Pierre Emmanuel Morange

Summary

Country: France

Publications

  1. pmc Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis
    Marine Germain
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 7:e38538. 2012
  2. doi request reprint Current knowledge on the genetics of incident venous thrombosis
    P E Morange
    INSERM, UMR_S1062, Nutrition Obesity and Risk of Thrombosis, Aix Marseille University, Marseille, France
    J Thromb Haemost 11:111-21. 2013
  3. doi request reprint KNG1 Ile581Thr and susceptibility to venous thrombosis
    Pierre Emmanuel Morange
    INSERM UMR_S 626, Laboratory of Haematology, CHU Timone, 246 rue Saint Pierre, Marseille Cedex 05, France
    Blood 117:3692-4. 2011
  4. doi request reprint Lessons from genome-wide association studies in venous thrombosis
    P E Morange
    INSERM, UMR_S 626, Marseille, France
    J Thromb Haemost 9:258-64. 2011
  5. pmc A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1
    Pierre Emmanuel Morange
    INSERM, UMR_S 626, Universite de la Mediterranee, Marseille, F 13385 France
    Am J Hum Genet 86:592-5. 2010
  6. doi request reprint Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs)
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 6:854-63. 2013
  7. ncbi request reprint Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Res 120:893-9. 2007
  8. ncbi request reprint Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Haemost 97:212-7. 2007
  9. doi request reprint Effect of CYP2C19*2 and *17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications
    Charlotte Grosdidier
    INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    Am J Cardiol 111:985-90. 2013
  10. ncbi request reprint High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Boulevard Saint Pierre, Marseille, Bouches du rhone, 13005 France
    Thromb Haemost 97:282-7. 2007

Collaborators

Detail Information

Publications49

  1. pmc Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis
    Marine Germain
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 7:e38538. 2012
    ..This variant was in fact the rs1799963, also known as the FII G20210A prothrombin mutation. This work may be of major interest not only for its scientific impact but also for its methodological findings...
  2. doi request reprint Current knowledge on the genetics of incident venous thrombosis
    P E Morange
    INSERM, UMR_S1062, Nutrition Obesity and Risk of Thrombosis, Aix Marseille University, Marseille, France
    J Thromb Haemost 11:111-21. 2013
    ....
  3. doi request reprint KNG1 Ile581Thr and susceptibility to venous thrombosis
    Pierre Emmanuel Morange
    INSERM UMR_S 626, Laboratory of Haematology, CHU Timone, 246 rue Saint Pierre, Marseille Cedex 05, France
    Blood 117:3692-4. 2011
    ..171, 95% confidence interval 0.889-1.541, P = .059). We also confirmed that the rs710446-C allele was associated with decreased aPTT levels, making this nonsynonymous Ile581Thr variant a new genetic risk factor for VT...
  4. doi request reprint Lessons from genome-wide association studies in venous thrombosis
    P E Morange
    INSERM, UMR_S 626, Marseille, France
    J Thromb Haemost 9:258-64. 2011
    ..While the GWAS revolution has just started to shift towards the next generation sequencing's burst, it is important to illustrate how the genetics research in venous thrombosis has benefit from the GWAS paradigm...
  5. pmc A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1
    Pierre Emmanuel Morange
    INSERM, UMR_S 626, Universite de la Mediterranee, Marseille, F 13385 France
    Am J Hum Genet 86:592-5. 2010
    ..The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway...
  6. doi request reprint Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs)
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 6:854-63. 2013
    ..We also aimed to identify predictors of bleeding and VLTPR in patients treated with thienopyridines...
  7. ncbi request reprint Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Res 120:893-9. 2007
    ..Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunteers, suggesting a possible mechanism for modulation of clopidogrel response...
  8. ncbi request reprint Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Haemost 97:212-7. 2007
    ..104). In conclusion, our study did not show any influence of 807 C/T polymorphism of GpIa gene on post-treatment platelet reactivity assessed by ADP-Ag, PRI VASP or P-selectin expression in 601 NSTE ACS patients...
  9. doi request reprint Effect of CYP2C19*2 and *17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications
    Charlotte Grosdidier
    INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    Am J Cardiol 111:985-90. 2013
    ..In addition, LTPR was associated with a greater risk of bleeding...
  10. ncbi request reprint High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Boulevard Saint Pierre, Marseille, Bouches du rhone, 13005 France
    Thromb Haemost 97:282-7. 2007
    ..24%, p=0.014). After being correlated with recurrent ischemic events after stenting for NSTE-ACS, the HPPR seems to be also a marker of increased risk of periprocedural MI for NSTE-ACS patients...
  11. doi request reprint Clopidogrel response: head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Arch Cardiovasc Dis 103:39-45. 2010
    ..We investigated the agreement between different platelet tests to identify clopidogrel non response...
  12. doi request reprint Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome
    Corinne Frere
    INSERM U626, Marseille, France
    Am J Cardiol 101:1088-93. 2008
    ..03). In conclusion, the present data suggest that the CYPC19*2 allele influences post-treatment platelet reactivity and clopidogrel response in patients with non-ST elevation acute coronary syndromes...
  13. doi request reprint Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, 13385 France
    Thromb Res 123:597-603. 2009
    ..We have prospectively investigated the association between aspirin and clopidogrel responses and the clinical predictors of non response...
  14. ncbi request reprint Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    J Am Coll Cardiol 48:1339-45. 2006
    ..We analyzed the benefit of a 600-mg clopidogrel loading dose on platelet reactivity and clinical outcomes after stenting for non-ST-segment elevation acute coronary syndrome (NSTE ACS)...
  15. doi request reprint Comparison of platelet reactivity and clopidogrel response in patients ≤ 75 Years Versus > 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am J Cardiol 108:1411-6. 2011
    ..They display greater post-treatment platelet reactivity. However, this greater platelet reactivity does not seem to be related to an impaired specific response to clopidogrel...
  16. doi request reprint Predictive values of post-treatment adenosine diphosphate-induced aggregation and vasodilator-stimulated phosphoprotein index for stent thrombosis after acute coronary syndrome in clopidogrel-treated patients
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Am J Cardiol 104:1078-82. 2009
    ....
  17. doi request reprint Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 1:649-53. 2008
    ....
  18. doi request reprint Comparison between initial and chronic response to clopidogrel therapy after coronary stenting for acute coronary syndrome and influence on clinical outcomes
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am Heart J 164:327-33. 2012
    ..Studies have addressed the benefit of tailored therapy based on initial response to clopidogrel loading dose. However, the appropriate timing for platelet testing remains uncertain...
  19. doi request reprint Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am J Cardiol 108:760-5. 2011
    ..The benefit of this tailored therapy was significantly reduced in CYP2C19*2 carriers. Therefore, these patients might require alternative strategies with new P2Y₁₂ blockers...
  20. pmc A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis
    Nicolas Greliche
    INSERM, UMR_S 937 Institute of Cardiometabolism And Nutrition ICAN, Universite Pierre et Marie Curie Paris 6, Paris F 75013, France
    BMC Med Genet 14:36. 2013
    ..This study was aimed to investigate whether pair-wise interactions between common single nucleotide polymorphisms (SNPs) could exist and modulate the risk of VT...
  21. doi request reprint Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting
    Mathieu Pankert
    Departement de Cardiologie, Centre Hospitalo Universitaire Timone, Marseille, France Aix Marseille Univ, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1062, Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1260, Nutrition, Obesity and Risk of Thrombosis, Faculty of Medicine, Marseille, France
    Am J Cardiol 113:54-9. 2014
    ..However, among obese patients, the presence of the MS strongly affects response to antiplatelet agents, indicating that the metabolic status might be a better predictor of platelet inhibition than BMI...
  22. ncbi request reprint Platelet reactivity in diabetic patients undergoing coronary stenting for acute coronary syndrome treated with clopidogrel loading dose followed by prasugrel maintenance therapy
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, F 13385 France
    Int J Cardiol 168:523-8. 2013
    ..The present study was designed to assess response to thienopyridine in diabetic patients undergoing PCI for ACS...
  23. doi request reprint CYP2C19*2 and *17 alleles have a significant impact on platelet response and bleeding risk in patients treated with prasugrel after acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 5:1280-7. 2012
    ..The present study was designed to assess the effect of genetic variants on chronic biological response to prasugrel and bleeding complications...
  24. doi request reprint Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, 13385 France
    Thromb Res 124:33-6. 2009
    ..Increased doses of antiplatelet therapy have been proposed to overcome the variability of response. However, the chronic dose of aspirin after DES remains controversial...
  25. pmc Genetics of venous thrombosis: insights from a new genome wide association study
    Marine Germain
    INSERM UMR_S 937 ICAN Institute, Universite Pierre et Marie Curie, Paris 6, Paris, France
    PLoS ONE 6:e25581. 2011
    ..Genetics factors are known to contribute to the susceptibility of the disease but how many genes are involved and their contribution to VT risk still remain obscure. We aimed to identify genetic variants associated with VT risk...
  26. ncbi request reprint Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    EuroIntervention 5:325-9. 2009
    ..We assessed prospectively the association between occurrence of post-discharge non-CABG-related TIMI major and minor bleeding and post-treatment platelet reactivity in patients with non-ST elevation acute coronary syndrome (NSTE ACS)...
  27. doi request reprint Aspirin noncompliance is the major cause of "aspirin resistance" in patients undergoing coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Am Heart J 157:889-93. 2009
    ..We investigated the hypothesis that biological aspirin "resistance" may often be related to noncompliance in patients undergoing coronary stenting...
  28. doi request reprint Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    J Am Coll Cardiol 54:1149-53. 2009
    ..This study sought to compare the effect of 2 proton pump inhibitors (PPIs) on platelet response to clopidogrel after coronary stenting for non-ST-segment elevation acute coronary syndrome (NSTE ACS)...
  29. doi request reprint Prasugrel monitoring and bleeding in real world patients
    Guillaume Cayla
    Institut de Cardiologie, INSERM UMRS937, Pitie Salpetriere Hospital, Universite Paris 6, Paris, France
    Am J Cardiol 111:38-44. 2013
    ..Minor or minimal bleeding is frequent, but not major bleeding. VASP was poorly correlated with the risk for minor or minimal bleeding...
  30. doi request reprint Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
    David Alexandre Tregouet
    INSERM, Unite Mixte de Recherche S, Paris, France
    Blood 113:5298-303. 2009
    ..However, using this large cohort of subjects, we were able to replicate the mild effects of 2 nonsynonymous SNPs, rs1613662 in GP6 and rs13146272 in CYP4V2, recently suspected to be associated with VTE...
  31. ncbi request reprint Fine mapping of quantitative trait nucleotides underlying thrombin-activatable fibrinolysis inhibitor antigen levels by a transethnic study
    Corinne Frere
    Institut National de la Sante et de la Recherche Medicale INSERM, Unite Mixté de Recherche UMR 626, Marseille, F 13385 France
    Blood 108:1562-8. 2006
    ..Although this transethnic comparison contributed to better map the putative CPB2 QTNs, further studies are required to clarify the role of the promoter region...
  32. doi request reprint Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project
    Tiphaine Oudot-Mellakh
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris 6, F 75013, Paris, France
    Br J Haematol 157:230-9. 2012
    ..We identified three independent loci associated with ACV (F2, F5 and PROCR) and replicated two independent effects on plasma PC levels at the PROCR locus...
  33. doi request reprint Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus. Results from the D.E.S.I.R. prospective cohort
    Marie Christine Alessi
    U626, INSERM, Marseille, France
    Thromb Haemost 106:416-22. 2011
    ..0009). In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels...
  34. doi request reprint ABO blood group and von Willebrand factor levels partially explained the incomplete penetrance of congenital thrombophilia
    William Cohen
    Inserm UMR 1062, Aix Marseille University, Marseille, France
    Arterioscler Thromb Vasc Biol 32:2021-8. 2012
    ..We aimed to study the association among ABO blood group, von Willebrand factor, factor VIII plasma levels, and the risk of venous thrombosis (VT) in a cohort of 1774 relatives from 500 families with inherited thrombophilia...
  35. doi request reprint High prevalence of laminopathies among patients with metabolic syndrome
    Anne Dutour
    INSERM UMR_S626, Universite de la Mediterranee, Marseille, France
    Hum Mol Genet 20:3779-86. 2011
    ....
  36. doi request reprint Recent advances in the pharmacogenetics of clopidogrel
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Hum Genet 131:653-64. 2012
    ..The purpose of this review is to discuss the contribution of individual genetic differences responsible for variations of action and clopidogrel efficacy...
  37. pmc Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
    Guillemette Antoni
    UMR_S 937, INSERM, Boulevard de l Hopital, Paris, France
    BMC Med Genet 12:102. 2011
    ..The aim of this work was to identify novel single nucleotide polymorphisms (SNPs) that could influence the variability of these traits...
  38. doi request reprint A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential
    Ares Rocañín-Arjó
    Pierre and Marie Curie University, INSERM, UMR_S 1166, Paris, France
    Blood 123:777-85. 2014
    ..These results pave the way for novel mechanistic pathways and therapeutic perspectives in the etiology of thrombin-related disorders. ..
  39. doi request reprint Multiple biomarkers for the prediction of ischemic stroke: the PRIME study
    Christof Prugger
    Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, UMR S970, Paris, France
    Arterioscler Thromb Vasc Biol 33:659-66. 2013
    ..To simultaneously evaluate 14 biomarkers from distinct biological pathways for risk prediction of ischemic stroke, including biomarkers of hemostasis, inflammation, and endothelial activation as well as chemokines and adipocytokines...
  40. ncbi request reprint Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact
    Corinne Frere
    INSERM UMR 626, Faculte de Medecine, Marseille, France
    Thromb Haemost 94:373-9. 2005
    ..This effect seems to be the consequence of the joint independent action of two polymorphisms, one in the 5' (G-1102T) and the other in the 3' region (T+1583A) of the TAFI gene...
  41. doi request reprint Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study
    Florence Canoui-Poitrine
    INSERM, U970, Paris Cardiovascular Research Centre PAARC, Universite Paris V, Paris, France
    Eur J Cardiovasc Prev Rehabil 16:550-5. 2009
    ..To test whether conventional risk factors and antihypertensive treatment were more predictive of stable angina (SA) than acute coronary syndrome (ACS) as the first presentation of coronary heart disease (CHD)...
  42. doi request reprint Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study
    Bénédicte Fontaine-Bisson
    INSERM, UMR_S 937, 75013, Paris, France
    J Mol Med (Berl) 88:193-201. 2010
    ..No robust interaction between SNPs located in different genes on the risk of MS was identified. In conclusion, we did not observe any convincing evidence that common polymorphisms of the lamina pathway could modulate the risk of MS...
  43. doi request reprint Diet modulates endogenous thrombin generation, a biological estimate of thrombosis risk, independently of the metabolic status
    Caroline Sanchez
    INSERM, UMR1062, Nutrition, Obesity, and Risk of Thrombosis, Marseille, France
    Arterioscler Thromb Vasc Biol 32:2394-404. 2012
    ..High endogenous thrombin potential (ETP) is associated with venous and arterial thrombosis. Better knowledge of environmental influences on ETP may help to prevent thrombosis...
  44. pmc miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells
    Alexandre Marchand
    UMR_S 956, INSERM, Paris, France
    PLoS ONE 7:e44532. 2012
    ..Our results strongly suggest that the regulation of PAI-1 molecule could be under the influence of several miRNAs whose measurement in the plasma of patients could be envisaged as a biomarker for inflammatory and thrombotic disorders...
  45. pmc Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study
    Choumous Kallel
    INSERM UMR, Aix Marseille Universite, France
    BMC Med Genet 13:103. 2012
    ..Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE)...
  46. ncbi request reprint ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome
    Corinne Frere
    INSERM, UMR 626, Faculté de Médecine CHU Timone, Marseille, France
    Thromb Haemost 98:838-43. 2007
    ..In patients with NSTE ACS undergoing PCI, ADP-Ag and PRI VASP identify low responders to clopidogrel with an increased risk of recurrent ischemic events with respective cut-off values of 70% and 53%...
  47. doi request reprint Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?
    Pierre Emmanuel Morange
    INSERM UMR S626, Faculty of Medicine, University of the Mediterranean, Marseille, France
    Br J Haematol 148:495-506. 2010
    ..This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci...
  48. ncbi request reprint Contribution of anti-β2glycoprotein I IgA antibodies to the diagnosis of anti-phospholipid syndrome: potential interest of target domains to discriminate thrombotic and non-thrombotic patients
    Laura Despierres
    Laboratoire d Immunologie, Service de Medecine Interne, Hopital de la Conception, Service de Medecine Interne, Hopital Nord, Service de Medecine Interne, Laboratoire d Hematologie, Hopital de la Timone, Laboratoire d Adhésion et d Inflammation, Universite Aix Marseille, Service de Gynecologie Obstetrique, Hôpital Nord and Laboratoire d Immunologie, UFR Pharmacie, Universite Aix Marseille, UMRS1076, Marseille, France
    Rheumatology (Oxford) 53:1215-8. 2014
    ..We evaluated the clinical utility of IgA aPL and of the determination of target domains of aβ2GPI IgA antibodies...
  49. doi request reprint Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology
    Pierre Emmanuel Morange
    Marie Christine Alessi, Laboratoire d Hematologie, Inserm UMR 1062, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, Marseille, F 13385 France, Tel 33 4 91 32 45 06, Fax 33 4 91 25 43 36, E mail
    Thromb Haemost 110:669-80. 2013
    ..In support of these data, central obesity independently predisposes not only to atherothrombosis but also to venous thrombosis. ..