Arnaud Nicot

Summary

Affiliation: INSERM
Location: Nantes, France
URL: cvscience.aviesan.fr/cv/47/arnaud-b-nicot
Summary:
Ass. Professor Inserm /University of Nantes (lUNAM) Neuroimmunology
Grants:
BQR", University Pierre & Marie Curie (UPMC), 2005

"Immuno_Sclérose", Région Pays de la Loire, 2011




Publications

  1. pmc Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis
    Arnaud Nicot
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Neurology and Neuroscience, Newark, NJ, United States
    Eur J Neurosci 21:2660-70. 2005
  2. ncbi request reprint Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A
    James A Waschek
    Mental Retardation Research Center, Semel Institute for Neuroscience, Jonsson Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1070:120-8. 2006
  3. ncbi request reprint Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation
    Stéphane J Baudouin
    Institut National de la Sante et de la Recherche Medicale, I N S E R M, Unité 643, I T E R T, CHU Hotel Dieu, University of Nantes, 30 Bd Jean Monnet, 44035 Nantes Cedex 01, France
    Mol Cell Neurosci 33:160-9. 2006
  4. pmc Gender and sex hormones in multiple sclerosis pathology and therapy
    Arnaud Nicot
    INSERM UMR S 546, Paris, F 75013 France
    Front Biosci (Landmark Ed) 14:4477-515. 2009
  5. doi request reprint NOV/CCN3 promotes maturation of cerebellar granule neuron precursors
    G Le Dreau
    INSERM, UMR S893, Hopital Saint Antoine, F 75012, Paris, France
    Mol Cell Neurosci 43:60-71. 2010
  6. pmc Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes
    Sébastien N Giraud
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche en Santé 546, Hopital Pitie Salpetriere, Paris F 75013, France
    Proc Natl Acad Sci U S A 107:8416-21. 2010
  7. pmc Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons
    M P Kurnellas
    Department of Neurology and Neuroscience, New Jersey Medical School UMDNJ, Newark, 07103, USA
    Cell Death Differ 17:1501-10. 2010
  8. ncbi request reprint NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins
    G Le Dreau
    INSERM, UMR_S 938, Centre de Recherche de Saint Antoine, Hopital Saint Antoine, Paris, France
    Glia 58:1510-21. 2010
  9. pmc Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury
    Michael P Kurnellas
    Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    FASEB J 19:298-300. 2005
  10. ncbi request reprint Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 24:8786-95. 2004

Collaborators

Detail Information

Publications20

  1. pmc Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis
    Arnaud Nicot
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Neurology and Neuroscience, Newark, NJ, United States
    Eur J Neurosci 21:2660-70. 2005
    ..The decrease in PMCA2 transcript and protein levels and the correlation between expression and disease course in two different EAE models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation...
  2. ncbi request reprint Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A
    James A Waschek
    Mental Retardation Research Center, Semel Institute for Neuroscience, Jonsson Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1070:120-8. 2006
    ..It remains to be determined if HH/GPCR antagonistic interactions play additional important roles in development, plasticity, tissue repair, cancer, and other processes...
  3. ncbi request reprint Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation
    Stéphane J Baudouin
    Institut National de la Sante et de la Recherche Medicale, I N S E R M, Unité 643, I T E R T, CHU Hotel Dieu, University of Nantes, 30 Bd Jean Monnet, 44035 Nantes Cedex 01, France
    Mol Cell Neurosci 33:160-9. 2006
    ..Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains...
  4. pmc Gender and sex hormones in multiple sclerosis pathology and therapy
    Arnaud Nicot
    INSERM UMR S 546, Paris, F 75013 France
    Front Biosci (Landmark Ed) 14:4477-515. 2009
    ..The different cellular targets as well as some molecular mechanisms likely involved are discussed...
  5. doi request reprint NOV/CCN3 promotes maturation of cerebellar granule neuron precursors
    G Le Dreau
    INSERM, UMR S893, Hopital Saint Antoine, F 75012, Paris, France
    Mol Cell Neurosci 43:60-71. 2010
    ..These findings identify a new paracrine role of NOV in the development of cerebellar granule neurons...
  6. pmc Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes
    Sébastien N Giraud
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche en Santé 546, Hopital Pitie Salpetriere, Paris F 75013, France
    Proc Natl Acad Sci U S A 107:8416-21. 2010
    ....
  7. pmc Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons
    M P Kurnellas
    Department of Neurology and Neuroscience, New Jersey Medical School UMDNJ, Newark, 07103, USA
    Cell Death Differ 17:1501-10. 2010
    ..This represents an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE...
  8. ncbi request reprint NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins
    G Le Dreau
    INSERM, UMR_S 938, Centre de Recherche de Saint Antoine, Hopital Saint Antoine, Paris, France
    Glia 58:1510-21. 2010
    ..Altogether, our data shed light on the signaling pathways operated by NOV and strongly suggest that NOV mediates astrocyte activation and, therefore, might play a role in neuroinflammation...
  9. pmc Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury
    Michael P Kurnellas
    Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    FASEB J 19:298-300. 2005
    ..Our findings suggest that a reduction in PMCA2 level or activity leading to delays in calcium clearance may cause neuronal damage and loss in the spinal cord...
  10. ncbi request reprint Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 24:8786-95. 2004
    ..In turn, these studies raise the potential clinical relevance of PACAP signaling dysfunctions in neuropsychiatric disorders characterized by social reciprocity impairments such as autism spectrum disorders...
  11. pmc Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression
    A Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 98:4758-63. 2001
    ..These observations highlight the critical role of lineage-specific expression of GPCR variants in determining mitogenic signaling in neural precursors...
  12. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:9244-54. 2002
    ..These observations suggest that G-protein-coupled receptors, such as PAC1, serve as sensors of environmental cues, coordinating diverse neurogenetic signals...
  13. ncbi request reprint Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction
    Arnaud Nicot
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Brain 126:398-412. 2003
    ..Altered mitochondrial function and impulse conduction may exacerbate neurological deficits at subsequent disease stages...
  14. pmc Exacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc)-null mice: evidence for a critical role of the central nervous system
    Pauline Gourdain
    INSERM, UMR S 938, Centre de Recherche Hopital Saint Antoine, Paris, France
    J Neuroinflammation 9:25. 2012
    ..However, alternative interpretations such as reduced resistance of neurons to autoimmune insult and exacerbated gliosis leading to neuronal deficits were not considered...