Jean Louis Montastruc

Summary

Country: France

Publications

  1. ncbi request reprint Long-term mortality results of the randomized controlled study comparing bromocriptine to which levodopa was later added with levodopa alone in previously untreated patients with Parkinson's disease
    J L Montastruc
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Informations sur le Médicament and Centre d Investigation Clinique, Faculté de Médecine and Hôpitaux de Toulouse, France
    Mov Disord 16:511-4. 2001
  2. ncbi request reprint [Pathological gambling behavior in a patient with Parkinson's disease treated with levodopa and bromocriptine]
    J L Montastruc
    Service de Pharmacologie Clinique du CHU de Toulouse, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament
    Rev Neurol (Paris) 159:441-3. 2003
  3. ncbi request reprint [Social pharmacology: a new topic in clinical pharmacology]
    J L Montastruc
    Laboratoire de Pharmacologie Médicale et Clinique de la Faculté de Médecine de Toulouse, Toulouse, France
    Therapie 57:420-6. 2002
  4. ncbi request reprint Gender differences in adverse drug reactions: analysis of spontaneous reports to a Regional Pharmacovigilance Centre in France
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, 31073 Toulouse, France
    Fundam Clin Pharmacol 16:343-6. 2002
  5. ncbi request reprint [Coxibs, which real therapeutic advance?: Recent pharmacoepidemiological data]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique du Centre Hospitalier Universitaire de Toulouse, France
    Therapie 59:201-5. 2004
  6. ncbi request reprint Perception of the risk of gastrointestinal adverse drug reactions with non-steroidal anti-inflammatory drugs (including coxibs): differences among general practitioners, gastroenterologists and rheumatologists
    J L Montastuc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, Faculte de Medecine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse cedex 7, France
    Eur J Clin Pharmacol 59:685-8. 2003
  7. ncbi request reprint [Use of the capture-recapture method to assess the frequency of "serious" adverse drug reactions: experience of Toulouse University Hospital]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Faculte de Medecine, Toulouse
    Bull Acad Natl Med 192:421-30; discussion 430-1. 2008
  8. ncbi request reprint [Pharmacologic criteria for medical substitution in opiate dependence]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Centre d Evaluation et d Informations sur la Pharmacodépendance CEIP, CHU de Toulouse, Toulouse, France
    Therapie 58:123-5. 2003
  9. ncbi request reprint [Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, UA 3696, IFR 126, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 61:29-38. 2006
  10. ncbi request reprint [Pharmacoepidemiology in clinical practice]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Faculté de médecine BP 7202, 31073 Toulouse
    Rev Prat 52:701-3. 2002

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Long-term mortality results of the randomized controlled study comparing bromocriptine to which levodopa was later added with levodopa alone in previously untreated patients with Parkinson's disease
    J L Montastruc
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Informations sur le Médicament and Centre d Investigation Clinique, Faculté de Médecine and Hôpitaux de Toulouse, France
    Mov Disord 16:511-4. 2001
    ..71-1.95]), in group D (0.98 [0.42-1.93]), or in group B/D (1.53 [0.70-2.92]). In this population, we were unable to find any favourable effect of an early use of bromocriptine on mortality in PD in comparison with levodopa alone...
  2. ncbi request reprint [Pathological gambling behavior in a patient with Parkinson's disease treated with levodopa and bromocriptine]
    J L Montastruc
    Service de Pharmacologie Clinique du CHU de Toulouse, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament
    Rev Neurol (Paris) 159:441-3. 2003
    ..This is the first case reported with bromocriptine. The main characteristics and the mechanism of this recently described and a unexpected, adverse drug reaction are discussed...
  3. ncbi request reprint [Social pharmacology: a new topic in clinical pharmacology]
    J L Montastruc
    Laboratoire de Pharmacologie Médicale et Clinique de la Faculté de Médecine de Toulouse, Toulouse, France
    Therapie 57:420-6. 2002
    ..The role of the Social Pharmacologist is to identify these social and irrational factors governing drug use in order to adapt and rationalize drug utilization in daily clinical practice...
  4. ncbi request reprint Gender differences in adverse drug reactions: analysis of spontaneous reports to a Regional Pharmacovigilance Centre in France
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, 31073 Toulouse, France
    Fundam Clin Pharmacol 16:343-6. 2002
    ..These results confirm that female gender is a risk factor for the development of ADRs...
  5. ncbi request reprint [Coxibs, which real therapeutic advance?: Recent pharmacoepidemiological data]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique du Centre Hospitalier Universitaire de Toulouse, France
    Therapie 59:201-5. 2004
    ..Currently marketed coxibs do not appear to meet the previously defined criteria for therapeutic advance...
  6. ncbi request reprint Perception of the risk of gastrointestinal adverse drug reactions with non-steroidal anti-inflammatory drugs (including coxibs): differences among general practitioners, gastroenterologists and rheumatologists
    J L Montastuc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, Faculte de Medecine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse cedex 7, France
    Eur J Clin Pharmacol 59:685-8. 2003
    ..To compare the perception of risk of gastrointestinal adverse drug reactions (ADRs) with non-steroidal anti-inflammatory drugs (NSAIDs) (including coxibs) in general practitioners, gastroenterologists and rheumatologists...
  7. ncbi request reprint [Use of the capture-recapture method to assess the frequency of "serious" adverse drug reactions: experience of Toulouse University Hospital]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Faculte de Medecine, Toulouse
    Bull Acad Natl Med 192:421-30; discussion 430-1. 2008
    ..9% of inpatients (95% CI 2.3, 3.5) during the first half of 2001. This study confirms the lack of exhaustiveness of ADR reporting, whatever the data source, and underlines the value of merging data from different databases...
  8. ncbi request reprint [Pharmacologic criteria for medical substitution in opiate dependence]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Centre d Evaluation et d Informations sur la Pharmacodépendance CEIP, CHU de Toulouse, Toulouse, France
    Therapie 58:123-5. 2003
    ..These criteria were applied to methadone, buprenorphine and other drugs that were proposed in the treatment of opioid dependence (such as morphine or codeine)...
  9. ncbi request reprint [Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, UA 3696, IFR 126, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 61:29-38. 2006
    ..It is also an important mediator for pleasure, hedonic regulations and sexual behaviour. This review also underlines the major role of spontaneous reports to the pharmacovigilance systems to identify new adverse drug reactions...
  10. ncbi request reprint [Pharmacoepidemiology in clinical practice]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Faculté de médecine BP 7202, 31073 Toulouse
    Rev Prat 52:701-3. 2002
  11. ncbi request reprint Pharmacovigilance for evaluating adverse drug reactions: value, organization, and methods
    Jean Louis Montastruc
    Medical and Clinical Pharmacology Laboratory, Pharmacoepidemiology Unit, EA 3696, IFR INSERM 126, Paul Sabatier University, School of Medicine, Toulouse, France
    Joint Bone Spine 73:629-32. 2006
  12. ncbi request reprint [Drug-induced tremor and acute movement disorders]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique du CHU de Toulouse, Toulouse, France
    Therapie 59:97-103. 2004
    ..Drug-induced tremor and movement disorders are often poorly described in the Summary of Products Characteristics (SPC)...
  13. doi request reprint The importance of drug-drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France
    Francois Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, UMR INSERM U1027, Equipe de Pharmacoépidémiologie, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Eur J Clin Pharmacol 68:767-75. 2012
    ..To quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database...
  14. ncbi request reprint [New methods for studying drug associated risk: experience of the Toulouse Regional Pharmacovigilance Center]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR INSERM 126, Faculte de Medecine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse 7, France
    Bull Acad Natl Med 189:493-502; discussion 502-5. 2005
    ..Finally, ADR perception analysis is a useful method to evaluate the perceived social and medical importance of drug risks in different populations (public, pharmacists, general practitioners, medical specialists)...
  15. ncbi request reprint Utilisation and safety of low molecular weight heparins: prospective observational study in medical inpatients
    Philippe Cestac
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse, France
    Drug Saf 26:197-207. 2003
    ....
  16. ncbi request reprint Assessing the feasibility of using an adverse drug reaction preventability scale in clinical practice: a study in a French emergency department
    Pascale Olivier
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France
    Drug Saf 25:1035-44. 2002
    ..To assess the preventability of adverse drug reactions (ADRs) leading to hospital admissions and to investigate the feasibility of the use of a standardised preventability scale in clinical practice...
  17. doi request reprint Factors related to orthostatic hypotension in Parkinson's disease
    Santiago Perez-Lloret
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, l Université de Toulouse, Toulouse, France
    Parkinsonism Relat Disord 18:501-5. 2012
    ..Orthostatic hypotension (OH), a frequent feature of Parkinson's disease (PD) can contribute to falls and is usually related to the disease itself and/or to drugs...
  18. pmc Using a capture-recapture method to assess the frequency of adverse drug reactions in a French university hospital
    Stephanie Lugardon
    Unit of Pharmacoepidemiology, EA 3696, IFR 126 Health and Society, University Paul Sabatier, Toulouse, France
    Br J Clin Pharmacol 62:225-31. 2006
    ....
  19. ncbi request reprint [Prescribing drugs by international non-proprietary name: the perception of health and non-health professionals]
    Julie Biga
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Unité de Pharmacoépidémiologie, Faculte de Medecine, Toulouse, France
    Therapie 60:401-7. 2005
    ..The aim of this study was to evaluate the perceptions of health professionals and non-health professionals with regard to prescribing drugs by their international non-proprietary name (INN) in the Midi-Pyrénées area, France...
  20. doi request reprint Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease
    Santiago Perez-Lloret
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Toulouse, France
    Clin Neuropharmacol 35:261-5. 2012
    ..Impulse-control disorders (ICDs) occur in patients with Parkinson disease (PD), especially in younger patients on dopamine therapies...
  21. doi request reprint Non-steroidal anti-inflammatory drugs (NSAIDs) and hypertension treatment intensification: a population-based cohort study
    Jean Pascal Fournier
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite Paul Sabatier, 37 Allees Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 68:1533-40. 2012
    ..We examined whether the introduction of NSAID into the treatment regimen would induce an intensification of hypertension treatment (defined as the introduction of a new antihypertensive drug)...
  22. ncbi request reprint Coxibs: evolution of prescription's behaviour in France
    Julie Biga
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmaco épidémiologie, EA 3696, IFR 126, Universite Paul Sabatier, Faculté de Médecine de Toulouse, Toulouse, France
    Fundam Clin Pharmacol 21:317-25. 2007
    ....
  23. doi request reprint Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France
    Anne Charlotte Danton
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 69:885-8. 2013
    ..Our aim was to characterize Adverse Drug Reactions (ADRs) related to drug-drug interactions (DDIs) related to involvement of cytochrome P450 (CYP450) isoenzymes in a pharmacovigilance database...
  24. ncbi request reprint Influence of HCV or HBV coinfection on adverse drug reactions to antiretroviral drugs in HIV patients
    Emmanuelle Guitton
    Laboratoire de Pharamcologie Médicale et Clinique, Unité de Pharmacoépidémiologie EA3696, IFR 126, Faculte de Medecine, 37 Allees Jules Guesde, Toulouse Cedex 7, 31073, France
    Eur J Clin Pharmacol 62:243-9. 2006
    ....
  25. ncbi request reprint Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, EA3696, Universite Paul Sabatier, Toulouse, France
    Fundam Clin Pharmacol 20:391-5. 2006
    ..These discrepancies could be explained in part not only by reporting rates, but also by difference in drug use patterns and/or by genetic or environmental factors...
  26. ncbi request reprint First French experience of ADR reporting by patients after a mass immunization campaign with Influenza A (H1N1) pandemic vaccines: a comparison of reports submitted by patients and healthcare professionals
    Genevieve Durrieu
    CHU Toulouse, Service de Pharmacologie Clinique, Ple Sant Socit, Radaptation, Toulouse, France
    Drug Saf 35:845-54. 2012
    ..For the first time, patients were offered the opportunity to report suspected ADRs to pandemic vaccines directly to regional pharmacovigilance centres...
  27. pmc Trends of reporting of 'serious'vs. 'non-serious' adverse drug reactions over time: a study in the French PharmacoVigilance Database
    Guillaume Moulis
    CHU Toulouse, Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Toulouse, F 31059, France
    Br J Clin Pharmacol 74:201-4. 2012
    ..Among them, 'seriousness' of the reaction is one of the most important. • However, evolution in the reporting of 'serious'vs.'non-serious' ADRs over time for the same drug remains unknown...
  28. doi request reprint Anxious and depressive symptoms in Parkinson's disease: the French cross-sectionnal DoPaMiP study
    Laurence Negre-Pages
    Department of Clinical Pharmacology, University Hospital, Toulouse, France
    Mov Disord 25:157-66. 2010
    ..Both symptoms were commonly associated in the same PD patients, but were correlated with different clinical/therapeutic features, suggesting different underlying pathophysiological mechanisms...
  29. ncbi request reprint Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
    Francois Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Eur J Clin Pharmacol 69:1589-97. 2013
    ..The aim of our study was to assess the prevalence of PIM in community-dwelling patients diagnosed with mild-to-moderate AD and identify the clinical factors associated with PIM prescriptions...
  30. ncbi request reprint Prevalence and costs of parkinsonian syndromes associated with orthostatic hypotension
    Karine Desboeuf
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U586, Faculte de Medecine, Toulouse, France
    Therapie 61:93-9. 2006
    ..To measure the frequency of and direct costs related to parkinsonian syndromes associated with orthostatic hypotension (OH)...
  31. ncbi request reprint Drug related falls: a study in the French Pharmacovigilance database
    Emmanuelle Souchet
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse Cedex, France
    Pharmacoepidemiol Drug Saf 14:11-6. 2005
    ..To investigate the risk of falls associated with drugs among the French population using data reported to the French spontaneous reporting system and recorded in the French Pharmacovigilance database...
  32. ncbi request reprint Clinical and economic analysis of spa therapy in Parkinson's disease
    Christine Brefel-Courbon
    Service de Pharmacologie Clinique, Laboratoire de Médecine Thermale, University Hospital, Toulouse, France
    Mov Disord 18:578-84. 2003
    ..This cost-effectiveness analysis suggests that spa therapy is more effective and less expensive than conventional treatment alone and could be beneficial in the management of PD...
  33. ncbi request reprint Modifications of low-molecular weight heparin use in a French university hospital after implementation of new guidelines
    Sophie Leclerc-Foucras
    Department of Anesthesiology, Toulouse University Hospital, Toulouse, France
    Drug Saf 30:409-17. 2007
    ..This study assesses LMWH use before and after the implementation of these guidelines...
  34. ncbi request reprint [Retrospective analysis of adverse effects of infliximab in a hospital rheumatology service]
    Cendrine Cabou
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, Faculte de Medecine, Toulouse, France
    Therapie 58:457-62. 2003
    ..4%. In conclusion, our data allowed a quantitative and qualitative assessment of infliximab-induced ADRs. Further studies are required in order to improve knowledge regarding ADRs induced by long-term treatment with infliximab...
  35. ncbi request reprint [Analysis of antiretroviral drugs-induced adverse effects]
    Magalie Baudrant
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, Faculte de Medecine, Toulouse, France
    Therapie 61:171-6. 2006
    ..6% of cases and required the withdrawal of suspected drugs in 57% of cases. Our data show an improvement of antiretroviral drug-induced ADRs reporting...
  36. pmc Cancer risk of anti-TNF-α at recommended doses in adult rheumatoid arthritis: a meta-analysis with intention to treat and per protocol analyses
    Guillaume Moulis
    CHU Toulouse, Service de Medecine Interne, Toulouse, France
    PLoS ONE 7:e48991. 2012
    ..Furthermore, the relative interest of modified intention to treat or per protocol analyses to assess such sparse events remains unknown...
  37. doi request reprint Bleeding adverse drug reactions (ADRs) in patients exposed to antiplatelet plus serotonin reuptake inhibitor drugs: analysis of the French Spontaneous Reporting Database for a controversial ADR
    Franck Maschino
    Service de Pharmacologie Clinique, Equipe de Pharmacoépidémiologie, Inserm U 1027, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 68:1557-60. 2012
    ....
  38. doi request reprint Drug-induced immune thrombocytopenia: a descriptive survey in the French PharmacoVigilance database
    Guillaume Moulis
    Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
    Platelets 23:490-4. 2012
    ..Ezetimibe may induce chronic ITP. Drug-induced ITP is rarely severe. Finally, this study also shows that chronicity of ITP does not rule out the possibility of an iatrogenic cause...
  39. doi request reprint Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study
    Isabelle Lacroix
    Centre Hospitalier Universitaire de Toulouse, Laboratoire de Pharmacologie Medicale et Clinique, Centre d Evaluation et d Information sur la Pharmacodépendance et d Addictovigilance, INSERM U1027, Universite de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 67:1053-9. 2011
    ..Ninety pregnant women exposed to buprenorphine and 45 to metadone were selected for the study...
  40. doi request reprint Life-threatening drug-associated hyperkalemia: a retrospective study from laboratory signals
    Pernelle Noize
    CHU de Toulouse, Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, F 31000 Toulouse, France
    Pharmacoepidemiol Drug Saf 20:747-53. 2011
    ..Life-threatening hyperkalemia may be induced by drugs and preventable in at-risk patients. This study was designed to describe cases of 'serious' drug-associated hyperkalemia...
  41. pmc Reporting rate of adverse drug reactions to the French pharmacovigilance system with three step 2 analgesic drugs: dextropropoxyphene, tramadol and codeine (in combination with paracetamol)
    Neda Tavassoli
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA3696, Universite de Toulouse, Faculte de Medecine, 31000 Toulouse, France
    Br J Clin Pharmacol 68:422-6. 2009
    ..The aim was to compare the reporting rate of ADRs between tramadol/paracetamol (TRM+P), codeine/paracetamol (COD+P) and dextropropoxyphene/paracetamol (DXP+P)...
  42. doi request reprint [Drug-related neuropathies: analysis of the French Adverse Drug Reaction Database 1995-2005]
    Genevieve Durrieu
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Universite Paul Sabatier, Faculte de Medecine, F 31000 Toulouse, France
    Presse Med 37:935-42. 2008
    ..Drug-induced neuropathies are mainly sensory and subacute. The pathophysiological mechanisms associated with them are not clearly established and few pharmacoepidemiologic studies are available...
  43. ncbi request reprint A 2-year prospective cohort study of antidementia drug non-persistency in mild-to-moderate Alzheimer's disease in Europe : predictors of discontinuation and switch in the ICTUS study
    Virginie Gardette
    Inserm UMR1027, 31073, Toulouse, France
    CNS Drugs 28:157-70. 2014
    ..There is no consensus on when and how to discontinue cholinesterase inhibitors (ChEI). Predictors of non-persistency of antidementia drugs have been poorly investigated, mostly during short-term periods and using administrative data...
  44. ncbi request reprint The nature of the scientific evidence leading to drug withdrawals for pharmacovigilance reasons in France
    Pascale Olivier
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse, France
    Pharmacoepidemiol Drug Saf 15:808-12. 2006
    ..The objective of our study was to determine the scientific evidences leading to drug withdrawal for pharmacovigilance reasons in France...
  45. ncbi request reprint Adverse drug reactions related to drugs used in orthostatic hypotension: a prospective and systematic pharmacovigilance study in France
    Atul Pathak
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Hopitaux de Toulouse, 37 Allees Jules Guesde, 31073, Toulouse Cedex 7, France
    Eur J Clin Pharmacol 61:471-4. 2005
    ..The aim of the present study was to investigate and characterise adverse drug reactions (ADRs) to drugs used in France for orthostatic hypotension (OH)...
  46. ncbi request reprint [Adverse drug reactions (ADRs) to antimalarial drugs. Analysis of spontaneous report from the French pharmacovigilance database (1996-2000)]
    Anne Angles
    Service de Pharmacologie Clinique du CHU de Toulouse, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse
    Presse Med 32:106-13. 2003
    ..This article assesses and analyses the antimalarial-induced ADRs reported to the French pharmacovigilance system...
  47. ncbi request reprint Alpha2 -adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet
    Michel Pelat
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U317, Faculte de Medecine, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    J Hypertens 20:957-64. 2002
    ..To investigate the status of alpha2-adrenoceptors in a model of obesity-related arterial hypertension...
  48. ncbi request reprint Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
    Atul Pathak
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Toulouse, France
    Mov Disord 20:1213-9. 2005
    ..9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening...
  49. ncbi request reprint [Family pharmacy: survey of a sample of patients in Midi-Pyrénées]
    Michel Bismuth
    Département universitaire de médecine générale, Faculté de Médecine de Toulouse, Toulouse, France
    Therapie 66:131-4. 2011
    ..Possession of drugs at home in the family pharmacy and self-medication are at risk...
  50. ncbi request reprint [Which analgesic after dextropropoxyphene withdrawal? A survey in a sample of general practitioners in southwest of France]
    Serge Bismuth
    Département Universitaire de Médecine Générale de Midi Pyrénées, Universite de Toulouse, Toulouse, France
    Therapie 66:25-8. 2011
    ..7%) and tramadol alone or associated with paracetamol (74.6%) in chronic pain. Switching to other level 2 analgesic drugs after the withdrawal of dextropropoxyphene should be closely monitored because the safety profile of other drugs...
  51. doi request reprint Prescribed drugs and violence: a case/noncase study in the French PharmacoVigilance Database
    Nadège Rouve
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur les Médicaments, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 67:1189-98. 2011
    ..Our aim was to identify prescribed drugs associated with violent behaviours using the French PharmacoVigilance Database (FPVD)...
  52. ncbi request reprint [Meningococcal serogroup C vaccine: a pharmacovigilance point of view]
    Haleh Bagheri
    Service de Pharmacologie Clinique du CHU de Toulouse, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculté de Médecine de Toulouse, France
    Therapie 60:287-94. 2005
    ..In October 2002, the Midi-Pyrenees centre of pharmacovigilance (Southwest of France) was in charge of an extensive pharmacovigilance follow-up of a campaign of meningococcal serogroup C vaccination performed in the Hautes-Pyrénées area...
  53. pmc Drugs and dilated cardiomyopathies: A case/noncase study in the French PharmacoVigilance Database
    Guillaume Montastruc
    Centre Hospitalier Universitaire, Poitiers, France
    Br J Clin Pharmacol 69:287-94. 2010
    ..To evaluate putative associations between drugs and dilated cardiomyopathy...
  54. doi request reprint Improving adverse drug reaction reporting in hospitals: results of the French Pharmacovigilance in Midi-Pyrénées region (PharmacoMIP) network 2-year pilot study
    Mireille Gony
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Drug Saf 33:409-16. 2010
    ..Several factors could favour under-reporting...
  55. doi request reprint [Drug-induced hyperglycemia: a study in the French pharmacovigilance database]
    Leila Chebane
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie EA 3696, Universite de Toulouse, Faculte de Medecine, Toulouse, France
    Therapie 65:447-58. 2010
    ..To analyse drugs inducing hyperglycemia by using data reported to the French spontaneous reporting system and recorded in the French PharmacoVigilance Database (FPVD)...
  56. ncbi request reprint [Writing and dispensing of NSAID prescriptions in late pregnancy: impact of health authorities' advice]
    Caroline Hurault
    Service de Pharmacologie Clinique, Unité Médicaments, grossesse et allaitement, Centre Hospitalier Universitaire, EA 3696 Université de Toulouse, F 31000 Toulouse, France
    Presse Med 37:767-74. 2008
    ....
  57. doi request reprint [Prevalence of diabetes in france and drug use: study based on the French pharmacovigilance database]
    Stéphanie Berthet
    Unité de Pharmacoépidémiologie, EA 3696, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 62:483-8. 2007
    ..The aim of this study was to investigate the use of the French Pharmacovigilance Database to estimate characteristics of drug utilization in specific diseases...
  58. ncbi request reprint [Prenatal exposure to psychoactive substances: results of NENUPHAR study]
    Isabelle Lacroix
    Service de Pharmacologie Clinique, Unité Médicaments, grossesse et allaitement, EA3696 IFR 126 Santé Société, 37 Allees Jules Guesde, 31000 Toulouse, France
    Therapie 62:177-83. 2007
    ..Many cases were exposed to cannabis which might increase neonatal disease risk. These results underline the impact of psychotropic use or abuse during pregnancy on neonatal outcomes...
  59. ncbi request reprint Risk of serious extrapyramidal symptoms in patients with Parkinson's disease receiving antidepressant drugs: a pharmacoepidemiologic study comparing serotonin reuptake inhibitors and other antidepressant drugs
    Mireille Gony
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémilogie and Centre Midi Pyrénées de Pharmacovigilance, de Pharmacoépidémilogie et d Informations sur le Médicament du Centre Hospitalier Universitaire, Faculté de Médecine de Toulouse, France
    Clin Neuropharmacol 26:142-5. 2003
    ..This study failed to find any significant difference in the occurrence of serious EPS according to the different classes of antidepressant drugs in patients with PD treated with dopaminergic antiparkinsonian drugs...
  60. ncbi request reprint Drug-induced yawning: a review of the French pharmacovigilance database
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR INSERM 126, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Drug Saf 30:327-31. 2007
    ..To review the reports with 'yawning' as an adverse drug reaction (ADR) reported into the French Pharmacovigilance Database...
  61. ncbi request reprint [Patterns of non steroidal anti-inflammatory drug use in ambulatory care]
    Stephanie Lugardon
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 61:109-14. 2006
    ..This study confirms the wide use of NSAIDs and describes their target population. It underlines the interest of Health Insurance System Database for better knowledge of drug use in ambulatory care in France...
  62. ncbi request reprint High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs
    Michel Pelat
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U317, Faculte de Medecine, Toulouse Cedex, France
    J Pharmacol Exp Ther 304:246-53. 2003
    ..These results also argue for the lack of a beta3-AR involvement in the control of heart rate and glycogenolysis in dogs...
  63. ncbi request reprint [Methods for the measurement of drug consumption: application to antibiotics]
    Agnes Sommet
    Unité de Pharmacoépidémiologie, EA 3696, Service de Pharmacologie Clinique, Universite Paul Sabatier, Toulouse, France
    Therapie 60:553-9. 2005
    ..The aim of this article is to present and compare the different methods used to study drug consumption...
  64. doi request reprint ["Serious" adverse drug reactions with tramadol: a 2010-2011 pharmacovigilance survey in France]
    Delphine Abadie
    Laboratoire de Pharmacologie Medicale et Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, et Centre Midi Pyrénées d Évaluation et d Information sur la Pharmacodépendance Addictovigilance, Universite de Toulouse, Faculte de Medecine, Centre Hospitalier Universitaire, Toulouse, France
    Therapie 68:77-84. 2013
    ..Tramadol is a weak opioid used as a step 2 analgesic, approved in France for moderate to severe pain. After dextropropoxyphene withdrawal, a national pharmacovigilance follow-up of tramadol was decided by the French Drug Agency...
  65. doi request reprint [Could we improve notification of adverse drugs reactions in hospital? Assessment of 5 years of network PharmacoMIP's activities]
    Julien Jacquot
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Équipe de Recherche de Pharmacoépidémiologie INSERM U1027, Centre Hospitalier Universitaire, Toulouse, France
    Therapie 67:231-6. 2012
    ..Spontaneous reporting of adverse drug reactions (ADR) is fundamental to drug safety surveillance (pharmacovigilance) and assessment of benefit/risk ratio. However, under-reporting remains the limit of the system...
  66. pmc Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study
    Jean Pascal Fournier
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite Paul Sabatier, Toulouse, France
    PLoS ONE 7:e34187. 2012
    ..Thus, monitoring of serum creatinine and potassium is recommended when a first dispensing of NSAID occur in patients treated with these drugs...
  67. doi request reprint Do Parkinson's disease patients disclose their adverse events spontaneously?
    Santiago Perez-Lloret
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculte de Medecine, Universite de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 68:857-65. 2012
    ..Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD)...
  68. doi request reprint A comparative study of adverse drug reactions during two heat waves that occurred in France in 2003 and 2006
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, INSERM U1027, Universite de Toulouse, Faculte de Medecine, Toulouse, 31000, France
    Pharmacoepidemiol Drug Saf 21:285-8. 2012
    ..Thus, we wanted to describe the main characteristics of heat-related 'serious' ADRs occurred in patients older than 70 years during these two events in France (2003 and 2006)...
  69. doi request reprint Drug-induced parkinsonism: a review of 17 years' experience in a regional pharmacovigilance center in France
    Emmanuelle Bondon-Guitton
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine de l Université de Toulouse, Toulouse and Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, Toulouse, France
    Mov Disord 26:2226-31. 2011
    ..Approximately 50% of drug-induced or -worsened parkinsonism cases spontaneously reported were related to drugs other than antipsychotics. Drug-induced or -worsened parkinsonism can also be explained by pharmacokinetic drug interactions...
  70. ncbi request reprint [Adverse cardiovascular and central neurologic reactions to sympathomimetics used as nasal decongestants: results of the French National Pharmacovigilance Survey]
    Pascale Olivier
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire de Toulouse, Faculté de Médecine de Toulouse, Toulouse, France
    Therapie 58:361-6. 2003
    ..Since most of the nasal decongestants are freely available without prescription, drug information is needed to advise prescribers and also patients about risk of 'serious' ADRs with these drugs...
  71. ncbi request reprint [Validation of a measurement scale: example of a French Adverse Drug Reactions Preventability Scale]
    Pascale Olivier
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Informations sur le Medicament Inserm U657, Faculte de Medecine, Toulouse, France
    Therapie 60:39-45. 2005
    ..This experience suggests the need for further studies to improve this French ADR preventability scale and validate it in differing circumstances, in order to provide a useful tool to enhance the rational use of drugs...
  72. doi request reprint Adverse drug reactions to dopamine agonists: a comparative study in the French Pharmacovigilance Database
    Santiago Perez-Lloret
    Service de Pharmacologie Clinique, EA 3696, INSERM CIC9023, UMR 825, Faculte de Medecine, Centre Hospitalier Universitaire et Université de Toulouse, Toulouse, France
    Mov Disord 25:1876-80. 2010
    ..001). Somnolence or ICD reports were less frequent with levodopa, whereas confusion was more frequently reported. In summary, our data show significant differences in the kind of ADRs reported for each DA...
  73. doi request reprint [Post-marketing safety profile of avocado-soybean unsaponifiables]
    Pascale Olivier
    Centre Hospitalier Universitaire de Toulouse, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Service de Pharmacologie Clinique, 31000 Toulouse, France
    Presse Med 39:e211-6. 2010
    ..To determine the post-marketing safety profile of avocado-soybean unsaponifiables since their commercialization in France until 2008...
  74. doi request reprint Adverse drug reactions to local anaesthetics: a review of the French pharmacovigilance database
    Regis Fuzier
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Universite de Toulouse, Faculte de Medecine, and Service de Pharmacologie Clinique, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Drug Saf 32:345-56. 2009
    ..The most common adverse drug reactions (ADRs) to LAs are neurological (seizures) and cardiac (conduction disorders, cardiac arrests). However, little is known about other adverse drug reactions (ADRs)...
  75. doi request reprint Drug prescribing before and during pregnancy in south west France: a retrolective study
    Sophie Crespin
    Service de Pharmacologie Clinique, CHU de Toulouse, Centre Midi Pyrnes de Pharmacovigilance, de Pharmaco pidmiologie et dInformation sur le Mdicament, Unit de Pharmaco pidmiologie, INSERM U1027, Universit de Toulouse, France
    Drug Saf 34:595-604. 2011
    ..Nevertheless, it is often possible to replace a drug with another one that has been better evaluated...
  76. ncbi request reprint Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease
    Frederic Courbon
    Service de Medecine Nucleaire, University Rangueil Hospital, Toulouse, France
    Mov Disord 18:890-7. 2003
    ..Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD...
  77. ncbi request reprint High maintenance dosage of clopidogrel is associated with a reduced risk of stent thrombosis in clopidogrel-resistant patients
    Neda Tavassoli
    Medical and Clinical Pharmacology Laboratory, Pharmacoepidemiology Unit, Faculty of Medicine, Toulouse University, Toulouse, France
    Am J Cardiovasc Drugs 10:29-35. 2010
    ..Some recent studies have suggested that a higher clopidogrel maintenance dosage could enhance ex vivo platelet inhibition and thereby overcome resistance to clopidogrel...
  78. ncbi request reprint [Drug prescription and pharmacovigilance in spa therapy: a comparative study at a 20-year interval (1987 versus 2007)]
    Fabien Fontanel
    Laboratoire d Hydrologie et Climatologie Médicale, Universite de Toulouse, Faculte de Medecine, Toulouse, France
    Therapie 63:135-40. 2008
    ..Spa therapy is often considered as a dedicated period for a global treatment of patients. However, the prescription behaviours of spa physicians remain largely unknown...
  79. ncbi request reprint Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption
    Sabine Gaubert
    Service Pharmacie, Centre Hospitalier Universitaire, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne, TSA 70034, 31059 Toulouse Cedex 9, France
    Fundam Clin Pharmacol 23:247-52. 2009
    ..This paper underlines the interest of a hospital-based drug committee to promote rational drug use. Finally, the present data allow us to discuss putative misuse of dextropropoxyphene...
  80. doi request reprint [Adverse drug reactions in pregnant women]
    Isabelle Lacroix
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Universite de Toulouse, Faculte de Medecine, Toulouse, France
    Therapie 62:455-60. 2007
    ..ADRs mainly occurred during the third trimester of pregnancy. The incidence of ADRs is very low in pregnant women. However, one must pay attention on the risk of anaphylactic reactions in pregnant women...
  81. ncbi request reprint [Profile of psychoactive substances consumption in workplace]
    Olivia Bœuf-Cazou
    Universite de Toulouse, Toulouse, France
    Therapie 66:155-65. 2011
    ..The aim of this study was to identify profiles of psychoactive substances consumers among workers according to their professional characteristics...
  82. doi request reprint Exposure to inhibitors of the renin-angiotensin system is a major independent risk factor for acute renal failure induced by sucrose-containing intravenous immunoglobulins: a case-control study
    Guillaume Moulis
    U1027 INSERM Pharmacoepidemiology Unit, Department of Clinical Pharmacology Centre Régional Midi Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d Informations sur les Médicaments, Toulouse University Hospital, University of Toulouse, Toulouse, France
    Pharmacoepidemiol Drug Saf 21:314-9. 2012
    ..This study was aimed at quantifying the risk of IVIg-RF associated with exposure to drugs that modify intrarenal hemodynamics...
  83. doi request reprint Statins and erectile dysfunction: results of a case/non-case study using the French Pharmacovigilance System Database
    Catherine Do
    Universite de Toulouse, UPS, Unité de Pharmacoépidémiologie EA 3696, Toulouse, France
    Drug Saf 32:591-7. 2009
    ..The relationship between ED and exposure to statins has not clearly been established even though a number of significant case reports have associated ED with exposure to statins...
  84. ncbi request reprint Vinorelbine-related cardiac events: a meta-analysis of randomized clinical trials
    Maryse Lapeyre-Mestre
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie, et d Information sur le Médicament, Faculty of Medicine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse Cedex, France
    Fundam Clin Pharmacol 18:97-105. 2004
    ..Vinorelbine-related cardiac events concern about 1% of treated patients in clinical trials. However, the risk associated with VNR seems to be similar to that of other chemotherapeutic agents in the same indications...
  85. ncbi request reprint [Taking drugs in the working environment: a study in a sample of 2106 workers in the Toulouse metropolitan area]
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, EA 3696, Unité de Pharmacoépidémiology, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 59:615-23. 2004
    ..The aim of this study was to investigate the frequency and characteristics of "supportive" drug use and addictive behaviour in the working environment...
  86. doi request reprint Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey
    Pascale Olivier
    Unit of Pharmacoepidemiology, University of Toulouse, Toulouse, France
    Drugs Aging 26:475-82. 2009
    ..Thus, the aim of this prospective study was to assess the incidence of ADRs and associated factors leading to hospital admissions in the elderly population...
  87. ncbi request reprint [Drugs and heat wave: SIRIUS, a multicentric case-control study in patients older than 65 years during 2007 summer in France]
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie EA3696, Universite de Toulouse, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 64:295-301. 2009
    ..To evaluate in real conditions the role of drugs in heat-related adverse effects...
  88. pmc Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line
    Sophie Buys
    INSERM U586, Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    Br J Pharmacol 139:1219-27. 2003
    ..6. Our findings demonstrate that AM regulates M(2) receptors expression in cardiomyocytes probably through a mechanism involving L1/G10D receptors. The 'in vivo' significance of this phenomenon remains to be demonstrated...
  89. ncbi request reprint What do pregnant women know about non-steroidal anti-inflammatory drugs?
    Christine Damase-Michel
    Service de Pharmacologie, Centre Hospitalier Universitaire, Unité de Pharmacoépidémiologie EA 3696, Faculte de Medecine, Universite de Toulouse, Toulouse, France
    Pharmacoepidemiol Drug Saf 18:1034-8. 2009
    ..Some NSAIDs, available over the counter, can be purchased easily by pregnant women. The present study evaluates pregnant womens' knowledge about NSAID use in pregnancy...
  90. doi request reprint Spinal anesthesia failure after local anesthetic injection into cerebrospinal fluid: a multicenter prospective analysis of its incidence and related risk factors in 1214 patients
    Regis Fuzier
    Unit of Pharmacoepidemiology, Clinical Pharmacology Department, University of Toulouse, Toulouse, France
    Reg Anesth Pain Med 36:322-6. 2011
    ..The aim of this prospective multicenter study was to assess the incidence of spinal anesthesia failure, excluding technical problems, and then to suggest independent factors leading to failure...
  91. pmc Drug safety of rosiglitazone and pioglitazone in France: a study using the French PharmacoVigilance database
    Stéphanie Berthet
    Unité INSERM 1027, Equipe de Pharmacoépidémiologie, Universite de Toulouse, Toulouse, France
    BMC Clin Pharmacol 11:5. 2011
    ..The aim of our study was to investigate the profile of adverse drug reactions (ADRs) related to TZDs and to investigate potential risk factors of these ADRs...
  92. doi request reprint Sufentanil is not superior to morphine for the treatment of acute traumatic pain in an emergency setting: a randomized, double-blind, out-of-hospital trial
    Vincent Bounes
    Pôle de Médecine d Urgences, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Ann Emerg Med 56:509-16. 2010
    ..We determine the best intravenous opioid titration protocol by comparing morphine and sufentanil for adult patients with severe traumatic acute pain in an out-of-hospital setting, with a physician providing care...
  93. doi request reprint [National Campaign of Vaccination against the flu A (H1N1)v: National Follow-up of Pharmacovigilance]
    Genevieve Durrieu
    Universite de Toulouse, Faculte de Medecine, Centre Hospitalier Universitaire, Toulouse, France
    Therapie 66:527-40. 2011
    ..The present study was performed to evaluate safety data collected by the French Network of Pharmacovigilance centres network, from October 21, 2009 to June 15, 2010...
  94. ncbi request reprint Does memantine induce bradycardia? A study in the French PharmacoVigilance Database
    Adeline Gallini
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, Hopitaux de Toulouse, Toulouse, France
    Pharmacoepidemiol Drug Saf 17:877-81. 2008
    ..To review the cardiovascular adverse drug reactions (ADRs) with memantine reported to the French PharmacoVigilance Database...
  95. ncbi request reprint Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy
    Christine Brefel-Courbon
    Department of Pharmacology and Centre Midi Pyrenees de Pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculty of Medecine, University Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Ann Neurol 62:102-5. 2007
    ..Zolpidem induced a transient improvement in motor and cognitive performances. This paradoxical effect could result from an activation of limbic loops modulating motivational processes...
  96. ncbi request reprint Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography study
    Christine Brefel-Courbon
    Service de Pharmacologie Clinique, University Hospital, Toulouse, France
    Mov Disord 20:1557-63. 2005
    ..This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain-induced activation in nociceptive pathways, which can be reduced by levodopa...
  97. ncbi request reprint Adverse drug reactions to anthelmintics
    Haleh Bagheri
    Department of Pharmacology, Midi Pyrenees Center of Pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France
    Ann Pharmacother 38:383-8. 2004
    ..Anthelmintics are commonly used in tropical areas, but are also prescribed in Western countries with other climates. However, pharmacoepidemiologic studies of these drugs are rare...
  98. ncbi request reprint Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature
    Anne Roussin
    Service de Pharmacologie Clinique, Centre d Evaluation et d Information sur la Pharmacodépendance de Toulouse, EA 3696, Universite Paul Sabatier, Faculte de Medecine, 31000 Toulouse, France
    Fundam Clin Pharmacol 21:459-66. 2007
    ..The aim of this review was to provide an overview of molecular, animal and clinical pharmacological data of the literature evidencing the potential for abuse and dependence of propofol...
  99. doi request reprint [What illegal substances are used by sportsmen? a study in Midi-Pyrénées Doping Preventing Medical Centre (AMPD-MP)]
    Ana Senard-Ojero
    Antenne Médicale de Prévention du Dopage AMPD Midi Pyrénées, CHU de Toulouse, Toulouse, France
    Therapie 65:459-63. 2010
    ..The aim of the study was to analyze the characteristics of sportsmen outpatient clinics in Antenne Médicale de Prevention du Dopage Midi-Pyrénées (AMPD-MP)...
  100. ncbi request reprint Follow-up of adverse drug reactions from peginterferon alfa-2b-ribavirin therapy
    Haleh Bagheri
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Hopitaux de Toulouse, Toulouse, France
    Pharmacotherapy 24:1546-53. 2004
    ..To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV)...
  101. ncbi request reprint QT dynamicity: a prognostic factor for sudden cardiac death in chronic heart failure
    Atul Pathak
    Club d Etude du Système Nerveux Autonome et INSERM U586, Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, 37 allés Jules Guesde, 31073 Toulouse Cedex, France
    Eur J Heart Fail 7:269-75. 2005
    ..The aim of this study was to determine whether impaired adaptation of the QT interval to changes in heart rate predicts sudden death in patients with chronic heart failure (CHF)...