Emeline Nandrot

Summary

Affiliation: Institut de la Vision
Location: Paris, France
URL: http://www.institut-vision.org/index.php?option=com_content&view=article&id=44%3Aequipe-de-nandrot&catid=17%3Afiches&Itemid=15&lang=en

Publications

  1. ncbi Spatial and temporal mapping of c-kit and its ligand, stem cell factor expression during human embryonic haemopoiesis
    M Teyssier-Le Discorde
    CEA DSV DRM SRHI Groupe de Recherche sur la Régulation et l Expression des Gènes, Hopital St Louis, Paris, France
    Br J Haematol 107:247-53. 1999
  2. doi In vitro differentiation of retinal pigment epithelium from adult retinal stem cells
    Claudia Aruta
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Pigment Cell Melanoma Res 24:233-40. 2011
  3. pmc Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration
    John J Graziotto
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Invest Ophthalmol Vis Sci 52:190-8. 2011
  4. doi EYS is a major gene for rod-cone dystrophies in France
    Isabelle Audo
    INSERM U968, Department of Genetics, Institut de la Vision, UPMC Univ Paris 06, 17 rue Moreau, Paris, France
    Hum Mutat 31:E1406-35. 2010
  5. doi Mertk in daily retinal phagocytosis: a history in the making
    Emeline F Nandrot
    Centre de Recherche Institut de la Vision, UPMC University of Paris 06, Paris, France
    Adv Exp Med Biol 664:133-40. 2010
  6. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
  7. pmc Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function
    Emeline F Nandrot
    Department of Ophthalmology, Dyson Vision Research Institute, New York, NY 10065, USA
    Ophthalmic Res 40:120-3. 2008
  8. pmc Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
    Adv Exp Med Biol 613:369-75. 2008
  9. pmc Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis
    Emeline F Nandrot
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:12005-10. 2007
  10. pmc MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin
    Silvia C Finnemann
    Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
    Adv Exp Med Biol 572:499-503. 2006

Collaborators

Detail Information

Publications19

  1. ncbi Spatial and temporal mapping of c-kit and its ligand, stem cell factor expression during human embryonic haemopoiesis
    M Teyssier-Le Discorde
    CEA DSV DRM SRHI Groupe de Recherche sur la Régulation et l Expression des Gènes, Hopital St Louis, Paris, France
    Br J Haematol 107:247-53. 1999
    ....
  2. doi In vitro differentiation of retinal pigment epithelium from adult retinal stem cells
    Claudia Aruta
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Pigment Cell Melanoma Res 24:233-40. 2011
    ..These data suggest that our protocol to differentiate RPE in vitro can provide a useful model for molecular and functional studies...
  3. pmc Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration
    John J Graziotto
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Invest Ophthalmol Vis Sci 52:190-8. 2011
    ..The retinal ultrastructure of Prpf31-knockout mice was also investigated...
  4. doi EYS is a major gene for rod-cone dystrophies in France
    Isabelle Audo
    INSERM U968, Department of Genetics, Institut de la Vision, UPMC Univ Paris 06, 17 rue Moreau, Paris, France
    Hum Mutat 31:E1406-35. 2010
    ..With a prevalence of 12% or more we provide evidence that EYS is a major gene for RP in France and probably elsewhere...
  5. doi Mertk in daily retinal phagocytosis: a history in the making
    Emeline F Nandrot
    Centre de Recherche Institut de la Vision, UPMC University of Paris 06, Paris, France
    Adv Exp Med Biol 664:133-40. 2010
    ..We now have a more precise picture of the sequence of molecular events governing retinal phagocytosis. However, requirement of MerTK ligands in vivo and linked signaling pathways still remain elusive so far...
  6. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
    ..The mutation spectrum comprises missense, splice-site, deletion, and nonsense mutations. We propose that the cCSNB phenotype in these patients is due to the absence of functional TRPM1 in retinal ON bipolar cells...
  7. pmc Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function
    Emeline F Nandrot
    Department of Ophthalmology, Dyson Vision Research Institute, New York, NY 10065, USA
    Ophthalmic Res 40:120-3. 2008
    ..We recently identified an important role for alphavbeta5 integrin receptors and their ligand Milk fat globule-EGF factor 8 (MFG-E8) in RPE phagocytosis...
  8. pmc Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
    Adv Exp Med Biol 613:369-75. 2008
  9. pmc Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis
    Emeline F Nandrot
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:12005-10. 2007
    ..Thus, MFG-E8 stimulates rhythmic POS phagocytosis by ligating apical alphavbeta5 receptors of the RPE. These results identify MFG-E8 as the first extracellular ligand in the retina that is essential for diurnal POS phagocytosis...
  10. pmc MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin
    Silvia C Finnemann
    Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
    Adv Exp Med Biol 572:499-503. 2006
  11. pmc Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout mice
    Emeline F Nandrot
    Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
    Adv Exp Med Biol 572:119-23. 2006
  12. pmc Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Am J Physiol Cell Physiol 290:C1256-62. 2006
    ..Furthermore, they indicate that alpha(v)beta(5) receptors at the same apical plasma membrane domain of RPE cells fulfill two separate functions that are synchronized by different diurnal rhythms...
  13. ncbi Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter
    Alexis Pierre Bemelmans
    BioVectys, c o laboratoire LGN, Hopital de la Pitie Salpetriere, Paris, France
    J Gene Med 7:1367-74. 2005
    ..To develop such a vector, we compared the expression of a reporter gene after subretinal injections of lentiviral constructs of various pseudotypes and with the transgene expression driven by various promoters...
  14. pmc Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Exp Med 200:1539-45. 2004
    ..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction...
  15. ncbi Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration
    Eric M Dufour
    CERTO, Equipe d accueil n degrees 2502 du Ministère de la Recherche, Universite Rene Descartes, Faculte de Medecine Necker, 156 rue de Vaugirard 75015 Paris, France
    Neurobiol Dis 14:166-80. 2003
    ..We also found differential levels of transcripts encoding proteins involved in phagocytosis, vesicle trafficking, the cytoskeleton, retinoic acid, and general metabolism...
  16. pmc Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts
    E Nandrot
    Centre de Recherches Thérapeutiques en Ophtalmologie de la Faculté de Médecine Necker, EA No 2502 du Ministére de la Recherche et de l Enseignement Supérieur, Universite Rene Descartes, Paris, France
    J Med Genet 40:262-7. 2003
    ..Furthermore, this is the first report of a mutation in this gene resulting in autosomal dominant congenital cerulean cataracts...
  17. ncbi Evidence of clinical and genetic heterogeneity in autosomal dominant congenital cerulean cataracts
    Latifa Hilal
    Laboratoire de Génétique et Biologie Moléculaire de la Faculté des Sciences, Université Ibn Tofail, Kenitra, Morocco
    Ophthalmic Genet 23:199-208. 2002
    ..This finding confirms the clinical and genetic heterogeneity of autosomal dominant congenital cerulean cataracts...
  18. ncbi Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis
    E Nandrot
    Universite Rene Descartes, Centre de Recherches Thérapeutiques en Ophtalmologie, Paris, France
    Neurobiol Dis 7:586-99. 2000
    ..The c-mer gene contains characteristic motifs of neural cell adhesion. A ligand of the c-mer receptor, Gas6, exhibits antiapoptotic properties...
  19. doi Animal Models, in "The Quest to Decipher RPE Phagocytosis"
    Emeline F Nandrot
    INSERM, U968, 17 rue Moreau, 75012, Paris, France
    Adv Exp Med Biol 801:77-83. 2014
    ..This chapter describes mouse and rat models related to defective phagocytosis, and how they have been a tremendous help for us to comprehend RPE phagocytosis, its rhythm, and its failures. ..