A Nehlig

Summary

Country: France

Publications

  1. ncbi request reprint Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia
    A Nehlig
    INSERM U 398, Faculte de Medecine, Strasbourg, France
    Diabetes Metab 23:18-29. 1997
  2. ncbi request reprint Brain uptake and metabolism of ketone bodies in animal models
    Astrid Nehlig
    INSERM U 405, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg Cedex, France
    Prostaglandins Leukot Essent Fatty Acids 70:265-75. 2004
  3. ncbi request reprint Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry
    Astrid Nehlig
    INSERM U 398, University Louis Pasteur, Faculty of Medicine, Strasbourg, France
    J Cereb Blood Flow Metab 24:1004-14. 2004
  4. ncbi request reprint Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    Epileptic Disord 6:247-53. 2004
  5. ncbi request reprint Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Brain Res 1082:32-42. 2006
  6. ncbi request reprint Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Glia 55:1238-50. 2007
  7. ncbi request reprint Dose-response study of caffeine effects on cerebral functional activity with a specific focus on dependence
    A Nehlig
    INSERM U 398, Faculte de Medecine, 11 rue Humann, Universite Louis Pasteur, 67085, Strasbourg, France
    Brain Res 858:71-7. 2000
  8. ncbi request reprint Age-dependent pathways of brain energy metabolism: the suckling rat, a natural model of the ketogenic diet
    A Nehlig
    INSERM U 398, Faculte de Medecine, Strasbourg, France
    Epilepsy Res 37:211-21. 1999
  9. ncbi request reprint Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures
    Astrid Nehlig
    Faculte de Medecine, INSERM U 398, University Louis Pasteur, 11 rue Humann, 67085 Strasbourg Cedex, France
    Epilepsy Res 51:189-97. 2002
  10. pmc The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    J Neurochem 109:207-13. 2009

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia
    A Nehlig
    INSERM U 398, Faculte de Medecine, Strasbourg, France
    Diabetes Metab 23:18-29. 1997
    ..Neuronal damage consecutive to severe and prolonged hypoglycaemia occurs mainly in the cerebral cortex, hippocampus and caudate-putamen as a result of active release of excitatory amino acids...
  2. ncbi request reprint Brain uptake and metabolism of ketone bodies in animal models
    Astrid Nehlig
    INSERM U 405, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg Cedex, France
    Prostaglandins Leukot Essent Fatty Acids 70:265-75. 2004
    ....
  3. ncbi request reprint Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry
    Astrid Nehlig
    INSERM U 398, University Louis Pasteur, Faculty of Medicine, Strasbourg, France
    J Cereb Blood Flow Metab 24:1004-14. 2004
    ..0% were localized in astrocytes on GFAP-labeled sections and 60.1% in neurons on MAP2-labeled sections. These data represent the first in vivo evidence of the compartmentation of uptake and metabolism of glucose in neurons and astrocytes...
  4. ncbi request reprint Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    Epileptic Disord 6:247-53. 2004
    ..Our data are concordant with the hypothesis that neuronal activity underlying the occurrence of spike-and-wave discharges does not seem to require an increase in metabolic demand and blood flow rates. [Published with videosequences]...
  5. ncbi request reprint Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Brain Res 1082:32-42. 2006
    ..These data show that acute pentylenetetrazol seizures induce a rapid up-regulation of the GLUT1 and GLUT3 mRNAs, but do not result in measurable increases in protein levels, suggesting translational regulation...
  6. ncbi request reprint Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Glia 55:1238-50. 2007
    ..Finally, the sequence of metabolic changes occurring during a transient increase of electrical activity in specific regions of the brain remains to be clarified...
  7. ncbi request reprint Dose-response study of caffeine effects on cerebral functional activity with a specific focus on dependence
    A Nehlig
    INSERM U 398, Faculte de Medecine, 11 rue Humann, Universite Louis Pasteur, 67085, Strasbourg, France
    Brain Res 858:71-7. 2000
    ..They also show that low doses of caffeine which reflect the usual human level of consumption fail to activate reward circuits in the brain and thus provide functional evidence of the very low addictive potential of caffeine...
  8. ncbi request reprint Age-dependent pathways of brain energy metabolism: the suckling rat, a natural model of the ketogenic diet
    A Nehlig
    INSERM U 398, Faculte de Medecine, Strasbourg, France
    Epilepsy Res 37:211-21. 1999
    ..Conversely, the homogeneous increase in cerebral betaHB uptake occurring between PN10 and PN17 at a period of active brain growth may rather reflect non-specific mechanisms of cell growth...
  9. ncbi request reprint Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures
    Astrid Nehlig
    Faculte de Medecine, INSERM U 398, University Louis Pasteur, 11 rue Humann, 67085 Strasbourg Cedex, France
    Epilepsy Res 51:189-97. 2002
    ..Thus, SE induced by lithium and pilocarpine early in life does not change the sensitivity to limbic seizures or seizures induced by GABA(A) antagonists during adulthood...
  10. pmc The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    J Neurochem 109:207-13. 2009
    ..This report extends the observation in humans that the KD does not appear to show effectiveness in intractable atypical absence epilepsy to this model of typical childhood absence epilepsy which responds to specific antiepileptic drugs...
  11. ncbi request reprint Metabolic activity is increased in discrete brain regions before the occurrence of spike-and-wave discharges in weanling rats with genetic absence epilepsy
    A Nehlig
    INSERM U 398, Universite Louis Pasteur, Strasbourg, France
    Brain Res Dev Brain Res 108:69-75. 1998
    ..Conversely, the full electrocortical maturation seems necessary for the expression of spike-and-wave discharges with the concurrent increase in LCMRglcs in adult GAERS...
  12. ncbi request reprint Local cerebral glucose utilization in adult and immature GAERS
    A Nehlig
    INSERM U 398, Universite Louis Pasteur, Faculte de Medecine, Strasbourg, France
    Epilepsy Res 32:206-12. 1998
    ....
  13. ncbi request reprint Are we dependent upon coffee and caffeine? A review on human and animal data
    A Nehlig
    INSERM U 398, Faculte de Medecine, Strasbourg, France
    Neurosci Biobehav Rev 23:563-76. 1999
    ....
  14. ncbi request reprint Modulation of absence seizures by branched-chain amino acids: correlation with brain amino acid concentrations
    F Dufour
    INSERM U 398, , 11 rue Humann, , France
    Neurosci Res 40:255-63. 2001
    ..Thus, BCAAs and alpha-KIC, by decreasing the effects of glutamatergic neurotransmission could facilitate those of GABAergic neurotransmission, which is known to increase the occurrence of seizures in GAERS...
  15. ncbi request reprint Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model
    Véronique André
    INSERM U 398, 405 and 666, Strasbourg, France
    Epilepsia 48:41-7. 2007
    ..Pharmacological protection of the basal cortices is necessary for a beneficial disease-modifying effect but this must be combined with protection of the hippocampus to prevent epileptogenesis in this model of TLE...
  16. ncbi request reprint Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat
    Véronique André
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:893-903. 2003
    ....
  17. ncbi request reprint Forebrain metabolic activation induced by the repetition of audiogenic seizures in Wistar rats
    A Pereira de Vasconcelos
    INSERM U398, Faculte de Medecine, Strasbourg, France
    Brain Res 762:114-20. 1997
    ....
  18. ncbi request reprint Modifications of local cerebral glucose utilization in thalamic structures following injection of a dopaminergic agonist in the nucleus accumbens--involvement in antiepileptic effects?
    V Riban
    Neurobiologie et Neuropharmacologie des Epilepsies Généralisées, INSERM U 398, Faculte de Medecine, F 67085 Strasbourg Cedex, France
    Exp Neurol 188:452-60. 2004
    ..Along with data from the literature, our data suggest that this nucleus could participate in the control of the basal ganglia over generalized epileptic seizures...
  19. ncbi request reprint Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy
    V Andre
    INSERM U 398, Faculty of Medicine, Universite Louis Pasteur, 11 rue Humann, 67085, Strasbourg, France
    Epilepsy Res 42:7-22. 2000
    ..Thus, the extensive neuronal damage occurring in the entorhinal and perirhinal cortices of the ECS-pilo rats seems to prevent the establishment of the hyperexcitable epileptic circuit...
  20. ncbi request reprint Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy
    V Andre
    INSERM U398, Faculty of Medicine, Universite Louis Pasteur, 11, rue Humann, 67085, Strasbourg, Cedex, France
    Epilepsy Res 47:99-117. 2001
    ..Furthermore, the study performed in non-epileptic rats indicates that chronic treatment with a GABAmimetic drug upregulates the expression of the protein GAD67 in specific areas of the brain, independently from the seizures...
  21. ncbi request reprint A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    ..In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE...
  22. doi request reprint The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats
    Ryosuke Hanaya
    INSERM U666, Strasbourg, France
    Neurobiol Dis 31:451-8. 2008
    ..The genetic background underlying the expression of audiogenic seizures sensitizes strongly the rats to a further insult and compromises their survival...
  23. ncbi request reprint Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage
    Anne Pereira de Vasconcelos
    Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Strasbourg, France
    J Cereb Blood Flow Metab 22:196-205. 2002
    ..Thus, the level of coupling between blood flow supply and metabolism is not involved in seizure-related brain damage in the developing brain, which appears to be resistant to the consequences of such a mismatch...
  24. ncbi request reprint Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy
    V Andre
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Hippocampus 11:452-68. 2001
    ..In particular, the reorganization of GABAergic axons in the dentate gyrus might contribute to synchronize hyperexcitability induced by the interneuron loss during the silent period, leading to the onset of chronic seizures...
  25. doi request reprint Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model
    Emmanuel Raffo
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Exp Neurol 219:414-23. 2009
    ..This indicates that the exposure to seizures during pregnancy is not harmful for the development of the fetus...
  26. ncbi request reprint Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat
    Marie Aude Rigoulot
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:529-35. 2003
    ..We explored whether the exposure to a low long-term dose of caffeine could protect the brain from neuronal damage and epileptogenesis in the lithium-pilocarpine model of temporal lobe epilepsy...
  27. pmc Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy
    Claire Leroy
    Psychopathologie et Pharmacologie de la Cognition, INSERM U405, Strasbourg, France
    J Physiol 557:473-87. 2004
    ..The failure of benzodiazepine and neurosteroid to potentiate inhibition early after SE may be a critical factor in the development of epileptogenesis and occurrence of seizures...
  28. ncbi request reprint Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle
    F Dufour
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg, France
    J Neurosci Res 66:923-30. 2001
    ..The exact origin of this apparent metabolic dysregulation of energy metabolism in GAERS that could underlie the origin of seizures in that strain remains to be explored further...
  29. ncbi request reprint Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
    Jennifer Francois
    INSERM U 398 and 666, Strasbourg, France
    Epilepsia 49:393-9. 2008
    ....
  30. ncbi request reprint Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat
    Ryosuke Hanaya
    INSERM U405, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Exp Neurol 204:720-32. 2007
    ..The process of reorganization in regions with neuronal damage is not fully clarified...
  31. ncbi request reprint Developmental characteristics of picrotoxin-induced convulsions in rats with genetic absence epilepsy
    Marguerite Vergnes
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085, Strasbourg Cedex, France
    Exp Neurol 184:549-51. 2003
    ..After 40 days of age, GAERS appeared definitely more prone than NERs to convulse in response to picrotoxin injection. A developmental imbalance in excitation/inhibition may parallel the occurrence of SWDs...
  32. ncbi request reprint Age-dependent consequences of seizures and the development of temporal lobe epilepsy in the rat
    C Dube
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Dev Neurosci 23:219-23. 2001
    ..In conclusion, the process of epileptogenesis and its functional consequences differ in P21 and adult rats. The factors underlying these age-related differences remain to be explored...
  33. ncbi request reprint Age-dependent regulation of seizure activity by nitric oxide in the developing rat
    A Pereira de Vasconcelos
    INSERM 398, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Brain Res Dev Brain Res 107:315-9. 1998
    ..At P21, l-Arg improved the outcome of seizures while LNA had no effect. These results demonstrated the age-dependent role of NO in epilepsy...
  34. ncbi request reprint Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy
    M A Rigoulot
    Institut National de la Santé et de la Recherche Médicale U398, Faculty of Medicine, Strasbourg, France
    J Pharmacol Exp Ther 308:787-95. 2004
    ..In conclusion, topiramate displayed neuroprotective properties only in CA1 and CA3 that were not sufficient to prevent epileptogenesis...
  35. ncbi request reprint Role of nitric oxide in pentylenetetrazol-induced seizures: age-dependent effects in the immature rat
    A P de Vasconcelos
    INSERM 398, Faculte de Medecine, Strasbourg, France
    Epilepsia 41:363-71. 2000
    ..To understand the pathophysiologic mechanisms involved in seizures and their consequences during development, we investigated the role of nitric oxide (NO) in severe pentylenetetrazol (PTZ)-induced seizures in immature rats...
  36. ncbi request reprint Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures
    Serge Chassagnon
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:1178-87. 2005
    ....
  37. ncbi request reprint Postnatal maturation of cytochrome oxidase and lactate dehydrogenase activity and age-dependent consequences of lithium-pilocarpine status epilepticus in the rat: a regional histoenzymology study
    Emmanuel Raffo
    INSERM U 405, Universite Louis Pasteur, 67085 Strasbourg, France
    Pediatr Res 56:647-55. 2004
    ....
  38. ncbi request reprint Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment
    Emmanuel Raffo
    INSERM U 666, 67085 Strasbourg, France
    Epilepsia 49:320-8. 2008
    ..Thresholds to pentylenetetrazol (PTZ) seizures were usually based only on clinical symptoms. Our purpose was to use electroclinical patterns to assess the efficacy of a ketogenic and/or calorie-restricted diet on PTZ-induced seizures...
  39. ncbi request reprint Effects of topiramate in two models of genetically determined generalized epilepsy, the GAERS and the Audiogenic Wistar AS
    Marie Aude Rigoulot
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Epilepsia 44:14-9. 2003
    ....
  40. ncbi request reprint Self-sustaining status epilepticus after a brief electrical stimulation of the perforant path: a 2-deoxyglucose study
    A Pereira de Vasconcelos
    INSERM U 398, Faculte de Medecine, 11 rue Humann, 67085, Strasbourg, France
    Brain Res 838:110-8. 1999
    ..Therefore, this new model allowing the development of a well-defined SSSE, appears to be particularly suitable for further studies on the mechanisms involved in status epilepticus...
  41. ncbi request reprint Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat
    Véronique André
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 43:1120-8. 2002
    ....
  42. ncbi request reprint Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches
    Anne Pereira de Vasconcelos
    INSERM U 398, Faculte de Medecine, 67085 Strasbourg Cedex, France
    Neurobiol Dis 18:270-81. 2005
    ..Neuronal NO appears to be not involved in the cerebrovascular response within the epileptic focus, but may rather have a role in the maintenance of distant LCBF regulation during seizures...
  43. ncbi request reprint What is animal experimentation telling us about new drug treatments of status epilepticus?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Epilepsia 48:78-81. 2007
    ..At this point, many data are still missing, namely which drugs could efficiently stop SE or which mechanisms of action should be searched for to prevent the harmful consequences of SE...
  44. ncbi request reprint The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy
    Jennifer Francois
    INSERM U666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Epilepsy Res 72:147-63. 2006
    ..In conclusion, although DZP-TPM treatment was able to partially protect two areas critical for epileptogenesis, the hippocampus and ventral entorhinal cortex, it was not sufficient to prevent epileptogenesis...
  45. ncbi request reprint Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model
    Catherine Roch
    UMR 7004 ULP CNRS IFR37, Institut de Physique Biologique, Faculte de Medecine, and INSERM U398, Faculte de Medecine, Strasbourg, France
    Epilepsia 43:1129-36. 2002
    ..Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of rats...
  46. ncbi request reprint Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice
    Anne Pereira de Vasconcelos
    INSERM U 398, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Neurobiol Dis 23:219-27. 2006
    ..Thus, endothelial NO is the mediator of the cerebrovascular response within the epileptic focus and participates in the maintenance of LCBF in distant areas...
  47. doi request reprint Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats
    Jennifer Francois
    INSERM U666, University Louis Pasteur, Strasbourg, France
    Int J Neuropsychopharmacol 12:1097-110. 2009
    ....
  48. ncbi request reprint EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    J Cereb Blood Flow Metab 26:1419-30. 2006
    ..It is, however, not clear to what extent the overexpression of EAAC1 contributes to epileptogenesis and in which area it may represent a preventive or compensatory or response to injury...
  49. ncbi request reprint In the lithium-pilocarpine model of epilepsy, brain lesions are not linked to changes in blood-brain barrier permeability: an autoradiographic study in adult and developing rats
    Claire Leroy
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg, Cedex, France
    Exp Neurol 182:361-72. 2003
    ....
  50. ncbi request reprint Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats
    Catherine Roch
    Institut de Physique Biologique UMR 7004 ULP CNRS IFR37, Faculte de Medecine, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
    Epilepsia 43:325-35. 2002
    ....
  51. doi request reprint Metabolic activity in the brain of juvenile and adult rats with a neonatal ventral hippocampal lesion
    Jennifer Francois
    INSERM U 666, University Louis Pasteur, Strasbourg, France
    Hippocampus 20:841-51. 2010
    ....
  52. doi request reprint NIRS-measured oxy- and deoxyhemoglobin changes associated with EEG spike-and-wave discharges in a genetic model of absence epilepsy: the GAERS
    Nadege Roche-Labarbe
    GRAMFC, EA 4293, Faculty of Medicine, University of Picardy, Amiens, France
    Epilepsia 51:1374-84. 2010
    ..We hypothesized that conflicting results from other techniques might be due to the averaging of a biphasic response such as the one we described in children...
  53. ncbi request reprint Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..These data suggest that seizure-related IL1-beta, NF-kappaB, and COX-2 expression may contribute to the pathophysiology of epilepsy by inducing neuronal death and astrocytic activation...
  54. doi request reprint Intact neurobehavioral development and dramatic impairments of procedural-like memory following neonatal ventral hippocampal lesion in rats
    L Lecourtier
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR, 7237 Université de Strasbourg CNRS, Strasbourg, France
    Neuroscience 207:110-23. 2012
    ..Interestingly, procedural or implicit memory impairments have also been reported in schizophrenic patients...
  55. ncbi request reprint Effects of remacemide in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
    Astrid Nehlig
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085 Cedex, Strasbourg, France
    Epilepsy Res 52:253-61. 2003
    ..The present results support the effects of remacemide in tonic/clonic seizure, which was the first target of the drug, and confirm the effect of the anticonvulsant on absence seizures...
  56. ncbi request reprint Basal levels of metabolic activity are elevated in Genetic Absence Epilepsy Rats from Strasbourg (GAERS): measurement of regional activity of cytochrome oxidase and lactate dehydrogenase by histochemistry
    Franck Dufour
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Exp Neurol 182:346-52. 2003
    ..However, they still do not allow us to understand why the ubiquitous mutation(s) generates spike-and-wave discharges only in the thalamocortical circuit...
  57. ncbi request reprint Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats
    Serge Chassagnon
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsy Res 69:100-18. 2006
    ....
  58. pmc Deletion of the STOP gene, a microtubule stabilizing factor, leads only to discrete cerebral metabolic changes in mice
    Ryosuke Hanaya
    INSERM U 666, Strasbourg, France
    J Neurosci Res 86:813-20. 2008
    ..These data might reflect hyperdopaminergic activity, olfactory deficits, and sleep disturbances in STOP-KO mice that have also been reported in schizophrenic patients...
  59. doi request reprint NIRS-measured oxy- and deoxyhemoglobin changes associated with EEG spike-and-wave discharges in children
    Nadege Roche-Labarbe
    GRAMFC, Faculte de Medecine, UPJV, Amiens, France
    Epilepsia 49:1871-80. 2008
    ..We aimed to determine if the GSWD were related to hemodynamic changes by using a new technique with high temporal resolution: near infrared spectroscopy (NIRS)...
  60. ncbi request reprint A robust statistics-based global energy function for the alignment of serially acquired autoradiographic sections
    Christophoros Nikou
    Université Louis Pasteur Strasbourg I, Institut de Physique Biologique, Faculte de Medecine, ULP CNRS UMR 7004, 4 rue Kirschleger, France
    J Neurosci Methods 124:93-102. 2003
    ..The method is evaluated qualitatively and quantitatively on real autoradiographic data. Rat brain autoradiographic volumes are reconstructed with registration errors less than 1 degree in rotation and less than 1 pixel in translation...
  61. doi request reprint Prolonged refractory status epilepticus with early and persistent restricted hippocampal signal MRI abnormality
    Laurent Chevret
    Pediatric Intensive Care Unit, CHU Bicetre, 78, rue du Gal Leclerc, 94275 Le Kremlin Bicetre, France
    J Neurol 255:112-6. 2008
    ..In long-term follow-up, the initial MRI signal abnormality developed into a cortical atrophy in all cases. The establishment of the diagnosis, etiology, and options for treatment are discussed...
  62. ncbi request reprint Epilepsy and neuroprotection: an illustrated review
    Alexis Arzimanoglou
    Epilepsy Unit, Child Neurology and Metabolic Diseases Departmentand INSERM E9935, University Hospital Robert Debré, Paris, France
    Epileptic Disord 4:173-82. 2002
    ..The review is designed to inform clinicians about the basic issues related to the subject, thus allowing them to follow the ongoing debate and participate with pertinent questions. (Published with video sequences)...
  63. ncbi request reprint Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults
    Torun Margareta Melø
    Department of Neuroscience, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
    Neurobiol Dis 28:227-35. 2007
    ....
  64. ncbi request reprint Models of pediatric epilepsies: strategies and opportunities
    Carl E Stafstrom
    University of Wisconsin, USA
    Epilepsia 47:1407-14. 2006
  65. ncbi request reprint Neuronal-glial interactions in rats fed a ketogenic diet
    Torun Margareta Melø
    Department of Neuroscience, Norwegian University of Science and Technology, NTNU, N 7489 Trondheim, Norway
    Neurochem Int 48:498-507. 2006
    ..The decreased glycolysis and oxidative metabolism of glucose as well as the increased astrocytic metabolism, may reflect adaptation of the brain to ketone bodies as major source of fuel...
  66. ncbi request reprint Cortical glutamate metabolism is enhanced in a genetic model of absence epilepsy
    Torun M Melø
    Department of Neuroscience, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Cereb Blood Flow Metab 26:1496-506. 2006
    ..Increased glutamatergic output from the cortex to hippocampus may be the underlying cause of improved learning in GAERS...
  67. ncbi request reprint Decreased expression of glutamate transporters in genetic absence epilepsy rats before seizure occurrence
    Magali Dutuit
    INSERM U433, Faculte de Medecine Laennec, Lyon, France
    J Neurochem 80:1029-38. 2002
    ..In contrast, the alteration of glutamate transporter expression, observed before the establishment of epileptic discharges, could reflect an abnormal maturation of the glutamatergic neurone-glia circuitry...
  68. ncbi request reprint Metabolism is normal in astrocytes in chronically epileptic rats: a (13)C NMR study of neuronal-glial interactions in a model of temporal lobe epilepsy
    Torun M Melø
    Department of Neuroscience, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Cereb Blood Flow Metab 25:1254-64. 2005
    ..This is, to our knowledge, the first study showing that metabolic disturbances are confined to neurons inside the epileptic circuit...
  69. ncbi request reprint Hypoglutamatergic activity in the STOP knockout mouse: a potential model for chronic untreated schizophrenia
    Eiliv Brenner
    Department of Neuroscience, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Neurosci Res 85:3487-93. 2007
    ....
  70. ncbi request reprint Vigabatrin, the GABA-transaminase inhibitor, damages cone photoreceptors in rats
    Agnès Duboc
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, INSERM U 592, UPMC, Bâtiment Kourislky, Paris Cedex 12, Paris, France
    Ann Neurol 55:695-705. 2004
    ..This study suggests that the visual field loss in vigabatrin-treated epileptic patients may result from a sequence of events starting from cone cell injury to a more severe disorganization of the photoreceptor layer...