. ncbi request reprint Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
    A Pessina
    Institute of Microbiology, Milan, Italy
    Toxicol Sci 75:355-67. 2003
    ....