Eric Oksenhendler

Summary

Country: France

Publications

  1. ncbi request reprint Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review
    Claire Larroche
    Department of Internal Medicine and Laboratory of Hematology, Hopital Avicenne, Bobigny, France
    Am J Hematol 69:119-26. 2002
  2. ncbi request reprint Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS
    Emmanuelle Boulanger
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, 1 avenue Claude Vellefaux, 75 475 Paris Cedex 10, France
    J Clin Oncol 23:4372-80. 2005
  3. ncbi request reprint High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease
    Eric Oksenhendler
    Department of Immunology and Hematology, Laboratory of Hematology, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    Blood 99:2331-6. 2002
  4. ncbi request reprint Combined chemotherapy including high-dose methotrexate in KSHV/HHV8-associated primary effusion lymphoma
    Emmanuelle Boulanger
    Department of Clinical Immunopathology, Hopital Saint Louis, AP HP, Paris, France
    Am J Hematol 73:143-8. 2003
  5. ncbi request reprint Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells
    Amelie Guihot
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie Paris 6, Paris, France
    Blood 111:1387-95. 2008
  6. ncbi request reprint Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study
    Lionel Galicier
    Departments of Clinical Immunology, Hopital St Louis, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 110:2846-54. 2007
  7. doi request reprint B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease
    Gael Mouillot
    Immunology Laboratory, INSERM UMR S945, CIB Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Paris, France
    J Clin Immunol 30:746-55. 2010
  8. ncbi request reprint HIV-associated multicentric Castleman disease
    Eric Oksenhendler
    Department of Clinical Immunology, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Curr Opin HIV AIDS 4:16-21. 2009
  9. ncbi request reprint Improved survival in HIV-related Hodgkin's lymphoma since the introduction of highly active antiretroviral therapy
    Laurence Gerard
    Service d Immuno Hématologie and Laboratoire d Anatomopathologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France
    AIDS 17:81-7. 2003
  10. doi request reprint Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease
    Laurence Gerard
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, France
    Blood 119:2228-33. 2012

Detail Information

Publications47

  1. ncbi request reprint Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review
    Claire Larroche
    Department of Internal Medicine and Laboratory of Hematology, Hopital Avicenne, Bobigny, France
    Am J Hematol 69:119-26. 2002
    ..The association of CD and lymphoma seems to be more than coincidental, and its pathogenesis is discussed...
  2. ncbi request reprint Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS
    Emmanuelle Boulanger
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, 1 avenue Claude Vellefaux, 75 475 Paris Cedex 10, France
    J Clin Oncol 23:4372-80. 2005
    ..The prognosis is poor, with reported median survival time shorter than 6 months. To date, no prognostic factor has been identified in this subset of lymphoma...
  3. ncbi request reprint High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease
    Eric Oksenhendler
    Department of Immunology and Hematology, Laboratory of Hematology, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    Blood 99:2331-6. 2002
    ..In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions...
  4. ncbi request reprint Combined chemotherapy including high-dose methotrexate in KSHV/HHV8-associated primary effusion lymphoma
    Emmanuelle Boulanger
    Department of Clinical Immunopathology, Hopital Saint Louis, AP HP, Paris, France
    Am J Hematol 73:143-8. 2003
    ..Complete remission was obtained in 3 out of 7 patients treated for AIDS-associated PEL with combined chemotherapy containing high-dose methotrexate...
  5. ncbi request reprint Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells
    Amelie Guihot
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie Paris 6, Paris, France
    Blood 111:1387-95. 2008
    ..Their differentiation increases with HHV-8 viral load. These results offer new insight into the pathophysiology of MCD...
  6. ncbi request reprint Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study
    Lionel Galicier
    Departments of Clinical Immunology, Hopital St Louis, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 110:2846-54. 2007
    ..We conclude that LMB86 regimen is highly effective in advanced HIV-related BL and should be proposed for patients with CD4 count higher than 200 x 10(6)/L or ECOG of 2 or less...
  7. doi request reprint B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease
    Gael Mouillot
    Immunology Laboratory, INSERM UMR S945, CIB Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Paris, France
    J Clin Immunol 30:746-55. 2010
    ..Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by recurrent infections and defective immunoglobulin production...
  8. ncbi request reprint HIV-associated multicentric Castleman disease
    Eric Oksenhendler
    Department of Clinical Immunology, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Curr Opin HIV AIDS 4:16-21. 2009
    ..On the basis of current knowledge on pathophysiology, we will illustrate different therapeutic approaches and try to provide guidelines at least for the initial care of the disease...
  9. ncbi request reprint Improved survival in HIV-related Hodgkin's lymphoma since the introduction of highly active antiretroviral therapy
    Laurence Gerard
    Service d Immuno Hématologie and Laboratoire d Anatomopathologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France
    AIDS 17:81-7. 2003
    ..To evaluate the evolving characteristics of HIV-related Hodgkin's lymphoma (HL) and survival of affected patients since the introduction of highly active antiretroviral therapy (HAART)...
  10. doi request reprint Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease
    Laurence Gerard
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, France
    Blood 119:2228-33. 2012
    ..Rituximab was associated with an 11-fold lower risk of developing lymphoma. KS exacerbation was the most challenging adverse event after rituximab therapy...
  11. doi request reprint Characteristics of non-Hodgkin lymphoma arising in HIV-infected patients with suppressed HIV replication
    Laurence Gerard
    Service d immunopathologie clinique, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, France
    AIDS 23:2301-8. 2009
    ..Despite effective treatment of HIV infection, some patients still develop non-Hodgkin lymphoma (NHL). We analysed patients with HIV-associated NHL and undetectable plasma HIV-RNA, according to the duration of HIV suppression...
  12. ncbi request reprint Prospective study of rituximab in chemotherapy-dependent human immunodeficiency virus associated multicentric Castleman's disease: ANRS 117 CastlemaB Trial
    Laurence Gerard
    Department of Clinical Immunology, Laboratory of Virology, Paris VII University, Paris, France
    J Clin Oncol 25:3350-6. 2007
    ..Single-agent chemotherapy is usually effective in HIV-associated multicentric Castleman's disease (MCD). However, in most patients, chemotherapy cannot be discontinued...
  13. ncbi request reprint Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma
    Amelie Guihot
    Laboratoire d Immunologie Cellulaire et Tissulaire du Pr Debre, INSERM UMR S 543, Batiment CERVI, Hopital Pitie Salpetriere, 47 bd de l Hopital, 75013, Paris, France
    J Infect Dis 194:1078-88. 2006
    ..We hypothesized that KS is linked to deficiencies in specific anti-HHV-8 T cell immunity...
  14. doi request reprint Infections in 252 patients with common variable immunodeficiency
    Eric Oksenhendler
    Department of Clinical Immunology, Hopital Saint Louis, Paris, France
    Clin Infect Dis 46:1547-54. 2008
    ..Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production...
  15. ncbi request reprint Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect
    Marion Malphettes
    Departement d Immunologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France
    Clin Infect Dis 49:1329-38. 2009
    ..Common variable immunodeficiency (CVID) is a primary immune deficiency defined by defective antibody production. In most series, a small proportion of patients present with opportunistic infections (OIs)...
  16. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  17. doi request reprint Parental consanguinity is associated with a severe phenotype in common variable immunodeficiency
    Claire Rivoisy
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hôpitaux de Paris and Université Paris Diderot, Sorbonne Paris Cité, EA3963, Paris, France
    J Clin Immunol 32:98-105. 2012
    ..Systematic investigation for parental consanguinity in patients with CVID provides useful information for specific clinical care and genetic screening...
  18. ncbi request reprint Idiopathic CD4 lymphocytopenia: clinical and immunologic characteristics and follow-up of 40 patients
    Alexis Régent
    From the Université Paris Descartes and Assistance Publique Hôpitaux de Paris AP HP, Hopital Cochin, Service de Medecine Interne, Paris AR, BT, LG, LM Institut Cochin, U016, CNRS, UMR8104, Universite Paris Descartes, Sorbonne Paris Cité 22, Paris AR, RC, BC DM, LM UPMC, Université Paris 6 and INSERM, UMR945, AP HP, Hopital Pitie Salpetriere, Laboratoire d Immunologie Cellulaire et Tissulaire, Paris BA, GC, PH, PD Université Paris 13 and AP HP, Departement de Medecine Interne, Hopital Avicenne, Bobigny AK Université Paris Diderot and AP HP, Département d immunologie clinique, Hopital Saint Louis, Paris EO UPMC, Université Paris 6 and AP HP, Hopital Pitie Salpetriere, Service de Medecine Interne, Kingston
    Medicine (Baltimore) 93:61-72. 2014
    ..In conclusion, ICL is a heterogeneous disorder often associated with deficiencies in CD8, CD19, and/or NK cells. Long-term prognosis may be related to initial CD4 and NK cell deficiency. ..
  19. ncbi request reprint Time course of organ dysfunction in thrombotic microangiopathy patients receiving either plasma perfusion or plasma exchange
    Michael Darmon
    Medical Intensive Care Unit, Assistance Publique Hopitaux de Paris, Saint Louis University Hospital, Paris, France
    Crit Care Med 34:2127-33. 2006
    ..Few studies have investigated adults with thrombotic microangiopathy (TMA) requiring intensive care unit (ICU) admission, and the treatment remains controversial...
  20. doi request reprint Peripheral T-cell lymphoma in HIV-infected patients: a study of 17 cases in the combination antiretroviral therapy era
    Laurent Gilardin
    Département d immunologie clinique, Hopital Saint Louis, AP HP, Paris, France
    Br J Haematol 161:843-51. 2013
    ..In this rare but severe complication of HIV infection the use of intensive chemotherapy does not appear to be beneficial for response, with increased toxicity...
  21. ncbi request reprint Immunoglobulin dosage and switch from intravenous to subcutaneous immunoglobulin replacement therapy in patients with primary hypogammaglobulinemia: decreasing dosage does not alter serum IgG levels
    Sylvain Thepot
    Departement d Immunologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Immunol 30:602-6. 2010
    ..The impact of reducing immunoglobulin dosage while switching from intravenous to subcutaneous replacement therapy was evaluated...
  22. doi request reprint 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma
    Pierre Alexandre Just
    Department of Nuclear Medicine, Saint Louis Hospital, Assistance Publique Hopitaux de Paris APHP, Paris, France
    AIDS Patient Care STDS 22:695-700. 2008
    ..PET/CT is also useful to monitor treatment response, as regression of initial disease can be early observed. Furthermore, PET/CT appears to have prognostic value, as a negative scan was always associated with a favorable outcome...
  23. doi request reprint Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-alpha expression
    Michelina Nascimbeni
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 8104, Paris, France
    Blood 113:6112-9. 2009
    ..Therefore, pDCs accumulated in spleens from HIV+ patients with high proviral loads, but they did not seem to be the main IFN-alpha producers...
  24. doi request reprint Human herpesvirus 8+ polyclonal IgMλ B-cell lymphocytosis mimicking plasmablastic leukemia/lymphoma in HIV-infected patients
    Eric Oksenhendler
    Department of Clinical Immunology, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
    Eur J Haematol 91:497-503. 2013
    ..MCD lesions characteristically contain HHV-8-infected polyclonal IgMλ plasmablasts. A high frequency of HHV-8-related non-Hodgkin lymphoma has been reported in these patients...
  25. ncbi request reprint Systemic non-Hodgkin lymphoma in HIV-infected patients with effective suppression of HIV replication: persistent occurrence but improved survival
    Laurence Gerard
    Service d Immuno Hématologie Hôpital Saint Louis, AP HP, Paris, France
    J Acquir Immune Defic Syndr 30:478-84. 2002
    ..Improvement in the overall survival rate in the post-HAART period was associated with more intensive chemotherapy regimens, increased complete remission rate, and a likely benefit of continuation or introduction of HAART...
  26. doi request reprint Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy
    Raphael Szalat
    Département d immunologie clinique, Hopital Saint Louis, Paris, France
    Blood 118:3777-84. 2011
    ..Monoclonal gammopathy therapy could thus be an option. Indeed, among the patients who received chemotherapy, hematologic remission was accompanied by improvement in xanthoma lesions in several cases...
  27. doi request reprint AIDS-related malignancies: state of the art and therapeutic challenges
    Jean Philippe Spano
    Pitie Salpetriere Hospital, Department of Medical Oncology, 47 Blvd de l Hopital, 75013 Paris, France
    J Clin Oncol 26:4834-42. 2008
    ..Special considerations of these AIDS-related and non-AIDS-related malignancies and their clinical and therapeutic aspects constitute the subject of this review...
  28. ncbi request reprint Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study
    Sylvain Choquet
    Hematology Unit, CHU La Pitié Salpêtrière Hospital, 47 bd de l Hopital, 75651 Paris Cedex 14, France
    Blood 107:3053-7. 2006
    ..We conclude that rituximab is effective and safe in PTLD, with stable responses at 1 year. The response rate and overall survival might be improved by combining rituximab with other treatments...
  29. ncbi request reprint [Rosai-Dorfman disease]
    Lionel Galicier
    Service d immunopathologie clinique, Hopital Saint Louis, Paris
    Presse Med 36:1669-75. 2007
    ..The treatment, when it is indicated, is not codified. It combines, according to the individual case, surgery, corticosteroids, antimetabolites and interferon alpha...
  30. ncbi request reprint Severe herpes virus (HSV-2) infection in two patients with myelodysplasia and undetectable NK cells and plasmacytoid dendritic cells in the blood
    Ali Dalloul
    Laboratoire d Imunologie Hôpital de la Pitié, Paris, France
    J Clin Virol 30:329-36. 2004
    ....
  31. pmc Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review
    Sandrine Leroy
    Department of Pediatric Immunology and Hematology, Necker Hospital, AP HP, Paris, France
    Pediatrics 129:e199-203. 2012
    ..Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection...
  32. ncbi request reprint [Common variable immunodeficiency]
    Eric Oksenhendler
    Département d immunologie clinique, Hopital Saint Louis, 75010 Paris
    Rev Prat 57:1687-90. 2007
    ..A specific genetic defect can be demonstrated in less than 5% of the cases. Therapy relies on IV or SC substitution using polyvalent immunoglobulins...
  33. ncbi request reprint Herpes simplex virus type 2 as a cause of severe meningitis in immunocompromised adults
    Herve Mommeja-Marin
    Department of Infectious Diseases, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, France
    Clin Infect Dis 37:1527-33. 2003
    ..HSV-2 can cause severe meningitis in immunocompromised patients. Early recognition and treatment might improve the outcome of such infections...
  34. ncbi request reprint Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression
    Wei Li Zhao
    ERM 0220, Institut Universitaire d Hematologie, Universite Paris VII, Paris, France
    Lab Invest 84:1512-9. 2004
    ..In addition to lymphoma cells themselves, the vascular component, a critical pathologic characteristic in AITL, also contributes to lymphoma progression...
  35. ncbi request reprint Infectious diseases as a trigger in thrombotic microangiopathies in intensive care unit (ICU) patients?
    Paul Coppo
    Department of Critical Care Medicine, Hôpital Saint Louis and University of Paris VII, 1 rue Claude Vellefaux, 75010, Paris, France
    Intensive Care Med 29:564-9. 2003
    ..We conducted a descriptive, retrospective study including all TMA adult patients admitted to our ICU, with a particular interest in infectious episodes as a trigger of TMA...
  36. ncbi request reprint Alpha-interferon-associated thrombotic microangiopathy: a clinicopathologic study of 8 patients and review of the literature
    Julien Zuber
    Departments of Nephrology, Hôpital St Louis and the Ile de France Nephrologist Study Group GENIF, Paris, France
    Medicine (Baltimore) 81:321-31. 2002
  37. ncbi request reprint HHV8-related non-Hodgkin's lymphoma of the spermatic cord in a patient with HIV-associated multicentric Castleman disease
    Emmanuelle Boulanger
    Am J Hematol 72:70-1. 2003
  38. doi request reprint Bortezomib (PS-341) in patients with human herpesvirus 8-associated primary effusion lymphoma
    Emmanuelle Boulanger
    Br J Haematol 141:559-61. 2008
  39. doi request reprint Mucosa-associated lymphoid tissue lymphoma in patients with human immunodeficiency virus infection
    Emmanuelle Boulanger
    Br J Haematol 140:470-4. 2008
  40. ncbi request reprint Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial
    Yves Levy
    Unit of Clinical Immunology, Hospital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    AIDS 17:343-51. 2003
    ..Intermittent interleukin-2 (IL-2) therapy leads to a sustained increase of CD4 T cells in HIV-1-infected patients...
  41. ncbi request reprint Long-term effects of intermittent interleukin-2 therapy in chronic HIV-infected patients (ANRS 048-079 Trials)
    Christine Durier
    INSERM SC10, Villejuif, France
    AIDS 21:1887-97. 2007
    ..Interleukin (IL)-2 therapy leads to significant CD4 cell increases in HIV-infected patients. Since phase III trials are ongoing, studies supporting the long-term feasibility of this strategy are needed...
  42. ncbi request reprint Extracavitary tumor after primary effusion lymphoma: relapse or second distinct lymphoma?
    Emmanuelle Boulanger
    Haematologica 92:1275-6. 2007
    ..HHV-8 episome clonality might help identify which event takes place...
  43. ncbi request reprint The EUROclass trial: defining subgroups in common variable immunodeficiency
    Claudia Wehr
    Department of Rheumatology and Clinical Immunology, University Clinic, Freiburg, Germany
    Blood 111:77-85. 2008
    ..The underlying defects of expanded transitional or CD21(low) B cells remain to be elucidated. This trial is re-gistered at http://www.uniklinik-freiburg.de/zks/live/uklregister/Oeffentlich.html as UKF000308...
  44. ncbi request reprint Prognostic value of anti-ADAMTS 13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS 13 activity
    Silvia Ferrari
    Baxter BioScience, Department of Discovery Research and Technical Assessment, Vienna, Austria
    Blood 109:2815-22. 2007
    ..High levels of inhibitory anti-ADAMTS13 IgG at presentation were associated with the persistence of an undetectable ADAMTS13 activity in remission, the latter being predictive for relapses within an 18-month delay...
  45. ncbi request reprint Failure of cidofovir in HIV-associated multicentric Castleman disease
    Alice Berezne
    Blood 103:4368-9; author reply 4369. 2004
  46. ncbi request reprint Distinct cellular origins of primary effusion lymphoma with and without EBV infection
    Rifat Hamoudi
    Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
    Leuk Res 28:333-8. 2004
    ..Our results indicate that EBV positive PELs are derived from germinal centre or post-germinal centre B-cells, whereas EBV negative PELs may originate from either germinal/post-germinal centre or naïve B-cells...
  47. ncbi request reprint Thoracic radiographic and CT findings of multicentric Castleman disease in HIV-infected patients
    Amelie Guihot
    Service de Pneumologie, Hopital Foch, Suresnes, France
    J Thorac Imaging 22:207-11. 2007
    ..In this pictorial essay, we describe different thoracic imaging of MCD, with particular emphasis on computed tomography findings, in 13 HIV-infected patients with histologically proved MCD...