Thierry Moreau

Summary

Country: France

Publications

  1. ncbi request reprint Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family
    Thierry Moreau
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, Tours, France
    Biochimie 90:284-95. 2008
  2. ncbi request reprint Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase
    Nicolas Guyot
    INSERM U618 Protéases et Vectorisation Pulmonaires and IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, 10 Bd Tonnellé, BP 3223, 37032 Tours Cedex, France
    Biochemistry 44:15610-8. 2005
  3. pmc Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases
    Marie Louise Zani
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, France
    Protein Sci 18:579-94. 2009
  4. doi request reprint The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function
    Kévin Baranger
    INSERM U618, Universite Francois Rabelais, Tours, France
    FEBS J 275:2008-20. 2008
  5. doi request reprint Naturally occurring substitutions of conserved residues in human immunodeficiency virus type 1 variants of different clades are involved in PG9 and PG16 resistance to neutralization
    Suzie Thenin
    Universite Francois Rabelais, INSERM U966, 10 blvd Tonnellé, 37032 Tours Cedex, France
    J Gen Virol 93:1495-505. 2012
  6. pmc Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate
    Kévin Baranger
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, Tours, France
    PLoS ONE 6:e20976. 2011
  7. doi request reprint Phage display as a powerful tool to engineer protease inhibitors
    Marie Louise Zani
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, 37000 Tours, France
    Biochimie 92:1689-704. 2010
  8. pmc Identification of neutralizing conformational epitopes on the human papillomavirus type 31 major capsid protein and functional implications
    Maxime J J Fleury
    INSERM U618, Universite Francois Rabelais, Tours, France
    Protein Sci 18:1425-38. 2009
  9. ncbi request reprint Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin
    Nicolas Guyot
    INSERM U618 Proteases et Vectorisation Pulmonaires, and IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, 10 boulevard Tonnelle, BP 3223, F 37032 Tours cedex, France
    Biol Chem 386:391-9. 2005
  10. ncbi request reprint Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
    Brice Korkmaz
    INSERM U618 Proteases et Vectorisation Pulmonaires, Universite Francois Rabelais, 10 boulevard Tonnelle, BP 3223, 37032 Tours Cedex, France
    Biochimie 90:227-42. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family
    Thierry Moreau
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, Tours, France
    Biochimie 90:284-95. 2008
    ....
  2. ncbi request reprint Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase
    Nicolas Guyot
    INSERM U618 Protéases et Vectorisation Pulmonaires and IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, 10 Bd Tonnellé, BP 3223, 37032 Tours Cedex, France
    Biochemistry 44:15610-8. 2005
    ..We believe this is the first demonstration that transglutaminase-mediated cross-linking of serine protease inhibitors to proteins preserves their inhibitory capacities...
  3. pmc Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases
    Marie Louise Zani
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, France
    Protein Sci 18:579-94. 2009
    ..Therefore, the inhibitors described herein have the appropriate properties to be further evaluated as therapeutic anti-inflammatory agents...
  4. doi request reprint The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function
    Kévin Baranger
    INSERM U618, Universite Francois Rabelais, Tours, France
    FEBS J 275:2008-20. 2008
    ..Thus, trappin-2 not only provides an antiprotease shield, but also may play an important role in the innate defense of the human lungs and mucosae against pathogenic microorganisms...
  5. doi request reprint Naturally occurring substitutions of conserved residues in human immunodeficiency virus type 1 variants of different clades are involved in PG9 and PG16 resistance to neutralization
    Suzie Thenin
    Universite Francois Rabelais, INSERM U966, 10 blvd Tonnellé, 37032 Tours Cedex, France
    J Gen Virol 93:1495-505. 2012
    ..By site-directed mutagenesis, we confirmed both in clades B and CRF01_AE that the substitutions K168E and I215M have a major impact on PG9 and PG16 neutralization sensitivity of pseudotyped viruses...
  6. pmc Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate
    Kévin Baranger
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, Tours, France
    PLoS ONE 6:e20976. 2011
    ..We have thus added to the corpus of knowledge on the biology of these potential therapeutic inhibitors of airway proteases...
  7. doi request reprint Phage display as a powerful tool to engineer protease inhibitors
    Marie Louise Zani
    INSERM U618 Proteases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, University of Tours, 37000 Tours, France
    Biochimie 92:1689-704. 2010
    ....
  8. pmc Identification of neutralizing conformational epitopes on the human papillomavirus type 31 major capsid protein and functional implications
    Maxime J J Fleury
    INSERM U618, Universite Francois Rabelais, Tours, France
    Protein Sci 18:1425-38. 2009
    ....
  9. ncbi request reprint Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin
    Nicolas Guyot
    INSERM U618 Proteases et Vectorisation Pulmonaires, and IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, 10 boulevard Tonnelle, BP 3223, F 37032 Tours cedex, France
    Biol Chem 386:391-9. 2005
    ..Taken together, these findings indicate that tryptase could likely be involved in the maturation of trappin-2 into elafin under physiological conditions...
  10. ncbi request reprint Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
    Brice Korkmaz
    INSERM U618 Proteases et Vectorisation Pulmonaires, Universite Francois Rabelais, 10 boulevard Tonnelle, BP 3223, 37032 Tours Cedex, France
    Biochimie 90:227-42. 2008
    ..This review focuses on the structural and functional properties of these proteases that may explain their specific biological roles, and facilitate their use as molecular targets for new therapeutic strategies...
  11. pmc The V1V2 domain and an N-linked glycosylation site in the V3 loop of the HIV-1 envelope glycoprotein modulate neutralization sensitivity to the human broadly neutralizing antibody 2G12
    Antoine Chaillon
    Universite Francois Rabelais, INSERM U966, Tours, France
    J Virol 85:3642-8. 2011
    ..Our results, supported by a molecular-modeling study, suggest that both the V1V2 loop and an additional PNGS in V3 might limit access to the 2G12 epitope...
  12. ncbi request reprint Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3
    Shila M Nobar
    Laboratoire d Enzymologie, INSERM U392, Universite Louis Pasteur de Strasbourg, Illkirch, France
    FEBS J 272:5883-93. 2005
    ..We conclude that in vivo oxidation of elafin and trappin strongly impairs their activity. Inhibitor-based therapy of inflammatory lung diseases must be carried out using oxidation-resistant variants of these molecules...