Research Topics
| G J NohynekSummaryCountry: France Publications
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Detail Information
Publications
An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]Gerhard J Nohynek
L Oreal Recherche, Corporate Safety, 25 29, quai Aulagnier, 92600 Asnières, France
Food Chem Toxicol 42:93-105. 2004..In conclusion, the topical use of KA as a skin lightening agent results in minimal exposure that poses no or negligible risk of genotoxicity or toxicity to the consumer...- Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safetyGerhard J Nohynek
L OREAL Research and Development, Worldwide Safety Department, Asnières, France
Crit Rev Toxicol 37:251-77. 2007.... - Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cellsEric K Dufour
L OREAL Research and Development, Worldwide Safety Department, 92600 Asnières, France
Mutat Res 607:215-24. 2006.... - In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolitesJean Luc Garrigue
L OREAL Research and Development, Worldwide Safety Department, 92665 Asnières sur Seine cedex, France
Mutat Res 608:58-71. 2006..Given that MAPPD and DAPPD were negative in the Ames and the MN tests, these acetylated conversion products are considered to be detoxified metabolites that are biologically less reactive than the parent molecule PPD... 
Nanotechnology, cosmetics and the skin: is there a health risk?G J Nohynek
L OREAL Research and Development, Worldwide Safety Department, Asnières, France
Skin Pharmacol Physiol 21:136-49. 2008....- Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?Gerhard J Nohynek
Global Safety Evaluation, L Oreal Research and Innovation, Asnières, France
Arch Toxicol 86:1063-75. 2012.... - Safety assessment of personal care products/cosmetics and their ingredientsGerhard J Nohynek
L Oreal R and D, Global Safety Evaluation, 92600 Asnières, France
Toxicol Appl Pharmacol 243:239-59. 2010..In the interest of all stakeholders, consumers, regulatory bodies and producers, there is an urgent need for an international harmonization on the status and safety requirements of these products and their ingredients... - Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dyeGerhard J Nohynek
L OREAL Research and Development, River Plaza Building, 25 29 quai Aulagnier, 92600 Asnières, France
Food Chem Toxicol 42:1885-91. 2004..9%, respectively. Overall, our results suggest that the human acetylation rate of PPD after topical application is independent of the NAT2 genotype status, most likely due to metabolism by epidermal NAT1 prior to systemic absorption... - Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytesGerhard J Nohynek
L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
Toxicol Lett 158:196-212. 2005..In conclusion, our data support the growing evidence that AAs are transformed in human skin and suggest that current practices of safety assessment of AAs should take these findings into account... - Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing ageG J Nohynek
L Oreal R and D, Worldwide Safety Evaluation, 25 29 quai Aulagnier, 92600 Asnières, France
Toxicol Lett 163:65-76. 2006..Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites... - Occupational exposure of hairdressers to [14C]-para-phenylenediamine-containing oxidative hair dyes: a mass balance studyFrédérique Hueber Becker
L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
Food Chem Toxicol 45:160-9. 2007.... - Eye irritation of low-irritant cosmetic formulations: correlation of in vitro results with clinical data and product compositionCaroline Debbasch
L OREAL Research and Development, Worldwide Safety Department, L Oreal R and D, 25 29 Quai Aulagnier 92600, Asnières sur Seine, France
Food Chem Toxicol 43:155-65. 2005..Although our results suggest that the IL-8 assay appears to be a promising screen for borderline-irritant formulations, further experiments are required to confirm and validate these preliminary results... - Human systemic exposure to a [14C]-para-phenylenediamine-containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skinFrédérique Hueber-Becker
L OREAL Research, Global Safety, River Plaza Building, 25 29 quai Aulagnier, 92600 Asnières, France
Food Chem Toxicol 42:1227-36. 2004..40 or 10.22 mgeq for human or pig skin, respectively. All results suggested that hair dyeing with oxidative hair dyes produces minimal systemic exposure that is unlikely to pose a risk to human health... - Toxicity and human health risk of hair dyesGerhard J Nohynek
L OREAL Research and Development, Worldwide Safety Department, 25 29, quai Aulagnier, 92600 Asnières, France
Food Chem Toxicol 42:517-43. 2004..In conclusion, the weight of evidence suggests that consumer or professional exposure to hair dyes poses no carcinogenic or other human health risks... - Predicting human skin absorption of chemicals: development of a novel quantitative structure activity relationshipWen Luo
Department of Toxicology, L Oreal USA, Clark, NJ 07066, USA
Toxicol Ind Health 23:39-45. 2007..Additionally, our models are reasonably predictive and have met both internal and external statistical validations...