Didier Morin

Summary

Country: France

Publications

  1. ncbi Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
    Didier Morin
    INSERM, U660, Creteil F 94010, France Université Paris XII, Creteil F 94010, France
    Biochem Pharmacol 72:911-8. 2006
  2. ncbi The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation
    Roland Zini
    INSERM, U841, Creteil, F 94010, France
    Free Radic Res 41:1159-66. 2007
  3. ncbi Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
    Catherine Plin
    INSERM, U660, , F-94010 France
    Eur J Pharmacol 528:162-8. 2005
  4. ncbi Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities
    Sandrine Pons
    INSERM, U955, Equipe 3, Creteil, 94000, France
    J Mol Cell Cardiol 54:82-9. 2013
  5. ncbi Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore
    Heidi Ligeret
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Free Radic Biol Med 36:919-29. 2004
  6. ncbi Fluoride curcumin derivatives: new mitochondrial uncoupling agents
    Heidi Ligeret
    , France
    FEBS Lett 569:37-42. 2004
  7. ncbi [3H]BHDP as a novel and selective ligand for sigma1 receptors in liver mitochondria and brain synaptosomes of the rat
    Anis Klouz
    Laboratoire de Pharmacologie, EA427, , , France
    FEBS Lett 553:157-62. 2003
  8. ncbi Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand
    Anis Klouz
    Unité d Expérimentation Animale, Faculte de Medecine de Tunis, Tunisia
    Eur J Pharmacol 578:292-9. 2008
  9. ncbi Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore
    Fatou Nsoure Obame
    INSERM U 841, F 94010 Creteil, France
    J Pharmacol Exp Ther 326:252-8. 2008
  10. ncbi Intercostal and abdominal respiratory motoneurons in the neonatal rat spinal cord: spatiotemporal organization and responses to limb afferent stimulation
    Aurore Giraudin
    Universite Victor Segalen Bordeaux 2, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition, Bâtiment 2A, 146 rue Leo Saignat, Bordeaux, France
    J Neurophysiol 99:2626-40. 2008

Collaborators

  • Jean Paul Tillement
  • Brigitte Onteniente
  • Roland Zini
  • Alain Berdeaux
  • Anis Klouz
  • Catherine Plin
  • Fatou Nsoure Obame
  • Heidi Ligeret
  • Sandrine Pons
  • Serge Labidalle
  • Aurore Giraudin
  • John Simmers
  • Laurent Juvin
  • Mesbah Lahouel
  • Marjolaine Duval
  • Pierre-Alain Carrupt
  • Pierre S Haddad
  • Aziz Elimadi
  • Imene Tabbi-Anneni
  • Lolita Portal
  • Valerie Martin
  • Bijan Ghaleh
  • Dorra Ben Saïd
  • Lobna Ouanes
  • Marie Jeanne Cabirol-Pol
  • Henda Ferchichi
  • Rana Assaly
  • Nadia Kourda
  • Mohamed Lakhal
  • Jean Luc Dubois-Randé
  • Marie-Jeanne Cabirol-Pol
  • Catherine Plin-Mercier
  • Pierre Alain Carrupt
  • Rachid Souktani
  • Salah Rhouati
  • Ammar Zellagui
  • Diane Vallerand
  • Sophie Barthelemy
  • Arnaud Lucien
  • Alain Grynberg
  • Vincent Berezowski
  • Anne Bescond-Jacquet
  • Cécile Héliès-Toussaint
  • Michel Wierzbicki
  • Rosa Sapena
  • Jun Liu
  • Vassilios Papadopoulos
  • Tangui Maurice

Detail Information

Publications19

  1. ncbi Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
    Didier Morin
    INSERM, U660, Creteil F 94010, France Université Paris XII, Creteil F 94010, France
    Biochem Pharmacol 72:911-8. 2006
    ..These data demonstrate that S-15176 interacts with several targets in mitochondria and these pharmacological properties should be considered in the examination of its health benefits as well as its potential cytotoxicity...
  2. ncbi The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation
    Roland Zini
    INSERM, U841, Creteil, F 94010, France
    Free Radic Res 41:1159-66. 2007
    ..Our results show that O(2)*(-), H(2)O(2) and HO* act on different mitochondrial targets to alter ATP synthesis, mostly through inhibition of NADH production...
  3. ncbi Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
    Catherine Plin
    INSERM, U660, , F-94010 France
    Eur J Pharmacol 528:162-8. 2005
    ..These data demonstrate that resveratrol ameliorates the liver injury induced by CPWR and appears as a promising drug to improve the primary function of the grafted liver after transplantation...
  4. ncbi Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities
    Sandrine Pons
    INSERM, U955, Equipe 3, Creteil, 94000, France
    J Mol Cell Cardiol 54:82-9. 2013
    ....
  5. ncbi Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore
    Heidi Ligeret
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Free Radic Biol Med 36:919-29. 2004
    ..These data suggest that the mechanism by which curcumin promotes PTP opening involves the reduction of Fe3+ to Fe2+, inducing hydroxyl radical (HO*) production and oxidation of thiol groups in the membrane, leading to pore opening...
  6. ncbi Fluoride curcumin derivatives: new mitochondrial uncoupling agents
    Heidi Ligeret
    , France
    FEBS Lett 569:37-42. 2004
    ..Moreover, they are able to induce PTP opening by promoting the oxidation of thiol groups and the release of cytochrome c, making these two molecules potential candidates for induction of apoptosis...
  7. ncbi [3H]BHDP as a novel and selective ligand for sigma1 receptors in liver mitochondria and brain synaptosomes of the rat
    Anis Klouz
    Laboratoire de Pharmacologie, EA427, , , France
    FEBS Lett 553:157-62. 2003
    ..Taken together, these results demonstrate that [(3)H]BHDP is a potent and selective ligand for sigma1 receptors showing cytoprotective effects in astrocytes...
  8. ncbi Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand
    Anis Klouz
    Unité d Expérimentation Animale, Faculte de Medecine de Tunis, Tunisia
    Eur J Pharmacol 578:292-9. 2008
    ..These data demonstrate that BHDP protects liver against the deleterious effects of ischemia-reperfusion and suggest that sigma(1) receptors play an important role in the protective effect...
  9. ncbi Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore
    Fatou Nsoure Obame
    INSERM U 841, F 94010 Creteil, France
    J Pharmacol Exp Ther 326:252-8. 2008
    ....
  10. ncbi Intercostal and abdominal respiratory motoneurons in the neonatal rat spinal cord: spatiotemporal organization and responses to limb afferent stimulation
    Aurore Giraudin
    Universite Victor Segalen Bordeaux 2, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition, Bâtiment 2A, 146 rue Leo Saignat, Bordeaux, France
    J Neurophysiol 99:2626-40. 2008
    ....
  11. ncbi Prevention of heart failure in rats by trimetazidine treatment: a consequence of accelerated phospholipid turnover?
    Imene Tabbi-Anneni
    Institut National de la Recherche Agronomique UR1154, Lipides Membranaires et Fonctions Cardiovasculaires, Faculte de Pharmacie, Chatenay Malabry, France
    J Pharmacol Exp Ther 304:1003-9. 2003
    ..This cytoprotection suggests that membrane homeostasis preservation may be considered as a therapeutic target in the treatment of heart failure...
  12. ncbi Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization
    Fatou Nsoure Obame
    INSERM U841, Equipe 3, Facultéde Médecine de Paris XII, 8 rue du General Sarrail, F 94010, Creteil, France
    J Pharmacol Exp Ther 323:336-45. 2007
    ..This is due to a reorganization of the balance between pro- and antiapoptotic proteins of the Bcl-2 family proteins at the level of mitochondrial membranes...
  13. ncbi Locomotor rhythmogenesis in the isolated rat spinal cord: a phase-coupled set of symmetrical flexion extension oscillators
    Laurent Juvin
    Universite Bordeaux 1, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition bâtiment 2A, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Physiol 583:115-28. 2007
    ....
  14. ncbi Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle
    Mesbah Lahouel
    Département de pharmacologie et phytochimie, Université de Jijel, Algeria
    Biochem Biophys Res Commun 355:252-7. 2007
    ..In addition, these data provide an additional mechanism by which ferulenol may alter cell function and demonstrate that mitochondrial dysfunction is an important determinant in Ferula plant toxicity...
  15. ncbi Implication of mitochondrial dysfunction and cell death in cold preservation--warm reperfusion-induced hepatocyte injury
    Marjolaine Duval
    , , , P.O. Box 6128, Downtown Station, , QC H3C 3J7, Canada
    Can J Physiol Pharmacol 84:547-54. 2006
    ..Combined protection of mitochondria and endoplasmic reticulum may thus represent an innovative therapeutic avenue to enhance liver graft viability and functional integrity...
  16. ncbi Dual effect of ebselen on mitochondrial permeability transition
    Didier Morin
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Biochem Pharmacol 65:1643-51. 2003
    ..These data demonstrate that ebselen is able to modulate the opening of the permeability transition pore and that it might be a critical event for both the proapoptotic and cytoprotective activities of the drug...
  17. ncbi Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver
    Didier Morin
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue du General Sarrail, F 94010 Creteil, France
    Biochem Pharmacol 68:2065-73. 2004
    ....
  18. ncbi Protection by cyclosporin A of mitochondrial and cellular functions during a cold preservation-warm reperfusion of rat liver
    Catherine Plin
    Laboratoire de Pharmacologie, , , France
    Eur J Pharmacol 495:111-8. 2004
    ..However, this target can be considered as a promising adjunct therapeutic approach to improve the primary function of the grafted liver after transplantation...
  19. ncbi Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes
    Anis Klouz
    , , , France
    Br J Pharmacol 135:1607-15. 2002
    ..The pharmacological significance of these sites and their role on mitochondrial function remain unknown...