L Mouthon

Summary

Country: France

Publications

  1. ncbi request reprint [Scleroderma renal crisis]
    Luis Teixeira
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hôpitaux de Paris AP HP et Université Paris Descartes, Paris
    Presse Med 35:1966-74. 2006
  2. ncbi request reprint [Therapeutic management of systemic sclerosis]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Faculte de Medecine
    Presse Med 35:1975-82. 2006
  3. doi request reprint Patient preference disability questionnaire in systemic sclerosis: a cross-sectional survey
    Luc Mouthon
    Paris Descartes University, UPRES EA 4058, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    Arthritis Rheum 59:968-73. 2008
  4. ncbi request reprint Scleroderma renal crisis
    Luc Mouthon
    From the Université Paris Descartes, Service de Medecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hôpitaux de Paris AP HP Institut Cochin, Inserm U1016, CNRS UMR 8104, Université Paris Descartes Université Paris Descartes, Faculté de Médecine Paris Descartes, Service d Anatomopathologie, and Service de Néphrologie, Hopital Necker, AP HP, Paris, France L Mouthon, MD, PhD G Bussone, MD, PhD A Berezné, MD, Universite Paris Descartes, Service de Medecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, AP HP, and Institut Cochin, Inserm U1016, CNRS UMR 8104, Université Paris Descartes L H Noël, MD, Institut Cochin, Inserm U1016, CNRS UMR 8104, Universite Paris Descartes, and Faculté de Médecine Paris Descartes, Service d Anatomopathologie, 100 W. 18th Ave
    J Rheumatol 41:1040-8. 2014
  5. pmc Association of gender with clinical expression, quality of life, disability, and depression and anxiety in patients with systemic sclerosis
    Christelle Nguyen
    Universite Paris Descartes, Faculté de Médecine Paris Descartes, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e17551. 2011
  6. pmc IgG from patients with systemic sclerosis bind to DNA antitopoisomerase 1 in normal human fibroblasts extracts
    Mathieu C Tamby
    Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Paris, France
    Biologics 2:583-91. 2008
  7. doi request reprint Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey
    Christelle Nguyen
    Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Faculté de Médecine Paris Descartes, Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Paris, France Service de médecine physique et réadaptation, Hopital Cochin, Faculté de Médecine Paris Descartes, Université Paris Descartes and Assistance Publique Hôpitaux de Paris, INSERM, Institut fédératif de recherche sur le handicap, Paris, France
    PLoS ONE 9:e90484. 2014
  8. pmc In vitro and in vivo properties differ among liquid intravenous immunoglobulin preparations
    F Dhainaut
    LFB Biotechnologies, Courtaboeuf, France Université Paris Descartes, Faculte de Medecine, Institut Cochin, Inserm U1016, Paris, France
    Vox Sang 104:115-26. 2013
  9. doi request reprint Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome)
    Luc Mouthon
    Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Inserm U1016, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France Electronic address
    J Autoimmun 48:99-103. 2014
  10. doi request reprint [Hand involvement in systemic sclerosis]
    Luc Mouthon
    Assistance Publique Hopitaux de Paris, Hopital Cochin, Universite Paris Descartes, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France Electronic address
    Presse Med 42:1616-26. 2013

Collaborators

Detail Information

Publications171 found, 100 shown here

  1. ncbi request reprint [Scleroderma renal crisis]
    Luis Teixeira
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hôpitaux de Paris AP HP et Université Paris Descartes, Paris
    Presse Med 35:1966-74. 2006
    ..Renal replacement therapy may be needed, but often (for almost half of patients) only temporarily...
  2. ncbi request reprint [Therapeutic management of systemic sclerosis]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Faculte de Medecine
    Presse Med 35:1975-82. 2006
    ..The efficacy of disease-modifying agents remains limited however, and none has yet demonstrated its ability to improve survival in a prospective randomized trial...
  3. doi request reprint Patient preference disability questionnaire in systemic sclerosis: a cross-sectional survey
    Luc Mouthon
    Paris Descartes University, UPRES EA 4058, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    Arthritis Rheum 59:968-73. 2008
    ..To assess patient priorities concerning disability in systemic sclerosis (SSc)...
  4. ncbi request reprint Scleroderma renal crisis
    Luc Mouthon
    From the Université Paris Descartes, Service de Medecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hôpitaux de Paris AP HP Institut Cochin, Inserm U1016, CNRS UMR 8104, Université Paris Descartes Université Paris Descartes, Faculté de Médecine Paris Descartes, Service d Anatomopathologie, and Service de Néphrologie, Hopital Necker, AP HP, Paris, France L Mouthon, MD, PhD G Bussone, MD, PhD A Berezné, MD, Universite Paris Descartes, Service de Medecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, AP HP, and Institut Cochin, Inserm U1016, CNRS UMR 8104, Université Paris Descartes L H Noël, MD, Institut Cochin, Inserm U1016, CNRS UMR 8104, Universite Paris Descartes, and Faculté de Médecine Paris Descartes, Service d Anatomopathologie, 100 W. 18th Ave
    J Rheumatol 41:1040-8. 2014
    ..Dialysis is frequently indicated but can be stopped in about half of patients, mainly those with good blood pressure control. Patients who need dialysis for more than 2 years qualify for renal transplantation. ..
  5. pmc Association of gender with clinical expression, quality of life, disability, and depression and anxiety in patients with systemic sclerosis
    Christelle Nguyen
    Universite Paris Descartes, Faculté de Médecine Paris Descartes, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e17551. 2011
    ..To assess the association of gender with clinical expression, health-related quality of life (HRQoL), disability, and self-reported symptoms of depression and anxiety in patients with systemic sclerosis (SSc)...
  6. pmc IgG from patients with systemic sclerosis bind to DNA antitopoisomerase 1 in normal human fibroblasts extracts
    Mathieu C Tamby
    Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Paris, France
    Biologics 2:583-91. 2008
    ..These two bands were further identified as DNA topoisomerase 1. Our results indicate that IgG from patients with diffuse systemic sclerosis bind DNA topoisomerase 1 in normal human fibroblasts extracts...
  7. doi request reprint Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey
    Christelle Nguyen
    Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Faculté de Médecine Paris Descartes, Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Paris, France Service de médecine physique et réadaptation, Hopital Cochin, Faculté de Médecine Paris Descartes, Université Paris Descartes and Assistance Publique Hôpitaux de Paris, INSERM, Institut fédératif de recherche sur le handicap, Paris, France
    PLoS ONE 9:e90484. 2014
    ..To identify clinical, functional and health-related quality of life (HRQoL) correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis (SSc)...
  8. pmc In vitro and in vivo properties differ among liquid intravenous immunoglobulin preparations
    F Dhainaut
    LFB Biotechnologies, Courtaboeuf, France Université Paris Descartes, Faculte de Medecine, Institut Cochin, Inserm U1016, Paris, France
    Vox Sang 104:115-26. 2013
    ..To compare in vitro and in vivo biological and biochemical properties of five liquid intravenous immunoglobulin (IVIg) preparations licensed for therapeutic use in Europe...
  9. doi request reprint Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome)
    Luc Mouthon
    Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Inserm U1016, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France Electronic address
    J Autoimmun 48:99-103. 2014
    ..Overall survival of EGPA patients is good, despite not uncommon relapses. ..
  10. doi request reprint [Hand involvement in systemic sclerosis]
    Luc Mouthon
    Assistance Publique Hopitaux de Paris, Hopital Cochin, Universite Paris Descartes, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France Electronic address
    Presse Med 42:1616-26. 2013
    ..Only a comprehensive care, taking into account the vascular, skin and joint manifestations, including physical therapy if needed can improve hand function in patients with systemic sclerosis...
  11. doi request reprint [Pathophysiology of ANCA-associated vasculitides]
    Luc Mouthon
    Institut Cochin, Inserm U 1016, Paris, France
    Presse Med 41:996-1003. 2012
    ..The role of B-lymphocytes in the pathogenesis of ANCA-associated vasculitides is now well documented by the effectiveness of rituximab in the treatment of this condition...
  12. doi request reprint Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma
    Hanadi Dib
    Inserm U1016, Institut Cochin, Paris, France
    Eur Respir J 39:1405-14. 2012
    ....
  13. doi request reprint IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction
    Guillaume Bussone
    INSERM U, Institut Cochin, Paris, France
    Ann Rheum Dis 71:596-605. 2012
    ..The authors investigated the presence of antibodies to human VSMCs in the serum of patients with systemic sclerosis with or without PAH and idiopathic PAH (iPAH)...
  14. doi request reprint SSc in 2011: From mechanisms to medicines
    Luc Mouthon
    Universite Paris Descartes, Faculte de Medecine, Service de Medecine Interne, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Nat Rev Rheumatol 8:72-4. 2012
    ..However, progress in the understanding of the mechanisms that underlie SSc pathogenesis could provide clues to novel targets for 2012 and beyond...
  15. ncbi request reprint [Interstitial lung disease in connective tissue disorders]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, AP HP, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, et Université Paris V
    Rev Pneumol Clin 61:211-9. 2005
    ..The treatment requires corticosteroids and/or immunosuppressants, depending on the nature of the associated connective tissue disease and ILD progression...
  16. ncbi request reprint [Intravenous immunoglobulin therapy]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, 75679 Paris Cedex 14
    Rev Prat 55:1049-56. 2005
    ..Mechanisms of action of IVIg are multiple and complicated. The development of new therapeutic trials in association with analyses of mechanisms of action should help to define new indication of IVIg therapy...
  17. doi request reprint Scleroderma renal crisis: a rare but severe complication of systemic sclerosis
    Luc Mouthon
    UPRES EA, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hospital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Clin Rev Allergy Immunol 40:84-91. 2011
    ..Patients who need dialysis for more than 2 years qualify for renal transplantation...
  18. doi request reprint Low influenza vaccination rate among patients with systemic sclerosis
    Luc Mouthon
    Department of Internal Medicine, Cochin Hospital, Paris Cedex 14, France
    Rheumatology (Oxford) 49:600-6. 2010
    ..To evaluate the influenza vaccination rate and factors influencing it in patients with SSc...
  19. ncbi request reprint [Intravenous immunoglobulins: therapeutic indications]
    L Mouthon
    Universite Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Service de Medecine Interne, Centre de Référence Vascularites et Sclérodermies, AP HP, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14 75, France
    Presse Med 34:1166-75. 2005
    ..Its mechanisms of action are multiple, complex, and not yet well elucidated. Adverse effects are only rarely associated with IVIg. They are well tolerated, and the risk of transmission of infectious agents appears only theoretical...
  20. ncbi request reprint [Benefits and risks of treatments used in systemic autoimmune diseases]
    L Mouthon
    Pôle de Médecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, AP HP, 27 rue du Faubourg St Jacques, 75679 Paris cedex, France
    Rev Med Interne 29:15-23. 2008
    ....
  21. doi request reprint Therapeutic options for systemic sclerosis related interstitial lung diseases
    Luc Mouthon
    Universite Paris Descartes, UPRES EA 4058, Pôle de Médecine Interne et Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Med 104:S59-69. 2010
    ..A subgroup of patients with rapidly progressive ILD might benefit from pulsed intravenous cyclophosphamide combined with prednisone 15 mg daily but this remains to be confirmed...
  22. ncbi request reprint [Indications for intravenous immunoglobulins]
    Luc Mouthon
    Universite Paris Descartes, Faculte de Medecine, Service de Médecine Interne et Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris
    Presse Med 35:714-9. 2006
    ....
  23. doi request reprint Endothelin-1 expression in scleroderma renal crisis
    Luc Mouthon
    Universite Paris Descartes, Faculté de Médecine Paris Descartes, Pôle de Médecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hopitaux de Paris AP HP, 75014 Paris, France
    Hum Pathol 42:95-102. 2011
    ..Endothelin-1 is overexpressed in glomeruli and arterioles of patients with scleroderma renal crisis, which suggests that endothelin-1 might be a therapeutic target in this condition...
  24. pmc Development and validation of a scale for mouth handicap in systemic sclerosis: the Mouth Handicap in Systemic Sclerosis scale
    L Mouthon
    Department of Internal Medicine, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 66:1651-5. 2007
    ..To develop and assess the reliability and construct validity of a scale assessing disability involving the mouth in systemic sclerosis (SSc)...
  25. ncbi request reprint [Immunoglobulins and physiopathology: actual indications]
    L Mouthon
    Hopital Cochin, Paris, France
    Rev Med Interne 28:11-7. 2007
    ..Mechanisms of action of IVIg are multiple and intricate. The development of new therapeutic trials in association with analyses of mechanisms of action should help to define new indications of IVIg therapy...
  26. doi request reprint Impact of digital ulcers on disability and health-related quality of life in systemic sclerosis
    L Mouthon
    Paris Descartes University, Department of Internal Medicine, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 69:214-7. 2010
    ..To assess the impact of digital ulcers (DUs) on disability and health-related quality of life (HRQoL) in systemic sclerosis (SSc)...
  27. ncbi request reprint [Systemic sclerosis: from physiopathology to treatment]
    L Mouthon
    UPRES EA 4058, Faculté de Médecine Paris Descartes, Universite Paris Descartes, 75005 Paris, France
    Rev Med Interne 28:S266-72. 2007
  28. pmc Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach
    Alexis Régent
    Inserm U1016, Institut Cochin, CNRS UMR 8104, 8 rue Mechain, F 75014 Paris, France
    Arthritis Res Ther 13:R107. 2011
    ..We thus decided to detect autoantibodies directed against endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in the serum of GCA patients and to identify their target antigens...
  29. pmc Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor β pathway in patients with systemic sclerosis
    Guillaume Bussone
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, 8 rue Mechain, F 75014 Paris, France
    Arthritis Res Ther 13:R74. 2011
    ..In this work, we aimed to identify new target autoantigens in SSc patients...
  30. ncbi request reprint [Diagnosis of primary immunodeficiency in adult patients]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, AP HP, Universite Paris Descartes, Faculte de Medecine, Paris 75
    Presse Med 35:903-11. 2006
    ..More rarely, other clinical manifestations such as granulomatosis, autoimmune manifestations, hemophagocytic syndrome, lymphoproliferation, or solid tumors may also lead to the identification of PID...
  31. ncbi request reprint [Primary immune deficiencies: also found in adults. A diagnosis to be aware of]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Descartes, Faculte de Medecine, Paris 75
    Presse Med 35:858-60. 2006
  32. ncbi request reprint [Causes and mechanisms of systemic vasculitides]
    Luc Mouthon
    Pôle de Médecine Interne, UPRES EA 4058, Universite Paris Descartes, Hopital Cochin, Paris
    Rev Prat 58:487-91. 2008
    ..polyarteritis nodosa unrelated to viral infection results from rheologic phenomenon that explain the localisation of vasculitis lesions at the bifurcation of arteries and the presence of microaneurysm...
  33. ncbi request reprint [Pathogenesis of primary systemic vasculitides (II): ANCA-negative vasculitides]
    P Guilpain
    Universite Paris Descartes, Faculte de Medecine, UPRES EA 1833, site Cochin, Paris
    Presse Med 34:1023-33. 2005
    ..A bacterial superantigen is suspected in Kawasaki disease but remains unproved...
  34. doi request reprint Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis
    P Dieude
    Universite Paris 7, and Hôpital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 60:225-33. 2009
    ..The aim of this study was to determine whether the IRF5 rs2004640 single-nucleotide polymorphism is associated with SSc...
  35. doi request reprint BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4
    P Dieude
    Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Arthritis Rheum 60:3447-54. 2009
    ....
  36. ncbi request reprint [Pathogenesis of primary systemic vasculitides (I): ANCA-positive vasculitides]
    P Guilpain
    Universite Paris Descartes, Faculte de Medecine, UPRES EA 1833, site Cochin, Paris
    Presse Med 34:1013-22. 2005
    ..Eosinophils may play a key role in the development of vasculitic lesions in CSS, although this remains to be proved...
  37. doi request reprint The oxidation induced by antimyeloperoxidase antibodies triggers fibrosis in microscopic polyangiitis
    P Guilpain
    Laboratoire d Immunologie, EA, UPRES 1833, Pôle de Médecine Interne et CentreNational de Référence pour lesVascularites Nécrosantes et laSclérodermie Systémique, UniversitéParis Descartes, Faculté deMédecine, Pavillon Gustave Roussy, 4e Etage, Hopital Cochin, 8 rue Mechain, 75014, Paris, France
    Eur Respir J 37:1503-13. 2011
    ..Oxidative stress, in particular the production of HOCl through the interaction of MPO with anti-MPO antibodies, could trigger the fibrotic process observed in MPA...
  38. doi request reprint B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease
    Gael Mouillot
    Immunology Laboratory, INSERM UMR S945, CIB Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Paris, France
    J Clin Immunol 30:746-55. 2010
    ..Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by recurrent infections and defective immunoglobulin production...
  39. doi request reprint STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis
    P Dieude
    Université Paris 7 and Service de Rhumatologie, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 60:2472-9. 2009
    ..The aim of this study was to determine whether the STAT4 rs7574865 single-nucleotide polymorphism is associated with SSc, and whether it interacts with IRF5...
  40. doi request reprint Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological features
    B Ranque
    Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Cochin Hospital, Faculty of Medicine, Paris Descartes University, the Public Assistance Hospitals of Paris AH HP, France
    Scand J Rheumatol 39:498-505. 2010
    ..Little is known about systemic sclerosis (SSc)-related myopathy. We aimed to compare the clinical and immunological features of SSc patients with or without associated myopathy...
  41. doi request reprint Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population
    J Wipff
    Rene Descartes University, Department of Rheumatology A, Cochin Hospital, Paris
    Scand J Rheumatol 38:291-4. 2009
    ..The aim of this study was to determine whether polymorphisms of the hypoxia-inducible factor 1A gene (HIF1A) affects susceptibility to SSc in a large French European Caucasian population...
  42. ncbi request reprint Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension
    M C Tamby
    Paris Descartes University, Faculty of Medicine, Paris, France
    Eur Respir J 28:799-807. 2006
    ..Immunoglobulin G from patients with idiopathic pulmonary arterial hypertension or scleroderma-associated pulmonary arterial hypertension express distinct reactivity profiles with fibroblasts antigens, suggesting distinct target antigens...
  43. ncbi request reprint Impact of pain in health related quality of life of patients with systemic sclerosis
    C Georges
    Internal Medicine Department, Saint Louis Hospital, Service de Medecine Interne, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Rheumatology (Oxford) 45:1298-302. 2006
    ..The aim of the study is as to evaluate the quality of life (QoL) in patients with either diffuse or limited SSc, and to examine the impact of pain on the QoL scores...
  44. doi request reprint The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis
    P Dieude
    Universite Paris 7, Paris, France
    Arthritis Rheum 58:2183-8. 2008
    ..We then conducted a meta-analysis of the most recent studies of SSc in order to verify the association or lack of association between the PTPN22 1858C>T variant and SSc...
  45. doi request reprint Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population
    J Wipff
    Universite Paris Descartes, INSERM U781, Hopital Necker, and Hôpital Cochin, Paris, France
    Arthritis Rheum 62:3093-100. 2010
    ..We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its vascular phenotype, including PAH...
  46. doi request reprint Risk factors for major infections in Wegener granulomatosis: analysis of 113 patients
    C Charlier
    Department of Internal Medicine, Hopital Cochin, Universite Paris Descartes, Faculte de Medicine, UPRES EA 4058, Assistance Publique Hopitaux de Paris, Paris Cedex 14, France
    Ann Rheum Dis 68:658-63. 2009
    ..To characterise major infectious complications and analyse potential risk factors in patients with Wegener granulomatosis (WG)...
  47. ncbi request reprint [Interstitial lung disease in systemic sclerosis]
    Luc Mouthon
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites et la Sclérodermie Systémique, AP HP, Paris
    Presse Med 35:1943-51. 2006
    ..A subgroup of patients with rapidly progressive ILD might benefit from intravenous cyclophosphamide pulses in association with 15 mg/d prednisone...
  48. ncbi request reprint Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension
    J Wipff
    Rene Descartes University, Medical Faculty, Rheumatology A Department, Cochin Hospital, AP HP, Paris, France
    Rheumatology (Oxford) 46:622-5. 2007
    ..A 6-base insertion in intron 7 (6bINS) of ENG has been reported to be associated with microvascular disturbance...
  49. ncbi request reprint Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients
    L Teixeira
    Internal Medicine Department and Reference Center for Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris, and UPRES EA 4058, Paris Descartes University, Faculty of Medicine, France
    Ann Rheum Dis 67:110-6. 2008
    ..To describe presentation and outcome of patients with scleroderma renal crisis (SRC)...
  50. doi request reprint High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis
    Y Allanore
    Rene Descartes University, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:284-91. 2008
    ..To evaluate predictors of pulmonary arterial hypertension (PAH) in a prospective cohort of patients with systemic sclerosis (SSc)...
  51. ncbi request reprint Validation of French version of the Scleroderma Health Assessment Questionnaire (SSc HAQ)
    C Georges
    AP HP, Internal Medicine, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France
    Clin Rheumatol 24:3-10. 2005
    ..In addition, we suggest the use of a new outcome measure, the SSc HAQ score, to assess this systemic disease more accurately...
  52. doi request reprint Angiotensin-converting enzyme gene does not contribute to genetic susceptibility to systemic sclerosis in European Caucasians
    Julien Wipff
    Paris Descartes Université, Rhumatologie A, Hopital Cochin, AP HP, Paris, France
    J Rheumatol 36:337-40. 2009
    ..To determine whether angiotensin-converting enzyme (ACE) polymorphisms including I/D and 2 single-nucleotide polymorphisms (SNP) affect susceptibility to systemic sclerosis (SSc) in a large French Caucasian population...
  53. doi request reprint A descriptive and prognostic study of systemic sclerosis-associated myopathies
    B Ranque
    Universite Paris Descartes, UPRES EA 4058, Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Hopital Cochin, Assistance Publique des Hopitaux de Paris, Paris, France
    Ann Rheum Dis 68:1474-7. 2009
    ..To describe the clinical characteristics and muscle pathological features of patients with systemic sclerosis (SSc) and myopathy and analyse their impact on muscle outcome...
  54. doi request reprint Antifibroblast antibodies from systemic sclerosis patients bind to {alpha}-enolase and are associated with interstitial lung disease
    B Terrier
    Paris Descartes University, UPRES EA, France
    Ann Rheum Dis 69:428-33. 2010
    ..To identify target antigens of antifibroblast antibodies (AFA) in systemic sclerosis (SSc) patients. Patients and..
  55. ncbi request reprint Antigen inhalation as a triggering factor in systemic small-sized-vessel vasculitis. Four cases
    L Mouthon
    Service de Medecine Interne, Hopital Avicenne, Universite Paris Nord, Bobigny, Cedex, France
    Ann Med Interne (Paris) 152:152-6. 2001
    ..Identifying such etiological factors could improve our understanding of the pathogenesis of systemic vasculitides and prevent relapses due to similar antigenic exposure...
  56. doi request reprint Long-term outcome of patients with polymyositis/ dermatomyositis and anti-PM-Scl antibody
    I Marie
    Department of Internal Medicine, CHU Rouen, 76031 Rouen Cedex, France
    Br J Dermatol 162:337-44. 2010
    ..To date, no series has analysed long-term outcome in patients with polymyositis/dermatomyositis (PM/DM) with anti-PM-Scl antibody...
  57. pmc Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis
    A Servettaz
    Universite Paris Descartes, Faculte de Medecine, IFR Alfred Jost, Paris, France, and Service de Médecine Interne, Centre National de Référence Sclérodermie Vascularites, AP HP, Hopital Cochin, Paris, France
    Ann Rheum Dis 66:1202-9. 2007
    ..To investigate the role of reactive oxygen species (ROS) in the development of the various patterns of systemic sclerosis (SSc) and the mechanisms of ROS production by endothelial cells and fibroblasts...
  58. doi request reprint Factors influencing influenza-vaccination in adults under immunosuppressive therapy for a systemic inflammatory disease
    F Lanternier
    Pôle de médecine, Groupe Hospitalier Cochin Saint Vincent De Paul, AP HP, Universite Paris Descartes, Paris, France
    Med Mal Infect 39:247-51. 2009
    ..The aim of this study was to evaluate flu vaccination rates and influencing factors in patients with systemic inflammatory diseases...
  59. doi request reprint Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis
    P Dieude
    Universite Paris Diderot, Hopital Bichat Claude Bernard, Paris, France
    Arthritis Rheum 63:1097-105. 2011
    ..The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations...
  60. doi request reprint Impact of systemic sclerosis on occupational and professional activity with attention to patients with digital ulcers
    A Berezne
    Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Department of Internal Medicine, Cochin Hospital, Paris, France
    Arthritis Care Res (Hoboken) 63:277-85. 2011
    ..To evaluate the impact of systemic sclerosis (SSc; scleroderma) and digital ulcers (DUs) on daily living and professional activities...
  61. doi request reprint Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype
    P Dieude
    Paris Diderot University, AP HP, INSERM U699, Paris, France
    Arthritis Rheum 63:3979-87. 2011
    ..This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype...
  62. ncbi request reprint Brachial plexopathy associated with diffuse edematous scleroderma
    L Mouthon
    Department of Internal Medicine, Hôpital Avicenne and Paris Nord University, 125, route de Stalingrad, 93000 Bobigny, France
    Ann Med Interne (Paris) 151:303-5. 2000
    ..After six months intravenous pulse cyclophosphamide therapy, dramatic improvement of skin and neurological involvement was observed...
  63. ncbi request reprint Severity of scleroderma lung disease is related to alveolar concentration of nitric oxide
    K P Tiev
    Dept of Internal Medicine, Faculty of Medicine, Université Paris Pierre et Marie Curie, Hopital Saint Antoine, Paris, France
    Eur Respir J 30:26-30. 2007
    ....
  64. ncbi request reprint Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect
    Marion Malphettes
    Departement d Immunologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, Paris, France
    Clin Infect Dis 49:1329-38. 2009
    ..Common variable immunodeficiency (CVID) is a primary immune deficiency defined by defective antibody production. In most series, a small proportion of patients present with opportunistic infections (OIs)...
  65. pmc Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension
    M C Tamby
    Laboratoire d Immunologie, Pavillon Gustave Roussy, UFR Cochin Port Royal, 8 rue Mechain, 75014 Paris, France
    Thorax 60:765-72. 2005
    ....
  66. pmc Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population
    J Wipff
    Rheumatology A Department, Cochin Hospital, Paris, France
    Ann Rheum Dis 65:1230-2. 2006
    ..38). The PTPN22*620W allele was also not associated with autoantibody patterns. Thus, the PTPN22*R620W polymorphism cannot be regarded as a genetic susceptibility factor for SSc in the French Caucasian population...
  67. pmc Polyarteritis nodosa and mixed cryoglobulinaemia related to hepatitis B and C virus coinfection
    P Garcia de la Pena Lefebvre
    Department of Internal Medicine, Hopital Avicenne, Universite Paris Nord, 125, route de Stalingrad, 93009 Bobigny Cedex, France
    Ann Rheum Dis 60:1068-9. 2001
    ..To determine the responsibility of hepatitis B virus (HBV) and hepatitis C virus (HCV) and therapeutic implications in a patient who developed systemic vasculitis...
  68. ncbi request reprint Stability of natural self-reactive antibody repertoires during aging
    S Lacroix-Desmazes
    INSERM U430, Hopital Broussais, Paris, France
    J Clin Immunol 19:26-34. 1999
    ....
  69. doi request reprint [Eosinophilic pleural effusion associated to Churg and Strauss syndrome]
    D Natali
    Service de Pneumologie, Faculté de Médecine Paris Descartes, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rev Pneumol Clin 64:229-33. 2008
    ..This case report enables us to discuss the different causes of EPE and to illustrate how it may be a manifestation of Churg and Strauss syndrome...
  70. ncbi request reprint Impact of cardiac magnetic resonance imaging for assessment of Churg-Strauss syndrome: a cross-sectional study in 20 patients
    J Marmursztejn
    Department of Cardiology, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris, France
    Clin Exp Rheumatol 27:S70-6. 2009
    ..To examine the diagnostic contributions of cardiac magnetic resonance imaging (CMRI) with delayed-enhancement (DE) in patients with Churg-Strauss syndrome (CSS)...
  71. ncbi request reprint Successful treatment of thymoma-associated pure red cell aplasia with intravenous immunoglobulins
    C Larroche
    Department of Internal Medicine, Hopital Avicenne, Universite Paris Nord, Bobigny, France
    Eur J Haematol 65:74-6. 2000
    ..After failure of thymectomy, corticosteroids and octreotide, a complete durable remission was obtained after a single 5-d cycle of IVIG...
  72. ncbi request reprint Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: a retrospective multicenter open-label study
    Alice Berezne
    Paris Descartes University, Faculty of Medicine, Department of Internal Medicine and Reference Center for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris France
    J Rheumatol 35:1064-72. 2008
    ..To evaluate the effects and safety of 6-month intravenous cyclophosphamide (CYC) followed by 18-month oral azathioprine (AZA) therapy in patients with systemic sclerosis (SSc) and worsening interstitial lung disease (ILD)...
  73. ncbi request reprint [Interstitial lung disease in systemic sclerosis]
    L Mouthon
    Service de Medecine Interne, Hopital Cochin, Centre de Référence pour la sclérodermie systémique, Assistance Publique Hôpitaux de Paris et Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France
    Rev Mal Respir 24:1035-46. 2007
    ..Interstitial lung diseases (ILD) in systemic sclerosis (SSc) are mainly encountered in patients with diffuse disease although they may occur less frequently in patients with limited cutaneous disease...
  74. ncbi request reprint Hydroxyethyl starch-induced renal insufficiency after plasma exchange in a patient with polymyositis and liver cirrhosis
    S Peron
    Department of Internal Medicine, Hĵpital Avicenne and Assistance Publique Hĵpitaux de Paris, France
    Clin Nephrol 55:408-11. 2001
    ..Renal insufficiency occurred with biopsy-proven osmotic nephrosis-like lesions, considered to be secondary to HES infusions and/or CyA...
  75. ncbi request reprint Osteomalacia revealing celiac disease and primary biliary cirrhosis-related Fanconi syndrome in a patient with systemic sclerosis
    B Terrier
    Department of Internal Medicine and French Reference Center for necrotizing vasculitides and systemic sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, France
    Clin Exp Rheumatol 26:467-70. 2008
    ..Thus, in the presence of vitamin deficiencies in a patient with SSc, together with a search for malabsorption syndrome secondary to bacterial overgrowth, CD and/or PBC-associated Fanconi syndrome should be investigated...
  76. ncbi request reprint Localized neurological necrotizing vasculitides. Three cases with isolated mononeuritis multiplex
    S Abgrall
    , , Nord, Bobigny, France
    J Rheumatol 28:631-3. 2001
    ..Our cases appear to be isolated vasculitic neuropathies, with vasculitis strictly limited to the peripheral neuromuscular system without nonspecific clinical and/or biological systemic involvement...
  77. ncbi request reprint Prevalence of systemic sclerosis in a French multi-ethnic county
    V Le Guern
    Department of Internal Medicine, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Bobigny, France
    Rheumatology (Oxford) 43:1129-37. 2004
    ..To assess the prevalence of systemic sclerosis (SSc) in a French multi-ethnic population and to examine ethnic differences...
  78. ncbi request reprint [Diagnosis of primary immune deficiencies in adults]
    L Mouthon
    Universite Paris Descartes, cité Cochin, Service de Medecine Interne, Assistance Publique Hopitaux de Paris, France
    Rev Med Interne 26:11-4. 2005
  79. ncbi request reprint Polymorphic markers of the fibrillin-1 gene and systemic sclerosis in European Caucasian patients
    Julien Wipff
    Department of Rheumatology A, Paris Descartes University, Medical Faculty, Cochin Hospital, AP HP, Paris, France
    J Rheumatol 35:643-9. 2008
    ..Significant associations have been found with the fibrillin-1 gene (FBN1) in Choctaw and Japanese populations. We investigated FBN1 polymorphisms in cohorts of European Caucasian patients...
  80. ncbi request reprint Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients
    Pascal Cohen
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
    Arthritis Rheum 57:686-93. 2007
    ..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)...
  81. ncbi request reprint Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome
    Régis Sablé-Fourtassou
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Ann Intern Med 143:632-8. 2005
    ..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied...
  82. ncbi request reprint [Autoantibodies in clinical practice]
    B Terrier
    Service de Medecine Interne, Hopital Cochin, Universite Paris Descartes, Faculte de Medecine, Asssistance Publique Hôpitaux de Paris, France
    Rev Mal Respir 23:743-5. 2006
  83. doi request reprint Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA genotype data
    S Abad
    Service de Medecine Interne, Laboratoire de recherche clinique et thérapeutique UPRES EA3409, Universite Paris XIII, Faculté Léonard de Vinci, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Paris, France
    Ocul Immunol Inflamm 16:3-8. 2008
    ..To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype...
  84. ncbi request reprint Noninvasive assessment of systolic pulmonary artery pressure in systemic lupus erythematosus: retrospective analysis of 93 patients
    E Fois
    Department of Internal Medicine and French Referral Centre for Necrotising Vasculitides and Systemic Sclerosis, Cochin Hospital, University Paris Descartes, Paris, France
    Clin Exp Rheumatol 28:836-41. 2010
    ..To describe the frequency of patients with an elevated systolic pulmonary artery pressure (sPAP) estimated by Doppler echocardiography in a population of SLE patients followed in a tertiary reference centre...
  85. ncbi request reprint Prognosis and outcome of 26 patients with systemic necrotizing vasculitis admitted to the intensive care unit
    B A Cruz
    Department of Internal Medicine, UPRES EA 3409 Recherche Clinique et Thérapeutique, Assistance Publique des Hopitaux de Paris, Universite Paris Nord, Bobigny, France
    Rheumatology (Oxford) 42:1183-8. 2003
    ..To investigate presenting features, prognostic factors and outcomes of patients with systemic necrotizing vasculitis (SNV) admitted to the intensive care unit (ICU)...
  86. ncbi request reprint Analysis of human self-reactive antibody repertoires by quantitative immunoblotting
    D Stahl
    INSERM Institut National de la Santé et de la Recherche Médicale U430 and Université Pierre et Marie Curie, Hopital Broussais, Paris, France
    J Immunol Methods 240:1-14. 2000
    ..The results are discussed in the light of our current understanding of the processes of selection of self-reactive B-cells and the pathophysiology of autoimmunity...
  87. doi request reprint [Anti-TNFalpha therapy in systemic autoimmune and/or inflammatory diseases]
    Alexis Régent
    UPRES EA 4058, Universite Paris Descartes, Faculte de Medecine, F 75005 Paris, France
    Presse Med 38:761-73. 2009
    ..Published data do not support the use of TNFalpha blockers in connective tissue diseases...
  88. ncbi request reprint [Systemic sclerosis: pathophysiology of a multifaceted disease]
    Amélie Servettaz
    Universite Paris Descartes, Faculté de Médecine Paris Descartes, UPRES EA 4058, Paris
    Presse Med 35:1903-15. 2006
    ..Some are directed against well-identified ubiquitous nuclear proteins and have no demonstrated pathogenic role. Other autoantibodies bind to endothelial cells or fibroblasts and may have a pathogenic role...
  89. doi request reprint NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis
    P Dieude
    Service de Rhumatologie, Paris Diderot University, INSERM U699, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
    Ann Rheum Dis 70:668-74. 2011
    ..NLRP1 provides a scaffold for the assembly of the inflammasome that promotes the processing and maturation of pro-IL-1β. In addition, NLRP1 variants were found to confer susceptibility to autoimmune disorders...
  90. doi request reprint Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension
    M Humbert
    Service de Pneumologie et Reanimation Respiratoire, Hopital Antoine Beclere, Assistance Publique Hopitaux de Paris, Universite Paris Sud 11, 157 rue de la Porte de Trivaux, 92140 Clamart, France
    Eur Respir J 36:549-55. 2010
    ..Survival of idiopathic, familial and anorexigen-associated PAH can be characterised by means of a novel risk-prediction equation using patients' characteristics at diagnosis...
  91. ncbi request reprint Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients
    Loic Guillevin
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
    Arthritis Rheum 49:93-100. 2003
    ....
  92. doi request reprint [Pregnancy in systemic sclerosis]
    Alice Berezne
    Faculte de Medecine, UPRES EA 4058, Pôle de Médecine Interne, Centre de Référence Maladies Auto Immunes Systémiques Rares, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris Cedex 14, France
    Presse Med 37:1636-43. 2008
    ..In order to minimize risks, a multidisciplinary approach is necessary to suggest the best timing for a pregnancy and provide adequate supportive treatment to SSc patients during the pregnancy...
  93. doi request reprint Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity
    Philippe Dieude
    Service de Rhumatologie, Hopital Bichat Claude Bernard, APHP, Université Diderot Paris 7, Paris, France
    J Rheumatol 37:987-92. 2010
    ..Our aim was to investigate whether IRF5 haplotypes confer susceptibility to SSc, and to perform genotype haplotype-phenotype correlation analyses...
  94. doi request reprint Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial
    Raphaele Seror
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Ann Rheum Dis 69:2125-30. 2010
    ....
  95. doi request reprint Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 359:2790-803. 2008
    ..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy...
  96. ncbi request reprint Brief communication: case reports of ribavirin treatment for chronic hepatitis E
    Vincent Mallet
    Institut Cochin, Université Paris Descartes Unité Mixte de Recherche S1016, Paris, France
    Ann Intern Med 153:85-9. 2010
    ..There is currently no accepted treatment of chronic hepatitis E virus (HEV) infection...
  97. ncbi request reprint Cardiac magnetic resonance imaging in Churg-Strauss-syndrome. Impact of immunosuppressants on outcome assessed in a prospective study on 8 patients
    Julien Marmursztejn
    Department of Cardiology, Hopital Cochin, UNIVERSITE DE PARIS, France
    Clin Exp Rheumatol 28:8-13. 2010
    ..To evaluate the effects of immunosuppressive therapy on cardiac abnormalities observed by cardiac magnetic resonance imaging (CMRI) in patients with Churg-Strauss syndrome (CSS)...
  98. doi request reprint [Dyspnea upon exertion in systemic scleroderma: from symptom to etiological diagnosis]
    Eric Hachulla
    Centre de référence des maladies auto immunes et des maladies systémique rares sclérodermie systémique, Service de Medecine Interne, Hopital Claude Huriez, CHRU, F 59037 Lille Cedex, France
    Presse Med 38:911-26. 2009
    ..Diastolic left ventricle dysfunction is another frequently encountered cause of dyspnea in systemic sclerosis. Other less common causes are pericarditis, respiratory muscle involvement, lung cancer, pulmonary embolism...
  99. ncbi request reprint Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations
    Julien Wipff
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    J Rheumatol 37:1164-7. 2010
    ..Our objective was to determine whether polymorphisms of SLC6A4 confer susceptibility to SSc and its vascular phenotype...
  100. doi request reprint Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 62:616-26. 2010
    ..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses...
  101. doi request reprint Pregnancies in systemic necrotizing vasculitides: report on 12 women and their 20 pregnancies
    Christian Pagnoux
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Universite Paris Descartes, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rheumatology (Oxford) 50:953-61. 2011
    ..To describe pregnancies of women with systemic necrotizing vasculitides (SNVs), i.e. PAN, WG, Churg-Strauss syndrome (CSS) or microscopic polyangiitis (MPA), followed over the past 15 years at four French centres...