Valerie Paradis

Summary

Country: France

Publications

  1. doi request reprint Benign liver tumors: an update
    Valerie Paradis
    Pathology Department, Beaujon Hospital, 100 bd du Général Leclerc, 92118 Clichy Cedex, France
    Clin Liver Dis 14:719-29. 2010
  2. doi request reprint Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
    Valerie Paradis
    Pathology Department, Beaujon Hospital, 100 Boulevard du General Leclerc, Clichy 92118, France
    Gut 62:911-9. 2013
  3. doi request reprint Histopathology of hepatocellular carcinoma
    Valerie Paradis
    Departement of Pathology, Beaujon Hospital Assistance Publique Hôpitaux de Paris, Clichy, France
    Recent Results Cancer Res 190:21-32. 2013
  4. ncbi request reprint Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Gastroenterology 126:1323-9. 2004
  5. ncbi request reprint A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia
    Valerie Paradis
    Service d Anatomie Pathologique and Service de Chirurgie, Hopital Beaujon, Clichy, France
    Gastroenterology 124:651-9. 2003
  6. doi request reprint Definition and natural history of metabolic steatosis: histology and cellular aspects
    V Paradis
    Pathology Department, Beaujon hospital Clichy, 92118 Clichy Cedex, France
    Diabetes Metab 34:638-42. 2008
  7. pmc Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index
    Valerie Paradis
    Centre National de la Recherche Scientifique FRE 2443, Faculte de Pharmacie, Paris V, France
    Am J Pathol 163:733-41. 2003
  8. ncbi request reprint Telangiectatic adenoma: an entity associated with increased body mass index and inflammation
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 46:140-6. 2007
  9. ncbi request reprint Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases
    Valerie Paradis
    Faculte de Pharmacie, CNRS UMR 8149, Paris, France
    Hepatology 41:40-7. 2005
  10. ncbi request reprint Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin
    Valerie Paradis
    Service d anatomie pathologie, Hopital Beaujon, and CNRS UMR 8149, Clichy, France
    Gastroenterology 130:2189-97. 2006

Detail Information

Publications98

  1. doi request reprint Benign liver tumors: an update
    Valerie Paradis
    Pathology Department, Beaujon Hospital, 100 bd du Général Leclerc, 92118 Clichy Cedex, France
    Clin Liver Dis 14:719-29. 2010
    ..This article is dedicated to hepatocellular tumors and also addresses hemangiomas as the most common benign liver tumors, and angiomyolipomas as a rare tumor often misdiagnosed...
  2. doi request reprint Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
    Valerie Paradis
    Pathology Department, Beaujon Hospital, 100 Boulevard du General Leclerc, Clichy 92118, France
    Gut 62:911-9. 2013
    ..HCC related to MS may occur either in advanced fibrosis or before the development of cirrhosis, suggesting involvement of different molecular pathways according to the features of background liver...
  3. doi request reprint Histopathology of hepatocellular carcinoma
    Valerie Paradis
    Departement of Pathology, Beaujon Hospital Assistance Publique Hôpitaux de Paris, Clichy, France
    Recent Results Cancer Res 190:21-32. 2013
    ..Prognosis of HCC remains poor, depending on delayed tumor diagnosis, the clinical status of the patient but also tumor behavior with a great propensity for angioinvasion...
  4. ncbi request reprint Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Gastroenterology 126:1323-9. 2004
    ..Therefore, the aim of the present study was to reconsider the classification of telangiectatic FNH with the help of a molecular approach...
  5. ncbi request reprint A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia
    Valerie Paradis
    Service d Anatomie Pathologique and Service de Chirurgie, Hopital Beaujon, Clichy, France
    Gastroenterology 124:651-9. 2003
    ..To gain insight into the pathogenesis of FNH, we performed a large-scale quantitative study of gene expression in FNH...
  6. doi request reprint Definition and natural history of metabolic steatosis: histology and cellular aspects
    V Paradis
    Pathology Department, Beaujon hospital Clichy, 92118 Clichy Cedex, France
    Diabetes Metab 34:638-42. 2008
    ..In addition to the commonly seen histopathological patterns of lesions, additional changes are reported in patients with diabetes, including glycogenic hepatopathy and hepatic hepatosclerosis...
  7. pmc Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index
    Valerie Paradis
    Centre National de la Recherche Scientifique FRE 2443, Faculte de Pharmacie, Paris V, France
    Am J Pathol 163:733-41. 2003
    ..It might be useful to correctly diagnose borderline lesion or small well-differentiated hepatocellular carcinomas whose diagnosis is often difficult on a histopathological basis...
  8. ncbi request reprint Telangiectatic adenoma: an entity associated with increased body mass index and inflammation
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 46:140-6. 2007
    ..Serum biomarkers of inflammation were increased in 90% of patients (19 of 22). After surgical resection, inflammatory marker levels returned to normal values in all patients tested...
  9. ncbi request reprint Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases
    Valerie Paradis
    Faculte de Pharmacie, CNRS UMR 8149, Paris, France
    Hepatology 41:40-7. 2005
    ..In conclusion, global protein profiling is an efficient approach that enabled us to identify a catalytic fragment ofvitronectin as a new serum marker of HCC in patients with chronic liver diseases...
  10. ncbi request reprint Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin
    Valerie Paradis
    Service d anatomie pathologie, Hopital Beaujon, and CNRS UMR 8149, Clichy, France
    Gastroenterology 130:2189-97. 2006
    ..We used this approach to monitor the kinetics of serum proteome in patients with chronic hepatitis C virus infection receiving a standard bitherapy regimen to predict treatment response...
  11. ncbi request reprint Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..001). Five HCCs, all from the MS group, developed on a preexisting liver cell adenoma, with three of them showing typical histological features of telangiectatic adenoma...
  12. ncbi request reprint Effects and regulation of connective tissue growth factor on hepatic stellate cells
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Lab Invest 82:767-74. 2002
    ..In conclusion, this study extends the role of CTGF in HSC activation and suggests that CTGF up-regulation might be a central pathway during HSC activation...
  13. ncbi request reprint Clonal analysis of micronodules in virus C-induced liver cirrhosis using laser capture microdissection (LCM) and HUMARA assay
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, Paris, France
    Lab Invest 80:1553-9. 2000
    ..Because monoclonality is a marker of neoplasia, cirrhosis with accumulation of monoclonal nodules may be carefully followed, and monoclonal nodules should be screened for additional markers to assess their biological behavior...
  14. ncbi request reprint hTERT expression in sporadic renal cell carcinomas
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, UPRES EA 1602, Faculte de Medecine, Paris Sud, France
    J Pathol 195:209-17. 2001
    ..01); and thirdly, that no correlation was observed between c-myc mRNA level and hTERT mRNA level. In conclusion, these results support the involvement of telomerase in RCC and the potential interest of hTERT mRNA quantification...
  15. ncbi request reprint High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Hepatology 34:738-44. 2001
    ..In conclusion, this study suggests that hyperglycemia and insulin are key-factors in the progression of fibrosis in patients with NASH through the up-regulation of CTGF...
  16. pmc Quantitative gene expression in Budd-Chiari syndrome: a molecular approach to the pathogenesis of the disease
    V Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, 110 bd du général Leclerc, 92118 Clichy Cedex, France
    Gut 54:1776-81. 2005
    ..In order to gain further insight into the pathogenesis of BCS, we investigated expression of a set of genes involved in the course of chronic liver diseases...
  17. ncbi request reprint Glycomics: a new taste of cirrhosis marker
    Valerie Paradis
    Pathology Department, Beaujon Hospital, Clichy and CNRS UMR 8149, 4 avenue de l Observatoire, 75006 Paris, France
    J Hepatol 43:913-4. 2005
  18. pmc De novo expression of CD44 in prostate carcinoma is correlated with systemic dissemination of prostate cancer
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Paris, France
    J Clin Pathol 51:798-802. 1998
    ..To evaluate the role of CD44 in early steps in the development of prostate cancer, and to assess the biological significance of preneoplastic lesions in prostate cancer...
  19. ncbi request reprint Expression of the RNA component of human telomerase (hTR) in prostate cancer, prostatic intraepithelial neoplasia, and normal prostate tissue
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, Universite Paris Sud, France
    J Pathol 189:213-8. 1999
    ..Furthermore, this study confirms previous experimental data suggesting that the basal cell layer is the stem cell compartment in prostate...
  20. ncbi request reprint Expression of vascular endothelial growth factor in renal cell carcinomas
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Virchows Arch 436:351-6. 2000
    ..This study suggests that VEGF is involved in angiogenesis in conventional RCCs and appears to be a potential prognostic factor in these tumors...
  21. ncbi request reprint Role of replicative senescence in the progression of fibrosis in hepatitis C virus (HCV) recurrence after liver transplantation
    Viviane Trak-Smayra
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Transplantation 77:1755-60. 2004
    ....
  22. ncbi request reprint Quantitative RT-PCR in cirrhotic nodules reveals gene expression changes associated with liver carcinogenesis
    Magali Colombat
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    J Pathol 201:260-7. 2003
    ..The decrease in the expression level of one of these genes, LYVE1, was associated with monoclonality in cirrhotic nodules...
  23. doi request reprint Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis
    Rami Moucari
    AP HP, Hopital Beaujon, Service d Hepatologie, Clichy F 92110, France
    Gastroenterology 134:416-23. 2008
    ..Our study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients...
  24. ncbi request reprint In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C
    Tarik Asselah
    INSERM U773, Centre de Recherche CRB3, Paris, 75018, France
    J Pathol 221:264-74. 2010
    ..This lack of gene induction may be explained by the inhibiting action of HCV per se (as suggested by in vitro studies) and/or by our finding of the localized nature of hepatocyte ER stress...
  25. ncbi request reprint Percutaneous radiofrequency ablation for hepatocellular carcinoma before liver transplantation: a prospective study with histopathologic comparison
    Pierre Yves Brillet
    Department of Radiology, APHP Hôpital Beaujon, 100 Boulevard du General Leclerc, Clichy 92118, France
    AJR Am J Roentgenol 186:S296-305. 2006
    ..The aims of this study were to determine the feasibility and efficacy of percutaneous radiofrequency ablation in patients with hepatocellular carcinoma waiting for liver transplantation and to compare the radiologic and pathologic findings...
  26. ncbi request reprint Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C
    Tarik Asselah
    Service d hépatologie and INSERM CRB3, AP HP Hôpital Beaujon, University of Paris VII, Paris, France
    Gastroenterology 129:2064-75. 2005
    ....
  27. ncbi request reprint Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective study
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS UMR 8149, Clichy, France
    Hepatology 46:380-7. 2007
    ..In multivariate analysis, triglyceride and HDL cholesterol were predictors of NASH in patients with genotype 1, whereas in patients with genotype 3, AST was the only predictor...
  28. doi request reprint Complete regression of locally advanced hepatocellular carcinoma induced by sorafenib allowing curative resection
    Sabine Irtan
    Department of HBP Surgery, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France
    Liver Int 31:740-3. 2011
    ..These first two cases of complete tumour necrosis after sorafenib treatment allow us to reconsider surgical treatment in patients with unresectable HCC responding to this medical treatment...
  29. ncbi request reprint Underestimation of the influence of satellite nodules as a risk factor for post-transplantation recurrence in patients with small hepatocellular carcinoma
    Aurelie Plessier
    Hepatology Unit, Hopital Beaujon, Clichy, France
    Liver Transpl 10:S86-90. 2004
    ..In conclusion, microscopic satellite nodules are a significant predictive factor of tumor recurrence in patients transplanted for small hepatocellular carcinoma...
  30. ncbi request reprint Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection
    Ivan Bieche
    Laboratoire de Génétique Moléculaire UPRES EA 3618, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Virology 332:130-44. 2005
    ..Some of the genes identified here could form the basis for new approaches aimed at refining IFN-based therapies for chronic HCV infection...
  31. doi request reprint Neither preoperative computed tomography nor intra-operative examination can predict metastatic lymph node in the hepatic pedicle in patients with colorectal liver metastasis
    Cédric Rau
    Department of HPB Surgery, Beaujon Hospital, Clichy, France
    Ann Surg Oncol 19:163-8. 2012
    ..Efficiency of preoperative computed tomography (CT) and intraoperative examination for the diagnosis of metastatic LN of hepatic pedicle is prospectively evaluated...
  32. ncbi request reprint A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas
    Safi Dokmak
    Department of Hepatobiliopancreatic Surgery, University of Paris 7 and Beaujon Hospital, Clichy, France
    Gastroenterology 137:1698-705. 2009
    ..Patients with multiple forms of HA are difficult to manage. We evaluated the characteristics and outcome of 122 patients with single and multiple HAs after surgery...
  33. doi request reprint Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University of Paris 7, Assistance Publique Hopitaux de Paris, Beaujon Hospital, Clichy, France
    Mod Pathol 22:273-81. 2009
    ..Sampling variability should be taken into consideration as a potential limitation to the assessment of prognostic and therapeutic markers in biopsy samples from metastatic pancreatic endocrine tumors...
  34. ncbi request reprint Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer
    Eva Comperat
    CNRS UMR 8149, Faculte de Pharmacie, Paris V, Paris, France
    Urology 72:873-7. 2008
    ..We wanted to gain better insight into the early molecular mechanisms of bladder carcinogenesis by evaluating Aurora-A gene expression, which is implicated in genomic stability and essential for mitosis...
  35. pmc Significant gene expression differences in histologically "Normal" liver biopsies: Implications for control tissue
    Tarik Asselah
    Service d Hépatologie and Institut National de la Santé et de la Recherche Médicale INSERM U733, CRB3, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Hopital Beaujon, Clichy, France
    Hepatology 48:953-62. 2008
    ..In chronic hepatitis C liver samples, a lower or higher expression of a IL8 was found depending on whether the controls were obtained percutaneously or surgically...
  36. pmc SCG10 expression on activation of hepatic stellate cells promotes cell motility through interference with microtubules
    Valerie Paradis
    Department of Pathology, INSERM U773, the Serviced Hépatologie, Beaujon Hospital, AP HP, University Paris Diderot, Paris, France
    Am J Pathol 177:1791-7. 2010
    ..SCG10 may represent a potential molecular target for anti-fibrosis therapies...
  37. ncbi request reprint p63 gene expression study and early bladder carcinogenesis
    Eva Comperat
    CNRS UMR 8149, Faculté de Pharmacie Paris V, Paris, France
    Urology 70:459-62. 2007
    ....
  38. ncbi request reprint Global proteomic analysis of microdissected cirrhotic nodules reveals significant biomarkers associated with clonal expansion
    Nathalie Guedj
    CNRS UMR 8149, Faculte de Pharmacie, Paris V, Paris, France
    Lab Invest 86:951-8. 2006
    ..This study confirms that proteome analysis can be achieved from a limited number of microdissected cells, and provides further insight into the process of clonal expansion and malignant transformation of cirrhotic nodules...
  39. doi request reprint Accuracy and disagreement of computed tomography and magnetic resonance imaging for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: role of biopsy
    Thomas Sersté
    Assistance Publique Hopitaux de Paris, APHP Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 55:800-6. 2012
    ..There was a disagreement regarding imaging findings between CT and MRI in 21 of 74 (28%) patients and no washout on both examinations in 23 of 74 patients (31%). In these 44 patients, liver biopsy provided an initial accurate diagnosis...
  40. doi request reprint Liver fibrosis in chronic hepatitis C virus infection: differentiating minimal from intermediate fibrosis with perfusion CT
    Maxime Ronot
    Unit for Training and Research in Medicine, Universite Paris 7 Denis Diderot, Paris, France
    Radiology 256:135-42. 2010
    ..To prospectively assess the utility of perfusion computed tomography (CT) for differentiating minimal from intermediate fibrosis in treatment-naïve patients with chronic hepatitis C virus (HCV) infection...
  41. doi request reprint Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib
    Violaine Ozenne
    Departments of Hepatology, Hopital Beaujon, Clichy, AP HP, France
    Eur J Gastroenterol Hepatol 22:1106-10. 2010
    ..The aims of this study were (i) to evaluate the tolerance and survival of sorafenib-treated patients, in a nonselected population, especially in Child-Pugh B patients; and (ii) to identify potential prognostic factors of survival...
  42. doi request reprint Extended liver resection for polycystic liver disease can challenge liver transplantation
    Beatrice Aussilhou
    Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France
    Ann Surg 252:735-43. 2010
    ....
  43. pmc Changes in autophagic response in patients with chronic hepatitis C virus infection
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Am J Pathol 178:2708-15. 2011
    ..Neither genotype nor viral load influenced the autophagy level. In conclusion, autophagy is altered in hepatocytes from CHC patients, likely due to a blockade of the last step of the autophagic process...
  44. ncbi request reprint Genetics, genomics, and proteomics: implications for the diagnosis and the treatment of chronic hepatitis C
    Tarik Asselah
    Service d Hépatologie and INSERM U773, CRB3, University of Paris VII, AP HP Hôpital Beaujon, Clichy, France
    Semin Liver Dis 27:13-27. 2007
    ..This article reviews genetic, genomic, and proteomic aspects associated with the natural history of HCV infection (i.e., viral clearance, fibrosis progression) and the response to therapy...
  45. ncbi request reprint Transcriptional profiling of pure fibrolamellar hepatocellular carcinoma reveals an endocrine signature
    Gabriel G Malouf
    Department of Medical Oncology, Beaujon University Hospital and INSERM U728, Clichy, France
    Hepatology 59:2228-37. 2014
    ..PCSK1 overexpression was validated by immunohistochemistry, yielding specific, diffuse staining of the protein throughout the cytoplasm, possibly corresponding to a functional form of this convertase...
  46. ncbi request reprint Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas
    Nicolas Poté
    Pathology Department, Beaujon Hospital, Assistance Publique Hopitaux de Paris, Clichy, France
    Hepatology 58:983-94. 2013
    ..Both peaks were validated in the training cohort and in an independent validation cohort (n = 23) by immunohistochemistry and western blot...
  47. doi request reprint High sensitivity of diffusion-weighted MR imaging for the detection of liver metastases from neuroendocrine tumors: comparison with T2-weighted and dynamic gadolinium-enhanced MR imaging
    Gaspard d'Assignies
    Department of Radiology, Assistance Publique Hopitaux de Paris, Hopital Beaujon, 100 bd du Général Leclerc, 92110 Clichy, France
    Radiology 268:390-9. 2013
    ....
  48. ncbi request reprint Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas
    Xiao Ying Wang
    Service d Anatomie Pathologique Hôpital Beaujon, Clichy, France
    Hum Pathol 37:1435-41. 2006
    ..Our results also suggest that GPC3 may be considered as an early marker of liver carcinogenesis because it is able to identify some cirrhotic macronodules with malignant potential...
  49. doi request reprint Plasma proteome to look for diagnostic biomarkers of early bacterial sepsis after liver transplantation: a preliminary study
    Catherine Paugam-Burtz
    Department of Anesthesiology and Critical Care, University Hospital, Assistance Publique Hopitaux de Paris, Hopital Beaujon, Bd du Général Leclerc, Clichy, France
    Anesthesiology 112:926-35. 2010
    ..This study used plasma profiling coupling Proteinchip array with surface-enhanced laser desorption ionization time-of-fly mass spectrometry to search for biomarkers of postoperative sepsis in patients who underwent liver transplantation...
  50. doi request reprint Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification
    Maxime Ronot
    Department of Radiology, Hôpital Beaujon Clichy, France INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hepatology 53:1182-91. 2011
    ..Agreement between MRI findings and routine histological analysis was observed in 74.5%, leading to a likelihood ratio of subtype diagnosis higher than 20...
  51. doi request reprint Proteomic assessment of markers for malignancy in the mucus of intraductal papillary mucinous neoplasms of the pancreas
    Olivier Corcos
    Service de gastroentérologie et d assistance nutritive, Hopital Beaujon, France
    Pancreas 41:169-74. 2012
    ..The aims of this study were to look for candidate protein profiles in IPMN mucus according to histological grade, using a differential proteomic technique, and to highlight protein peaks associated with malignant transformation...
  52. ncbi request reprint Liver extracellular matrix in health and disease
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS FRE2443, Hopital de Bicetre, 78 Avenue Géneral Leclerc, 94275 Le Kremlin Bicetre, France
    J Pathol 200:504-15. 2003
    ..In addition to these experimental data, experience from chronic hepatitis C now allows the development of new concepts and perspectives such as liver fibrosis regression and antifibrotic therapies...
  53. ncbi request reprint Liver transplantation for hepatocellular carcinoma: role of biopsy
    Francois Durand
    Pôle des Maladies de l Appareil Digestif, Hepatology, Hospital Beaujon, Clichy, France
    Liver Transpl 13:S17-23. 2007
    ..Negative biopsy findings do not exclude the presence of HCC. Patients with negative biopsy findings should either undergo a second biopsy or an enhanced surveillance protocol...
  54. doi request reprint Liver tumours in patients with Fanconi anaemia: a report of three cases
    Violaine Ozenne
    Department of Hepatology, Hopital Beaujon, APHP, Clichy, France
    Eur J Gastroenterol Hepatol 20:1036-9. 2008
    ..With prolongation of survival, continued development of liver tumours can be expected. Routine detection should therefore be considered in these patients as curative resection can be performed...
  55. doi request reprint Diffusion-weighted and T2-weighted MR imaging for colorectal liver metastases detection in a rat model at 7 T: a comparative study using histological examination as reference
    Mathilde Wagner
    Laboratory of Physiological and Molecular Imaging of the Abdomen IPMA and Department of Radiology, University Paris Diderot, Sorbonne Paris Cité, INSERM UMR 773, University Hospitals Paris Nord Val de Seine, Beaujon, Assistance Publique Hopitaux de Paris, 100 Boulevard du General Leclerc, 92118, Clichy Cedex, France
    Eur Radiol 23:2156-64. 2013
    ..To compare diffusion-weighted (DW) and T2-weighted MR imaging in detecting colorectal liver metastases in a rat model, using histological examination as a reference method...
  56. doi request reprint In situ proteomic analysis by MALDI imaging identifies ubiquitin and thymosin-β4 as markers of malignant intraductal pancreatic mucinous neoplasms
    Vinciane Rebours
    Pancreatology Department, Beaujon Hospital, AP HP, Clichy, Paris Diderot University, France INSERM U773 CRB3, Paris Diderot University, Paris, France Electronic address
    Pancreatology 14:117-24. 2014
    ..The aim was to investigate the in situ IPMN proteome using MALDI (Matrix-Assisted Laser Desorption/Ionisation) imaging and to characterize biomarkers associated with the grade of dysplasia...
  57. ncbi request reprint Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes
    Aude Fregeville
    Service d Anatomie Pathologique, Clichy, France
    Gastroenterology 129:1150,1365. 2005
  58. ncbi request reprint The role of replicative senescence in chronic allograft nephropathy
    Sophie Ferlicot
    Department of Pathology, Bicetre Hospital, Universite Paris Sud, Le Kremlin Bicetre Cedex, France
    Hum Pathol 34:924-8. 2003
    ..These results suggest that replicative senescence is a mechanism that might be involved in the development of CAN. The age of the donor appears to be the major determinant factor in replicative senescence...
  59. doi request reprint Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
    Pierre Bedossa
    Assistance Publique Hopitaux de Paris, Beaujon Hospital, Pathology Department, Clichy, France
    Hepatology 56:1751-9. 2012
    ..In the validation series, the interobserver agreement for the diagnosis of NASH was excellent (κ = 0.80) between liver pathologists. There was no discrepancy between the initial diagnosis and the diagnosis proposed using the algorithm...
  60. pmc Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
    Viviane Trak-Smayra
    Department of Pathology, Saint Joseph University, Beirut, Lebanon
    Int J Exp Pathol 92:413-21. 2011
    ..Association between apoptosis and microvesicular steatosis in obese mice suggests common mitochondrial abnormalities. Enhanced hepatic FAO in db/db mice is associated with fibrosis aggravation...
  61. doi request reprint Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas
    Nathalie Guedj
    Department of Pathology, Beaujon Hospital, 100 Boulevard du General Leclerc, 92118 Clichy, France
    J Hepatol 51:93-101. 2009
    ..Hepatic cholangiocarcinomas are tumors with poor prognosis and with increasing incidence worldwide. The aim of the study was to compare morphological features and protein profiles of hilar and peripheral cholangiocarcinomas...
  62. doi request reprint Changing trends in malignant transformation of hepatocellular adenoma
    Olivier Farges
    Department of Hepato biliary Surgery, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Universite Paris 7, Clichy, France
    Gut 60:85-9. 2011
    ..HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this study was to characterise malignancy occurring within HCA...
  63. ncbi request reprint Approaches for treatment of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Department of Pathology, Service d Anatomie Pathologique, Hopital Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94725 Le Kremlin Bicêtre, France
    Clin Liver Dis 7:195-210. 2003
    ..It is likely that in the future, besides viral eradication, another treatment goal in chronic HCV infection will be to reverse existing fibrosis, but considerable work is necessary before making this a reality...
  64. ncbi request reprint Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH)
    Sophie Ferlicot
    Services d anatomie pathologique, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Pathol 200:661-6. 2003
    ..It is an easy, accurate, and reproducible in situ method for assessing telomeres in the context of cell type and tissue architecture...
  65. doi request reprint Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases
    Emilie Tissandié
    INSERM U699, Paris, France
    Kidney Int 80:1352-63. 2011
    ..Hence, common mechanisms appear to be shared by diseases of distinct origins, indicating that common environmental factors may influence the development of IgAN...
  66. doi request reprint Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: an intention-to-treat analysis
    David Fuks
    Department of Hepato pancreato biliary Surgery, Assistance Publique Hopitaux de Paris, Clichy, France Université Denis Didero, Paris 7, France
    Hepatology 55:132-40. 2012
    ..38 [range, 1.10-7.29]), satellite nodules (HR 2.46 [range, 1.01-6.68]), tumor size > 3 cm (HR 1.34 [range, 1.03-3.12]), poorly differentiated tumor (HR 3.18 [range, 1.31-7.70]), and liver cirrhosis (HR 1.90 [range, 1.04-3.12])...
  67. ncbi request reprint Dystroglycan expression in hepatic stellate cells: role in liver fibrosis
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, Universite Paris Sud, France
    Lab Invest 82:1053-61. 2002
    ..Dystroglycan interaction with laminin should be implicated in the concentration of pericellular laminin and in the constitution of a perisinusoidal basement membrane during liver fibrosis...
  68. doi request reprint Epithelial-to-mesenchymal transition and acquired resistance to sunitinib in a patient with hepatocellular carcinoma
    Hélène Marijon
    Department of Medical Oncology APHP, Beaujon University Hospital, Paris 7 Diderot, Clichy, France
    J Hepatol 54:1073-8. 2011
    ..Herein, we report translational data from a post-treatment surgical specimen in a patient who experienced acquired resistance to sunitinib...
  69. doi request reprint Obliterative portal venopathy: portal hypertension is not always present at diagnosis
    Dominique Cazals-Hatem
    Service d Anatomie Pathologique, Hôpital Beaujon AP HP, Clichy and Institut National de la Santé et de la Recherche Médicale U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Denis Diderot Paris 7, France
    J Hepatol 54:455-61. 2011
    ..Previous studies on obliterative portal venopathy (OPV) have been biased due to the selection of patients with non-cirrhotic portal hypertension. The aim of this study was to clarify the characteristics of OVP diagnosed by liver biopsy...
  70. doi request reprint [Pathology of cholangiocarcinoma]
    Nathalie Guedj
    Hopital Beaujon, Clichy, France
    Ann Pathol 30:455-63. 2010
    ..In this chapter, we will describe the different gross features and histological characteristic of CC and will detail the major histopronostic criteria of these tumors...
  71. doi request reprint High serum level of alpha-fetoprotein in focal nodular hyperplasia of the liver
    Wadad Mneimneh
    Pathology Department, Beaujon Hospital, Clichy, France
    Pathol Int 61:491-4. 2011
    ..These findings are concordant with the hypothesis that FNH is a regenerative process, and suggest that regenerative areas in the liver might be the source of AFP production...
  72. doi request reprint Preoperative liver hypertrophy induced by portal flow occlusion before major hepatic resection for colorectal metastases can be impaired by bevacizumab
    Beatrice Aussilhou
    Department of HPB Surgery, Beaujon Hospital, University Paris, Clichy, France
    Ann Surg Oncol 16:1553-9. 2009
    ..This prospective study evaluated the effect of bevacizumab on the hypertrophy of the future liver remnant (FLR) after portal vein occlusion (PVO) before major hepatectomy for colorectal liver metastases...
  73. ncbi request reprint The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study
    Jean Marie Trawalé
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Liver Int 30:725-32. 2010
    ..This retrospective, one-point-in-time study aimed to report the results of the analysis of renal biopsy specimens obtained in patients with cirrhosis...
  74. ncbi request reprint Acute pulmonary embolism: a rare complication of a large non-parasitic hepatic cyst
    Sophie Buyse
    Fédération d Hépato Gastroentérologie et INSERM U481, Service de Radiologie, Service d Anatomie Pathologique, Service de Chirurgie viscérale and Service de Médecine Interne, Hopital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 16:1241-4. 2004
    ..The patient was treated with heparin. Surgical evacuation of the cyst using the 'fenestration' technique was also performed. There was no recurrent pulmonary embolism or hepatic cyst during a 1-year follow-up period...
  75. ncbi request reprint Algorithm for immediate cytologic diagnosis of hepatic tumors
    Lawrence F Pupulim
    Service de Radiologie, Hopital Beaujon, Assistance Publique des Hopitaux de Paris, Universite Paris, 100, Blvd du Général Leclerc, 92110 Clichy, France
    AJR Am J Roentgenol 190:W208-12. 2008
    ..The purpose of this study was to analyze the diagnostic accuracy of on-site cytologic assessment compared with definitive cytologic examination in the detection and correct subtyping of malignant hepatic lesions...
  76. doi request reprint Selective portal vein ligation and embolization induce different tumoral responses in the rat liver
    Leon Maggiori
    Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique Hopitaux de Paris AP HP, Clichy, France
    Surgery 149:496-503. 2011
    ..Impact of such techniques on tumor growth is not well known. This experimental study aimed to assess impact of PVE and PVL on LM growth in a murine model of colorectal LM...
  77. ncbi request reprint Imaging mass spectrometry provides fingerprints for distinguishing hepatocellular carcinoma from cirrhosis
    Julie Le Faouder
    Institut Fédératif de Recherche Claude Bernard, Université Paris Diderot, Paris, France
    J Proteome Res 10:3755-65. 2011
    ..This approach might provide a new tool for diagnosis of difficult HCC cases and an opportunity for identifying candidate biomarkers...
  78. ncbi request reprint Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    ..Sampling variability becomes a major limitation when using more accurate methods such as automated image analysis...
  79. ncbi request reprint Progression of liver fibrosis in women infected with hepatitis C: long-term benefit of estrogen exposure
    Vincent Di Martino
    Service d Hepato Gastroenterologie, GH Pitié Salpétrière, Paris, France
    Hepatology 40:1426-33. 2004
    ..Pregnancies may have a beneficial impact on the long-term progression of liver fibrosis...
  80. doi request reprint Heat-zone effect after surface application of dissecting sealer on the "in situ margin" after tumorectomy for liver tumors
    Reza Kianmanesh
    Department of Hepato Pancreato Biliary Surgery and Transplantation, Beaujon Hospital APHP, University of Paris VII, Clichy, France
    J Am Coll Surg 206:1122-8. 2008
    ..The aim of this study was to evaluate the effect of surface application of a saline-linked dissecting sealer (TL) on the tumor bed that might contain residual microscopic tumor cells after resection (in situ margin)...
  81. ncbi request reprint Amanita phalloides poisoning: reassessment of prognostic factors and indications for emergency liver transplantation
    Luc Escudie
    Hepatology Unit and INSERM U773, Hospital Beaujon, Clichy, France
    J Hepatol 46:466-73. 2007
    ..Amanita phalloides poisoning is an uncommon cause of acute liver failure with an especially rapid course. The aim of this study was to re-assess transplantation criteria in patients with mushroom poisoning...
  82. ncbi request reprint Expression of epidermal growth factor receptor and proliferative activity of cyst epithelium in human renal cystic diseases
    Eva Comperat
    CNRS UMR 8149, and Service d Anatomie Pathologique, Centre Hospitalier Universitaire Bicêtre, Paris, France
    Urol Int 76:269-73. 2006
    ..EGF-r function and proliferative activity in cyst formation in PKD remains to be explored. EGF-r and Ki-67 expressions are not predictive of development of carcinoma in PKD...
  83. ncbi request reprint Hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: helical CT and MR imaging findings with clinical-pathologic comparison
    Riccardo Iannaccone
    Department of Radiology, Hopital Beaujon, Clichy, France
    Radiology 243:422-30. 2007
    ..To retrospectively evaluate the clinical, pathologic, and helical computed tomographic (CT) and magnetic resonance (MR) imaging findings of hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD)...
  84. ncbi request reprint [Regression of hepatic fibrosis physiopathological aspects and clinical reality]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA 8067, Hôpital Bicêtre Le Kremlin Bicêtre 94
    Presse Med 32:704-10. 2003
    ..Although these treatments have shown efficacy on experimental models of fibrosis, to date, there are no published results formally confirming the efficacy and safety of these treatments in man...
  85. ncbi request reprint Expression of connective tissue growth factor in experimental rat and human liver fibrosis
    V Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Hepatology 30:968-76. 1999
    ..In conclusion, this study shows that CTGF is strongly expressed during liver fibrogenesis, and hepatic stellate cells seem to be the major cellular sources of CTGF in the liver...
  86. ncbi request reprint Prevalence of sclerosing cholangitis in adults with autoimmune hepatitis: a prospective magnetic resonance imaging and histological study
    Maïté Lewin
    Department of Radiology, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Hepatology 50:528-37. 2009
    ..4; 95% confidence interval 1.4-4.7) and the percentage of patients with IHBD MRCP abnormalities was not different among F3-F4 AIH patients (n = 24) and cirrhotic controls (46% versus 59%; NS)...
  87. ncbi request reprint Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC
    Jessica Zucman-Rossi
    INSERM, U674, IUH, CEPH, Paris, France
    Hepatology 43:515-24. 2006
    ....
  88. ncbi request reprint Polymorphonuclear neutrophils are a source of hepatocyte growth factor in patients with severe alcoholic hepatitis
    Julien Taieb
    Hepatology Department, Pitie Salpetriere Hospital, 47, Boulevard de l Hopital, 75651, Cedex 13, Paris, France
    J Hepatol 36:342-8. 2002
    ..As AH is accompanied by inflammation, neutrophilia and polymorphonuclear neutrophil (PMN) infiltration of the liver, we postulated that PMN could be a source of HGF in such patients...
  89. ncbi request reprint Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
    V Paradis
    Service d'Anatomie Pathologique, , , France
    Hum Pathol 32:327-32. 2001
    ..Detection of replicative senescent cells may then serve as a predictive marker of a hepatocellular carcinoma in the surrounding tissue. HUM PATHOL 32:327-332...
  90. ncbi request reprint In situ detection of telomerase enzymatic activity in human hepatocellular carcinogenesis
    N Youssef
    Service d'Anatomie Pathologique, , , EA 1602, , , France
    J Pathol 194:459-65. 2001
    ..ISTRAP is a sensitive technique that allows the study of telomerase expression in the morphological context...
  91. pmc Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation
    C Francoz
    Hepatology Unit, Hospital Beaujon, 92110, Clichy, France
    Gut 54:691-7. 2005
    ..The aims of this study were: (a) to determine the prevalence of and risk factors for splanchnic vein thrombosis in cirrhotic patients awaiting transplantation and (b) to assess the usefulness of anticoagulation...
  92. doi request reprint Hepatocellular carcinoma--what's new?
    M P Vullierme
    Service de Radiologie, Hopital Beaujon, Clichy, France
    J Visc Surg 147:e1-12. 2010
    ..This efficacy is however still limited and its indication is therefore restricted to Child-Pugh A, OMS 0-2 patients in whom a potentially curative treatment is contraindicated...
  93. doi request reprint Serum proteomic profiling of obese patients: correlation with liver pathology and evolution after bariatric surgery
    V Trak-Smayra
    Centre de Recherche Biomédical Bichat Beaujon, INSERM U773, Paris, France
    Gut 58:825-32. 2009
    ..To date, diagnosis of steatosis and NASH relies on liver biopsy. The aim of the study was to identify serum markers of steatosis and NASH in obese patients using SELDI-TOF ProteinChip...
  94. ncbi request reprint Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms
    E Comperat
    Service Central d Anatomie et Cytologie Pathologiques et d Urologie, hôpital La Pitié Salpêtrière, 83, Bd de l Hopital, 75013, Paris, France
    Virchows Arch 450:419-24. 2007
    ..03 in the NILGC group. Aurora-A is a more sensitive marker than MIB-1 to predict relapse in pTa bladder neoplasias. The combination of both markers seems to have a very powerful predictive value of recurrence (p<0.001)...
  95. ncbi request reprint Impact of different combined preservation modalities on warm ischemic kidneys: effect on oxidative stress, hydrostatic perfusion characteristics and tissue damage
    Elodie Fabre
    Laboratoire de Chirurgie Expérimentale UPRES EA 1602, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Urol Res 30:89-96. 2002
    ..The reperfusion of HPP with UWCSS emphasises the stress initiated by CS. In addition an increase in damage occurred in the CS + HPP group...
  96. ncbi request reprint Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C
    R Morra
    UMR CNRS 8149, Pharmacy Faculty, Paris 5 University, Paris, and Biopredictive, Paris, France
    Aliment Pharmacol Ther 26:847-58. 2007
    ..FibroTest has been validated for the diagnosis of liver fibrosis in patients with chronic hepatitis C...
  97. ncbi request reprint [Is it useful to isolate a chromophobe cell variant among carcinomas of the kidney?]
    A Vieillefond
    Service d Anatomie Pathologique, CHU Bicetre, Le Kremlin Bicetre
    Arch Anat Cytol Pathol 40:250-4. 1992
    ....
  98. doi request reprint [Prognosis factors of cholangiocarcinoma: contribution of recent molecular biology tools]
    G Malouf
    Service d Oncologie Medicale, Hopital Beaujon, 100, boulevard du General Leclerc, 92118 Clichy Cedex, France
    Bull Cancer 96:405-15. 2009
    ..This 'protein/gene signature' could open the way for developing valid and reproducible predictors of survival based on protein or gene profiles...