Laurent Papazian

Summary

Country: France

Publications

  1. ncbi request reprint Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome
    Jean Marie Forel
    Réanimation Médicale, Assistance Publique Hopitaux de Marseille, Hopital Sainte Marguerite, Marseille, France
    Crit Care Med 34:2749-57. 2006
  2. pmc Symptoms of depression in ICU physicians
    Nathalie Embriaco
    Aix Marseille University, URMITE CNRS UMR 7278, 13005 Marseille, France APHM, Hopital Nord, Réanimation des détresses Respiratoires et des Infections sévères, 13015, Marseille, France
    Ann Intensive Care 2:34. 2012
  3. pmc Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy
    Jean Marie Forel
    Service de Réanimation des Détresses Respiratoires et Infections Sévères, Assistance Publique Hopitaux de Marseille, URMITE CNRS UMR 6236, Aix Marseille Univ, Marseille 13015, France
    Crit Care 16:R65. 2012
  4. pmc Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study
    Boris Jung
    Intensive Care Unit, Department of Anaesthesia and Critical Care, Saint Eloi Teaching Hospital, Universite Montpellier 1, 80 avenue Augustin Fliche, F 34295 Montpellier, Cedex 5, France
    Crit Care 15:R238. 2011
  5. ncbi request reprint Early antibiotic treatment for BAL-confirmed ventilator-associated pneumonia: a role for routine endotracheal aspirate cultures
    Fabrice Michel
    Réanimation Médicale, Hopital Sainte Marguerite, 13274 Marseille Cedex 9, France
    Chest 127:589-97. 2005
  6. doi request reprint Neuromuscular blockers in early acute respiratory distress syndrome
    Laurent Papazian
    Assistance Publique Hôpitaux de Marseille Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee Aix Marseille II, Marseille, France
    N Engl J Med 363:1107-16. 2010
  7. doi request reprint Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
  8. ncbi request reprint High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
  9. ncbi request reprint Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care Med 32:113-9. 2004
  10. ncbi request reprint Protective ventilation influences systemic inflammation after esophagectomy: a randomized controlled study
    Pierre Michelet
    Réanimation Polyvalente, Hopital Sainte Marguerite, 13274 Marseille Cedex 9, France
    Anesthesiology 105:911-9. 2006

Detail Information

Publications69

  1. ncbi request reprint Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome
    Jean Marie Forel
    Réanimation Médicale, Assistance Publique Hopitaux de Marseille, Hopital Sainte Marguerite, Marseille, France
    Crit Care Med 34:2749-57. 2006
    ..To evaluate the effects of neuromuscular blocking agents (NMBAs) on pulmonary and systemic inflammation in patients with acute respiratory distress syndrome ventilated with a lung-protective strategy...
  2. pmc Symptoms of depression in ICU physicians
    Nathalie Embriaco
    Aix Marseille University, URMITE CNRS UMR 7278, 13005 Marseille, France APHM, Hopital Nord, Réanimation des détresses Respiratoires et des Infections sévères, 13015, Marseille, France
    Ann Intensive Care 2:34. 2012
    ..abstract:..
  3. pmc Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy
    Jean Marie Forel
    Service de Réanimation des Détresses Respiratoires et Infections Sévères, Assistance Publique Hopitaux de Marseille, URMITE CNRS UMR 6236, Aix Marseille Univ, Marseille 13015, France
    Crit Care 16:R65. 2012
    ..We aimed to determine the incidence, outcome, and risk factors of bacterial VAP complicating severe ARDS in patients ventilated by using a strictly standardized lung-protective strategy...
  4. pmc Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study
    Boris Jung
    Intensive Care Unit, Department of Anaesthesia and Critical Care, Saint Eloi Teaching Hospital, Universite Montpellier 1, 80 avenue Augustin Fliche, F 34295 Montpellier, Cedex 5, France
    Crit Care 15:R238. 2011
    ..In this study, we sought describe the incidence and outcomes of severe metabolic or mixed acidemia in critically ill patients as well as the use of sodium bicarbonate therapy to treat these illnesses...
  5. ncbi request reprint Early antibiotic treatment for BAL-confirmed ventilator-associated pneumonia: a role for routine endotracheal aspirate cultures
    Fabrice Michel
    Réanimation Médicale, Hopital Sainte Marguerite, 13274 Marseille Cedex 9, France
    Chest 127:589-97. 2005
    ....
  6. doi request reprint Neuromuscular blockers in early acute respiratory distress syndrome
    Laurent Papazian
    Assistance Publique Hôpitaux de Marseille Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee Aix Marseille II, Marseille, France
    N Engl J Med 363:1107-16. 2010
    ..We evaluated clinical outcomes after 2 days of therapy with neuromuscular blocking agents in patients with early, severe ARDS...
  7. doi request reprint Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
    ..To assess the incidence, risk factors, and outcome of active cytomegalovirus (CMV) infection in nonimmunosuppressed intensive care unit (ICU) patients...
  8. ncbi request reprint High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  9. ncbi request reprint Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care Med 32:113-9. 2004
    ..To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome...
  10. ncbi request reprint Protective ventilation influences systemic inflammation after esophagectomy: a randomized controlled study
    Pierre Michelet
    Réanimation Polyvalente, Hopital Sainte Marguerite, 13274 Marseille Cedex 9, France
    Anesthesiology 105:911-9. 2006
    ..The aim of this study was to determine the effectiveness of a protective ventilatory strategy to reduce systemic inflammation in patients undergoing esophagectomy...
  11. ncbi request reprint Comparison of prone positioning and high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome
    Laurent Papazian
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Faculte de Medecine de Marseille, Universite de la Mediterranee, Marseille, France
    Crit Care Med 33:2162-71. 2005
    ..The aim of this study was to compare physiologic and proinflammatory effects of HFOV, prone positioning, or their combination in severe acute respiratory distress syndrome (ARDS)...
  12. ncbi request reprint A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients
    Laurent Papazian
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:755-62. 2007
    ..The aim of this study was therefore to determine the rate of contributive open-lung biopsy and whether it improved the prognosis of ARDS patients...
  13. pmc Influence of support on intra-abdominal pressure, hepatic kinetics of indocyanine green and extravascular lung water during prone positioning in patients with ARDS: a randomized crossover study
    Pierre Michelet
    Service de Réanimation Chirurgicale, hopitaux Sud, Marseille, France
    Crit Care 9:R251-7. 2005
    ..The aim of this study was to evaluate whether the type of support modifies IAP, extravascular lung water (EVLW) and the plasma disappearance rate of indocyanine green (PDRICG) during PP...
  14. ncbi request reprint Comparison of lung injury after normal or small volume optimized resuscitation in a model of hemorrhagic shock
    Antoine Roch
    hopitaux Sud, Service de Reanimation Medicale, 13274 Marseille Cedex 9, France
    Intensive Care Med 33:1645-54. 2007
    ..To compare lung injury induced by a hemorrhagic shock resuscitated with normal saline or with small volumes of a hypertonic/hyperoncotic solution...
  15. doi request reprint Molecular detection of microorganisms in distal airways of patients undergoing lung cancer surgery
    Xavier Benoit D'Journo
    Department of Thoracic Surgery and Diseases of the Esophagus, Aix Marseille University and Assistance Publique Hôpitaux de Marseille, Hopital Nord, Marseille, France
    Ann Thorac Surg 93:413-22. 2012
    ....
  16. doi request reprint FIO2 and acute respiratory distress syndrome definition during lung protective ventilation
    Jérôme Allardet-Servent
    Service de Reanimation Medicale, Hopital Sainte Marguerite, 270 boulevard Sainte Marguerite, 13274 Marseille Cedex 9, France
    Crit Care Med 37:202-7, e4-6. 2009
    ..A high FIO2 level has been reported to variably alter PaO2/FIO2. We investigated the effect of high FIO2 levels on the course of P/F in lung protective mechanically ventilated patients with acute respiratory distress syndrome...
  17. pmc Generation of a single pulmonary pressure-volume curve does not durably affect oxygenation in patients with acute respiratory distress syndrome
    Antoine Roch
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care 10:R85. 2006
    ....
  18. ncbi request reprint NH2 terminal pro-brain natriuretic peptide plasma level as an early marker of prognosis and cardiac dysfunction in septic shock patients
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Crit Care Med 33:1001-7. 2005
    ..To investigate N-terminal pro-brain natriuretic peptide (NT-proBNP) level as a prognostic factor and a marker of myocardial dysfunction in patients with septic shock...
  19. pmc Serologic prevalence of amoeba-associated microorganisms in intensive care unit pneumonia patients
    Sabri Bousbia
    Aix Marseille Universite, URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France
    PLoS ONE 8:e58111. 2013
    ..Amoeba-associated microorganisms (AAMs) are frequently isolated from hospital water networks and are reported to be associated to cases of community and hospital-acquired pneumonia...
  20. pmc Repertoire of intensive care unit pneumonia microbiota
    Sabri Bousbia
    URMITE, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, CNRS IRD UMR 6236, Marseille, France
    PLoS ONE 7:e32486. 2012
    ..Differences in the microbiota of different forms of pneumonia were documented...
  21. doi request reprint Pulmonary capillary blood flow and cardiac output measurement by partial carbon dioxide rebreathing in patients with acute respiratory distress syndrome receiving lung protective ventilation
    Jérôme Allardet-Servent
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Marseille Cedex 9, France
    Anesthesiology 111:1085-92. 2009
    ..The aim of this study was to investigate the agreement between partial rebreathing and thermodilution for the determination of pulmonary capillary blood flow and cardiac output in the setting of acute respiratory distress syndrome...
  22. doi request reprint Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia
    Sami Hraiech
    Aix Marseille Universite, URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France
    Antimicrob Agents Chemother 57:5120-1. 2013
    ..03]). ..
  23. pmc Phenotype and functions of natural killer cells in critically-ill septic patients
    Jean Marie Forel
    Faculte de Medecine, Aix Marseille Universite, URMITE UMR CNRS 7278, Marseille, France
    PLoS ONE 7:e50446. 2012
    ..Natural killer cells, as a major source of interferon-γ, contribute to the amplification of the inflammatory response as well as to mortality during severe sepsis in animal models...
  24. doi request reprint Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia
    Sami Hraiech
    Aix Marseille Univ, URMITE CNRS UMR 6236, 13005 Marseille, France
    J Antimicrob Chemother 67:2452-8. 2012
    ..We assessed its efficacy in reducing the lung bacterial load and histological lesions when given via inhalation in a rat model of chronic Pseudomonas aeruginosa pneumonia...
  25. pmc Tropheryma whipplei in patients with pneumonia
    Sabri Bousbia
    CNRS IRD Faculte de Medecine, Marseille, France
    Emerg Infect Dis 16:258-63. 2010
    ..We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia...
  26. ncbi request reprint Prone position and positive end-expiratory pressure in acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, Hôpitax Sud, Marseille, France
    Crit Care Med 31:2719-26. 2003
    ..To determine whether positive end-expiratory pressure (PEEP) and prone position present a synergistic effect on oxygenation and if the effect of PEEP is related to computed tomography scan lung characteristic...
  27. doi request reprint Airway colonisation and postoperative pulmonary complications after neoadjuvant therapy for oesophageal cancer
    Xavier Benoit D'Journo
    Department of Thoracic surgery and Diseases of the Oesophagus, Sainte Marguerite University Hospital, Marseille, France
    Eur J Cardiothorac Surg 33:444-50. 2008
    ..To evaluate the clinical relevance of preoperative airway colonisation in patients undergoing oesophagectomy for cancer after a neoadjuvant chemoradiotherapy...
  28. ncbi request reprint Risk of post-traumatic stress symptoms in family members of intensive care unit patients
    Elie Azoulay
    Service de Reanimation Medicale, Hopital Saint Louis, Paris, France
    Am J Respir Crit Care Med 171:987-94. 2005
    ..Intensive care unit (ICU) admission of a relative is a stressful event that may cause symptoms of post-traumatic stress disorder (PTSD)...
  29. doi request reprint Interferon-γ production by natural killer cells and cytomegalovirus in critically ill patients
    Laurent Chiche
    Réanimation Détresses Respiratoires et Infections Sévères, Assistance Publique Hopitaux de Marseille, URMITE CNRS UMR, Université Aix Marseille II, Marseille, France
    Crit Care Med 40:3162-9. 2012
    ..The current study was designed to evaluate the possible role of natural killer cells in the reactivation of cytomegalovirus in these patients...
  30. doi request reprint Right ventricular function during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome
    Christophe Guervilly
    Aix Marseille Universite, URMITE CNRS UMR, APHM, Hopital Nord, Reanimation, Marseille, France
    Crit Care Med 40:1539-45. 2012
    ..To evaluate the effect of mean airway pressure under high-frequency oscillatory ventilation on right ventricular function...
  31. ncbi request reprint Paralytics in critical care: not always the bad guy
    Jean Marie Forel
    Réanimation Médicale, Hopitaux de Marseille, URMITE CNRS UMR 6236, Universite de la Mediterranee, Marseille, France
    Curr Opin Crit Care 15:59-66. 2009
    ..This review analyzes the effects of NMBAs on thoracopulmonary mechanics, gas exchange, patient outcome and their potential adverse effects...
  32. doi request reprint Advances in Mimivirus pathogenicity
    Agnès Vincent
    Departement d Anesthesie Reanimation, Hopital de la Conception, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Marseille, France
    Intervirology 53:304-9. 2010
    ..Identification by PCR techniques remains difficult, probably because of the high level of polymorphism of nucleotide sequences of giant viruses. More studies are needed to confirm the clinical impact of Mimivirus in humans...
  33. doi request reprint Effect of hypertonic saline pre-treatment on ischemia-reperfusion lung injury in pig
    Antoine Roch
    Service de Reanimation, hopitaux Sud, Marseille, France
    J Heart Lung Transplant 27:1023-30. 2008
    ..This study investigated the effects of the pre-treatment by intravenous hypertonic saline in a pig model of single lung ischemia-reperfusion...
  34. ncbi request reprint High level of burnout in intensivists: prevalence and associated factors
    Nathalie Embriaco
    Medical Intensive Care Unit, Hôpital Sainte Marguerite Teaching Hospital, Universite de la Mediterranee, Marseille 13009, France
    Am J Respir Crit Care Med 175:686-92. 2007
    ..Professional burnout is a psychological syndrome arising in response to chronic interpersonal stressors on the job. There is the perception that intensivists are particularly exposed to stress because lives are literally in their hands...
  35. ncbi request reprint Burnout syndrome among critical care healthcare workers
    Nathalie Embriaco
    Intensive Care Unit, Saint Louis and Sainte Marguerite Teaching Hospitals, Assistance Publique Hopitaux de Paris, University Paris 7, Paris and Assistance Publique, Hopitaux de Marseille, Marseille, France
    Curr Opin Crit Care 13:482-8. 2007
    ..Because ICUs are characterized by a high level of work-related stress, a factor known to increase the risk of burnout syndrome, we sought to review the available literature on burnout syndrome in ICU healthcare workers...
  36. pmc Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit
    Antoine Roch
    Medical Intensive Care Unit, Hopital Nord, Chemin des Bourrely, Marseille 13015, France
    Crit Care 15:R36. 2011
    ..The aim of this study was to evaluate factors influencing short- and long-term survival in medical patients aged 80 and over following admission to an intensive care unit...
  37. ncbi request reprint Are clinical isolates of Pseudomonas aeruginosa more virulent than hospital environmental isolates in amebal co-culture test?
    Lukas Fenner
    Unite des Rickettsies, Service de Reanimation Medicale, Hopital Sainte Marguerite, Faculte de Medecine de Marseille, Universite de la Mediterranee, France
    Crit Care Med 34:823-8. 2006
    ..aeruginosa strains. In this study we have developed a simple amebal co-culture test with Acanthamoeba polyphaga to compare the virulence of P. aeruginosa between human and environmental isolates...
  38. ncbi request reprint High-frequency percussive ventilation attenuates lung injury in a rabbit model of gastric juice aspiration
    Jérôme Allardet-Servent
    Service de Reanimation Medicale, Hopital Sainte Marguerite, 270 boulevard Sainte Marguerite, 13274 Marseille Cedex 9, France
    Intensive Care Med 34:91-100. 2008
    ....
  39. ncbi request reprint Helium-oxygen reduces work of breathing in mechanically ventilated patients with chronic obstructive pulmonary disease
    Marc Gainnier
    Medical Intensive Care Unit, Hopital Sainte Marguerite, 13274 Marseille 9, France
    Intensive Care Med 29:1666-70. 2003
    ..To evaluate whether helium-oxygen mixture reduces inspiratory work of breathing (WOB) in sedated, paralyzed, and mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease (COPD)...
  40. ncbi request reprint Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Crit Care Med 32:811-7. 2004
    ....
  41. ncbi request reprint Perioperative risk factors for anastomotic leakage after esophagectomy: influence of thoracic epidural analgesia
    Pierre Michelet
    Departement d Anesthesie Reanimation, Marseille, France
    Chest 128:3461-6. 2005
    ..The aim of this study was to evaluate the influence of thoracic epidural analgesia (TEA) on the incidence of anastomotic leakage after esophagectomy...
  42. doi request reprint Evaluation of the diagnostic value of fluorescent in situ hybridization in a rat model of bacterial pneumonia
    Thérèse Atieh
    Aix Marseille Universite, URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, 13005 Marseille, France
    Diagn Microbiol Infect Dis 76:425-31. 2013
    ..4% and diagnostic accuracy: 96.7% versus 66.4%), whereas both approaches had 100% specificity. FISH could be useful especially on negative biopsies from patients with suspected infectious pneumonia. ..
  43. pmc Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig
    Antoine Roch
    Aix Marseille Univ, URMITE CNRS UMR 6236, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Crit Care 15:R219. 2011
    ..In the present study, we investigated the influence of hypovolaemic shock requiring fluid loading on the plasma and pulmonary pharmacokinetic parameters of caspofungin in the pig...
  44. pmc Ameba-associated microorganisms and diagnosis of nosocomial pneumonia
    Pierre Berger
    Centre Hospitalier Universitaire La Timone, Marseille, France
    Emerg Infect Dis 12:248-55. 2006
    ..This finding suggested its clinical relevance. Therefore, AAM might cause nosocomial pneumonia and should be suspected when conventional microbiologic results are negative...
  45. ncbi request reprint Cardiopulmonary effects of lipid emulsions in patients with ARDS
    Marion Faucher
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Chest 124:285-91. 2003
    ..Lipid emulsions have been suspected of inducing certain modifications in gas exchange and pulmonary hemodynamics. The aim of this prospective study was to evaluate the hemodynamic and pulmonary effects of two lipid emulsions...
  46. ncbi request reprint Usefulness of ultrasonography in predicting pleural effusions > 500 mL in patients receiving mechanical ventilation
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Chest 127:224-32. 2005
    ..To assess the accuracy of chest ultrasonography in predicting pleural effusions > 500 mL in patients receiving mechanical ventilation...
  47. doi request reprint The role of viruses in nosocomial pneumonia
    Laurent Chiche
    Réanimation Médicale, Assistance Publique Hopitaux de Marseille, URMITE CNRS UMR 6236, Universite de la Mediterranee, Marseille, France
    Curr Opin Infect Dis 24:152-6. 2011
    ..This review analyzes their place as causal pathogens in ventilator-associated pneumonia, as well as their effects on ICU patients' outcomes...
  48. ncbi request reprint [Crohn disease and abdominal tuberculosis: complications related to a diagnostic error]
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Marseille
    Presse Med 35:51-4. 2006
    ..We report the case of a patient with abdominal tuberculosis initially treated as Crohn disease...
  49. doi request reprint Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions
    Jessica Matta
    Centre d immunologie de Marseille Luminy, Institut National de la Sante et de la Recherche Medicale, Marseille Cedex 09, France
    Blood 122:394-404. 2013
    ..These findings reveal that B7-H6 is not only implicated in tumor immunosurveillance but also participates in the inflammatory response in infectious conditions...
  50. pmc Detection of plant DNA in the bronchoalveolar lavage of patients with ventilator-associated pneumonia
    Sabri Bousbia
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, CNRS IRD UMR 6236 198, Marseille, France
    PLoS ONE 5:e11298. 2010
    ..Herein, we found by molecular technique that vegetable and tobacco DNA may be detected in the bronchoalveolar lavage from patients with ventilator-associated pneumonia (VAP)...
  51. doi request reprint Clinical significance of a positive serology for mimivirus in patients presenting a suspicion of ventilator-associated pneumonia
    Agnès Vincent
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:111-8. 2009
    ..The aim of this study was to determine whether a positive serology for mimivirus was associated with increased morbidity and mortality in patients with a suspicion of ventilator-associated pneumonia (VAP)...
  52. doi request reprint The role of neuromuscular blockers in ARDS: benefits and risks
    Sami Hraiech
    Aix Marseille Univ, URMITE CNRS UMR 6236, France
    Curr Opin Crit Care 18:495-502. 2012
    ..However, their use remains controversial because the potential benefits of these agents are counterbalanced by possible adverse effects. This review summarizes advantages and risks of NMBAs based on the most recent literature...
  53. doi request reprint Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation
    Marie Kempf
    Faculte de Medecine et de Pharmacie, URMITE CNRS IRD, UMR, Aix Marseille Univ, France
    APMIS 121:64-71. 2013
    ..These results demonstrate a current evolution in the A. baumannii epidemiology in Marseille with a switch from an epidemic situation to an endemic situation and with several circulating clones...
  54. pmc High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome
    Christophe Guervilly
    Réanimation Médicale Détresses Respiratoires Aigües Infections Sévères, URMITE CNRS UMR 6236, Hopital Nord, Assistance Publique, Hopitaux de Marseille, Chemin des Bourrely, 13015 Marseille, France
    Crit Care 15:R31. 2011
    ..Their prognostic interest was also investigated...
  55. doi request reprint Extracorporeal membrane oxygenation for severe influenza A (H1N1) acute respiratory distress syndrome: a prospective observational comparative study
    Antoine Roch
    Service de Reanimation, Hopital Sainte Marguerite, hopitaux Sud, 13274, Marseille Cedex 9, France
    Intensive Care Med 36:1899-905. 2010
    ..To compare characteristics, clinical evolution and outcome in adult patients with influenza A (H1N1) acute respiratory distress syndrome (ARDS) treated with or without extracorporeal membrane oxygenation (ECMO)...
  56. doi request reprint Palliative noninvasive ventilation in patients with acute respiratory failure
    Elie Azoulay
    Service de Reanimation Medicale, APHP, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Intensive Care Med 37:1250-7. 2011
    ....
  57. pmc Fluid management in acute lung injury and ards
    Antoine Roch
    Réanimation Détresses Respiratoires et Infections Sévères, Hopital Nord, Marseille 13015, France
    Ann Intensive Care 1:16. 2011
    ..In this sense, the use of beta-2 agonists may be beneficial but further studies are needed to confirm preliminary promising results...
  58. ncbi request reprint Junior versus senior physicians for informing families of intensive care unit patients
    Delphine Moreau
    Service de Reanimation Medicale, Hopital Saint Louis, Paris, France
    Am J Respir Crit Care Med 169:512-7. 2004
    ..9 vs. 34.4%, p = 0.004). Specialty residents, if given opportunities for acquiring experience, can become proficient in communicating with families and share this task with senior physicians...
  59. ncbi request reprint Can the tomographic aspect characteristics of patients presenting with acute respiratory distress syndrome predict improvement in oxygenation-related response to the prone position?
    Laurent Papazian
    Polyvalent Intenstive Care Unit, Hopital Sainte Marguerite, Marseille, France
    Anesthesiology 97:599-607. 2002
    ..Therefore, we conducted a prospective study to identify computed tomographic scan aspects that could accurately predict who will respond to the prone position...
  60. ncbi request reprint Effects of helium-oxygen mixtures on endotracheal tubes: an in vitro study
    Patrick Gerbeaux
    Emergency Department, Hopital Conception, 147 Bd Baille, Marseille Cedex 5 13385, France
    J Biomech 38:33-7. 2005
    ..To determine flow pattern and critical Reynolds numbers in endotracheal tubes submitted to different helium-oxygen mixtures under laboratory conditions...
  61. ncbi request reprint Hemodynamics in experimental gastric juice induced aspiration pneumonitis
    Alain Fraisse
    Cardiologie Pediatrique, Departement de Cardiologie, Hopital de la Timone, 264 rue St Pierre, 13385, Marseille Cedex 5, France
    Intensive Care Med 33:300-7. 2007
    ..To characterize hemodynamic changes during experimental aspiration pneumonitis, paying special attention to echocardiographic assessment...
  62. doi request reprint Role of open-lung biopsy in acute respiratory distress syndrome
    Stéphane Yannis Donati
    Service de Reanimation Polyvalente, CH Font Pré, Toulon, France
    Curr Opin Crit Care 14:75-9. 2008
    ....
  63. ncbi request reprint Low-tidal-volume ventilation
    Laurent Chiche
    N Engl J Med 357:2518-9; author reply 2519-20. 2007
  64. ncbi request reprint Burnout syndrome in critical care nursing staff
    Marie Cecile Poncet
    Medical ICU, Saint Louis Hospital and Paris 7 University, Assistance Publique, Hopitaux de Paris, Paris, France
    Am J Respir Crit Care Med 175:698-704. 2007
    ..Burnout syndrome (BOS) associated with stress has been documented in health care professionals in many specialties. The intensive care unit (ICU) is a highly stressful environment. Little is known about BOS in critical care nursing staff...
  65. ncbi request reprint Long-term outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseilles, France
    Crit Care Med 31:2651-6. 2003
    ..To evaluate long-term survival and functional outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage...
  66. pmc Parachlamydiaceae as rare agents of pneumonia
    Gilbert Greub
    Emerg Infect Dis 9:755-6. 2003
  67. ncbi request reprint Ability of family members to predict patient's consent to critical care research
    Magali Ciroldi
    Medical Intensive Care Unit, AP HP, Saint Louis Teaching Hospital, Paris 7 University, Paris, France
    Intensive Care Med 33:807-13. 2007
    ..The accuracy with which surrogates consent to research on behalf of patients has not been evaluated in the intensive care unit (ICU)...
  68. ncbi request reprint Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
    Djillali Annane
    Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin, PRES UniverSud, Paris, France
    Lancet 370:676-84. 2007
    ..However, no large comparative trial has yet been done. We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock...
  69. ncbi request reprint How can earlier antibiotic efficacy be provided for ventilator-associated pneumonia without promoting bacterial resistance? Is initial monotherapy or a combination of antibiotics the right answer?
    Laurent Papazian
    Crit Care Med 36:994-5. 2008