A T Nurden

Summary

Country: France

Publications

  1. ncbi request reprint Analysis of the amino acid requirement for a normal alphaIIbbeta3 maturation at alphaIIbGlu324 commonly mutated in Glanzmann thrombasthenia
    Sandrine Milet-Marsal
    UMR CNRS 5533, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Thromb Haemost 88:655-62. 2002
  2. ncbi request reprint Platelet membrane glycoproteins: historical perspectives
    A T Nurden
    Institut Fédératif de Recherche 4, CHU Bordeaux, Pessac, France
    J Thromb Haemost 4:3-9. 2006
  3. ncbi request reprint Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia
    Paquita Nurden
    Centre de Référence des Pathologies Plaquettaires and Institut Fédératif de Recherche No 4, Laboratoire d Hematologie, Hopital Cardiologique, 33604 Pessac, France
    Blood 108:2587-95. 2006
  4. ncbi request reprint Type 2N von Willebrand disease due to compound heterozygosity for R854Q and a novel R763G mutation at the cleavage site of von Willebrand factor propeptide
    Lysiane Hilbert
    Laboratoire français du Franctionnement et des Biotechnologies, Lille, France
    Thromb Haemost 96:290-4. 2006
  5. doi request reprint Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Semin Thromb Hemost 37:698-706. 2011
  6. doi request reprint Are bone defects in rare patients with Glanzmann's thrombasthenia associated with ITGB3 or ITGA2B mutations?
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Platelets 22:547-51. 2011
  7. doi request reprint Platelets, inflammation and tissue regeneration
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Thromb Haemost 105:S13-33. 2011
  8. ncbi request reprint Platelets and tissue remodeling: extending the role of the blood clotting system
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, 33600 Pessac, France
    Endocrinology 148:3053-5. 2007
  9. doi request reprint Altered megakaryocytopoiesis in von Willebrand type 2B disease
    A T Nurden
    Centre de Reference des Pathologies Plaquettaires, Hopital Xavier Arnozan, Pessac, France
    J Thromb Haemost 7:277-81. 2009
  10. ncbi request reprint Platelet membrane glycoproteins: a look back into the past and a view to the future
    Alan T Nurden
    CRPP PTIB, Hopital Xavier Arnozan, 33604 Pessac, France
    Thromb Haemost 98:49-54. 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Analysis of the amino acid requirement for a normal alphaIIbbeta3 maturation at alphaIIbGlu324 commonly mutated in Glanzmann thrombasthenia
    Sandrine Milet-Marsal
    UMR CNRS 5533, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Thromb Haemost 88:655-62. 2002
    ....
  2. ncbi request reprint Platelet membrane glycoproteins: historical perspectives
    A T Nurden
    Institut Fédératif de Recherche 4, CHU Bordeaux, Pessac, France
    J Thromb Haemost 4:3-9. 2006
  3. ncbi request reprint Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia
    Paquita Nurden
    Centre de Référence des Pathologies Plaquettaires and Institut Fédératif de Recherche No 4, Laboratoire d Hematologie, Hopital Cardiologique, 33604 Pessac, France
    Blood 108:2587-95. 2006
    ..Immunolocalization showed VWF not only associated with platelets, but already on the megakaryocyte surface and within internal channels. In this family, type 2B VWD is clearly associated with abnormal platelet production...
  4. ncbi request reprint Type 2N von Willebrand disease due to compound heterozygosity for R854Q and a novel R763G mutation at the cleavage site of von Willebrand factor propeptide
    Lysiane Hilbert
    Laboratoire français du Franctionnement et des Biotechnologies, Lille, France
    Thromb Haemost 96:290-4. 2006
    ..We conclude that R763G is a new type 2N VWD mutation located in the VWF propeptide which alters the proteolytic processing of VWF and consequently its binding to FVIII...
  5. doi request reprint Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Semin Thromb Hemost 37:698-706. 2011
    ..Our purpose is to review the mutations in the ITGA2B and ITGB3 genes that lead to anisotropy and to discuss mechanisms by which this can be brought about...
  6. doi request reprint Are bone defects in rare patients with Glanzmann's thrombasthenia associated with ITGB3 or ITGA2B mutations?
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Platelets 22:547-51. 2011
    ..Modelling strongly suggested that both mutations act by destabilizing the αIIb beta propeller. So it appears likely that this patient has a combination of co-expressed genetic defects...
  7. doi request reprint Platelets, inflammation and tissue regeneration
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Thromb Haemost 105:S13-33. 2011
    ..The above mentioned roles of platelets are now discussed...
  8. ncbi request reprint Platelets and tissue remodeling: extending the role of the blood clotting system
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, 33600 Pessac, France
    Endocrinology 148:3053-5. 2007
  9. doi request reprint Altered megakaryocytopoiesis in von Willebrand type 2B disease
    A T Nurden
    Centre de Reference des Pathologies Plaquettaires, Hopital Xavier Arnozan, Pessac, France
    J Thromb Haemost 7:277-81. 2009
    ....
  10. ncbi request reprint Platelet membrane glycoproteins: a look back into the past and a view to the future
    Alan T Nurden
    CRPP PTIB, Hopital Xavier Arnozan, 33604 Pessac, France
    Thromb Haemost 98:49-54. 2007
  11. doi request reprint Genetic testing in the diagnostic evaluation of inherited platelet disorders
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Semin Thromb Hemost 35:204-12. 2009
    ..Knowledge of the mutation in GT and whether it affects either of the ITGA2B or ITGB3 genes will be essential as we enter the period where accurate prenatal diagnosis and gene therapy may become viable options...
  12. doi request reprint New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura
    Alan T Nurden
    French National Reference Centre for Platelet Disorders, Hopital Xavier Arnozan, Pessac, France
    Lancet 373:1562-9. 2009
    ..However, long-term side-effects are being assessed and the exact role of these agents in the overall treatment strategy of chronic idiopathic thrombocytopenic purpura remains to be established...
  13. pmc Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, 33600 Pessac, France
    Thromb Haemost 100:45-51. 2008
    ....
  14. ncbi request reprint Platelets and wound healing
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Front Biosci 13:3532-48. 2008
    ..We now review the ways in which platelets participate in these processes...
  15. ncbi request reprint Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia
    A T Nurden
    UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    J Thromb Haemost 2:813-9. 2004
    ..Our studies highlight an unusual mixture of defects giving rise to severe bleeding in a child and describe the first pathological missense mutation affecting a C-terminal residue of the calf-2 domain of alpha(IIb)...
  16. ncbi request reprint The gray platelet syndrome: clinical spectrum of the disease
    Alan T Nurden
    IFRN 4 CRPP, Laboratoire d Hematologie, Hopital Cardiologique, 33604 Pessac, France
    Blood Rev 21:21-36. 2007
    ..In this review, we document the clinical and molecular heterogeneity in GPS, a unique disease of the biogenesis of platelet alpha-granules and of the storage of growth factors and secretable proteins...
  17. doi request reprint Advances in our understanding of the molecular basis of disorders of platelet function
    A Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, Pessac, France
    J Thromb Haemost 9:76-91. 2011
    ....
  18. ncbi request reprint A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia
    Alan T Nurden
    UMR 5533 CNRS, Hopital Cardiologique, 33604 Pessac, France
    Platelets 13:101-11. 2002
    ....
  19. ncbi request reprint Inherited disorders of platelets: an update
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Institut Fédératif de Recherche n 4, CHU Bordeaux, Pessac, France
    Curr Opin Hematol 13:157-62. 2006
    ..To overview inherited syndromes that affect platelets and to discuss current data on the molecular origin and management of these rare diseases...
  20. ncbi request reprint Polymorphisms and platelet genotyping: the shape of things to come
    A T Nurden
    Institut Fédératif No 4 and Centre de Référence des Pathologies Plaquettaires, Centre Hospitalier Universitaire de Bordeaux, Pessac, France
    J Thromb Haemost 4:1194-6. 2006
  21. doi request reprint Increasing the platelet count in chronic ITP
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Hôpital Xavier Arnosan, 33600 Pessac, France
    Lancet 371:362-4. 2008
  22. pmc Glanzmann thrombasthenia
    Alan T Nurden
    IFR No4 CRPP, Laboratoire d Hematologie, Hopital Cardiologique, 33604 Pessac, France
    Orphanet J Rare Dis 1:10. 2006
    ..Administration of recombinant factor VIIa is an increasingly used therapeutic alternative. GT can be a severe hemorrhagic disease, however the prognosis is excellent with careful supportive care...
  23. ncbi request reprint Qualitative disorders of platelets and megakaryocytes
    A T Nurden
    Institut Fédératif de Recherche n 4, CHU Bordeaux, Pessac, France
    J Thromb Haemost 3:1773-82. 2005
    ....
  24. ncbi request reprint Does ATP act through P2X(1) receptors to regulate platelet activation and thrombus formation?
    A T Nurden
    Institut Fédératif No 4 and Centre de Référence des Pathologies Plaquettaires, Centre Hospitalier Universitaire de Bordeaux, Pessac, France
    J Thromb Haemost 5:907-9. 2007
  25. ncbi request reprint Inherited defects of platelet function
    A T Nurden
    UMR 5533 CNRS, Hopital Cardiologique, 33604 Pessac, France
    Rev Clin Exp Hematol 5:314-34; quiz following 431. 2001
    ..Platelet disorders are examples of rare diseases; nevertheless they have provided essential information in the elucidation of the molecular basis of platelet function...
  26. ncbi request reprint Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia
    J Ruan
    UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    Br J Haematol 105:523-31. 1999
    ....
  27. ncbi request reprint Flow cytometry reveals activated GP IIb-IIIa complexes on platelets from patients undergoing thrombolytic therapy after acute myocardial infarction
    C Bihour
    Unité de Recherche Associée 1464 Centre National de la Recherche Scientifique, Institut Fédératif de Recherche Coeur Vaisseaux Thrombose, Hopital Cardiologique, Pessac, France
    Blood Coagul Fibrinolysis 6:395-410. 1995
    ..Thus platelets of some fibrinolytic patients have an increased tendency for surface activation within the first 72 h after treatment, a finding which would be compatible with an increased thrombotic tendency...
  28. ncbi request reprint Analysis of platelet membrane glycoprotein polymorphisms in Glanzmann thrombasthenia showed the French gypsy mutation in the alphaIIb gene to be strongly linked to the HPA-1b polymorphism in beta3
    B Jacquelin
    UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    J Thromb Haemost 1:573-5. 2003
    ....
  29. doi request reprint Natural history of platelet antibody formation against αIIbβ3 in a French cohort of Glanzmann thrombasthenia patients
    M Fiore
    centre de référence des pathologies plaquettaires CRPP, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, Pessac, France
    Haemophilia 18:e201-9. 2012
    ....
  30. ncbi request reprint Glycoprotein Ia-IIa (VLA-2) and glycoprotein Ib-IX complexes are processed independently during thrombin-induced platelet activation
    P Nurden
    URA 1464 CNRS, , Pessac, France
    J Lab Clin Med 124:579-88. 1994
    ..Our results therefore show that two-way trafficking of adhesion receptors can occur during platelet activation. This would imply that GP Ib-IX and VLA-2 are attached to different elements within the membrane cytoskeleton...
  31. ncbi request reprint Double heterozygosity of the GPIIb gene in a Swiss patient with Glanzmann's thrombasthenia
    J Ruan
    UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    Br J Haematol 102:918-25. 1998
    ..It was a T --> C base transition at position 1787 of GPIIb cDNA and results in a Ile565 to Thr substitution. The two GPIIb mutations identified in this study will provide new information on GPIIb-IIIa structure and biosynthesis...
  32. ncbi request reprint [A study of platelet activation following coronary angioplasty. Effect on acute occlusion and restenosis]
    C Durrieu-Jais
    Unite de Soins Intensifs, Hopital Cardiologique, Pessac
    Arch Mal Coeur Vaiss 89:1259-65. 1996
    ..Activated platelets may play a role in constituting acute occlusion by thrombosis but their detection was not predictive of restenosis...
  33. doi request reprint An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis
    P Nurden
    CRPP PTIB, Hopital Xavier Arnozan, Pessac, France
    J Thromb Haemost 7:1541-9. 2009
    ..In rare cases of immune thrombocytopenic purpura (ITP), autoantibodies to GPVI result in receptor shedding. Objectives: To investigate a possible pathogenic role of plasma anti-GPVI antibody located in a woman with lupus nephritis...
  34. ncbi request reprint [From the physiopathology of thrombosis to therapeutic targets]
    P Nurden
    UMR 5533 CNRS, , 33604 Pessac
    Arch Mal Coeur Vaiss 94:1210-7. 2001
    ....
  35. ncbi request reprint Characterisation, cloning and sequencing of a conformation-dependent monoclonal antibody to the alphaIIbbeta3 integrin: interest for use in thrombus detection
    M Dabadie
    Equipe Imagerie Médical EA 1699, Laboratoire de Biophysique, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux, France
    Platelets 12:395-405. 2001
    ..In vivo experiments in atherosclerotic rabbits followed by immunohistological analysis, revealed a specific binding of XIIF9 on platelets engaged in thrombus formation, demonstrating real clinical potential for such MAbs in imaging...
  36. ncbi request reprint Analysis of the V genes coding for a monospecific human antibody to myosin and functional expression of single chain Fv fragments
    J Laroche-Traineau
    CNRS UMR 5533, Hopital Cardiologique, Pessac, France
    FEBS Lett 460:86-92. 1999
    ..The expression product in Escherichia coli was a 35 kDa scFv fragment with the antigen-binding specificity of the parental mAb...
  37. doi request reprint Inherited platelet disorders
    A T Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Haemophilia 18:154-60. 2012
    ..Stem cell or bone marrow transplantation has been successful for several diseases while gene therapy shows promise in the Wiskott-Aldrich syndrome...
  38. doi request reprint Use of autologous platelet-rich clots for the prevention of local injury bleeding in patients with severe inherited mucocutaneous bleeding disorders
    P Nurden
    Centre de Reference des Pathologies Plaquettaires, Hopital Xavier Arnozan, Pessac, France
    Haemophilia 17:620-4. 2011
    ..This new procedure is simple, safe and inexpensive; it provides extra security for patients with a bleeding risk undergoing dentistry or superficial surgery...
  39. doi request reprint Thrombocytopenia after abciximab use results from different mechanisms
    Sophie Lajus
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Thromb Haemost 103:651-61. 2010
    ..Five antibodies were platelet-activating. In conclusion, the mechanisms responsible for this complication of anti-aIIbb3 therapy are multiple and often associated with a complex immune response...
  40. ncbi request reprint New insights into and novel applications for platelet-rich fibrin therapies
    Eduardo Anitua
    Biotechnology Institute I MAS D, c San Antonio 15, 01005 Vitoria, Spain
    Trends Biotechnol 24:227-34. 2006
    ..This article highlights the use of this technology and discusses some of the obstacles and challenges that need to be addressed to maintain progress in this field...
  41. ncbi request reprint Mutations in the beta3 gene giving rise to type I Glanzmann thrombasthenia in two families in Portugal
    Loida Corbillon Garcia
    Hospital de Santo Antonio, Serviço de Hematologia Clínica, Porto, Portugal
    Platelets 15:15-22. 2004
    ..For both patients a single mutated allele was inherited from each parent. Evidence is accumulating that nonsense mutations leading to a truncated beta3 may be a frequent cause of type I Glanzmann thrombasthenia in the Iberian peninsula...
  42. ncbi request reprint Autologous platelets as a source of proteins for healing and tissue regeneration
    Eduardo Anitua
    Biotechnology Unit, IFR No 4, Hopital Cardiologique, Avenue Magellan, 33604 Pessac, France
    Thromb Haemost 91:4-15. 2004
    ..Our aim is to review these advances and discuss the ways in which platelets may provide such unexpected beneficial therapeutic effects...
  43. ncbi request reprint A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor
    Catherine Strassel
    INSERM U311 Etablissement Français du Sang, Strasbourg, France
    Biochemistry 42:4452-62. 2003
    ..Thus, a single amino acid substitution in the extracellular domain of GPIbbeta can affect both the maturation of GPIbalpha and GPIX stability. GPIbbeta has a pivotal role in regulating GPIb-IX-V biosynthesis...
  44. ncbi request reprint Advantages of fast-acting ADP receptor blockade in ischemic heart disease
    Alan T Nurden
    Arterioscler Thromb Vasc Biol 23:158-9. 2003
  45. ncbi request reprint Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system
    Paquita Nurden
    Centre National de la Recherche Scientifique CNRS, Hopital Cardiologique, Pessac, France
    Blood 101:1400-8. 2003
    ..Pharmacologic antagonism of ADP or TXA(2) receptors in antithrombotic therapy may need to take into account blockade of internal receptor pools...
  46. ncbi request reprint A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen
    Paquita Nurden
    UMR 5533 CNRS, Hopital Cardiologique, Pessac and Académie des Sciences, and Institut de France, Paris, France
    Br J Haematol 118:1143-51. 2002
    ..Our studies implied that alphaIIbbeta3 in platelets may bind fibrinogen in different activation states and that this patient specifically lacked high-affinity binding...
  47. ncbi request reprint Evidence that the platelet integrin alphaIIb beta3 is regulated by the integrin-linked kinase, ILK, in a PI3-kinase dependent pathway
    Jean Max Pasquet
    UMR 5533 CNRS, Hopital Cardiologique du Haut Leveque, Pessac, France
    Thromb Haemost 88:115-22. 2002
    ..Thus ILK transiently associates with and phosphorylates beta3 in a PI3-kinase dependent manner suggesting that it participates at an intermediate stage in a critical mechanism for assuring large stable aggregates...
  48. ncbi request reprint Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood
    Jasper A Remijn
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:686-91. 2002
    ..This was confirmed by complete inhibition on the addition of creatine phosphate/creatine phosphokinase...
  49. ncbi request reprint Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model
    Christel Poujol
    UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Exp Hematol 30:352-60. 2002
    ..To study how giant platelets are produced in vivo, we used a model of GPIbalpha-deficient mice (GPIbalpha(null)) and mice rescued with the human GPIbalpha transgene (GPIbalpha(null;hTg))...
  50. ncbi request reprint Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis
    Jean Francois Viallard
    Department of Internal Medicine, Hopital Haut Leveque, 5 avenue Magellan, 33604 Pessac, France
    Blood 99:2612-4. 2002
    ..In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration...
  51. ncbi request reprint Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome
    Paquita Nurden
    Institut Federatif de Recherche No 4, Laboratoire d Hematologie, Hopital Cardiologique, Pessac, France
    Blood 104:107-14. 2004
    ..Our results may provide a molecular explanation for the subgroup of patients with severely deficient collagen-induced platelet aggregation as previously described for GPS in the literature...
  52. ncbi request reprint Activation of mesangial cells by platelets in systemic lupus erythematosus via a CD154-dependent induction of CD40
    Yahsou Delmas
    Departement de Nephrologie, Hopital Pellegrin, Bordeaux, France
    Kidney Int 68:2068-78. 2005
    ..We examined whether platelets could activate mesangial cells and the potential role of the platelet-associated CD154...
  53. ncbi request reprint Identification of human scFvs targeting atherosclerotic lesions: selection by single round in vivo phage display
    Remy Robert
    Résonance Magnétique des Systèmes Biologiques, Centre National Recherche Scientifique CNRS, UMR 5536, université Bordeaux 2 Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Biol Chem 281:40135-43. 2006
    ..This is the first time that single round in vivo biopanning has been used to select human antibodies as candidates for diagnostic imaging and for obtaining insight into targets displayed in atherosclerotic plaques...
  54. ncbi request reprint Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells
    Eduardo Anitua
    Biotechnology Institute IMASD, Unidad de Cirugía Artroscópica Mikel Sanchez, Vitoria, Spain
    Plast Reconstr Surg 119:950-9. 2007
    ....
  55. ncbi request reprint Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture
    Eduardo Anitua
    Biotechnology Institute, c San Antonio 15, 01005 Vitoria, Spain
    J Orthop Res 23:281-6. 2005
    ..These results suggest that administering autologous platelet-rich clots may be beneficial to the treatment of tendon injuries by inducing cell proliferation and promoting the synthesis of angiogenic factors during the healing process...
  56. ncbi request reprint Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII
    Helen Yarovoi
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 105:4674-6. 2005
    ..It appears that FVIII's interaction with VWF and its intracellular transportation, storage, and secretion differ greatly depending on the cell type. The molecular basis for these differences now needs to be elucidated...
  57. ncbi request reprint Delayed immunologic thrombocytopenia induced by abciximab
    Paquita Nurden
    IFR4 FR21, Laboratoire d Hematologie, Hopital Cardiologique, 33604 Pessac, France
    Thromb Haemost 92:820-8. 2004
    ..In summary, these results show that abciximab-dependent thrombocytopenia can be delayed and potentially prothrombotic...
  58. ncbi request reprint GPIIb/IIIa antagonists and other anti-integrins
    Alan T Nurden
    Laboratoire d Hematologie, UMR 5533 CNRS, Hopital Cardiologique, Pessac, France
    Semin Vasc Med 3:123-30. 2003
    ..The problems of using anti-integrin therapy are discussed in this article as are ways of improving its efficacity. Final thoughts provide ideas for a new generation of inhibitors...
  59. doi request reprint Congenital disorders associated with platelet dysfunctions
    Paquita Nurden
    CRPP PTIB, Hopital Xavier Arnozan, Pessac, France
    Thromb Haemost 99:253-63. 2008
    ..Substitute therapies are available including rFVIIa and the potential use of TPO analogues for FT. Stem cell or bone marrow transplanation is being used for severe diseases while gene therapy may be on the horizon...
  60. ncbi request reprint [Platelet-associated CD154: a new interface in haemostasis and in the inflammatory reaction]
    Yahsou Delmas
    GREF Inserm E362, IFR 66, Université de Bordeaux 2 et Département de Néphrologie, Hopital Pellegrin, France
    Med Sci (Paris) 21:825-31. 2005
    ....
  61. ncbi request reprint Inherited thrombocytopenias
    Alan T Nurden
    Haematologica 92:1158-64. 2007
  62. ncbi request reprint Platelet-associated CD154 in immune thrombocytopenic purpura
    Anne Solanilla
    CNRS FRE 2617 and UMR 5540, Universite de Bordeaux 2, France
    Blood 105:215-8. 2005
    ..Therefore, platelet-associated CD154 expression is increased in ITP and is able to drive the activation of autoreactive B lymphocytes in this disease...
  63. ncbi request reprint Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities
    Eduardo Anitua
    Biotechnology Institute I MAS D, San Antonio 15, 01005 Vitoria, Spain
    J Biomed Mater Res A 77:285-93. 2006
    ....