Richard Moreau

Summary

Country: France

Publications

  1. ncbi request reprint Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trail
    Richard Moreau
    Service d Hépatologie and INSERM Unité 481, Hopital Beaujon, Clichy, France
    Liver Int 26:46-54. 2006
  2. ncbi request reprint Molecular and structural basis of portal hypertension
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy 92118, France
    Clin Liver Dis 10:445-57, vii. 2006
  3. pmc Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study
    R Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Gut 50:90-4. 2002
  4. ncbi request reprint Clinical characteristics and outcome of patients with cirrhosis and refractory ascites
    Richard Moreau
    Service d Hépatologie and INSERM U 481, 92118 Clichy, France
    Liver Int 24:457-64. 2004
  5. ncbi request reprint Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Paris, France
    Hepatology 36:1070-8. 2002
  6. ncbi request reprint The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 43:385-94. 2006
  7. ncbi request reprint Hepatorenal syndrome in patients with cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 17:739-47. 2002
  8. ncbi request reprint Diagnosis and treatment of acute renal failure in patients with cirrhosis
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, 92118 Clichy, France
    Best Pract Res Clin Gastroenterol 21:111-23. 2007
  9. ncbi request reprint Acute renal failure in patients with cirrhosis: perspectives in the age of MELD
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Hepatology 37:233-43. 2003
  10. doi request reprint Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: a cross-over study
    Thomas Sersté
    INSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3 Clichy, Paris, France
    J Hepatol 55:794-9. 2011

Detail Information

Publications81

  1. ncbi request reprint Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trail
    Richard Moreau
    Service d Hépatologie and INSERM Unité 481, Hopital Beaujon, Clichy, France
    Liver Int 26:46-54. 2006
    ..The question of which colloid (albumin or synthetic colloids) used for plasma expansion following paracentesis or other complications requiring fluid loading in patients with cirrhosis remains controversial...
  2. ncbi request reprint Molecular and structural basis of portal hypertension
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy 92118, France
    Clin Liver Dis 10:445-57, vii. 2006
    ....
  3. pmc Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study
    R Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Gut 50:90-4. 2002
    ....
  4. ncbi request reprint Clinical characteristics and outcome of patients with cirrhosis and refractory ascites
    Richard Moreau
    Service d Hépatologie and INSERM U 481, 92118 Clichy, France
    Liver Int 24:457-64. 2004
    ..In patients with cirrhosis, refractory ascites is associated with a poor prognosis and is an indication for liver transplantation. However, factors that determine prognosis remain unclear...
  5. ncbi request reprint Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Paris, France
    Hepatology 36:1070-8. 2002
    ..Terlipressin administration may be a novel approach for the treatment of arterial hypotension and hyporeactivity to alpha(1)-adrenergic constrictors in patients with cirrhosis and septic shock...
  6. ncbi request reprint The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 43:385-94. 2006
    ..Further studies are needed in all these fields...
  7. ncbi request reprint Hepatorenal syndrome in patients with cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 17:739-47. 2002
    ..In contrast, administration of the vasopressin analog terlipressin, a splanchnic and systemic vasoconstrictor, may improve renal function and be used while awaiting liver transplantation...
  8. ncbi request reprint Diagnosis and treatment of acute renal failure in patients with cirrhosis
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, 92118 Clichy, France
    Best Pract Res Clin Gastroenterol 21:111-23. 2007
    ..Studies are needed on the natural course and treatment (e.g., renal-replacement therapy) of acute tubular necrosis in patients with cirrhosis...
  9. ncbi request reprint Acute renal failure in patients with cirrhosis: perspectives in the age of MELD
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Hepatology 37:233-43. 2003
    ..Little is known about the natural course and treatment (i.e., renal replacement therapy) of cirrhosis-associated acute tubular necrosis...
  10. doi request reprint Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: a cross-over study
    Thomas Sersté
    INSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3 Clichy, Paris, France
    J Hepatol 55:794-9. 2011
    ..The aim of this study was to investigate the incidence of PICD before and after discontinuation of beta-blockers in patients with cirrhosis and refractory ascites. A self control cross-over study was performed...
  11. pmc Pretransplant fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae and infection after liver transplant, France
    Frederic Bert
    Hopital Beaujon, Clichy, France
    Emerg Infect Dis 18:908-16. 2012
    ..Transplant candidates should be systematically screened for carriage, and posttransplant infection in carriers should be treated with carbapenems...
  12. ncbi request reprint Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis
    Arnaud Galbois
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    Hepatology 49:175-84. 2009
    ..LPS-induced down-regulation of scavenger receptor, class B, type I (SR-BI) expression was abolished in cirrhotic monocytes...
  13. doi request reprint Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease score
    Claire Francoz
    Hepatology and Liver Intensive Care Unit, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3
    Liver Transpl 16:1169-77. 2010
    ..True GFR seems to have a better prognostic value than creatinine and creatinine-based equations. Specific equations are needed in patients with cirrhosis to improve prognostic scores...
  14. doi request reprint Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites
    Thomas Sersté
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    J Hepatol 57:274-80. 2012
    ..This study assessed the prognostic value of severe hyponatremia and the MELDNa score in these patients...
  15. doi request reprint Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
    Xavier Treton
    INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Paris, France
    Gastroenterology 141:1024-35. 2011
    ..Animal studies have shown that altered endoplasmic reticulum (ER) stress response initiates intestinal inflammation in epithelial tissues, but abnormalities associated with ER stress have not been identified in patients with UC...
  16. ncbi request reprint Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: role of Akt signaling
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM, Hopital Beaujon, Clichy, France
    Gastroenterology 129:303-14. 2005
    ..In this study, we investigated the signal transduction pathway of bacterial translocation-induced aortic NOS up-regulation in cirrhotic rats...
  17. ncbi request reprint In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C
    Tarik Asselah
    INSERM U773, Centre de Recherche CRB3, Paris, 75018, France
    J Pathol 221:264-74. 2010
    ..This lack of gene induction may be explained by the inhibiting action of HCV per se (as suggested by in vitro studies) and/or by our finding of the localized nature of hepatocyte ER stress...
  18. ncbi request reprint Glomerular filtration rate equations for liver-kidney transplantation in patients with cirrhosis: validation of current recommendations
    Claire Francoz
    Department of Hepatology, Liver Intensive Care Unit and Transplantation, Hospital Beaujon, Clichy, France INSERM U773, CRB3, University Denis Diderot Paris 7, Paris, France
    Hepatology 59:1514-21. 2014
    ..None of those who survived more than 1 year after LT alone (n = 8) developed renal dysfunction thereafter. In multivariate analysis, discordant patients were older (P = 0.03) and had lower sodium level (P = 0.02)...
  19. doi request reprint Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis
    Didier Lebrec
    INSERM, Unité 773, Centre de Recherche Biomédicle Bichat Beaujon CRB3, Paris, France and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Gastroenterology 138:1755-62. 2010
    ..We performed a randomized, placebo-controlled, double-blind trial of its effects in patients with cirrhosis...
  20. doi request reprint 10-Fold increase (2006-11) in the rate of healthy subjects with extended-spectrum β-lactamase-producing Escherichia coli faecal carriage in a Parisian check-up centre
    Marie Hélène Nicolas-Chanoine
    Hopital Beaujon, AP HP, Clichy, France
    J Antimicrob Chemother 68:562-8. 2013
    ..In 2006, 0.6% of healthy subjects living in the Paris area had extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in their gut. To assess the evolution of this rate, a study identical to that of 2006 was conducted in 2011...
  21. doi request reprint Lipopolysaccharide-induced mitochondrial DNA depletion
    Amal Choumar
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Paris, France
    Antioxid Redox Signal 15:2837-54. 2011
    ..In addition to the acute damage caused by reactive species, decreased levels of mitochondrial transcripts contribute to mitochondrial dysfunction...
  22. ncbi request reprint Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats
    Eugene Malyshev
    INSERM U773, Research Center Bichat Beaujon CRB3, Beaujon Hospital, Clichy, France
    J Gastroenterol Hepatol 22:2195-201. 2007
    ..The aim of this study was to evaluate the effects of modulating aortic and superior mesenteric arteries (SMA) iNOS on arterial eNOS activity and expression in rats with cirrhosis...
  23. doi request reprint Detection of bacterial DNA in serum and ascitic fluid of asymptomatic outpatients with cirrhosis and non-neutrocytic ascites
    Thomas Sersté
    Service d Hepatologie, Hôpital AP HP Beaujon, Clichy, France
    Liver Int 31:494-8. 2011
    ..The aim of this prospective study was to investigate the presence of bactDNA in AF and serum among cirrhotic outpatients with non-neutrocytic ascites...
  24. doi request reprint Possible mechanisms involved in the discrepancy of hepatic and aortic endothelial nitric oxide synthases during the development of cirrhosis in rats
    Morvarid Shir Mohammadi
    INSERM, U773, Centre de Recherche Biomédical Bichat Beaujon, Hopital Beaujon, Clichy, France
    Liver Int 29:692-700. 2009
    ..The aim of this study was to evaluate the regulation of eNOS and its major modulators in the liver and aorta during the development of cirrhosis in rats...
  25. doi request reprint Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis
    Sonia Gandoura
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Clichy and Paris, France
    J Hepatol 58:936-48. 2013
    ..Lipopolysaccharide (LPS)-expressing bacteria cause severe inflammation in cirrhotic patients. The global gene response to LPS is unknown in cirrhotic immune cells...
  26. doi request reprint Bleeding in patients with Budd-Chiari syndrome
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    J Hepatol 54:56-63. 2011
    ..This study aimed to assess the incidence, severity, and risk factors of major bleeding in patients with Budd-Chiari syndrome (BCS) receiving anticoagulation therapy...
  27. ncbi request reprint Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascites
    Thomas Sersté
    Institut National de la Santé et de la Recherche Médicale Unité 773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hepatology 52:1017-22. 2010
    ..0001]. The independent variables of mortality were Child-Pugh class C, hyponatremia and renal failure as causes of refractory ascites, and beta-blocker therapy...
  28. ncbi request reprint Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure
    Dominique Thabut
    AP HP Service d Hépato Gastroentérologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Hepatology 46:1872-82. 2007
    ..001). In multivariate analysis, only model for end-stage liver disease score and presence of SIRS, but not infection, remained associated with a poor outcome...
  29. doi request reprint Cirrhotic patients in the medical intensive care unit: early prognosis and long-term survival
    Vincent Das
    Service de Reanimation Medicale, Paris, France
    Crit Care Med 38:2108-16. 2010
    ..To reassess the prognosis of patients with cirrhosis admitted to the intensive care unit...
  30. pmc Genetic diversity and virulence profiles of Escherichia coli isolates causing spontaneous bacterial peritonitis and bacteremia in patients with cirrhosis
    Frederic Bert
    Service de Microbiologie, Hopital Beaujon, 100 Boulevard du General Leclerc, 92110 Clichy, France
    J Clin Microbiol 48:2709-14. 2010
    ..However, approximately half of the isolates belong to familiar clonal groups and exhibit extensive virulence profiles that may be associated with greater invasive potential...
  31. ncbi request reprint The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study
    Jean Marie Trawalé
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Liver Int 30:725-32. 2010
    ..This retrospective, one-point-in-time study aimed to report the results of the analysis of renal biopsy specimens obtained in patients with cirrhosis...
  32. ncbi request reprint Multifactorial aetiology of hepatic infarction: a case report with literature review
    Sven Francque
    Service d Hépatologie and INSERM U481, Hopital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 16:411-5. 2004
    ..Because hepatic infarction is usually explained by the concurrence of several factors impairing the hepatic blood supply, an extensive search for associated conditions is necessary even when a conspicuous cause is present...
  33. pmc Mitochondrial DNA maintenance is regulated in human hepatoma cells by glycogen synthase kinase 3β and p53 in response to tumor necrosis factor α
    Nathalie Vadrot
    INSERM U773, CRB3, Equipe Moreau, Universite Paris 7 Denis Diderot, Faculte de Medecine X Bichat, Paris, France
    PLoS ONE 7:e40879. 2012
    ..This study is the first to report the involvement of GSK3β in TNF-α induced mtDNA depletion. We suggest that p53 binding to GSK3β, TFAM and D-loop could induce recovery of mtDNA content through mtDNA repair...
  34. doi request reprint Model for end-stage liver disease exceptions in the context of the French model for end-stage liver disease score-based liver allocation system
    Claire Francoz
    Departments of Hepatology, Beaujon Hospital, Clichy, France
    Liver Transpl 17:1137-51. 2011
    ..MELD exceptions were discussed in an attempt to reconcile the concepts of transparency, equity, justice, and utility...
  35. ncbi request reprint Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Gastroenterology 122:1869-77. 2002
    ....
  36. ncbi request reprint High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats
    Dominique Thabut
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Paris 75018, France
    Hepatology 46:1893-906. 2007
    ..rHDL administration decreased hepatic TNFalpha, LBP, iNOS, and caveolin-1 expression, restored hepatic eNOS and Akt activity, and significantly lowered the portal pressure and intrahepatic vascular resistance...
  37. ncbi request reprint The impact of preoperative hepatic hydrothorax on the outcome of adult liver transplantation
    Thomas Sersté
    Hepatology and Liver Intensive Care, Hospital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 22:207-12. 2010
    ..Orthotopic liver transplantation (OLT) is the best option in case of end-stage liver disease. The impact of hepatic hydrothorax on pre-transplant and post-transplant courses has not been clearly investigated...
  38. doi request reprint Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis
    Nicolas Coant
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Paris and Clichy, France
    J Hepatol 55:784-93. 2011
    ..Thus, we investigated the role of GSK3 in LPS-induced cytokine production by peripheral blood mononuclear cells (PBMCs) or monocytes from patients with advanced cirrhosis and normal subjects...
  39. ncbi request reprint Relationship between protein kinase C alterations and nitric oxide overproduction in cirrhotic rat aortas
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Liver 22:178-83. 2002
    ..Therefore, the relationships between NOS and PKC activities were studied in cirrhotic rat aortas...
  40. ncbi request reprint Cyclic AMP-phosphodiesterases inhibitor improves sodium excretion in rats with cirrhosis and ascites
    Mina Ahloulay
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, 92118 Clichy, France
    Liver Int 25:403-9. 2005
    ..Cyclic AMP (cAMP) regulates sodium reabsorption in the proximal nephron. This study investigates the role of cAMP metabolism in renal dysfunction in cirrhosis...
  41. ncbi request reprint Evolution of hypoxemia in patients with severe cirrhosis
    Isabelle Colle
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 17:1106-9. 2002
    ..The aim of this study was to follow a series of patients with cirrhosis and to compare patients with and without hypoxemia to determine their risk of complications and survival rate...
  42. doi request reprint Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis
    Didier Lebrec
    Unité 773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, INSERM, Paris, France
    Eur J Clin Pharmacol 68:533-41. 2012
    ..To assess the effect of tezosentan, a parenteral dual ET receptor antagonist, on splanchnic and systemic hemodynamics in patients with cirrhosis. In addition, the safety, pharmacokinetics, and pharmacodynamics of tezosentan were evaluated...
  43. doi request reprint Central role of mitochondria in drug-induced liver injury
    Dominique Pessayre
    INSERM, U, Centre de Recherche Bichat Beaujon CRB, Faculte de Medecine Xavier Bichat, Paris, France
    Drug Metab Rev 44:34-87. 2012
    ..New drug molecules should be screened for possible mitochondrial effects...
  44. pmc In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae
    Suzanne Bialek-Davenet
    Service de Microbiologie, Hôpital AP HP Beaujon, Clichy, France
    Antimicrob Agents Chemother 55:2795-802. 2011
    ..This study shows that the ramR and soxR genes control the expression of efflux systems in K. pneumoniae and suggests the existence of efflux pumps other than AcrAB and of other loci involved in the regulation of AcrAB expression...
  45. ncbi request reprint Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome
    Anne Rabiller
    Laboratoire de Chirurgie Expérimentale UPRES, Centre Chirurgical Marie Lannelongue, Universite Paris Sud, 133 avenue de la Resistance, 92350 Le Plessis Robinson, Paris, France
    Am J Respir Crit Care Med 166:514-7. 2002
    ..Norfloxacin may reduce HPS severity by inhibiting Gram-negative bacterial translocation, thereby decreasing NO production by pulmonary intravascular macrophages. Bacterial translocation may be the key to the pathogenesis of HPS...
  46. doi request reprint Microbial epidemiology and outcome of bloodstream infections in liver transplant recipients: an analysis of 259 episodes
    Frederic Bert
    Department of Microbiology, APHP, Beaujon Hospital, Clichy, France
    Liver Transpl 16:393-401. 2010
    ..47). In conclusion, BSIs are frequent and early complications after liver transplantation and are mostly caused by gram-negative bacilli. A BSI in the first posttransplant month is a significant predictor of 1-year survival...
  47. doi request reprint Autophagy in liver diseases
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    J Hepatol 53:1123-34. 2010
    ..This decrease in autophagy contributes to the formation of Mallory-Denk bodies and to liver cell death. Hepatic autophagy is defective in the liver in obesity and its upregulation improves insulin sensitivity...
  48. ncbi request reprint Severe sepsis in cirrhosis
    Thierry Gustot
    INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Paris 75018, France
    Hepatology 50:2022-33. 2009
    ....
  49. pmc Changes in autophagic response in patients with chronic hepatitis C virus infection
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Am J Pathol 178:2708-15. 2011
    ..Neither genotype nor viral load influenced the autophagy level. In conclusion, autophagy is altered in hepatocytes from CHC patients, likely due to a blockade of the last step of the autophagic process...
  50. doi request reprint Noninvasive assessment of portal hypertension in patients with cirrhosis
    Dominique Thabut
    Institut National de la Santé et de la Recherche Médicale Unité 773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hepatology 53:683-94. 2011
    ..Although most of these noninvasive methods effectively identify severe portal hypertension, methods for diagnosing moderate portal hypertension need to be developed; this shows that further investigation is needed in this field...
  51. ncbi request reprint Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M
    Khalid A Tazi
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    J Hepatol 45:280-9. 2006
    ..Thus, we investigated ex vivo the signaling pathways of TNF-alpha production before and after LPS incubation in monocytes from noninfected Child-Pugh C patients with advanced cirrhosis and healthy subjects...
  52. doi request reprint Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Gastroenterology 135:840-8, 848.e1-3. 2008
    ..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
  53. ncbi request reprint Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective study
    Isabelle O Colle
    Service d Hépatologie and INSERM U481, Hopital Beaujon, Clichy, France
    Hepatology 37:401-9. 2003
    ..In addition, the absence of portopulmonary hypertension at evaluation does not exclude the occasional occurrence of acquired portopulmonary hypertension profile after listing...
  54. doi request reprint Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
    Richard Moreau
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Gastroenterology 144:1426-37, 1437.e1-9. 2013
    ..We aimed to identify diagnostic criteria of ACLF and describe the development of this syndrome in European patients with AD...
  55. doi request reprint Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis
    Pierre Emmanuel Rautou
    INSERM Unité 970, Paris Cardiovascular Research Center PARCC, Paris, France
    Gastroenterology 143:166-76.e6. 2012
    ..We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension...
  56. doi request reprint Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases
    Emilie Tissandié
    INSERM U699, Paris, France
    Kidney Int 80:1352-63. 2011
    ..Hence, common mechanisms appear to be shared by diseases of distinct origins, indicating that common environmental factors may influence the development of IgAN...
  57. ncbi request reprint The quest for new therapies in patients with cirrhosis and sepsis. Time to move from the lab to the bedside
    Jean Jacques Quioc
    INSERM, U 773, Centre de Recherche Biomédicale Bichat Beaujon CRB 3, Hopital Beaujon, Clichy
    Gastroenterol Clin Biol 30:819-22. 2006
  58. ncbi request reprint Protein array technology to investigate cytokine production by monocytes from patients with advanced alcoholic cirrhosis: An ex vivo pilot study
    Khalid A Tazi
    INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Paris, France
    Hepatol Res 39:706-15. 2009
    ..Conclusion: In patients with advanced cirrhosis, peripheral blood monocytes spontaneously produce proinflammatory cytokines, presumably in response to unrestricted TLR signaling...
  59. ncbi request reprint Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography
    Francois Durand
    Hepatology and Liver Intensive Care Unit, Hospital Beaujon, Clichy, France INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, France Electronic address
    J Hepatol 60:1151-7. 2014
    ..Waiting-list mortality in patients with cirrhosis and a relatively low MELD score is a matter of concern. The aim of this study was to determine whether a marker of muscle waste could improve prognostication...
  60. ncbi request reprint Diagnostic accuracy of the Multistix 8 SG reagent strip in diagnosis of spontaneous bacterial peritonitis
    Jean Baptiste Nousbaum
    Services d Hépato Gastroentérologie de, Brest, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    Hepatology 45:1275-81. 2007
    ..04). Using a threshold of 2+ for positivity of the reagent strip, sensitivity was 45.3% for the diagnosis of SBP, specificity was 99.2%, positive predictive value was 77.9%, and negative predictive value was 96.9%...
  61. ncbi request reprint Pulmonary hemodynamics and gas exchange after liver transplantation in patients with cirrhosis
    Emmanuel Rassiat
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Dig Dis Sci 47:746-9. 2002
    ..Moreover, it has no major effect on gas exchange in patients with cirrhosis without hypoxemia...
  62. ncbi request reprint Levels and initial course of serum alanine aminotransferase can predict outcome of patients with Budd-Chiari syndrome
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Clin Gastroenterol Hepatol 7:1230-5. 2009
    ..An increased level of serum alanine aminotransferase (ALT) is an objective marker for acute liver injury. We analyzed the significance of changes in ALT levels in Budd-Chiari syndrome patients...
  63. ncbi request reprint Coagulation disorders in patients with cirrhosis and severe sepsis
    Aurelie Plessier
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, et Service d Hepatologie, Hopital Beaujon, Clichy, France
    Liver Int 23:440-8. 2003
    ..In patients with cirrhosis, severe sepsis may stimulate the extrinsic coagulation pathway resulting in thrombin generation and fibrin formation...
  64. ncbi request reprint Portal cavernoma-associated cholangiopathy: a clinical and MR cholangiography coupled with MR portography imaging study
    Bertrand Condat
    Service d Hepatologie, Fédération Médico chirurgicale d Hépatogastroentérologie, Hopital Beaujon, AP HP, Paris, France
    Hepatology 37:1302-8. 2003
    ..MR cholangiography coupled with MR portography is an effective noninvasive examination for simultaneous visualization of bile ducts and their relationship to the cavernoma...
  65. ncbi request reprint Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter study
    Richard Moreau
    INSERM U 481 et Service d Hépatologie, Hopital Beaujon, Clichy, France
    Gastroenterology 122:923-30. 2002
    ..Although the administration of terlipressin improves renal function, its effect on survival is unknown. This study investigated predictive factors of survival in patients with type 1 HRS treated with terlipressin...
  66. ncbi request reprint A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis
    Pierre Nahon
    Service d Hepatologie, Hopital Jean Verdier, AP HP, Bondy, France
    J Hepatol 56:426-32. 2012
    ..We assessed the role of the G(-463)A-MPO, T(-262)C-CAT, Ala16Val-SOD2, and Pro198Leu-GPx1 variants in modulating HCC development in patients with HCV-induced cirrhosis...
  67. doi request reprint MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice
    Abdellah Mansouri
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, Paris, France
    Dig Dis 28:756-75. 2010
    ..In the model of prolonged ethanol consumption, the protective effects of DFO suggested the role of iron reacting with hydrogen peroxide to form mtDNA-damaging hydroxyl radical...
  68. doi request reprint Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors
    Richard Moreau
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Service d Hepatologie, Hopital Beaujon, Clichy, France
    Nephron Physiol 109:p73-9. 2008
    ..Vasopressor therapy with terlipressin plus intravenous albumin is the medical treatment of choice for type 1 HRS...
  69. ncbi request reprint Lack of prognostic usefulness of hepatic venous pressures and hemodynamic values in a select group of patients with severe alcoholic cirrhosis
    Pierre Deltenre
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Am J Gastroenterol 97:1187-90. 2002
    ..Prognostic assessment of patients with alcoholic cirrhosis is still controversial. A prospective study was performed to evaluate hemodynamic values as prognostic factors of death in a group of patients with severe alcoholic cirrhosis...
  70. ncbi request reprint The evaluation of renal function and disease in patients with cirrhosis
    Claire Francoz
    Hepatology and Liver Intensive Care Unit, Hospital Beaujon, Clichy, France
    J Hepatol 52:605-13. 2010
    ..In candidates for transplantation, attention should therefore be focused on vascular lesions which may represent a risk factor for nephrotoxicities induced by calcineurin-inhibitors...
  71. ncbi request reprint [Implication of nitrogen oxide producing enzymes in the pathophysiology of fulminant hepatitis]
    Richard Moreau
    INSERM U 481, Hopital Beaujon, Clichy, France
    Gastroenterol Clin Biol 26:1182-4. 2002
  72. ncbi request reprint Hyponatremia in cirrhosis. Pathophysiology, prevalence, prognostic value, treatment
    Richard Moreau
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Acta Gastroenterol Belg 71:379-85; discussion 386. 2008
    ..Pharmacological treatments of hypervolemic hyponatremia using drugs that antagonize the binding of AVP to V2 receptors are under evaluation in patients with cirrhosis...
  73. pmc NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon
    Nicolas Coant
    INSERM, U773, Centre de Recherche Bichat Beaujon, CRB3, BP 416, 16 rue Henri Huchard, Paris 75018, France
    Mol Cell Biol 30:2636-50. 2010
    ..This finding provides the molecular basis for the role of NOX1 in cell proliferation and postmitotic differentiation...
  74. ncbi request reprint The growing evidence that renal function should be improved in patients with cirrhosis and hepatorenal syndrome before liver transplantation
    Richard Moreau
    J Hepatol 40:159-61. 2004
  75. ncbi request reprint Clinical course, predictive factors and prognosis in patients with cirrhosis and type 1 hepatorenal syndrome treated with Terlipressin: a retrospective analysis
    Isabelle Colle
    Laboratoire d Hémodynamique Splanchmique et de Biologie Vasculaire, Institut National de la Santé et de la Recherge Médicale, Clinchy, France
    J Gastroenterol Hepatol 17:882-8. 2002
    ..The aim of the present retrospective study was to investigate the predictive factors and prognosis of patients with type 1 HRS treated with terlipressin...
  76. ncbi request reprint [Are the diagnosis and measurement of portal hypertension of interest?]
    Didier Lebrec
    Gastroenterol Clin Biol 29:967-8. 2005
  77. ncbi request reprint VEGF-induced angiogenesis drives collateral circulation in portal hypertension
    Richard Moreau
    J Hepatol 43:6-8. 2005
  78. ncbi request reprint Are nitric oxide synthases new players in the pathophysiology of fulminant hepatic failure?
    Richard Moreau
    J Hepatol 37:678-80. 2002
  79. ncbi request reprint In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats
    Khalid A Tazi
    INSERM U773, Centre de Recherche Bichat Beaujon CRB3, Paris 75018, France
    J Hepatol 46:1075-88. 2007
    ..We hypothesized that an altered UPR in the liver may sensitize cirrhotic livers to LPS-induced, TNFalpha-mediated apoptosis. Thus, we examined in vivo UPR and NF-kappaB activity in livers from cirrhotic and normal LPS-challenged rats...
  80. ncbi request reprint The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club
    Kevin P Moore
    Centre for Hepatology, Royal Free and University College Medical School, UCL, London, United Kingdom
    Hepatology 38:258-66. 2003
    ..Liver transplantation should be considered for all ascitic patients, and this should preferably be performed prior to the development of renal dysfunction to prevent further compromise of their prognosis...
  81. doi request reprint Viridans group streptococci causing spontaneous bacterial peritonitis and bacteremia in patients with end-stage liver disease
    Frederic Bert
    Liver Transpl 14:710-1; author reply 712. 2008