Florence Morfin

Summary

Country: France

Publications

  1. ncbi request reprint [Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
    F Morfin
    Laboratoire de virologie des Hospices civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08
    Ann Biol Clin (Paris) 61:33-40. 2003
  2. ncbi request reprint Cytomegalovirus and adenovirus infections and diseases among 75 paediatric unrelated allogeneic bone marrow transplant recipients
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, France
    J Med Virol 72:257-62. 2004
  3. ncbi request reprint Drug targets in herpes simplex and Epstein Barr Virus infections
    Geneviève Billaud
    Laboratoire de Virologie Est, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron, France
    Infect Disord Drug Targets 9:117-25. 2009
  4. pmc Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir
    F Morfin
    Laboratoire de virologie des Hospices civils de Lyon, 69373 Lyon, France
    Antimicrob Agents Chemother 43:2412-6. 1999
  5. ncbi request reprint Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene
    F Morfin
    Laboratory of Virology, Hospices Civils de Lyon, Lyon, France
    J Med Virol 62:247-50. 2000
  6. ncbi request reprint Detection of measles vaccine in the throat of a vaccinated child
    Florence Morfin
    Laboratory of Virology, Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Vaccine 20:1541-3. 2002
  7. ncbi request reprint Herpes simplex virus resistance to antiviral drugs
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Cedex 08, Lyon, France
    J Clin Virol 26:29-37. 2003
  8. ncbi request reprint HSV excretion after bone marrow transplantation: a 4-year survey
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    J Clin Virol 30:341-5. 2004
  9. ncbi request reprint Differential susceptibility of adenovirus clinical isolates to cidofovir and ribavirin is not related to species alone
    Florence Morfin
    Laboratoire de Virologie et Pathogenèse Humaine, Universite Lyon 1, CNRS FRE 3011, Lyon, France
    Antivir Ther 14:55-61. 2009
  10. doi request reprint Genotypic detection of acyclovir-resistant HSV-1: characterization of 67 ACV-sensitive and 14 ACV-resistant viruses
    Emilie Frobert
    Laboratoire de Virologie, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron Cedex, Lyon, France
    Antiviral Res 79:28-36. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint [Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
    F Morfin
    Laboratoire de virologie des Hospices civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08
    Ann Biol Clin (Paris) 61:33-40. 2003
    ..Alternative treatments using drugs such as foscarnet or cidofovir which have a different mechanism of action compared to acyclovir, are recommended but these molecules are often more toxic than acyclovir...
  2. ncbi request reprint Cytomegalovirus and adenovirus infections and diseases among 75 paediatric unrelated allogeneic bone marrow transplant recipients
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, France
    J Med Virol 72:257-62. 2004
    ....
  3. ncbi request reprint Drug targets in herpes simplex and Epstein Barr Virus infections
    Geneviève Billaud
    Laboratoire de Virologie Est, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron, France
    Infect Disord Drug Targets 9:117-25. 2009
    ..One alternative is to develop drugs with different mechanisms of action. The present article reviews potential targets, viral and cellular, for which specific inhibitors have been identified...
  4. pmc Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir
    F Morfin
    Laboratoire de virologie des Hospices civils de Lyon, 69373 Lyon, France
    Antimicrob Agents Chemother 43:2412-6. 1999
    ..These areas are putative candidates for a genotypic diagnosis of ACV resistance...
  5. ncbi request reprint Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene
    F Morfin
    Laboratory of Virology, Hospices Civils de Lyon, Lyon, France
    J Med Virol 62:247-50. 2000
    ..These results corroborate the clinical relevance of this mutation, which is associated with acyclovir-resistant recurrent infections in humans...
  6. ncbi request reprint Detection of measles vaccine in the throat of a vaccinated child
    Florence Morfin
    Laboratory of Virology, Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Vaccine 20:1541-3. 2002
    ..In the case presented here, the vaccine virus was isolated in the throat, showing that subcutaneous injection of an attenuated measles strain can result in respiratory excretion of this virus...
  7. ncbi request reprint Herpes simplex virus resistance to antiviral drugs
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Cedex 08, Lyon, France
    J Clin Virol 26:29-37. 2003
    ..A high level of gene polymorphism has also been reported for these genes, especially for TK. These results are useful for the development of rapid genotypic assays for the detection of mutations associated with resistance...
  8. ncbi request reprint HSV excretion after bone marrow transplantation: a 4-year survey
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    J Clin Virol 30:341-5. 2004
    ..Herpes simplex virus (HSV) oral excretions are common after bone marrow transplantation (BMT)...
  9. ncbi request reprint Differential susceptibility of adenovirus clinical isolates to cidofovir and ribavirin is not related to species alone
    Florence Morfin
    Laboratoire de Virologie et Pathogenèse Humaine, Universite Lyon 1, CNRS FRE 3011, Lyon, France
    Antivir Ther 14:55-61. 2009
    ..All the serotypes tested were susceptible to cidofovir, whereas only serotypes from species C were sensitive to ribavirin. Here, we aimed to extend these investigations to clinical isolates...
  10. doi request reprint Genotypic detection of acyclovir-resistant HSV-1: characterization of 67 ACV-sensitive and 14 ACV-resistant viruses
    Emilie Frobert
    Laboratoire de Virologie, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron Cedex, Lyon, France
    Antiviral Res 79:28-36. 2008
    ..DNA polymerase gene was afterwards explored. With this rapid PCR-based assay, ACV-resistant HSV could be detected directly in clinical specimens within 24 h...
  11. doi request reprint Effects of mutations on herpes simplex virus 1 thymidine kinase functionality: an in vitro assay based on detection of monophosphate forms of acyclovir and thymidine using HPLC/DAD
    Nicolas Malartre
    Laboratoire de Virologie Est, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Antiviral Res 95:224-8. 2012
    ..A reliable link between HSV UL23 TK mutations and ACV resistance is necessary for developing a powerful genotyping tool to detect ACV resistance quickly in clinical samples...
  12. doi request reprint Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases
    Isabelle Schuffenecker
    Laboratoire de virologie des Hospices civils de Lyon, Hopital Femme Mere Enfant, 59 Boulevard Pinel, F 69677 Bron Cedex, France
    J Clin Virol 54:337-41. 2012
    ..Although data documenting the frequency and severity of human parechovirus type 3 (HPeV-3) infection in infants have been published in Canada, the USA, the UK and the Netherlands, no data from France are available...
  13. ncbi request reprint S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target
    Anna Greco
    INSERM U369, Faculté de Médecine Lyon R T H Laennec, Lyon, France
    FASEB J 19:1128-30. 2005
    ..Our data provide the opportunity to develop molecules with a novel mechanism of action for the treatment of herpes infection...
  14. ncbi request reprint Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study
    Emilie Frobert
    Laboratoire de Virologie Est, Hospices Civils de Lyon, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Antiviral Res 73:147-50. 2007
    ..Mutations His105Pro, Leu364Pro and Asp162Ala lead to the loss of TK activity that could result in ACV-resistance...
  15. ncbi request reprint In vitro susceptibility of adenovirus to antiviral drugs is species-dependent
    Florence Morfin
    Laboratory of Virology, Edouard Herriot Hospital, Lyon, France
    Antivir Ther 10:225-9. 2005
    ..If our in vitro findings are predictive of virological responses in vivo, these results suggest that ribavirin would not be effective for management of non-C species adenovirus infections after HSCT...
  16. ncbi request reprint A screening dye-uptake assay to evaluate in vitro susceptibility of herpes simplex virus isolates to acyclovir
    Christelle Danve
    Laboratory of Virology, 8 avenue Rockefeller, 69373 Cedex 08, Lyon, France
    J Virol Methods 105:207-17. 2002
    ..This test appeared to be half the cost and much easier to carry out than the conventional dye-uptake assay, and consequently is well suited for large scale surveillance...
  17. ncbi request reprint Influenza burden in febrile infants and young children in a pediatric emergency department
    Dominique Ploin
    Département d information médicale des Hospices Civils de Lyon, Lyon, France
    Pediatr Infect Dis J 26:142-7. 2007
    ..In France, epidemiologic data in children in ambulatory settings are scarce. We aimed to measure the burden of influenza in young children...
  18. pmc A pharmacodynamic model of ganciclovir antiviral effect and toxicity for lymphoblastoid cells suggests a new dosing regimen to treat cytomegalovirus infection
    Audrey Janoly-Dumenil
    Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France
    Antimicrob Agents Chemother 56:3732-8. 2012
    ..This optimal profile could be obtained by intravenous (i.v.) ganciclovir at 10 mg/kg of body weight twice daily (b.i.d.) at days 1, 2, 8.5, and 9.5 in stem cell transplant patients with normal renal function...
  19. ncbi request reprint Human parainfluenza virus type 4 infections: a report of 20 cases from 1998 to 2002
    Geneviève Billaud
    Laboratoire de Virologie, Domaine Rockefeller, Hospices Civils de Lyon, 69373 Lyon Cedex 08, Lyon, France
    J Clin Virol 34:48-51. 2005
    ..Human Parainfluenza Viruses (HPIV) type 4 are responsible for respiratory infections. Unlike HPIV types 1-3, they are associated with mild infections and appear to be infrequent. Thus, they often go undetected...
  20. doi request reprint The clinical interest of HSV1 semi-quantification in bronchoalveolar lavage
    Emilie Frobert
    Virology Laboratory, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    J Clin Virol 58:265-8. 2013
    ..Quantitative PCR for HSV is not commonly available in clinical routine. Real-time PCR tests are, however, used commonly and provide semi-quantitative information based on the cycle threshold (Ct)...
  21. pmc Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease
    Nisrine Falah
    VirPatH, EMR 4610, Virologie et Pathologie Humaine, Universite Lyon 1, Universite de Lyon, Faculté de médecine Lyon Est, Secteur Laennec, Lyon, France
    J Virol 86:691-704. 2012
    ..To our knowledge, this is the first report validating a compound against HRV infection in a mouse model...
  22. ncbi request reprint Detection of human influenza A (H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors
    Vanessa Escuret
    Virologie et Pathologie Humaine, CNRS FRE 3011, Universite Lyon 1, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Clin Virol 41:25-8. 2008
    ..Neuraminidase inhibitors (NAIs) have been used since 2005 in France...
  23. ncbi request reprint Topical imiquimod for recurrent acyclovir-resistant HSV infection
    Valerie Martinez
    Am J Med 119:e9-11. 2006