N Moore

Summary

Country: France

Publications

  1. ncbi request reprint Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice
    Karine Titier
    Department of Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen, Bordeaux, France
    Toxicol Appl Pharmacol 199:52-60. 2004
  2. ncbi request reprint [Antidepressant adverse effects in the elderly: analysis of spontaneous reports in France]
    Mathilde Daurel-Receveur
    Centre de Pharmacovigilance, Departement de Pharmacologie, Universite Victor Segalen, CHU, Bordeaux, France
    Therapie 60:61-5. 2005
  3. ncbi request reprint Less use of NSAIDs in long-term than in recent chondroitin sulphate users in osteoarthritis: a pharmacy-based observational study in France
    Rajaa Lagnaoui
    Universite Victor Segalen, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Therapie 61:341-6. 2006
  4. ncbi request reprint Diclofenac potassium 12.5mg tablets for mild to moderate pain and fever: a review of its pharmacology, clinical efficacy and safety
    Nicholas Moore
    Department of Pharmacology, Universite Victor Segalen, Bordeaux, France
    Clin Drug Investig 27:163-95. 2007
  5. doi request reprint Prevalence of cholinesterase inhibitors in subjects with dementia in Europe
    Antoine Pariente
    INSERM, U657, F33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 17:655-60. 2008
  6. pmc Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database
    P Blin
    Department of Pharmacology, Bat du Tondu, Case 40, Universite de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetologia 55:644-53. 2012
  7. doi request reprint Cardiovascular risks associated with low-dose ibuprofen and diclofenac as used OTC
    Nicholas Moore
    Université Bordeaux Segalen, Department of Pharmacology, 146 rue Leo Saignat, 33076 Bordeaux, France 33 0 557571560 33 0 557574671
    Expert Opin Drug Saf 13:167-79. 2014
  8. pmc Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study
    Sinem Ezgi Gulmez
    INSERM CIC P0005 Pharmaco épidémiologie, INSERM U657, Service de Pharmacologie, Université Bordeaux Segalen, Bâtiment Le Tondu, Case 41, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Drug Saf 36:135-44. 2013
  9. pmc Immunomodulatory and antitumour effects of abnormal Savda Munziq on S180 tumour-bearing mice
    Ainiwaer Aikemu
    Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, Xinjiang, People s Republic of China
    BMC Complement Altern Med 12:157. 2012
  10. doi request reprint The past, present and perhaps future of pharmacovigilance: homage to Folke Sjoqvist
    Nicholas Moore
    Department of Pharmacology, INSERM U657, CIC P0005, University of Bordeaux, Bordeaux, France
    Eur J Clin Pharmacol 69:33-41. 2013

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice
    Karine Titier
    Department of Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen, Bordeaux, France
    Toxicol Appl Pharmacol 199:52-60. 2004
    ..These results underscore the importance of interpreting HERG channel data and electrophysiological data in the context of other pharmacokinetic parameters such as myocardium to plasma distribution...
  2. ncbi request reprint [Antidepressant adverse effects in the elderly: analysis of spontaneous reports in France]
    Mathilde Daurel-Receveur
    Centre de Pharmacovigilance, Departement de Pharmacologie, Universite Victor Segalen, CHU, Bordeaux, France
    Therapie 60:61-5. 2005
    ..However, the consequences of adverse effects such as hyponatraemia are far from negligible in the elderly...
  3. ncbi request reprint Less use of NSAIDs in long-term than in recent chondroitin sulphate users in osteoarthritis: a pharmacy-based observational study in France
    Rajaa Lagnaoui
    Universite Victor Segalen, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Therapie 61:341-6. 2006
    ..Compared to recent users, long-term users of CS400 had a significantly lower current (44.4 versus 52.5%, p < 0.05) and long-term use of NSAIDs (11.8% versus 18.5%, p < 0.05), and of analgesics (70.3 versus 79.3%, p < 0.01)...
  4. ncbi request reprint Diclofenac potassium 12.5mg tablets for mild to moderate pain and fever: a review of its pharmacology, clinical efficacy and safety
    Nicholas Moore
    Department of Pharmacology, Universite Victor Segalen, Bordeaux, France
    Clin Drug Investig 27:163-95. 2007
    ..Patients are generally capable of taking diclofenac potassium appropriately. A maximum OTC treatment duration of 5 days for pain and 3 days for fever is recommended...
  5. doi request reprint Prevalence of cholinesterase inhibitors in subjects with dementia in Europe
    Antoine Pariente
    INSERM, U657, F33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 17:655-60. 2008
    ..To evaluate the prevalence of cholinesterase inhibitor (ChI) treatment in subjects with dementia in European countries...
  6. pmc Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database
    P Blin
    Department of Pharmacology, Bat du Tondu, Case 40, Universite de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetologia 55:644-53. 2012
    ..The investigation period was from 1 January 2003 to 30 June 2010...
  7. doi request reprint Cardiovascular risks associated with low-dose ibuprofen and diclofenac as used OTC
    Nicholas Moore
    Université Bordeaux Segalen, Department of Pharmacology, 146 rue Leo Saignat, 33076 Bordeaux, France 33 0 557571560 33 0 557574671
    Expert Opin Drug Saf 13:167-79. 2014
    ..As over-the-counter (OTC) NSAIDs are widely used for the treatment of common painful disorders, without medical supervision, their cardiovascular risks need to be assessed...
  8. pmc Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study
    Sinem Ezgi Gulmez
    INSERM CIC P0005 Pharmaco épidémiologie, INSERM U657, Service de Pharmacologie, Université Bordeaux Segalen, Bâtiment Le Tondu, Case 41, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Drug Saf 36:135-44. 2013
    ..Most NSAIDs are thought to be able to cause hepatic injury and acute liver failure (ALF), but the event rates of those leading to transplantation (ALFT) remain uncertain...
  9. pmc Immunomodulatory and antitumour effects of abnormal Savda Munziq on S180 tumour-bearing mice
    Ainiwaer Aikemu
    Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, Xinjiang, People s Republic of China
    BMC Complement Altern Med 12:157. 2012
    ..Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. This study attempts to confirm these effects in vivo and measure effects on the immune system...
  10. doi request reprint The past, present and perhaps future of pharmacovigilance: homage to Folke Sjoqvist
    Nicholas Moore
    Department of Pharmacology, INSERM U657, CIC P0005, University of Bordeaux, Bordeaux, France
    Eur J Clin Pharmacol 69:33-41. 2013
    ....
  11. doi request reprint A review of the pharmacokinetic profile of transmucosal fentanyl formulations
    Nicholas Moore
    Department of Pharmacology, Bordeaux 2 University, 33076 Bordeaux, France
    Curr Med Res Opin 28:1781-90. 2012
    ....
  12. pmc Physicochemical characteristics and bronchial epithelial cell cytotoxicity of Folpan 80 WG(R) and Myco 500(R), two commercial forms of folpet
    Mireille Canal-Raffin
    Laboratoire Santé Travail Environnement EA 3672, Universite Bordeaux 2, Bordeaux, France
    Part Fibre Toxicol 4:8. 2007
    ..abstract:..
  13. pmc The self-reported Montgomery-Asberg Depression Rating Scale is a useful evaluative tool in Major Depressive Disorder
    Bruno Fantino
    ADIM AGORAS, Lyon, France
    BMC Psychiatry 9:26. 2009
    ..The objective of this study was to assess the psychometric properties of the 9-item, patient-administered version of the Montgomery-Asberg Depression Rating Scale (MADRS-S)...
  14. pmc Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial
    Alain Jacquet
    Department of Pharmacology, University of Bordeaux, 146 rue Leo Saignat, 33076, Bordeaux, France
    Arthritis Res Ther 11:R192. 2009
    ..This study tested the effects of a food supplement, Phytalgic, on pain and function in patients with osteoarthritis and their use of analgesic and NSAIDs...
  15. pmc Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case-control study
    Yola Moride
    Faculty of Pharmacy, Universite de Montreal, Montreal, Canada
    Arthritis Res Ther 7:R333-42. 2005
    ..At the time of introduction of COX-2 inhibitors into the formulary, prescription channeling could confound risk comparisons across products...
  16. ncbi request reprint A simple method to estimate sample sizes for safety equivalence studies using inverse sampling
    Nicholas Moore
    Department de Pharmacologie, Universite Victor Segalen, Case 36, 33076, Bordeaux, Cedex, France
    J Clin Epidemiol 56:433-5. 2003
    ..The number of patients to be included can be derived directly from expected event rates...
  17. ncbi request reprint Integrity of scientific data: transparency of clinical trial data
    Nicholas Moore
    Departement de Pharmacologie, Universite de Bordeaux, Bordeaux, France
    Therapie 62:203-9, 211-6. 2007
    ..Various statistical methods can be used to identify unusual data patterns that could suggest fraud. Once fraud is identified, its management is often not foreseen. Here again, clear procedures or recommendations would be of help...
  18. ncbi request reprint Risk factors for adverse events in analgesic drug users: results from the PAIN study
    Nicholas Moore
    Department of Pharmacology, Universite Victor Segalen, 33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 12:601-10. 2003
    ....
  19. ncbi request reprint Biases affecting the proportional reporting ratio (PPR) in spontaneous reports pharmacovigilance databases: the example of sertindole
    Nicholas Moore
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, BP36, 33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 12:271-81. 2003
    ..This excess risk was not predicted in preclinical data and had not been found in premarketing trials...
  20. ncbi request reprint Prospective, multicentre, randomized, double-blind study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorder
    Nicholas Moore
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen, Bordeaux, France
    Int Clin Psychopharmacol 20:131-7. 2005
    ..3%, P<0.01). Adjusted remitter rates were 56.1% and 43.6%, respectively (P<0.05). Tolerability was similar in both groups. This randomized double-blind trial confirms that escitalopram has a superior effect to citalopram in MDD...
  21. doi request reprint Are generic drugs really inferior medicines?
    N Moore
    Department of Pharmacology, University of Bordeaux, Bordeaux, France
    Clin Pharmacol Ther 88:302-4. 2010
    ....
  22. ncbi request reprint NSAID use profiles derived from reimbursement data in France
    Nicholas Moore
    Departement de Pharmacologie, EA3676, IFR99, Universite Victor Segalen Bordeaux 2, Bordeaux, France France
    Therapie 59:541-6. 2004
    ....
  23. ncbi request reprint The role of the clinical pharmacologist in the management of adverse drug reactions
    N Moore
    Department of Pharmacology, Victor Segalen University, Bordeaux, France
    Drug Saf 24:1-7. 2001
    ..Helping clinicians cope with individual patient problems will also improve the clinical pharmacologist's integration into the healthcare process...
  24. ncbi request reprint Ibuprofen: a journey from prescription to over-the-counter use
    Nicholas Moore
    Departement de Pharmacologie, CHU de Bordeaux, Universite Victor Segalen, INSERM U657 Case 36, 33076 Bordeaux Cedex, France
    J R Soc Med 100:2-6. 2007
    ..This review will aim to distinguish the safety of OTC or non-prescription use of ibuprofen from its prescription use...
  25. ncbi request reprint Comparison of patient questionnaires, medical records, and plasma assays in assessing exposure to benzodiazepines in elderly subjects
    N Moore
    Department of Pharmacology, Universite Victor Segalen, Bordeaux, France
    Clin Pharmacol Ther 69:445-50. 2001
    ..This study endeavored to compare sources of information on current exposure to benzodiazepines in elderly subjects...
  26. ncbi request reprint Channelling of COX-2 inhibitors to patients at higher gastrointestinal risk but not at lower cardiovascular risk: the Cox2 inhibitors and tNSAIDs description of users (CADEUS) study
    F Depont
    INSERM U657, Bordeaux, France
    Pharmacoepidemiol Drug Saf 16:891-900. 2007
    ..To describe the characteristics of users of cyclo-oxygenase (COX)-2 inhibitors and traditional nonselective non-steroidal anti-inflammatory drugs (tNSAIDs) in France...
  27. ncbi request reprint The CADEUS study: methods and logistics
    F Depont
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 16:571-80. 2007
    ..We report here the methodology, logistics and study design performances...
  28. ncbi request reprint Benzodiazepine use in an elderly community-dwelling population. Characteristics of users and factors associated with subsequent use
    A Fourrier
    Departement de Pharmacologie Clinique, Universite Victor Segalen Bordeaux 2, France
    Eur J Clin Pharmacol 57:419-25. 2001
    ..The objective of this study was to describe determinants of current and subsequent benzodiazepine use in an elderly population, the Paquid cohort...
  29. ncbi request reprint Patterns of risperidone prescription: a utilization study in south-west France
    K Martin
    Departement de Pharmacologie, IFR de Santé Publique, Universite Victor Segalen, Bordeaux, France
    Acta Psychiatr Scand 109:202-6. 2004
    ..To describe the patterns of prescriptions associated with risperidone in naturalistic clinical practice...
  30. pmc Benzodiazepines and hip fractures in elderly people: case-control study
    C Pierfitte
    , , Centre Hospitalier Universitaire de Bordeaux, 33076 Bordeaux Cedex, France
    BMJ 322:704-8. 2001
    ..1 to 3.1). CONCLUSION: Except for lorazepam, the presence of benzodiazepines in plasma was not associated with an increased risk of hip fracture. The method used to ascertain exposure could influence the results of case-control studies...
  31. doi request reprint Effect of treatment gaps in elderly patients with dementia treated with cholinesterase inhibitors
    A Pariente
    University Bordeaux Segalen, Bordeaux, France
    Neurology 78:957-63. 2012
    ..To determine the effect of treatment gaps on the risk of institutionalization or death among community-dwelling elderly patients treated with cholinesterase inhibitors (ChIs)...
  32. ncbi request reprint Antidepressants: general practitioners' opinions and clinical practice
    S Rambelomanana
    INSERM U657, Bordeaux, France
    Acta Psychiatr Scand 113:460-7. 2006
    ..To describe and compare general practitioners' (GPs) opinions on antidepressant drugs and their prescriptions to depressed patients...
  33. ncbi request reprint Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain
    N Moore
    Department of Pharmacology, University Victor Segalen, Bordeaux, France
    Int J Clin Pract 56:732-4. 2002
    ..In conclusion, in patients with CF/ST, ibuprofen used at over-the-counter doses is as well tolerated as paracetamol and much better tolerated than aspirin...
  34. ncbi request reprint Benzodiazepine use in patients hospitalized in a department of internal medicine: frequency and clinical correlates
    R Lagnaoui
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, 33 076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 10:531-5. 2001
    ....
  35. ncbi request reprint Adverse drug reactions in a department of systemic diseases-oriented internal medicine: prevalence, incidence, direct costs and avoidability
    R Lagnaoui
    Department of Pharmacology, Universite Victor Segalen, Bordeaux, France
    Eur J Clin Pharmacol 56:181-6. 2000
    ..To increase the knowledge base, we did a study of the frequency, hazard function, avoidability, and cost of ADRs as a cause for admission in internal medicine, or when occurring after admission...
  36. ncbi request reprint A new method for assessing drug causation provided agreement with experts' judgment
    Yannick Arimone
    INSERM U657, 33076 Bordeaux Cedex, France
    J Clin Epidemiol 59:308-14. 2006
    ..The many methods proposed for causality assessment of adverse drug reaction (ADR) generally rely on algorithms. They have no clear relationship to probabilities, however, a situation we attempted to improve...
  37. ncbi request reprint Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model
    Anwar Umar
    Department of Pharmacology, Universite Victor Segalen, 33076 Bordeaux, France
    Fundam Clin Pharmacol 18:559-63. 2004
    ..The interactions with aspirin do not seem to affect all NSAIDs to equal levels. The clinical impact of this needs to be confirmed in adequately powered clinical trials or pharmaco-epidemiological studies...
  38. doi request reprint Use of the recommended drug combination for secondary prevention after a first occurrence of acute coronary syndrome in France
    J Bezin
    University of Bordeaux, Bordeaux, 33076, France
    Eur J Clin Pharmacol 70:429-36. 2014
    ..The aim of this study was to describe use and persistence of the recommended drug combination after the first occurrence of ACS in France...
  39. ncbi request reprint High-performance liquid chromatographic method with diode array detection to identify and quantify atypical antipsychotics and haloperidol in plasma after overdose
    K Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 788:179-85. 2003
    ..Both inter- and intra-day variation coefficients were lower than 11% for all drugs. This simple and rapid method (run time<15 min) is currently used for poison management...
  40. doi request reprint Impact of prescriber nonresponse on patient representativeness
    Annie Fourrier-Reglat
    INSERM, Unité 657, IFR 99, Bordeaux, France
    Epidemiology 19:186-90. 2008
    ..Our objective was to compare the characteristics of patients whose prescriber did or did not respond...
  41. ncbi request reprint [Assessment of the handling of inhaler devices: an observational study of children in primary care]
    L Malot
    Departement de Pediatrie, centre de recherche CEDRE, Hôpital Pellegrin Enfants, CHU de Bordeaux, France
    Arch Pediatr 14:1190-5. 2007
    ..The correct use of inhaler devices is important for the efficacy of the treatment of childhood asthma. Few studies have compared the use of inhaler devices in real life, in particular in children...
  42. ncbi request reprint Antidepressants: psychiatrists' opinions and clinical practice
    F Depont
    Departments of Pharmacology and Adult Psychiatry, Public Health Research Institute IFR99, Universite Victor Segalen, Bordeaux, France
    Acta Psychiatr Scand 108:24-31. 2003
    ..To describe and compare psychiatrists' opinion on antidepressant drugs and their prescriptions to depressed patients...
  43. ncbi request reprint Benzodiazepine utilization patterns in Alzheimer's disease patients
    Rajaa Lagnaoui
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 12:511-5. 2003
    ..Benzodiazepines (BZD) are commonly prescribed in the elderly. Persons with dementia may be at a greater risk of adverse reactions of BZD such as cognitive impairment...
  44. ncbi request reprint Neuroleptics and mortality in schizophrenia: prospective analysis of deaths in a French cohort of schizophrenic patients
    Christine Montout
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, 33076, Bordeaux, France
    Schizophr Res 57:147-56. 2002
    ..The putative role of neuroleptics in the known excess mortality of subjects with schizophrenia remains disputed. The aim of this study was to assess the link between mortality and the class of neuroleptic...
  45. ncbi request reprint [Plasmatic dosage of antiretroviral drugs by high performance liquid chromathography ]
    K Titier
    Laboratoire de Pharmacologie Clinique et de Toxicologie, Hôpital Pellegrin et Université Victor Ségalen, Bordeaux, France
    Therapie 57:169-74. 2002
    ..2% to 110.9% and both inter- and intra-day coefficients of variation were lower than 11%. The extraction recoveries were higher than 62%. This method is simple and shows good specificity with respect to commonly coprescribed drugs...
  46. ncbi request reprint Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care
    M Molimard
    Departement de Pharmacologie, CHU Pellegrin Carreire, 33076 Bordeaux Cedex, France
    J Aerosol Med 16:249-54. 2003
    ..There is a need for continued education of prescribers and users in the proper use of these devices to improve treatment efficacy...
  47. pmc The EULEV cohort study: rates of and factors associated with continuation of levetiracetam after 1 year
    Cécile Droz-Perroteau
    Université Victor Segalen CIC0005, INSERM CHU de Bordeaux INSERM U657 CHU de Bordeaux, Bordeaux Cedex CHU de Nancy, Nancy, France
    Br J Clin Pharmacol 71:121-7. 2011
    ..When an anti-epileptic drug first becomes available; however, there is evidence of channelling to more severe patients than thereafter...
  48. ncbi request reprint Agreement of expert judgment in causality assessment of adverse drug reactions
    Yannick Arimone
    INSERM, U 657, 33076, Bordeaux Cedex, France
    Eur J Clin Pharmacol 61:169-73. 2005
    ..Global introspection is, with operational algorithms and Bayes' theorem, one of the three main approaches used to assess the causal relationship between a drug treatment and the occurrence of an adverse event...
  49. ncbi request reprint Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    J Anal Toxicol 31:200-7. 2007
    ..This specific and sensitive method allows management of intoxication and is suitable for the routine determination of antidepressants in forensic investigation...
  50. ncbi request reprint [Contact dermatitis caused by acetazolamide under occlusion]
    Amélie Daveluy
    Centre de Pharmacovigilance, Departement de Pharmacologie, INSERM U657, Universite Victor Segalen, CHU, Bordeaux
    Presse Med 36:1756-8. 2007
    ..Acetazolamide is a carbonic anhydrase inhibitor used topically for local secondary treatment of posttraumatic or postoperative edema...
  51. ncbi request reprint Patterns and frequency of atypical antipsychotic prescribing in psychiatric medical centers: a cross-sectional national survey
    Thierno Diatta
    Universite Victor Segalen, Pharmacology Department, 33076 Bordeaux, France
    Fundam Clin Pharmacol 21:371-8. 2007
    ..4; 95% CI 0.3-0.6). This study shows the important use of atypical antipsychotic drugs especially in schizophrenic patients and younger patients...
  52. doi request reprint Factors associated with serious adverse reactions to cholinesterase inhibitors: a study of spontaneous reporting
    Antoine Pariente
    Service de Pharmacologie, INSERM U657, BP 36, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    CNS Drugs 24:55-63. 2010
    ..Cholinesterase inhibitors are used in Alzheimer's disease, mostly in elderly persons with co-morbidities and receiving co-medications that could increase the risk of serious adverse reactions...
  53. pmc The impact of medicinal drugs on traffic safety: a systematic review of epidemiological studies
    Ludivine Orriols
    Equipe Avenir Prévention et Prise en Charge des Traumatismes, Centre de Recherche INSERM U897 Epidémiologie et Biostatistiques, Universite Victor Segalen Bordeaux 2, France
    Pharmacoepidemiol Drug Saf 18:647-58. 2009
    ..To evaluate the quality of epidemiological research into effects of medicinal drugs on traffic safety and the current knowledge in this area...
  54. doi request reprint Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats
    Mireille Canal-Raffin
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 865:106-13. 2008
    ..Applying these methods, a plasma toxicokinetic study of folpet in rats after intratracheal administration of Folpan 80WG showed that inhalation of folpet could be a route of exposure with an important systemic absorption...
  55. ncbi request reprint Impact of safety alerts on measures of disproportionality in spontaneous reporting databases: the notoriety bias
    Antoine Pariente
    Department of Pharmacology, Universite Victor Segalen, Bordeaux, France
    Drug Saf 30:891-8. 2007
    ..Disproportionality analysis of spontaneous reporting is increasingly used, but it may be influenced in unknown ways by safety alerts (notoriety bias)...
  56. ncbi request reprint [Selective serotonin reuptake inhibitors and acne]
    Amélie Daveluy
    Centre de Pharmacovigilance, Département de Pharmacologie INSERM U657, Universite Victor Segalen, CHU, Bordeaux, France
    Therapie 61:71-2. 2006
  57. ncbi request reprint An easy to use method to approximate Poisson confidence limits
    Bernard Begaud
    Department de Pharmacologie, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    Eur J Epidemiol 20:213-6. 2005
    ..It allows computation of Poisson confidence limits both for count or rates and proportions...
  58. ncbi request reprint Potential impact of oral contraceptive choice on myocardial infarction mortality and deep vein thrombosis
    Karin Martin
    Department of Pharmacology, Victor Segalen University, Bordeaux, France
    J Fam Plann Reprod Health Care 31:37-9. 2005
    ....
  59. ncbi request reprint Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death
    Karine Titier
    Dept de Pharmacologie, Universite Victor Segalen, CHU de Bordeaux, INSERM Réseau de Pharmacoépidémiologie, Bordeaux, France
    Drug Saf 28:35-51. 2005
    ..The assessment of cardiovascular safety, both preclinical and during premarketing clinical trials, needs to be supported by appropriately powered pharmacoepidemiology studies...
  60. ncbi request reprint Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma
    Mireille Canal-Raffin
    Department of Clinical Pharmacology and Toxicology, EA 3676, IFR 99, University Victor Segalen Bordeaux 2, Bât IA, 33076 Bordeaux Cedex, France
    J Chromatogr B Analyt Technol Biomed Life Sci 814:61-7. 2005
    ..The limit of quantification concentration was 5 ng/ml. The absolute recovery of sertindole was higher than 99%. This rapid and sensitive method could be used for therapeutic drug monitoring as well as for overdose management...
  61. ncbi request reprint [Celecoxib prescription: data from the "Sécurité Sociale" database of the Aquitaine Region, South-Western, France]
    Annie Fourrier-Reglat
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen Bordeaux, Bordeaux, France
    Therapie 60:25-9. 2005
    ..The objective of this study was to describe the characteristics of subjects beginning celecoxib treatment and the evolution of treatment over a 6-month period...
  62. ncbi request reprint Patterns and correlates of benzodiazepine use in the French general population
    Rajaa Lagnaoui
    Departement de Pharmacologie, EA 3676, IFR 99, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
    Eur J Clin Pharmacol 60:523-9. 2004
    ..To investigate the prevalence of current use of benzodiazepines (BZDs) and related drugs in the French general population and factors associated with this use...
  63. ncbi request reprint In vivo and in vitro myocardial binding of risperidone and 9-hydroxyrisperidone
    Karine Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Toxicol Appl Pharmacol 180:145-9. 2002
    ..5-fold higher than plasma levels. Binding parameters were similar both in vivo and in vitro. From this model, the relevance of in vitro electrophysiological studies to clinical plasma concentrations can be approached...
  64. ncbi request reprint High-performance liquid chromatographic method with diode array detection for identification and quantification of the eight new antidepressants and five of their active metabolites in plasma after overdose
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, Bordeaux, France
    Ther Drug Monit 25:581-7. 2003
    ..This method allows simple and rapid (run time 18 min) identification and quantification of the eight new antidepressants and five of their active metabolites. This method can be used for toxicologic purpose...
  65. pmc Differences between clinical trials and postmarketing use
    Karin Martin
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, Bordeaux, France
    Br J Clin Pharmacol 57:86-92. 2004
    ....
  66. ncbi request reprint Benzodiazepines and injurious falls in community dwelling elders
    Antoine Pariente
    Institut National de la Santé et la Recherche Médicale INSERM, U657, Bordeaux, France
    Drugs Aging 25:61-70. 2008
    ..Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences...
  67. ncbi request reprint Benzodiazepine use and risk of dementia: a nested case-control study
    Rajaa Lagnaoui
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, 33 076 Bordeaux, France
    J Clin Epidemiol 55:314-8. 2002
    ..0; 95% CI, 0.6-1.6). Our finding suggest that former use of benzodiazepines could be a risk factor for dementia, but more detailed investigation are needed...
  68. pmc Prescription medicines and the risk of road traffic crashes: a French registry-based study
    Ludivine Orriols
    Equipe Avenir Prévention et Prise en Charge des Traumatismes, Centre de Recherche INSERM U897 Epidémiologie et Biostatistiques, Institut de Santé Publique d Épidémiologie et de Développement ISPED, Universite Victor Segalen Bordeaux 2, France
    PLoS Med 7:e1000366. 2010
    ..The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction...
  69. ncbi request reprint [Increase in thyroid pathologies in France: myth or reality]
    Karin Martin-Latry
    Universite Victor Segalen Bordeaux 2, Departement de Pharmacologie, Bordeaux, France
    Therapie 62:362-4. 2007
  70. doi request reprint Comparison of three methods (consensual expert judgement, algorithmic and probabilistic approaches) of causality assessment of adverse drug reactions: an assessment using reports made to a French pharmacovigilance centre
    Hélène Théophile
    Universite de Bordeaux, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Drug Saf 33:1045-54. 2010
    ..They approximately belong to three main categories: expert judgement, operational algorithms and probabilistic approaches...
  71. doi request reprint Effect of date of drug marketing on disproportionality measures in pharmacovigilance: the example of suicide with SSRIs using data from the UK MHRA
    Antoine Pariente
    INSERM, U657, Bordeaux, France
    Drug Saf 32:441-7. 2009
    ....
  72. doi request reprint Cutaneous adverse effects of ketoprofen for topical use: clinical patterns and costs
    Pernelle Noize
    Centre Regional de Pharmacovigilance, Departement de Pharmacologie, Universite Victor Segalen, Centre Hospitalier Universitaire, Bordeaux, France
    Am J Clin Dermatol 11:131-6. 2010
    ..Therefore, the French Medicine Agency progressively introduced warnings and contraindications to its use. Despite this, serious adverse drug reactions (ADRs) still occur...
  73. doi request reprint Concordance between prescriber- and patient-reported previous medical history and NSAID indication in the CADEUS cohort
    Annie Fourrier-Reglat
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 19:474-81. 2010
    ..In the CADEUS study, both patients and their prescribers reported medical data allowing investigation of the concordance between these sources...
  74. doi request reprint Factors associated with persistence of cholinesterase inhibitor treatments in the elderly
    Antoine Pariente
    Faculty of Pharmacy, University of Montreal, QC, Canada
    Pharmacoepidemiol Drug Saf 19:680-6. 2010
    ..To identify factors associated with one-year persistence of cholinesterase inhibitor (ChI) treatments...
  75. pmc Effectiveness of antibiotics for acute sinusitis in real-life medical practice
    Patrick Blin
    Universite Bordeaux 2, INSERM CIC 0005, Bordeaux, France
    Br J Clin Pharmacol 70:418-28. 2010
    ..Most episodes of acute sinusitis resolve spontaneously. Antibiotics have demonstrated efficacy for the treatment of acute bacterial sinusitis in clinical trials yet little is known of their effectiveness in real-life treatment settings...
  76. pmc Hospitalizations for gastrointestinal and cardiovascular events in the CADEUS cohort of traditional or Coxib NSAID users
    David Laharie
    Universite Victor Segalen, Bordeaux, France
    Br J Clin Pharmacol 69:295-302. 2010
    ..To assess hospital admission rates for gastrointestinal (GI) or cardiovascular (CV) events in real-life use of nonsteroidal anti-inflammatory drugs (NSAIDs)...
  77. pmc Inter-expert agreement of seven criteria in causality assessment of adverse drug reactions
    Yannick Arimone
    INSERM U 657, Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, France
    Br J Clin Pharmacol 64:482-8. 2007
    ..To evaluate agreement between five senior experts when assessing seven causality criteria and the probability of drug causation...
  78. doi request reprint A potential competition bias in the detection of safety signals from spontaneous reporting databases
    Antoine Pariente
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Pharmacoepidemiol Drug Saf 19:1166-71. 2010
    ..To study whether reports related to known drug-event associations could hinder the detection of new signals by increasing the detection thresholds when using disporportionality analyses in spontaneous reporting (SR) databases...
  79. ncbi request reprint Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    Ther Drug Monit 27:634-40. 2005
    ..It can be used to evaluate patient adherence to daily oral therapy, drug-drug interactions, or pharmacokinetic/pharmacodynamic relationships...
  80. ncbi request reprint Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs
    Mireille Canal-Raffin
    Department of Clinical Pharmacology and Toxicology, INSERM U657, IFR 99, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    Biopharm Drug Dispos 27:171-9. 2006
    ..1 times higher than plasma concentrations. Using these data, the relevance of in vitro electrophysiological studies to clinical plasma concentrations has been appraised...
  81. doi request reprint Cardiovascular and gastrointestinal safety of NSAIDs: a systematic review of meta-analyses of randomized clinical trials
    F Salvo
    Departement de Pharmacologie, Universite de Bordeaux, Bordeaux, France
    Clin Pharmacol Ther 89:855-66. 2011
    ..Our systematic review of MAs included information on the incidence of CV and GI events and identified important knowledge gaps regarding, in particular, the CV safety of traditional NSAIDs...
  82. ncbi request reprint [Drug evaluation in France: comparison of two approaches]
    J Dangoumau
    , , 33076 Bordeaux, France
    Therapie 56:307-14. 2001
    ..give indications for reimbursement) and the time distortion. Discrepancies can also be explained thus, but some can result from differences in appreciation of the data...
  83. ncbi request reprint Comparison of patient questionnaires and plasma assays in intentional drug overdoses
    Marcelle Diane Matsika
    EA 3676, Department of Pharmacology, Victor Segalen University, 33076 Bordeaux Cedex, France
    Basic Clin Pharmacol Toxicol 95:31-7. 2004
    ..However these results found at the population level may not be true at an individual level...
  84. doi request reprint Medical and non-medical direct costs of chronic low back pain in patients consulting primary care physicians in France
    Fanny Depont
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    Fundam Clin Pharmacol 24:101-8. 2010
    ..6% to investigations, and 12.5% to physician fees. In multivariate analysis, the factors associated with the cost of chronic LBP were disease severity (RMDQ score) and age of the patients. LBP is a disease that is both common and costly...
  85. ncbi request reprint Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    Stephane Picard
    Department of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
    Blood 109:3496-9. 2007
    ..Therefore, monitoring of imatinib plasma levels could be very useful for the management of patients with CML or should at least be checked in the case of treatment failure or suboptimal response...
  86. ncbi request reprint Use of psychotropic drugs in 0 to 5 years old children in Aquitaine (France): prevalence and associated factors
    Laurie Lévy
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 15:504-9. 2006
    ..To describe the use of psychotropic drugs in children aged 0-5 years, in the Aquitaine region of South-west France and identify associated socio-demographic, familial and medical factors...
  87. pmc A signal of increased risk of hypoglycaemia with angiotensin receptor blockers caused by confounding
    Fleur Gregoire
    CHU de Bordeaux, Bordeaux, France
    Br J Clin Pharmacol 66:142-5. 2008
    ..To study reporting of hypoglycaemia in angiotensin receptor blocker (ARB) users, and to investigate the possibility of confounding...
  88. ncbi request reprint Simplified high-performance liquid chromatographic method for determination of risperidone and 9-hydroxyrisperidone in plasma after overdose
    K Titier
    Department of Pharmacology and Toxicology, EA 525, University Victor Segalen, Place Amelie Raba Leon, 33076 Bordeaux, Cedex, France
    J Chromatogr B Analyt Technol Biomed Life Sci 772:373-8. 2002
    ..A good inter-assay accuracy (<116%) was achieved with inter-assay precision less than 12%. Quantification limits were 10 ng/ml. This rapid method (run time <5 min) is currently used for poison management...
  89. doi request reprint Benzodiazepine-like hypnotics and the associated risk of road traffic accidents
    L Orriols
    Equipe Prévention et Prise en Charge des Traumatismes, Centre de Recherche INSERM U897 Epidémiologie et Biostatistiques, Institut de Santé Publique d Epidémiologie et de Développement, Universite Victor Segalen, Bordeaux, France
    Clin Pharmacol Ther 89:595-601. 2011
    ..The results related to benzodiazepine hypnotics are consistent with those of previous studies...
  90. pmc Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus
    B Mortemousque
    Service d Ophtalmologie, CHU de Bordeaux, 33076 Bordeaux, France
    Br J Ophthalmol 88:336-40. 2004
    ..A double masked randomised trial comparing 0.05% mequitazine eye drops with 0.05% levocabastine and placebo was carried out in otherwise healthy volunteers allergic to house dust mites (Dermatophagoides pteronyssinus)...
  91. ncbi request reprint High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, University Victor Segalen, Pellegrin Hospital, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ther Drug Monit 24:417-24. 2002
    ..This method allows accurate therapeutic monitoring of amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, efavirenz, and nevirapine...
  92. doi request reprint A method to measure deferasirox in plasma using HPLC coupled with MS/MS detection and its potential application
    Emmanuelle Chauzit
    Département de Pharmacologie Clinique et Toxicologie, CHU de Bordeaux, Bordeaux, France
    Ther Drug Monit 32:476-81. 2010
    ..It allows evaluation of patient compliance, drug-drug interactions, and further investigations of pharmacokinetic/pharmacodynamic relationships...
  93. doi request reprint Comparison of health insurance claims and patient interviews in assessing drug use: data from the Three-City (3C) Study
    Pernelle Noize
    INSERM, Unit 657, Pharmaco épidémiologie et évaluation de l impact des produits de santé sur les populations, Bordeaux, France
    Pharmacoepidemiol Drug Saf 18:310-9. 2009
    ..Drug exposure is often presumed from health insurance claims but this may not correspond exactly to what subjects actually take. This study was designed to investigate French reimbursement databases in assessing drug use...
  94. ncbi request reprint Fully automated analytical method for mycophenolic acid quantification in human plasma using on-line solid phase extraction and high performance liquid chromatography with diode array detection
    Mathilde Daurel-Receveur
    CHU de Bordeaux, Département de Pharmacologie Clinique et de Toxicologie, Bordeaux F33000, France
    Ther Drug Monit 28:505-11. 2006
    ..6% to 100.4% and the interday accuracy varied from 97.1% to 100.8%. The extraction efficiency was greater than 90%. This method is simple and shows a good specificity with respect to commonly co-prescripted drugs...
  95. ncbi request reprint Postmortem redistribution of two antipsychotic drugs, haloperidol and thioridazine, in the rat
    Nadege Castaing
    CHU de Bordeaux, Laboratoire de Pharmacologie Clinique et Toxicologie, F 33076 Bordeaux, France
    J Anal Toxicol 30:419-25. 2006
    ..For the lungs, a decrease of 50% was observed between 0 and 48 h. Only myocardium and muscle concentrations did not change with the postmortem delay...
  96. ncbi request reprint The safety of drugs for OTC use: what evidence is required for an NSAID switch?
    Thomas M MacDonald
    Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Pharmacoepidemiol Drug Saf 11:577-84. 2002
    ..2 with at least 90% power for an event rate of 5%. An example of a possible pharmacy-based randomized study design to demonstrate safety equivalence of OTC analgesics is given...
  97. ncbi request reprint A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data
    Eric Van Ganse
    Pharmacoepidemiology Unit, EA 3091 CHU Lyon, France
    Pharmacoepidemiol Drug Saf 14:249-55. 2005
    ..A large-scale, blinded, randomised trial was conducted to compare the tolerability of paracetamol (acetaminophen), aspirin and ibuprofen at OTC doses, with patient-reported adverse event (AE) data as the primary outcome...
  98. ncbi request reprint Cost-effectiveness of escitalopram vs. citalopram in major depressive disorder
    Bruno Fantino
    Association pour le Développement de l Information Médicalisée, Lyon, France
    Int Clin Psychopharmacol 22:107-15. 2007
    ..This prospective economic analysis demonstrated that escitalopram is a cost-effective first-line treatment option for major depressive disorder...
  99. ncbi request reprint Rates of spontaneous reporting of adverse drug reactions in France
    Bernard Begaud
    JAMA 288:1588. 2002
  100. ncbi request reprint European commission consultation on pharmacovigilance
    Patrick Waller
    Pharmacoepidemiol Drug Saf 17:108-9. 2008
  101. ncbi request reprint The European sertindole safety and exposure survey: a follow-up study of 8600 patients
    Joseph Peuskens
    University Psychiatric Centre, Campus St Jozef Kortenberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Pharmacoepidemiol Drug Saf 16:804-11. 2007
    ..A regulatory signal suggested that sertindole was associated with a 10-fold increased risk of death. This observational study aimed to identify deaths and their causes in patients treated with sertindole...