Mickael Naassila

Summary

Country: France

Publications

  1. ncbi request reprint Intracerebroventricular injection of antisense oligos to nNOS decreases rat ethanol intake
    M Naassila
    Laboratoire de Physiologie et Unité de Recherches sur les Adaptations Physiologiques et Comportementales, Faculte de Pharmacie, Universite de Picardie Jules Verne, 1 rue des Louvels, 80000, Amiens, France
    Pharmacol Biochem Behav 67:629-36. 2000
  2. ncbi request reprint Effect of prenatal and postnatal ethanol exposure on the developmental profile of mRNAs encoding NMDA receptor subunits in rat hippocampus
    Mickael Naassila
    Laboratoire de Physiologie et Unité de Recherches sur les Adaptations Physiologiques et Comportementales, Environnement Toxique Périnatal, Faculte de Pharmacie, Amiens, France
    J Neurochem 80:850-60. 2002
  3. ncbi request reprint Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors
    Mickael Naassila
    Laboratoire de Physiologie Alcoologie, Universite de Picardie Jules Verne, Faculte de Pharmacie, 80000 Amiens, France
    J Neurosci 22:10487-93. 2002
  4. ncbi request reprint Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice
    Mickael Naassila
    EA2088 ETP APC Environnement Toxique Périnatal Adaptations Physiologiques et Comportementales, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, 80000 Amiens, France
    Neuropharmacology 46:243-53. 2004
  5. doi request reprint Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure
    Estelle Barbier
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, 80000 Amiens, France
    Neuropharmacology 55:1199-211. 2008
  6. ncbi request reprint The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure
    Vincent Warnault
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France, and IFR 114, Lille, France
    J Neurochem 102:741-52. 2007
  7. doi request reprint Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens
    Stéphanie Alaux-Cantin
    INSERM ERI 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Universite de Picardie Jules Verne, UFR de Pharmacie, SFR CAP Santé, 1 rue des Louvels, Amiens 80000, France
    Neuropharmacology 67:521-31. 2013
  8. doi request reprint Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression
    Catherine Vilpoux
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, Amiens, France
    Alcohol Clin Exp Res 33:945-69. 2009
  9. ncbi request reprint CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors
    Hakim Houchi
    Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Jeune Equipe, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, Amiens, France
    Neuropsychopharmacology 30:339-49. 2005
  10. pmc Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats
    Emmanuelle Simon O'Brien
    Equipe Région INSERM ERI 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France
    Neuropsychopharmacology 36:1518-30. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Intracerebroventricular injection of antisense oligos to nNOS decreases rat ethanol intake
    M Naassila
    Laboratoire de Physiologie et Unité de Recherches sur les Adaptations Physiologiques et Comportementales, Faculte de Pharmacie, Universite de Picardie Jules Verne, 1 rue des Louvels, 80000, Amiens, France
    Pharmacol Biochem Behav 67:629-36. 2000
    ..The anticraving drug, acamprosate reduced both ethanol intake (by 58%) and ethanol preference. All these results suggest that nNOS is involved in the regulation of alcohol dependence...
  2. ncbi request reprint Effect of prenatal and postnatal ethanol exposure on the developmental profile of mRNAs encoding NMDA receptor subunits in rat hippocampus
    Mickael Naassila
    Laboratoire de Physiologie et Unité de Recherches sur les Adaptations Physiologiques et Comportementales, Environnement Toxique Périnatal, Faculte de Pharmacie, Amiens, France
    J Neurochem 80:850-60. 2002
    ..As these subunits have been shown to modulate the functional properties of NMDA receptors, these results suggest that this altered expression could be involved in the neurodevelopmental disorders associated with fetal ethanol exposure...
  3. ncbi request reprint Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors
    Mickael Naassila
    Laboratoire de Physiologie Alcoologie, Universite de Picardie Jules Verne, Faculte de Pharmacie, 80000 Amiens, France
    J Neurosci 22:10487-93. 2002
    ..These data suggest that activating the A2A receptors may play a role in suppressing alcohol-drinking behavior and is associated with the sensitivity to the intoxicating effects of acute ethanol administration...
  4. ncbi request reprint Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice
    Mickael Naassila
    EA2088 ETP APC Environnement Toxique Périnatal Adaptations Physiologiques et Comportementales, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, 80000 Amiens, France
    Neuropharmacology 46:243-53. 2004
    ..Our results suggest that CB1 receptors participate in the regulation of ethanol drinking and demonstrate that their disruption lead to increased ethanol sensitivity and withdrawal severity...
  5. doi request reprint Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure
    Estelle Barbier
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, 80000 Amiens, France
    Neuropharmacology 55:1199-211. 2008
    ..Such long-term neurochemical alterations in transmitter systems and in the behavioral responses to ethanol and other drugs of abuse may confer an increased liability for addiction in exposed offspring...
  6. ncbi request reprint The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure
    Vincent Warnault
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France, and IFR 114, Lille, France
    J Neurochem 102:741-52. 2007
    ..We conclude that lifelong deletion of CB1 receptors impairs neuroadaptations of both NMDA and GABA(A) receptors after chronic ethanol exposure and that the endocannabinoid/CB1 receptor system is involved in alcohol dependence...
  7. doi request reprint Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens
    Stéphanie Alaux-Cantin
    INSERM ERI 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Universite de Picardie Jules Verne, UFR de Pharmacie, SFR CAP Santé, 1 rue des Louvels, Amiens 80000, France
    Neuropharmacology 67:521-31. 2013
    ....
  8. doi request reprint Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression
    Catherine Vilpoux
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, Amiens, France
    Alcohol Clin Exp Res 33:945-69. 2009
    ..Ethanol-dependence is a chronic pathology with repeated cycles of withdrawal, craving, and relapse. Specific molecular and cellular mechanisms underlie these transition stages...
  9. ncbi request reprint CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors
    Hakim Houchi
    Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, Jeune Equipe, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, Amiens, France
    Neuropsychopharmacology 30:339-49. 2005
    ..Altogether, the present results indicate that lifelong deletion of CB1 receptors reduced ethanol-induced CPP and that these reduced rewarding effects of ethanol are correlated to an overexpression of striatal dopamine D2 receptors...
  10. pmc Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats
    Emmanuelle Simon O'Brien
    Equipe Région INSERM ERI 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France
    Neuropsychopharmacology 36:1518-30. 2011
    ..Thus, 5-HT and NE transmissions during sensitization expression may mediate the effect of milnacipran on sensitization induction. These results support that SNRIs may have a potential use in alcoholism treatment...
  11. doi request reprint Perinatal alcohol exposure in rat induces long-term depression of respiration after episodic hypoxia
    Myriam Kervern
    Equipe Région INSERM 24 Groupe de Recherche sur l Alcool et les Pharmacodèpendances, Faculte de Pharmacie, Amiens, France
    Am J Respir Crit Care Med 179:608-14. 2009
    ....
  12. doi request reprint Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum
    Rémi Legastelois
    INSERM ERI 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances GRAP, UFR de Pharmacie, Structure Fédérative de Recherche CAP Santé, Universite de Picardie Jules Verne, Amiens, France
    Alcohol Clin Exp Res 37:1143-53. 2013
    ..We also investigated gene regulations in the striatum of sensitized mice using epigenetic- and signal transduction-related PCR arrays...
  13. ncbi request reprint Chronic ethanol exposure differentially regulates NOS1 mRNA levels depending on rat brain area
    Mickael Naassila
    Universite de Picardie Jules Verne, Faculte de Pharmacie, EA 2088 Environnement Toxique Périnatal Adaptations Physiologiques et Comportementales, 1 rue des Louvels, 80000 Amiens, France
    Neurosci Lett 338:221-4. 2003
    ..p. daily for 1 week) treatment. These data further support that NOS1 is regulated by chronic exposure to ethanol and that these effects are related to modifications of mRNA levels...
  14. ncbi request reprint High extracellular calcium concentrations directly stimulate osteoclast apoptosis
    F Lorget
    Laboratoires de Pharmacie Clinique et de Physiologie, Faculte de Pharmacie, 1 rue des Louvels, Amiens, F 80037, France
    Biochem Biophys Res Commun 268:899-903. 2000
    ..Our results are consistent with the concept that in the presence of high [Ca](e) generated during bone demineralization, osteoclasts are subjected to negative-feedback regulation due, at least in part, to the induction of apoptosis...
  15. pmc Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice
    Béatrice Botia
    Universite de Picardie Jules Verne, Unite de Formation et de Recherche de Pharmacie, Research Group on Alcohol and Pharmacodependences, Institut National de la Santé et de la Recherche Médicale ERI 24, Amiens, France
    PLoS ONE 7:e47527. 2012
    ....
  16. doi request reprint Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis
    Eric Nguyen-Khac
    Service d Hepato Gastroenterologie, centre hospitalier universitaire d Amiens, Amiens, France
    Eur J Gastroenterol Hepatol 22:794-800. 2010
    ..We studied the role of TNFR1 and TNFR2 gene polymorphism in AAH patients...
  17. ncbi request reprint Biphasic effect of acamprosate on NMDA but not on GABAA receptors in spontaneous rhythmic activity from the isolated neonatal rat respiratory network
    Olivier Pierrefiche
    GRAP JE Groupe de Recherche sur l Alcool et les Pharmacodépendances, UFR de Pharmacie, Universite de Picardie Jules Verne, 1, rue des Louvels, 80036 Amiens, France
    Neuropharmacology 47:35-45. 2004
    ..These results show that the effects of acamprosate are mediated via both GABAA and NMDA receptors and suggest a partial co-agonist role on NMDA receptors, at the level of a spontaneously active network...
  18. doi request reprint The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals
    Hakim Houchi
    Groupe de Recherche sur l Alcool and les Pharmacodépendances, INSERM ERI, UFR de Pharmacie, Universite de Picardie Jules Verne, France
    Addict Biol 18:812-25. 2013
    ..In conclusion, our findings demonstrated the effectiveness of the A2AR agonist CGS 21680 in a preclinical model of alcohol addiction and suggested that the adenosinergic pathway is a promising target to treat alcohol addiction...
  19. doi request reprint "Beetrack": a software for 2D open field locomotion analysis in honey bees
    Michel B C Sokolowski
    Universite de Picardie, Jules Verne, INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, 1 rue des Louvels, F 80037 Amiens Cedex 1, France
    J Neurosci Methods 207:211-7. 2012
    ..A spatial analysis can also be performed to detect if the bees are using preferentially one part of the box. The software has been successfully tested with eight honey bees and promise to be an interesting tool in the pharmacology field...
  20. doi request reprint Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats
    E Barbier
    Equipe Région INSERM 24 ERI24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, 1 rue des Louvels, 80000 Amiens, France
    Neuroscience 161:427-40. 2009
    ....
  21. ncbi request reprint Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice
    H Houchi
    Equipe Région INSERM 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France
    Genes Brain Behav 7:887-98. 2008
    ....