G J Nohynek

Summary

Country: France

Publications

  1. ncbi An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]
    Gerhard J Nohynek
    L Oreal Recherche, Corporate Safety, 25 29, quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:93-105. 2004
  2. ncbi Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, Asnières, France
    Crit Rev Toxicol 37:251-77. 2007
  3. ncbi Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells
    Eric K Dufour
    L OREAL Research and Development, Worldwide Safety Department, 92600 Asnières, France
    Mutat Res 607:215-24. 2006
  4. ncbi In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolites
    Jean Luc Garrigue
    L OREAL Research and Development, Worldwide Safety Department, 92665 Asnières sur Seine cedex, France
    Mutat Res 608:58-71. 2006
  5. doi Nanotechnology, cosmetics and the skin: is there a health risk?
    G J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, Asnières, France
    Skin Pharmacol Physiol 21:136-49. 2008
  6. doi Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?
    Gerhard J Nohynek
    Global Safety Evaluation, L Oreal Research and Innovation, Asnières, France
    Arch Toxicol 86:1063-75. 2012
  7. doi Safety assessment of personal care products/cosmetics and their ingredients
    Gerhard J Nohynek
    L Oreal R and D, Global Safety Evaluation, 92600 Asnières, France
    Toxicol Appl Pharmacol 243:239-59. 2010
  8. ncbi Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye
    Gerhard J Nohynek
    L OREAL Research and Development, River Plaza Building, 25 29 quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:1885-91. 2004
  9. ncbi Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
    Toxicol Lett 158:196-212. 2005
  10. ncbi Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age
    G J Nohynek
    L Oreal R and D, Worldwide Safety Evaluation, 25 29 quai Aulagnier, 92600 Asnières, France
    Toxicol Lett 163:65-76. 2006

Collaborators

Detail Information

Publications15

  1. ncbi An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]
    Gerhard J Nohynek
    L Oreal Recherche, Corporate Safety, 25 29, quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:93-105. 2004
    ..In conclusion, the topical use of KA as a skin lightening agent results in minimal exposure that poses no or negligible risk of genotoxicity or toxicity to the consumer...
  2. ncbi Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, Asnières, France
    Crit Rev Toxicol 37:251-77. 2007
    ....
  3. ncbi Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells
    Eric K Dufour
    L OREAL Research and Development, Worldwide Safety Department, 92600 Asnières, France
    Mutat Res 607:215-24. 2006
    ....
  4. ncbi In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolites
    Jean Luc Garrigue
    L OREAL Research and Development, Worldwide Safety Department, 92665 Asnières sur Seine cedex, France
    Mutat Res 608:58-71. 2006
    ..Given that MAPPD and DAPPD were negative in the Ames and the MN tests, these acetylated conversion products are considered to be detoxified metabolites that are biologically less reactive than the parent molecule PPD...
  5. doi Nanotechnology, cosmetics and the skin: is there a health risk?
    G J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, Asnières, France
    Skin Pharmacol Physiol 21:136-49. 2008
    ....
  6. doi Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?
    Gerhard J Nohynek
    Global Safety Evaluation, L Oreal Research and Innovation, Asnières, France
    Arch Toxicol 86:1063-75. 2012
    ....
  7. doi Safety assessment of personal care products/cosmetics and their ingredients
    Gerhard J Nohynek
    L Oreal R and D, Global Safety Evaluation, 92600 Asnières, France
    Toxicol Appl Pharmacol 243:239-59. 2010
    ..In the interest of all stakeholders, consumers, regulatory bodies and producers, there is an urgent need for an international harmonization on the status and safety requirements of these products and their ingredients...
  8. ncbi Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye
    Gerhard J Nohynek
    L OREAL Research and Development, River Plaza Building, 25 29 quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:1885-91. 2004
    ..9%, respectively. Overall, our results suggest that the human acetylation rate of PPD after topical application is independent of the NAT2 genotype status, most likely due to metabolism by epidermal NAT1 prior to systemic absorption...
  9. ncbi Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
    Toxicol Lett 158:196-212. 2005
    ..In conclusion, our data support the growing evidence that AAs are transformed in human skin and suggest that current practices of safety assessment of AAs should take these findings into account...
  10. ncbi Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age
    G J Nohynek
    L Oreal R and D, Worldwide Safety Evaluation, 25 29 quai Aulagnier, 92600 Asnières, France
    Toxicol Lett 163:65-76. 2006
    ..Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites...
  11. ncbi Occupational exposure of hairdressers to [14C]-para-phenylenediamine-containing oxidative hair dyes: a mass balance study
    Frédérique Hueber-Becker
    L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 45:160-9. 2007
    ....
  12. ncbi Eye irritation of low-irritant cosmetic formulations: correlation of in vitro results with clinical data and product composition
    Caroline Debbasch
    L OREAL Research and Development, Worldwide Safety Department, L Oreal R and D, 25 29 Quai Aulagnier 92600, Asnières sur Seine, France
    Food Chem Toxicol 43:155-65. 2005
    ..Although our results suggest that the IL-8 assay appears to be a promising screen for borderline-irritant formulations, further experiments are required to confirm and validate these preliminary results...
  13. ncbi Human systemic exposure to a [14C]-para-phenylenediamine-containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skin
    Frédérique Hueber-Becker
    L OREAL Research, Global Safety, River Plaza Building, 25 29 quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:1227-36. 2004
    ..40 or 10.22 mgeq for human or pig skin, respectively. All results suggested that hair dyeing with oxidative hair dyes produces minimal systemic exposure that is unlikely to pose a risk to human health...
  14. ncbi Toxicity and human health risk of hair dyes
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, 25 29, quai Aulagnier, 92600 Asnières, France
    Food Chem Toxicol 42:517-43. 2004
    ..In conclusion, the weight of evidence suggests that consumer or professional exposure to hair dyes poses no carcinogenic or other human health risks...
  15. ncbi Predicting human skin absorption of chemicals: development of a novel quantitative structure activity relationship
    Wen Luo
    Department of Toxicology, L Oreal USA, Clark, NJ 07066, USA
    Toxicol Ind Health 23:39-45. 2007
    ..Additionally, our models are reasonably predictive and have met both internal and external statistical validations...