C Pagnoux

Summary

Country: France

Publications

  1. ncbi Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients
    Pascal Cohen
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
    Arthritis Rheum 57:686-93. 2007
  2. doi A paradigm of diagnostic criteria for polyarteritis nodosa: analysis of a series of 949 patients with vasculitides
    Corneliu Henegar
    Hopital Cochin, Paris 5 René Descartes University, Assistance Publique Hopitaux de Paris, France
    Arthritis Rheum 58:1528-38. 2008
  3. ncbi [Cerebral vasculitis]
    C Pagnoux
    Pôle de Médecine Interne, centre de référence maladies rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, Universite Paris 5, Paris
    Rev Neurol (Paris) 164:F109-17. 2008
  4. doi Rituximab maintenance therapy for granulomatosis with polyangiitis and microscopic polyangiitis
    Claire Roubaud-Baudron
    Department of Internal Medicine, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    J Rheumatol 39:125-30. 2012
  5. ncbi Churg-Strauss syndrome
    Christian Pagnoux
    Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermies, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Curr Opin Rheumatol 19:25-32. 2007
  6. doi [Pregnancy and vasculitides]
    Christian Pagnoux
    Pôle de Médecine Interne, Centre de Référence Groupe I Maladies Rares, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris Cedex 14, France
    Presse Med 37:1657-65. 2008
  7. ncbi Churg-Strauss syndrome: evolving concepts
    Christian Pagnoux
    Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Discov Med 9:243-52. 2010
  8. doi Extraocular manifestations of birdshot chorioretinopathy in 118 French patients
    Christian Pagnoux
    Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
    Presse Med 39:e97-e102. 2010
  9. ncbi Vasculitides secondary to infections
    C Pagnoux
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5, Paris, France
    Clin Exp Rheumatol 24:S71-81. 2006
  10. doi Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 62:616-26. 2010

Collaborators

Detail Information

Publications86

  1. ncbi Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients
    Pascal Cohen
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
    Arthritis Rheum 57:686-93. 2007
    ..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)...
  2. doi A paradigm of diagnostic criteria for polyarteritis nodosa: analysis of a series of 949 patients with vasculitides
    Corneliu Henegar
    Hopital Cochin, Paris 5 René Descartes University, Assistance Publique Hopitaux de Paris, France
    Arthritis Rheum 58:1528-38. 2008
    ..To establish a set of clinical and paraclinical criteria potentially useful as a diagnostic screening tool for polyarteritis nodosa (PAN)...
  3. ncbi [Cerebral vasculitis]
    C Pagnoux
    Pôle de Médecine Interne, centre de référence maladies rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, Universite Paris 5, Paris
    Rev Neurol (Paris) 164:F109-17. 2008
  4. doi Rituximab maintenance therapy for granulomatosis with polyangiitis and microscopic polyangiitis
    Claire Roubaud-Baudron
    Department of Internal Medicine, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    J Rheumatol 39:125-30. 2012
    ....
  5. ncbi Churg-Strauss syndrome
    Christian Pagnoux
    Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermies, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Curr Opin Rheumatol 19:25-32. 2007
    ..The most recent clinical studies on its pathogenesis and therapeutic management are reviewed here...
  6. doi [Pregnancy and vasculitides]
    Christian Pagnoux
    Pôle de Médecine Interne, Centre de Référence Groupe I Maladies Rares, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris Cedex 14, France
    Presse Med 37:1657-65. 2008
    ....
  7. ncbi Churg-Strauss syndrome: evolving concepts
    Christian Pagnoux
    Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Discov Med 9:243-52. 2010
    ..Hence, progress is needed in Churg-Strauss syndrome's therapeutic management, and better understanding of the complex disease mechanisms may aid such a quest...
  8. doi Extraocular manifestations of birdshot chorioretinopathy in 118 French patients
    Christian Pagnoux
    Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
    Presse Med 39:e97-e102. 2010
    ..Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations...
  9. ncbi Vasculitides secondary to infections
    C Pagnoux
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5, Paris, France
    Clin Exp Rheumatol 24:S71-81. 2006
    ..In the near future, newer antiviral agents will probably also have their place in the therapeutic armamentarium for these patients...
  10. doi Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 62:616-26. 2010
    ..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses...
  11. ncbi [Wegener's granulomatosis]
    Christian Pagnoux
    Service de Medecine Interne, Centre de référence national maladies rares, vascularites nécrosantes et sclérodermies, Hopital Cochin, AP HP, université Paris V René Descartes, Paris, France
    Presse Med 36:860-74. 2007
    ..Today, however, they are reserved for refractory cases...
  12. doi Churg-Strauss syndrome: evidence for disease subtypes?
    Christian Pagnoux
    Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Curr Opin Rheumatol 22:21-8. 2010
    ..Conversely, physiopathogenetic mechanisms are not completely elucidated and clearly multiple, thereby suggesting the existence of different disease subtypes...
  13. doi Remittent non-destructive polysynovitis in P-ANCA-positive vasculitis patients with anti-CCP antibodies
    Christian Pagnoux
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75879 Paris cedex 14, France
    Joint Bone Spine 77:604-7. 2010
    ....
  14. ncbi Atherosclerosis in ANCA-associated vasculitides
    Christian Pagnoux
    Department of Internal Medicine, French National Referral Center for Necrotizing Vasculitides and Systemic Sclerodermas, Hopital Cochin, Universite Paris 5 Rene Descartes, Paris, France
    Ann N Y Acad Sci 1107:11-21. 2007
    ..Until their precise identification, it remains important to take into consideration and treat, every time it is necessary and possible, the other well-known cardiovascular risk factors...
  15. doi Reporting of corticosteroid use in systemic disease trials: evidence from a systematic review of the potential impact on treatment effect
    Christian Pagnoux
    INSERM U738, Universite Paris Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Care Res (Hoboken) 62:1002-8. 2010
    ..To study how corticosteroid therapy is planned and described in reports of systemic disease trials and estimate the impact of the between-arm difference in corticosteroid dose on treatment effect...
  16. doi Encrusting cystitis due to Corynebacterium urealyticum in a patient with ANCA-associated vasculitis: case report and review of the literature
    Christian Pagnoux
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Semin Arthritis Rheum 41:297-300. 2011
    ..The relevant literature on this infection is reviewed...
  17. doi Pregnancies in systemic necrotizing vasculitides: report on 12 women and their 20 pregnancies
    Christian Pagnoux
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Universite Paris Descartes, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rheumatology (Oxford) 50:953-61. 2011
    ..To describe pregnancies of women with systemic necrotizing vasculitides (SNVs), i.e. PAN, WG, Churg-Strauss syndrome (CSS) or microscopic polyangiitis (MPA), followed over the past 15 years at four French centres...
  18. doi Wegener's granulomatosis strictly and persistently localized to one organ is rare: assessment of 16 patients from the French Vasculitis Study Group database
    Christian Pagnoux
    Department of Internal Medicine, Hopital Cochin, 75879 Paris cedex 14, France
    J Rheumatol 38:475-8. 2011
    ..To study the frequency and characteristics of patients with Wegener's granulomatosis (WG) strictly and persistently localized to one organ...
  19. ncbi [Wegener's granulomatosis and microscopic polyangiitis]
    Christian Pagnoux
    Centre de référence maladies auto immunes et maladies systémiques rares, vascularites nécrosantes et sclérodermie systémique, Pôle de médecine, Hopital Cochin, Universite Paris 5, Paris
    Rev Prat 58:522-32. 2008
    ..Ten-year survival rate now exceeds 80%, but relapses are frequent. The precise place of new biologics, such as rituximab, needs to be further defined...
  20. ncbi Plasma exchange for systemic lupus erythematosus
    Christian Pagnoux
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Rene Descartes, Paris, 27, rue du Faubourg Saint Jacques, 75689 Paris Cedex 14, France
    Transfus Apher Sci 36:187-93. 2007
    ..The use of newer technologies, like immunoadsorption, possibly in combination with recent biologics, might, in the future, offer some new perspectives for extracorporeal therapy of systemic lupus erythematosus...
  21. ncbi [Wegener's granulomatosis]
    C Pagnoux
    Centre de référence national maladies rares Groupe I, groupe français d étude des vascularites, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rev Med Interne 28:S261-2. 2007
  22. ncbi Therapeutic strategies for systemic necrotizing vasculitides
    Loic Guillevin
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, université Paris René Descartes, Paris, France
    Allergol Int 56:105-11. 2007
    ..Some of them have achieved promising positive effects, for example, anti-CD20 monoclonal antibodies, and are now being evaluated in prospective trials...
  23. ncbi [Microscopic polyangiitis]
    Christian Pagnoux
    Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
    Presse Med 36:895-901. 2007
    ..Biological therapies are under evaluation. The remission rate is above 80% with these regimens, and the relapse rate is around 30% at 5 years, lower than for Wegener's granulomatosis...
  24. doi Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological features
    B Ranque
    Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Cochin Hospital, Faculty of Medicine, Paris Descartes University, the Public Assistance Hospitals of Paris AH HP, France
    Scand J Rheumatol 39:498-505. 2010
    ..Little is known about systemic sclerosis (SSc)-related myopathy. We aimed to compare the clinical and immunological features of SSc patients with or without associated myopathy...
  25. doi Risk factors for major infections in Wegener granulomatosis: analysis of 113 patients
    C Charlier
    Department of Internal Medicine, Hopital Cochin, Universite Paris Descartes, Faculte de Medicine, UPRES EA 4058, Assistance Publique Hopitaux de Paris, Paris Cedex 14, France
    Ann Rheum Dis 68:658-63. 2009
    ..To characterise major infectious complications and analyse potential risk factors in patients with Wegener granulomatosis (WG)...
  26. doi Impact of digital ulcers on disability and health-related quality of life in systemic sclerosis
    L Mouthon
    Paris Descartes University, Department of Internal Medicine, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 69:214-7. 2010
    ..To assess the impact of digital ulcers (DUs) on disability and health-related quality of life (HRQoL) in systemic sclerosis (SSc)...
  27. ncbi Primary angiitis of the central nervous system
    A Neel
    Department of Internal Medicine, Hotel Dieu, Centre Hospitalier Universitaire de Nantes, France
    Clin Exp Rheumatol 27:S95-107. 2009
    ..Only multicenter studies and prospective therapeutic trials will be able to clarify these issues on therapy and eventually provide some data on PACNS physiopathogenesis, which remains a poorly explored domain...
  28. ncbi Adjunction of rituximab to steroids and immunosuppressants for refractory/relapsing Wegener's granulomatosis: a study on 8 patients
    B Brihaye
    French Vasculitis Study Group, Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Clin Exp Rheumatol 25:S23-7. 2007
    ..But the frequency of and time to responses to rituximab, and its effects on various clinical WG manifestations remain to be thoroughly evaluated...
  29. doi Infliximab efficacy and safety against refractory systemic necrotising vasculitides: long-term follow-up of 15 patients
    L Josselin
    Department of Internal Medicine, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 67:1343-6. 2008
    ..However, its safety and ability to induce and maintain remission over the long term remain unknown...
  30. ncbi Impact of cardiac magnetic resonance imaging for assessment of Churg-Strauss syndrome: a cross-sectional study in 20 patients
    J Marmursztejn
    Department of Cardiology, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris, France
    Clin Exp Rheumatol 27:S70-6. 2009
    ..To examine the diagnostic contributions of cardiac magnetic resonance imaging (CMRI) with delayed-enhancement (DE) in patients with Churg-Strauss syndrome (CSS)...
  31. doi A descriptive and prognostic study of systemic sclerosis-associated myopathies
    B Ranque
    Universite Paris Descartes, UPRES EA 4058, Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Hopital Cochin, Assistance Publique des Hopitaux de Paris, Paris, France
    Ann Rheum Dis 68:1474-7. 2009
    ..To describe the clinical characteristics and muscle pathological features of patients with systemic sclerosis (SSc) and myopathy and analyse their impact on muscle outcome...
  32. doi Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Rheum 58:586-94. 2008
    ....
  33. pmc Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts
    Christian Pagnoux
    Hopital Cochin, AP HP, UNIVERSITE DE PARIS, Paris, France
    Arthritis Rheum 58:2908-18. 2008
    ..This study was undertaken to evaluate the applicability of those predictors in an independent cohort followed up by the French Vasculitis Study Group...
  34. doi High frequency of venous thromboembolic events in Churg-Strauss syndrome, Wegener's granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients
    Y Allenbach
    The National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Department of Internal Medicine, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Ann Rheum Dis 68:564-7. 2009
    ..To determine the frequency and risk factors of venous thromboembolic events (VTE) in Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and, the so far unstudied, Churg-Strauss syndrome (CSS) and polyarteritis nodosa (PAN)...
  35. doi The oxidation induced by antimyeloperoxidase antibodies triggers fibrosis in microscopic polyangiitis
    P Guilpain
    Laboratoire d Immunologie, EA, UPRES 1833, Pôle de Médecine Interne et CentreNational de Référence pour lesVascularites Nécrosantes et laSclérodermie Systémique, UniversitéParis Descartes, Faculté deMédecine, Pavillon Gustave Roussy, 4e Etage, Hopital Cochin, 8 rue Mechain, 75014, Paris, France
    Eur Respir J 37:1503-13. 2011
    ..Oxidative stress, in particular the production of HOCl through the interaction of MPO with anti-MPO antibodies, could trigger the fibrotic process observed in MPA...
  36. ncbi Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP)
    Jean Benoit Arlet
    Department of Internal Medicine, Faculty of Medicine, Cochin Hospital, Paris Descartes University, Assistance Publique Hopitaux de Paris, AP HP, Paris, France
    Neuromuscul Disord 16:334-6. 2006
    ..A marked response was observed in both patients, with partial to complete recovery of muscle strength, which was sustained...
  37. doi Pulmonary fibrosis associated with ANCA-positive vasculitides. Retrospective study of 12 cases and review of the literature
    B Hervier
    Department of Internal Medicine, CHU Nantes 44093, France
    Ann Rheum Dis 68:404-7. 2009
    ..To describe the clinical presentation of the association between pulmonary fibrosis (PF) and systemic vasculitis related to antineutrophil cytoplasmic antibodies (ANCA-V)...
  38. ncbi [Endobronchial stenosis in Wegener's granulomatosis]
    B Hervier
    Service de Medecine Interne, CHU Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex, France
    Rev Med Interne 27:453-7. 2006
    ..Endobronchial stenoses are rare in the course of Wegener's granulomatosis, and they occur even more rarely than subglottic stenoses...
  39. ncbi When should immunosuppressants be prescribed to treat systemic vasculitides?
    Loic Guillevin
    Service de Medecine Interne, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
    Intern Med 42:313-7. 2003
    ..The new therapeutic strategies comprise also new immunosuppressants and new immunomodulating agents which could replace or be associated to the "older drugs"...
  40. ncbi Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome
    Régis Sablé-Fourtassou
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Ann Intern Med 143:632-8. 2005
    ..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied...
  41. pmc Vasculitis restricted to the lower limbs: a clinical and histopathological study
    M Khellaf
    Service de Medecine Interne, Hopital Henri Mondor, Universite Paris XII, France
    Ann Rheum Dis 66:554-6. 2007
    ..Rare cases of vasculitis restricted to the lower limbs have been reported, but the characteristics, outcome and response to treatment of this entity are not well known...
  42. doi Factors influencing influenza-vaccination in adults under immunosuppressive therapy for a systemic inflammatory disease
    F Lanternier
    Pôle de médecine, Groupe Hospitalier Cochin Saint Vincent De Paul, AP HP, Universite Paris Descartes, Paris, France
    Med Mal Infect 39:247-51. 2009
    ..The aim of this study was to evaluate flu vaccination rates and influencing factors in patients with systemic inflammatory diseases...
  43. doi [Pregnancy and inflammatory myopathies]
    Dalia Dimitri
    Service d Histologie, Centre de Référence des maladies Neuromusculaires, Garches Necker Mondor Hendaye, INSERM U841, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Presse Med 37:1652-6. 2008
    ..Maternal disease should be treated with corticosteroids, using the same dosage and regimen as for non-pregnant women and according to the disease activity and severity...
  44. ncbi [Classification of systemic vasculitides]
    Loic Guillevin
    Service de Medecine Interne, Centre de référence maladies rares Vascularites et Sclérodermies systémiques, Hopital Cochin, université Paris V René Descartes, Paris
    Rev Prat 58:480-6. 2008
    ....
  45. ncbi [Treatment of systemic vasculitides]
    Lïc Guillevin
    Service de Medecine Interne, Centre de référence maladies rares Vascularites et Sclérodermies systémiques, Hopital Cochin, université Paris V René Descartes, Paris
    Rev Prat 58:541-4. 2008
    ..The treatment duration of non-infectious vasculitides is typically 18 to 24 months. The improvement in prognosis is due to the treatment as well as to anti-infectious prophylaxis and careful management of potential complications...
  46. doi Patient preference disability questionnaire in systemic sclerosis: a cross-sectional survey
    Luc Mouthon
    Paris Descartes University, UPRES EA 4058, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    Arthritis Rheum 59:968-73. 2008
    ..To assess patient priorities concerning disability in systemic sclerosis (SSc)...
  47. ncbi Cardiac magnetic resonance imaging in Churg-Strauss-syndrome. Impact of immunosuppressants on outcome assessed in a prospective study on 8 patients
    Julien Marmursztejn
    Department of Cardiology, Hopital Cochin, UNIVERSITE DE PARIS, France
    Clin Exp Rheumatol 28:8-13. 2010
    ..To evaluate the effects of immunosuppressive therapy on cardiac abnormalities observed by cardiac magnetic resonance imaging (CMRI) in patients with Churg-Strauss syndrome (CSS)...
  48. doi Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease
    Achille Aouba
    Department of Internal Medicine, French National Referral Center for Langerhans Cell Histiocytosis, Hopital Cochin, Université de Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Blood 116:4070-6. 2010
    ..Therefore, our results support a central role of the IL-1 network, which seemed to be overstimulated in ECD. Its specific blockade using anakinra thereby opens new pathophysiology and therapeutic perspectives in ECD...
  49. doi Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial
    Raphaele Seror
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Ann Rheum Dis 69:2125-30. 2010
    ....
  50. doi Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 359:2790-803. 2008
    ..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy...
  51. ncbi Seasonal variations in onset of Wegener's granulomatosis: increased in summer?
    Alfred Mahr
    Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes, Paris, France
    J Rheumatol 33:1615-22. 2006
    ..Investigators have reported significant seasonal variations of onset of Wegener's granulomatosis (WG), but those data were not confirmed by others. We reexamined the hypothesis of a seasonal pattern of onset of WG...
  52. ncbi Indications for biotherapy in systemic vasculitides
    Loic Guillevin
    Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermie, Hopital Cochin, Universite Paris Descartes, Paris, France
    Clin Rev Allergy Immunol 32:85-96. 2007
    ..Results of international ongoing trials will determine whether the agents may also have a place as first-line treatment...
  53. ncbi [Classification of systemic vasculatides]
    Loic Guillevin
    Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
    Presse Med 36:845-53. 2007
    ....
  54. ncbi Indication for plasma exchange for systemic necrotizing vasculidities
    Loic Guillevin
    Department of Internal Medicine, Referral Center for Rare Diseases, Vasculitis and Scleroderma, Hopital Cochin, AP HP, Université de Paris René Descartes, 27, rue du Faubourg Saint Jacques, Paris, France
    Transfus Apher Sci 36:179-85. 2007
    ..Although PE does not improve survival, their adjunction to corticosteroids and immunosuppressants for patients with alveolar hemorrhage could also limit the severity of this severe manifestation...
  55. ncbi [Treatment of ANCA-associated vascularitides]
    Loic Guillevin
    Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
    Presse Med 36:922-7. 2007
    ..These biologics must be prescribed extremely cautiously and only in trial settings, especially in view of the adverse effects, few but severe, recently been reported with them...
  56. ncbi Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patients
    Anne Bourgarit
    Department of Internal Medicine, Hopital Avicenne, UPRES EA 3409 Université Paris XIII, France
    Medicine (Baltimore) 84:323-30. 2005
    ..Cyclophosphamide-induced cytopenia and infection were responsible for 2 deaths. Despite these iatrogenic complications, early deaths were more frequently the consequence of insufficient or inappropriate therapy...
  57. ncbi Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patients
    Loic Guillevin
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 84:313-22. 2005
    ..The major cause of death is gastrointestinal tract involvement. Importantly, the frequency of HBV-PAN has decreased in relation to improved blood safety and vaccination campaigns...
  58. doi Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patients
    Valerie Martinez
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Rheum 58:308-17. 2008
    ....
  59. ncbi Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated
    Christian Pagnoux
    Hopital Cochin, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, Paris Cedex 14, France
    Medicine (Baltimore) 84:115-28. 2005
    ....
  60. ncbi Treatment of refractory and/or severe ANCA-associated systemic necrotizing vasculitides
    Loic Guillevin
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris, Paris, France
    Isr Med Assoc J 10:89-91. 2008
    ..Some of them (e.g., anti-tumor necrosis factor-alpha and anti-CD20 monoclonal antibodies) have achieved promising results and are now often used to treat severe cases...
  61. doi [Central nervous system vasculitides: an update]
    A Neel
    Service de Medecine Interne, Hopital Hotel Dieu, CHU de Nantes, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Rev Med Interne 33:381-9. 2012
    ..Prospective interdisciplinary studies are necessary to improve our approach to these patients...
  62. pmc Increased prevalence of subclinical atherosclerosis in patients with small-vessel vasculitis
    G Chironi
    Centre de Medecine Preventive Cardiovasculaire, Groupe Hospitalier Broussais HEGP, Universite Paris V, Paris, France
    Heart 93:96-9. 2007
    ..This study aimed to bring additional arguments supporting this hypothesis...
  63. ncbi Indications for plasma exchange in systemic lupus erythematosus in 2005
    C Pagnoux
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Rene Descartes, Paris, France
    Lupus 14:871-7. 2005
    ....
  64. doi Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schönlein Purpura
    Evangeline Pillebout
    Nephrology Department, Hopital Saint Louis, 1 av C Vellefaux, Paris, France
    Kidney Int 78:495-502. 2010
    ..The small population size of our study does not permit definitive conclusions; however, we suggest that treatment of adults with severe HSP by adding cyclophosphamide provides no benefit compared with steroids alone...
  65. doi Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
    Arthritis Rheum 62:1186-97. 2010
    ....
  66. doi Analysis of Wegener's granulomatosis responses to rituximab: current evidence and therapeutic prospects
    Achille Aouba
    Department of Internal Medicine and the French Vasculitis Study Group, Assistance Publique Hopitaux de Paris, Universite Paris, 5 René Descartes, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Clin Rev Allergy Immunol 34:65-73. 2008
    ..This promising biotherapy opens the way for other therapeutic agents targeting B lymphocytes and to improve our understanding of the pathophysiology of ANCA-associated vasculitis...
  67. ncbi [Antileukotrienes and Churg-Strauss syndrome]
    Philippe Guilpain
    Service de Medecine Interne, AP HP, Hopital Cochin, Universite Paris V, Paris, France
    Presse Med 36:890-4. 2007
    ..The onset of Churg-Strauss syndrome in patients treated with LTRA usually requires that they stop this treatment. Prescription of LTRA In patients with Churg-Strauss syndrome should be discussed with specialists...
  68. ncbi Pathogenic effects of antimyeloperoxidase antibodies in patients with microscopic polyangiitis
    Philippe Guilpain
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 56:2455-63. 2007
    ..The aim of this study was to investigate whether anti-MPO antibodies can activate MPO to generate an oxidative stress that is potentially deleterious to the endothelium...
  69. ncbi Prevalence and characteristics of moderate to severe pulmonary hypertension in systemic sclerosis with and without interstitial lung disease
    David Launay
    Department of Internal Medicine, National Center for Vascular Manifestations of Scleroderma, Regional University Hospital Claude Huriez Hospital, Lille, France
    J Rheumatol 34:1005-11. 2007
    ..To determine the prevalence and characteristics of moderate to severe pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) with and without interstitial lung disease (ILD)...
  70. doi Rituximab reversed cardiac involvement of Wegener's granulomatosis: magnetic resonance imaging assessment
    Benoit Brihaye
    French Vasculitis Study Group, Department of Internal Medicine, AP HP, Hopital Cochin, Université Paris 5 Descartes, F 75679 Paris cedex 14, France
    Presse Med 37:412-5. 2008
    ..We report the disease course of a patient who received rituximab to treat cardiac involvement documented by contrast-enhanced cardiac magnetic resonance imaging (ceCMR)...
  71. doi Differences in patients with systemic sclerosis recruited from associations and tertiary care settings
    Caroline Mestre-Stanislas
    Universite Paris Descartes, Faculte de Medecine, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Presse Med 39:e205-9. 2010
    ..To compare patients with systemic sclerosis (SSc) recruited from a patient association or a tertiary care setting...
  72. doi Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registry
    Benjamin Terrier
    Bicetre Hospital, Assistance Publique Hopitaux de Paris, and Paris 11 University, Le Kremlin Bicetre, France
    Arthritis Rheum 62:2458-66. 2010
    ..However, in 2 recent randomized controlled trials (RCTs) of RTX, the primary end points were not met. We undertook this study to evaluate the safety and efficacy of RTX in off-trial patients with SLE seen in regular clinical practice...
  73. doi [Periostitis in systemic necrotizing vasculitides: Study of the 4 cases identified among the 1762 patients of the FVSG database and review of the literature]
    Sophie Périchon
    Pôle de Médecine Interne, centre de référence vascularites systémiques nécrosantes et sclérodermie systémique, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
    Presse Med 39:e165-73. 2010
    ..Periostitis (periosteal new bone formation) is a rare manifestation of systemic necrotizing vasculitis...
  74. ncbi Long-term outcome of 37 patients with Wegener's granulomatosis with renal involvement
    Jacques Eric Gottenberg
    Department of Internal Medicine, Nationale referral center for Vasculitides and Scleroderma, Hopital Cochin, AP HP, Universite Paris 5, Paris
    Presse Med 36:771-8. 2007
    ..This prospective study sought to assess the long-term outcome and identify prognostic factors of patients with kidney disease related to Wegener's granulomatosis (WG)...
  75. ncbi Peripheral neuropathy in systemic vasculitides
    Christian Pagnoux
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris V, Paris, France
    Curr Opin Rheumatol 17:41-8. 2005
    ..However, it carries no poor prognostic value in vasculitides. Recent advances have been made in understanding the pathogenetic mechanisms of PNS involvement...
  76. ncbi Cardiac involvement in small and medium-sized vessel vasculitides
    C Pagnoux
    Department of Internal Medicine, Hopital Cochin, Universite Paris, Paris, France
    Lupus 14:718-22. 2005
    ..This regimen has dramatically improved the overall prognosis of affected patients...
  77. pmc Development and validation of a scale for mouth handicap in systemic sclerosis: the Mouth Handicap in Systemic Sclerosis scale
    L Mouthon
    Department of Internal Medicine, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 66:1651-5. 2007
    ..To develop and assess the reliability and construct validity of a scale assessing disability involving the mouth in systemic sclerosis (SSc)...
  78. ncbi [Digestive manifestations of systemic vascular diseases]
    C Pagnoux
    Service de Medecine Interne, centre de référence national Plan Maladies Rares, vascularites et sclérodermie, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris V, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rev Med Interne 27:S56-8. 2006
  79. doi Cerebral vasculopathy is associated with severe vascular manifestations in systemic sclerosis
    Benjamin Terrier
    Descartes University, Faculty of Medicine, Department of Internal Medicine and French Reference Centre for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, 75679 Paris Cedex 14, France
    J Rheumatol 36:1486-94. 2009
    ..To investigate brain involvement in patients with systemic sclerosis (SSc)...
  80. ncbi How can patient care be improved beyond medical treatment?
    Christian Pagnoux
    Department of Internal Medicine, Hopital Cochin, 27 rue du Faubourg Saint Jacques, Universite Paris 5, AP HP, 75679 Paris Cedex 14, France
    Best Pract Res Clin Rheumatol 19:337-44. 2005
    ..A multifaceted and point-by-point approach to patient care is needed to further improve quality of life whenever possible...
  81. ncbi Lymph node paradoxical enlargement during treatment for tuberculous spondylodiscitis (Pott's disease)
    Antoine Froissart
    Service de Medecine Interne I, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75013 Paris, France
    Joint Bone Spine 74:292-5. 2007
    ..Paradoxical reactions during adapted antituberculous treatment are defined as a transient, clinical and/or radiological enlargement of pre-existent lesions or appearance of new ones...
  82. ncbi Central nervous system involvement in Wegener granulomatosis
    Raphaele Seror
    Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes Paris 5, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 85:54-65. 2006
    ....
  83. ncbi Plasma exchange for rheumatoid arthritis
    Raphaele Seror
    Department of Internal Medicine, Hopital Cochin, 27, rue du fauborg Saint Jacques, Universite Rene Descartes, Assistance Publique Hopitaux de Paris, 75679 Paris Cedex 14, France
    Transfus Apher Sci 36:195-9. 2007
    ..But, the emergence of effective biologics has clearly restrained their use and limited their indications to some rare patients with refractory and severe RA...
  84. ncbi [Abdominal and digestive manifestations in systemic vasculitides]
    Christian Pagnoux
    Service de Medecine Interne, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679 Paris 14
    Ann Med Interne (Paris) 154:457-67. 2003
    ..Prompt surgical and medical care of these seriously ill patients has lowered mortality from nearly 100% twenty years ago to approximately 23 to 56% currently...
  85. ncbi Indications of plasma exchanges for systemic vasculitides
    Loic Guillevin
    Department of Internal Medicine, Hopital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
    Ther Apher Dial 7:155-60. 2003
    ..We review herein these indications of plasma exchanges in the light of the results of major trials...
  86. ncbi JC virus leukoencephalopathy complicating Wegener's granulomatosis
    Christian Pagnoux
    Travail du Service de Rhumatologie, Groupe Hospitalier Bichat Claude Bernard, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
    Joint Bone Spine 70:376-9. 2003
    ..No specific or effective treatments are available. Immunosuppressant drugs should be discontinued if possible...