Didier Morin

Summary

Country: France

Publications

  1. ncbi request reprint Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
    Didier Morin
    INSERM, U660, Creteil F 94010, France Université Paris XII, Creteil F 94010, France
    Biochem Pharmacol 72:911-8. 2006
  2. doi request reprint Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion
    Stéphanie Paradis
    INSERM, U955, Equipe 3, 8 rue du General Sarrail, Créteil Cedex 94000, France
    Cardiovasc Res 98:420-7. 2013
  3. doi request reprint Mild hypothermia reduces per-ischemic reactive oxygen species production and preserves mitochondrial respiratory complexes
    Renaud Tissier
    INSERM, U955, Equipe 3, Creteil, 94000, France
    Resuscitation 84:249-55. 2013
  4. doi request reprint Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities
    Sandrine Pons
    INSERM, U955, Equipe 3, Creteil, 94000, France
    J Mol Cell Cardiol 54:82-9. 2013
  5. ncbi request reprint The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation
    Roland Zini
    INSERM, U841, Creteil, F 94010, France
    Free Radic Res 41:1159-66. 2007
  6. ncbi request reprint Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
    Catherine Plin
    INSERM, U660, Creteil, F 94010 France
    Eur J Pharmacol 528:162-8. 2005
  7. doi request reprint Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes
    Alexandra d Anglemont de Tassigny
    INSERM U955, Equipe 3, Creteil F 94010, France Université Paris Est, Faculte de Medecine, Creteil F 94010, France Institut Supérieur des BioSciences, Faculte de Medecine, Creteil F 94010, France
    Mitochondrion 13:688-97. 2013
  8. ncbi request reprint Fluoride curcumin derivatives: new mitochondrial uncoupling agents
    Heidi Ligeret
    Laboratoire de Pharmacologie Créteil, France
    FEBS Lett 569:37-42. 2004
  9. ncbi request reprint Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore
    Heidi Ligeret
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Free Radic Biol Med 36:919-29. 2004
  10. ncbi request reprint [3H]BHDP as a novel and selective ligand for sigma1 receptors in liver mitochondria and brain synaptosomes of the rat
    Anis Klouz
    Laboratoire de Pharmacologie, EA427, Faculte de Medecine, Creteil, France
    FEBS Lett 553:157-62. 2003

Collaborators

  • Alain Berdeaux
  • Roland Zini
  • Jean Paul Tillement
  • Valerio Leoni
  • Sophie Schaller
  • Brigitte Onteniente
  • Anis Klouz
  • Catherine Plin
  • Fatou Nsoure Obame
  • Sandrine Pons
  • Heidi Ligeret
  • Alexandra d Anglemont de Tassigny
  • Bijan Ghaleh
  • Renaud Tissier
  • Stéphanie Paradis
  • Rana Assaly
  • Serge Labidalle
  • Aurore Giraudin
  • John Simmers
  • Mesbah Lahouel
  • Laurent Juvin
  • Marjolaine Duval
  • Pierre Alain Carrupt
  • Pierre S Haddad
  • Aziz Elimadi
  • Sophie Barthelemy
  • Imene Tabbi-Anneni
  • Rebecca M Pruss
  • Fanny Lidouren
  • Lys Darbera
  • Mourad Chenoune
  • Valerie Martin
  • Claudio Caccia
  • Lolita Portal
  • Mohamed Lakhal
  • Lobna Ouanes
  • Catherine Plin-Mercier
  • Marie Jeanne Cabirol-Pol
  • Dorra Ben Saïd
  • Henda Ferchichi
  • Nadia Kourda
  • Jean Luc Dubois-Randé
  • Ammar Zellagui
  • Salah Rhouati
  • Rachid Souktani
  • Diane Vallerand
  • Géraldine Bouchard Doulakas
  • Marie Françoise Boussard
  • Michel Wierzbicki
  • Anne Bescond-Jacquet
  • Cécile Héliès-Toussaint
  • Alain Grynberg
  • Arnaud Lucien
  • Romeo Cecchelli
  • Vincent Berezowski
  • Tangui Maurice
  • Jun Liu
  • Rosa Sapena
  • Vassilios Papadopoulos

Detail Information

Publications22

  1. ncbi request reprint Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
    Didier Morin
    INSERM, U660, Creteil F 94010, France Université Paris XII, Creteil F 94010, France
    Biochem Pharmacol 72:911-8. 2006
    ..These data demonstrate that S-15176 interacts with several targets in mitochondria and these pharmacological properties should be considered in the examination of its health benefits as well as its potential cytotoxicity...
  2. doi request reprint Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion
    Stéphanie Paradis
    INSERM, U955, Equipe 3, 8 rue du General Sarrail, Créteil Cedex 94000, France
    Cardiovasc Res 98:420-7. 2013
    ..This study, thus, sought to determine whether cholesterol could play a role in the cardioprotective effect of TSPO ligands...
  3. doi request reprint Mild hypothermia reduces per-ischemic reactive oxygen species production and preserves mitochondrial respiratory complexes
    Renaud Tissier
    INSERM, U955, Equipe 3, Creteil, 94000, France
    Resuscitation 84:249-55. 2013
    ..Mitochondrial dysfunction is critical following ischemic disorders. Our goal was to determine whether mild hypothermia could limit this dysfunction through per-ischemic inhibition of reactive oxygen species (ROS) generation...
  4. doi request reprint Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities
    Sandrine Pons
    INSERM, U955, Equipe 3, Creteil, 94000, France
    J Mol Cell Cardiol 54:82-9. 2013
    ....
  5. ncbi request reprint The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation
    Roland Zini
    INSERM, U841, Creteil, F 94010, France
    Free Radic Res 41:1159-66. 2007
    ..Our results show that O(2)*(-), H(2)O(2) and HO* act on different mitochondrial targets to alter ATP synthesis, mostly through inhibition of NADH production...
  6. ncbi request reprint Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
    Catherine Plin
    INSERM, U660, Creteil, F 94010 France
    Eur J Pharmacol 528:162-8. 2005
    ..These data demonstrate that resveratrol ameliorates the liver injury induced by CPWR and appears as a promising drug to improve the primary function of the grafted liver after transplantation...
  7. doi request reprint Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes
    Alexandra d Anglemont de Tassigny
    INSERM U955, Equipe 3, Creteil F 94010, France Université Paris Est, Faculte de Medecine, Creteil F 94010, France Institut Supérieur des BioSciences, Faculte de Medecine, Creteil F 94010, France
    Mitochondrion 13:688-97. 2013
    ..Thus, preventive administration of TSPO ligands may represent a novel pharmacological strategy to protect the heart during doxorubicin treatment. ..
  8. ncbi request reprint Fluoride curcumin derivatives: new mitochondrial uncoupling agents
    Heidi Ligeret
    Laboratoire de Pharmacologie Créteil, France
    FEBS Lett 569:37-42. 2004
    ..Moreover, they are able to induce PTP opening by promoting the oxidation of thiol groups and the release of cytochrome c, making these two molecules potential candidates for induction of apoptosis...
  9. ncbi request reprint Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore
    Heidi Ligeret
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Free Radic Biol Med 36:919-29. 2004
    ..These data suggest that the mechanism by which curcumin promotes PTP opening involves the reduction of Fe3+ to Fe2+, inducing hydroxyl radical (HO*) production and oxidation of thiol groups in the membrane, leading to pore opening...
  10. ncbi request reprint [3H]BHDP as a novel and selective ligand for sigma1 receptors in liver mitochondria and brain synaptosomes of the rat
    Anis Klouz
    Laboratoire de Pharmacologie, EA427, Faculte de Medecine, Creteil, France
    FEBS Lett 553:157-62. 2003
    ..Taken together, these results demonstrate that [(3)H]BHDP is a potent and selective ligand for sigma1 receptors showing cytoprotective effects in astrocytes...
  11. ncbi request reprint Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand
    Anis Klouz
    Unité d Expérimentation Animale, Faculte de Medecine de Tunis, Tunisia
    Eur J Pharmacol 578:292-9. 2008
    ..These data demonstrate that BHDP protects liver against the deleterious effects of ischemia-reperfusion and suggest that sigma(1) receptors play an important role in the protective effect...
  12. ncbi request reprint Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore
    Fatou Nsoure Obame
    INSERM U 841, F 94010 Creteil, France
    J Pharmacol Exp Ther 326:252-8. 2008
    ....
  13. doi request reprint Intercostal and abdominal respiratory motoneurons in the neonatal rat spinal cord: spatiotemporal organization and responses to limb afferent stimulation
    Aurore Giraudin
    Universite Victor Segalen Bordeaux 2, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition, Bâtiment 2A, 146 rue Leo Saignat, Bordeaux, France
    J Neurophysiol 99:2626-40. 2008
    ....
  14. ncbi request reprint Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization
    Fatou Nsoure Obame
    INSERM U841, Equipe 3, Facultéde Médecine de Paris XII, 8 rue du General Sarrail, F 94010, Creteil, France
    J Pharmacol Exp Ther 323:336-45. 2007
    ..This is due to a reorganization of the balance between pro- and antiapoptotic proteins of the Bcl-2 family proteins at the level of mitochondrial membranes...
  15. pmc Locomotor rhythmogenesis in the isolated rat spinal cord: a phase-coupled set of symmetrical flexion extension oscillators
    Laurent Juvin
    Universite Bordeaux 1, UMR CNRS 5227, Laboratoire Mouvement Adaptation Cognition bâtiment 2A, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Physiol 583:115-28. 2007
    ....
  16. ncbi request reprint Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle
    Mesbah Lahouel
    Département de pharmacologie et phytochimie, Université de Jijel, Algeria
    Biochem Biophys Res Commun 355:252-7. 2007
    ..In addition, these data provide an additional mechanism by which ferulenol may alter cell function and demonstrate that mitochondrial dysfunction is an important determinant in Ferula plant toxicity...
  17. ncbi request reprint Implication of mitochondrial dysfunction and cell death in cold preservation--warm reperfusion-induced hepatocyte injury
    Marjolaine Duval
    Département de Pharmacologie et Groupe d étude sur les protéines membranaires, Faculte de Medecine, Universite de Montreal, P O Box 6128, Downtown Station, Montreal, QC H3C 3J7, Canada
    Can J Physiol Pharmacol 84:547-54. 2006
    ..Combined protection of mitochondria and endoplasmic reticulum may thus represent an innovative therapeutic avenue to enhance liver graft viability and functional integrity...
  18. ncbi request reprint Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver
    Didier Morin
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue du General Sarrail, F 94010 Creteil, France
    Biochem Pharmacol 68:2065-73. 2004
    ....
  19. ncbi request reprint Protection by cyclosporin A of mitochondrial and cellular functions during a cold preservation-warm reperfusion of rat liver
    Catherine Plin
    Laboratoire de Pharmacologie, Faculte de Medecine, Universite Paris XII, France
    Eur J Pharmacol 495:111-8. 2004
    ..However, this target can be considered as a promising adjunct therapeutic approach to improve the primary function of the grafted liver after transplantation...
  20. ncbi request reprint Dual effect of ebselen on mitochondrial permeability transition
    Didier Morin
    Laboratoire de Pharmacologie, Faculte de Medecine, Creteil, France
    Biochem Pharmacol 65:1643-51. 2003
    ..These data demonstrate that ebselen is able to modulate the opening of the permeability transition pore and that it might be a critical event for both the proapoptotic and cytoprotective activities of the drug...
  21. ncbi request reprint Prevention of heart failure in rats by trimetazidine treatment: a consequence of accelerated phospholipid turnover?
    Imene Tabbi-Anneni
    Institut National de la Recherche Agronomique UR1154, Lipides Membranaires et Fonctions Cardiovasculaires, Faculte de Pharmacie, Chatenay Malabry, France
    J Pharmacol Exp Ther 304:1003-9. 2003
    ..This cytoprotection suggests that membrane homeostasis preservation may be considered as a therapeutic target in the treatment of heart failure...
  22. pmc Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes
    Anis Klouz
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, F 94010 Creteil, France
    Br J Pharmacol 135:1607-15. 2002
    ..The pharmacological significance of these sites and their role on mitochondrial function remain unknown...