Genevieve Nguyen

Summary

Country: France

Publications

  1. doi request reprint Renin and prorenin receptor in hypertension: what's new?
    Genevieve Nguyen
    Center for Interdisciplinary Research in Biology and Experimental Medicine Unit Collège de France, Institut National de la Sante et de la Recherche Medicale INSERM, 11 place Marcelin Berthelot, Paris, France
    Curr Hypertens Rep 13:79-85. 2011
  2. doi request reprint Renin, (pro)renin and receptor: an update
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM and Collège de France Early Development and Pathologies Center for Interdisciplinary Research in Biology and Experimental Medicine Unit, 11 place Marcelin Berthelot, 75005, Paris, France
    Clin Sci (Lond) 120:169-78. 2011
  3. doi request reprint Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity
    Genevieve Nguyen
    Centre for Interdisciplinary Research in Biology, UMR INSERM U1050 CNRS 7241, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05
    Hypertension 63:297-302. 2014
  4. ncbi request reprint The (pro)renin receptor: a new kid in town
    Genevieve Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, and Collège de France, Unit of Experimental Medicine, Paris, France
    Semin Nephrol 27:519-23. 2007
  5. doi request reprint Physiology and pharmacology of the (pro)renin receptor
    Genevieve Nguyen
    Institut de la Santé et de la Recherche Médicale Unit 833 and Collège de France, Experimental Medecine Unit, 11 place Marcelin Berthelot, 75005 Paris, France
    Curr Opin Pharmacol 8:127-32. 2008
  6. doi request reprint The (pro)renin receptors
    Genevieve Nguyen
    INSERM Unit 833, College de France, 11 place Marcelin Berthelot, Paris, France
    J Mol Med (Berl) 86:643-6. 2008
  7. doi request reprint Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, INSERM Unit 833 and Collège de France, 11 place Marcelin Berthelot, 75005, Paris, France
    Exp Physiol 93:557-63. 2008
  8. doi request reprint The biology of the (pro)renin receptor
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, College de France, Paris, France
    J Am Soc Nephrol 21:18-23. 2010
  9. ncbi request reprint The (pro)renin receptor in health and disease
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, INSERM Unit 833 and Experimental Medicine Unit, College de France, 11 place Marcelin Berthelot, 75005, Paris, France
    Ann Med 42:13-8. 2010
  10. ncbi request reprint The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology
    Genevieve Nguyen
    Institut National de la Sante et de la Recherche Medicale, College de France, Experimental Medicine Unit, Paris, France
    Curr Opin Nephrol Hypertens 16:129-33. 2007

Collaborators

Detail Information

Publications24

  1. doi request reprint Renin and prorenin receptor in hypertension: what's new?
    Genevieve Nguyen
    Center for Interdisciplinary Research in Biology and Experimental Medicine Unit Collège de France, Institut National de la Sante et de la Recherche Medicale INSERM, 11 place Marcelin Berthelot, Paris, France
    Curr Hypertens Rep 13:79-85. 2011
    ....
  2. doi request reprint Renin, (pro)renin and receptor: an update
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM and Collège de France Early Development and Pathologies Center for Interdisciplinary Research in Biology and Experimental Medicine Unit, 11 place Marcelin Berthelot, 75005, Paris, France
    Clin Sci (Lond) 120:169-78. 2011
    ..The present review will summarize our knowledge of (pro)renin-dependent functions of PRR and will discuss the newly recognized functions of PRR related to the V-ATPase and to Wnt signalling...
  3. doi request reprint Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity
    Genevieve Nguyen
    Centre for Interdisciplinary Research in Biology, UMR INSERM U1050 CNRS 7241, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05
    Hypertension 63:297-302. 2014
    ....
  4. ncbi request reprint The (pro)renin receptor: a new kid in town
    Genevieve Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, and Collège de France, Unit of Experimental Medicine, Paris, France
    Semin Nephrol 27:519-23. 2007
    ..This review updates the recent findings on (P)RR; its role in hypertension, cardiac fibrosis, diabetic nephropathy, and retinopathy; and the effects of a putative (P)RR antagonist...
  5. doi request reprint Physiology and pharmacology of the (pro)renin receptor
    Genevieve Nguyen
    Institut de la Santé et de la Recherche Médicale Unit 833 and Collège de France, Experimental Medecine Unit, 11 place Marcelin Berthelot, 75005 Paris, France
    Curr Opin Pharmacol 8:127-32. 2008
    ....
  6. doi request reprint The (pro)renin receptors
    Genevieve Nguyen
    INSERM Unit 833, College de France, 11 place Marcelin Berthelot, Paris, France
    J Mol Med (Berl) 86:643-6. 2008
    ..Experimental models suggest that increased (P)RR synthesis and/or activation may be relevant to diseases, especially to high blood pressure, to cardiac fibrosis associated with hypertension, and to diabetic nephropathy...
  7. doi request reprint Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, INSERM Unit 833 and Collège de France, 11 place Marcelin Berthelot, 75005, Paris, France
    Exp Physiol 93:557-63. 2008
    ..Although this rise can be interpreted as evidence of effective renin-angiotensin system blockade, it could also result in increased (P)RR activation...
  8. doi request reprint The biology of the (pro)renin receptor
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, College de France, Paris, France
    J Am Soc Nephrol 21:18-23. 2010
    ..Furthermore, the early embryonic lethality seen in PRR-null mice suggests PRR has additional essential cellular functions we do not understand...
  9. ncbi request reprint The (pro)renin receptor in health and disease
    Genevieve Nguyen
    Institut de la Sante et de la Recherche Medicale, INSERM Unit 833 and Experimental Medicine Unit, College de France, 11 place Marcelin Berthelot, 75005, Paris, France
    Ann Med 42:13-8. 2010
    ..On the contrary, the human and the animal mutations are calling our attention to an essential role of (P)RR during early development, in particular in neuronal development...
  10. ncbi request reprint The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology
    Genevieve Nguyen
    Institut National de la Sante et de la Recherche Medicale, College de France, Experimental Medicine Unit, Paris, France
    Curr Opin Nephrol Hypertens 16:129-33. 2007
    ..The present review summarizes the findings, suggesting that it may play pathological role in cardiac and renal fibrosis, and in hypertensive and diabetic nephropathy...
  11. ncbi request reprint Increased cyclooxygenase-2, hyperfiltration, glomerulosclerosis, and diabetic nephropathy: put the blame on the (pro)renin receptor?
    G Nguyen
    Institut National de la Sante et de la Recherche Medicale, Unit 36, College de France, Unit of Experimental Medicine, Paris, France
    Kidney Int 70:618-20. 2006
    ....
  12. ncbi request reprint Renin/prorenin-receptor biochemistry and functional significance
    Genevieve Nguyen
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005, Paris, France
    Curr Hypertens Rep 6:129-32. 2004
    ..In this article, we review the biochemical characteristics of this receptor and of other renin-binding proteins, and discuss their physiologic significance...
  13. ncbi request reprint Renin/prorenin receptors
    G Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, College de France, Unit of Experimental Medicine, Paris, France
    Kidney Int 69:1503-6. 2006
    ....
  14. doi request reprint [The prorenin receptor]
    Diane Bracquart
    INSERM Unité 833, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    J Soc Biol 203:303-10. 2009
    ....
  15. ncbi request reprint Elevated blood pressure and heart rate in human renin receptor transgenic rats
    Celine A Burckle
    INSERM U36, Paris, France
    Hypertension 47:552-6. 2006
    ..The rise in aldosterone may underlie, at least in part, the observed cardiovascular phenotype of TGR(SMMHC-HRR)...
  16. ncbi request reprint The renin receptor: the facts, the promise and the hope
    Genevieve Nguyen
    National Institute for Health and Medical Research, INSERM Unit 489, Tenon Hospital, Paris, France
    Curr Opin Nephrol Hypertens 12:51-5. 2003
    ..The search for a receptor of renin was based on the idea that tissue (pro)renin is taken up from the circulation and on data suggesting that renin has cellular effects independent of angiotensin II...
  17. pmc Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM U489, and Association Claude Bernard, Hopital Tenon, Paris, France
    J Clin Invest 109:1417-27. 2002
    ..This discovery emphasizes the role of the cell surface in angiotensin II generation and opens new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II...
  18. ncbi request reprint [The (pro)renin receptor: biology and functional significance]
    Genevieve Nguyen
    INSERM U36, Pathologie Vasculaire et Endocrinologie Renale, 11 place Marcelin Berthelot, 75005, Paris
    Bull Acad Natl Med 188:621-8; discussion 628-9. 2004
    ..This recent discovery of a functional (pro)renin receptor forces the emergence of a new concept that casts renin as potentially playing a direct role in tissue damage, especially in situations where the tissue RAS is activated...
  19. ncbi request reprint Potential role of the (pro)renin receptor in cardiovascular and kidney diseases
    Christelle Cousin
    Inserm Unité 833 and Collège de France, Paris, France
    J Nephrol 23:508-13. 2010
    ..Finally, a mutation in the (P)RR gene is responsible for mental retardation and epilepsy, indicating that (P)RR is essential during brain development...
  20. doi request reprint Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma
    Christelle Cousin
    Institut National de la Santé et de la Recherche Médicale and Collège de France, Paris, France
    Hypertension 53:1077-82. 2009
    ..In conclusion, our results show that s(P)RR is generated intracellularly by furin cleavage, and that s(P)RR detected in plasma is able to bind renin...
  21. pmc A role of the (pro)renin receptor in neuronal cell differentiation
    Aurelie Contrepas
    Institut National de la Sante et de la Recherche Medicale, Unit 833 and Collège de France, Experimental Medicine Unit, Paris, France
    Am J Physiol Regul Integr Comp Physiol 297:R250-7. 2009
    ..In conclusion, our results show that (P)RR is expressed in mouse brain and suggest that the XLMR and epilepsy phenotype might result from a dominant-negative effect of the Delta4-(P)RR protein...
  22. ncbi request reprint The (pro)renin receptor: biochemistry and potential significance
    Genevieve Nguyen
    INSERM U36, College de France, Paris
    J Renin Angiotensin Aldosterone Syst 6:166-7. 2005
  23. ncbi request reprint Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation
    I Kazes
    INSERM U489 and Association Claude Bernard, Tenon Hospital, and Unité de Pharmacologie Cellulaire, Unité Associée, Pasteur Institute INSERM U485, Paris, France
    Blood 96:3064-9. 2000
    ..In conclusion, our results demonstrate the expression of the trimolecular complex components (MT1-MMP/TIMP2/MMP2) by blood platelets as well as the ability of MMP inhibitors to modulate the aggregating response...
  24. ncbi request reprint Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinase
    I Kazes
    INSERM U 489, Hopital Tenon, Paris, France
    Kidney Int 54:1976-84. 1998
    ..In spite of evidence for the synthesis of MT1-MMP shown by immunoblotting, immunocytochemistry and RT-PCR, and of TIMP2, MMP2 was found exclusively in a latent form in human mesangial cells (HMC) serum-free culture medium...