G Mithieux

Summary

Country: France

Publications

  1. ncbi request reprint Rat small intestine is an insulin-sensitive gluconeogenic organ
    M Croset
    , , Lyon, France
    Diabetes 50:740-6. 2001
  2. doi request reprint Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity
    F Delaere
    INSERM U855, Institut National de la Sante et de Recherche Medicale, Faculte de Medecine Laennec, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Diabetes Metab 36:257-62. 2010
  3. doi request reprint Brain, liver, intestine: a triumvirate to coordinate insulin sensitivity of endogenous glucose production
    G Mithieux
    Institut National de la Sante et de la Recherche Medicale, U855, Lyon, France
    Diabetes Metab 36:S50-3. 2010
  4. ncbi request reprint Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin
    Gilles Mithieux
    INSERM, Unit 449, Lyon F 69008, France
    Biochem Pharmacol 72:198-203. 2006
  5. ncbi request reprint A novel function of intestinal gluconeogenesis: central signaling in glucose and energy homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U 855, Lyon, France
    Nutrition 25:881-4. 2009
  6. doi request reprint Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U855, Universite de Lyon, Lyon, France
    Curr Opin Clin Nutr Metab Care 12:419-23. 2009
  7. doi request reprint [Intestinal metabolism and control of the appetite: from genes to diseases]
    G Mithieux
    INSERM U855, UCBL Lyon 1, Institut Fédératif de Recherche Lyon Est, Rue Guillaume Paradin, Lyon Cedex 08, France
    Ann Endocrinol (Paris) 69:112-5. 2008
  8. ncbi request reprint Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin
    Gilles Mithieux
    INSERM, Unit 449, Lyon F 69008, France
    Biochem Pharmacol 72:1757-62. 2006
  9. ncbi request reprint Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U449, Lyon, F 69372, France
    Cell Metab 2:321-9. 2005
  10. ncbi request reprint Contribution of intestine and kidney to glucose fluxes in different nutritional states in rat
    Gilles Mithieux
    INSERM, U449, Lyon, F 69372 France
    Comp Biochem Physiol B Biochem Mol Biol 143:195-200. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Rat small intestine is an insulin-sensitive gluconeogenic organ
    M Croset
    , , Lyon, France
    Diabetes 50:740-6. 2001
    ..These studies identify small intestine as a new insulin-sensitive tissue and a third gluconeogenic organ, possibly involved in the pathophysiology of diabetes...
  2. doi request reprint Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity
    F Delaere
    INSERM U855, Institut National de la Sante et de Recherche Medicale, Faculte de Medecine Laennec, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Diabetes Metab 36:257-62. 2010
    ..These data emphasize the importance of the gut-brain axis in the understanding and treatment of obesity and type 2 diabetes...
  3. doi request reprint Brain, liver, intestine: a triumvirate to coordinate insulin sensitivity of endogenous glucose production
    G Mithieux
    Institut National de la Sante et de la Recherche Medicale, U855, Lyon, France
    Diabetes Metab 36:S50-3. 2010
    ..This signal may modulate the sensation of hunger and satiety and insulin sensitivity of hepatic glucose fluxes as well, via the modulation of hypothalamic activity...
  4. ncbi request reprint Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin
    Gilles Mithieux
    INSERM, Unit 449, Lyon F 69008, France
    Biochem Pharmacol 72:198-203. 2006
    ....
  5. ncbi request reprint A novel function of intestinal gluconeogenesis: central signaling in glucose and energy homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U 855, Lyon, France
    Nutrition 25:881-4. 2009
    ..Because these beneficial effects may take place in the context of established physiopathology, they allow one to envision new strategies of prevention or treatment of obesity and type 2 diabetes in humans...
  6. doi request reprint Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U855, Universite de Lyon, Lyon, France
    Curr Opin Clin Nutr Metab Care 12:419-23. 2009
    ..It can also contribute to the control of glucose homeostasis via its high glycolytic capacity and a recently described function, gluconeogenesis...
  7. doi request reprint [Intestinal metabolism and control of the appetite: from genes to diseases]
    G Mithieux
    INSERM U855, UCBL Lyon 1, Institut Fédératif de Recherche Lyon Est, Rue Guillaume Paradin, Lyon Cedex 08, France
    Ann Endocrinol (Paris) 69:112-5. 2008
  8. ncbi request reprint Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin
    Gilles Mithieux
    INSERM, Unit 449, Lyon F 69008, France
    Biochem Pharmacol 72:1757-62. 2006
    ....
  9. ncbi request reprint Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U449, Lyon, F 69372, France
    Cell Metab 2:321-9. 2005
    ..All these effects are absent after denervation of the portal vein. Thus, portal sensing of intestinal gluconeogenesis may be a novel mechanism connecting the macronutrient composition of diet to food intake...
  10. ncbi request reprint Contribution of intestine and kidney to glucose fluxes in different nutritional states in rat
    Gilles Mithieux
    INSERM, U449, Lyon, F 69372 France
    Comp Biochem Physiol B Biochem Mol Biol 143:195-200. 2006
    ..These data emphasize the coordinate interactions among the three gluconeogenic organs in glucose homeostasis when nutritional conditions are changing...
  11. ncbi request reprint Influence of diabetes surgery on a gut-brain-liver axis regulating food intake and internal glucose production
    G Mithieux
    Institut National de la Santé et de la Recherche Médicale U855, Lyon, France
    Nutr Hosp 28:109-14. 2013
    ..Therefore, a synergy between incretin effects and intestinal gluconeogenesis might be a key feature explaining the rapid improvement of glucose control in obese diabetics after bypass surgery...
  12. ncbi request reprint New data and concepts on glutamine and glucose metabolism in the gut
    G Mithieux
    INSERM U 449, Faculté de Médecine R T H Laënnec, Rue Guillaume Paradin, F69372 Lyon Cédex 08, France
    Curr Opin Clin Nutr Metab Care 4:267-71. 2001
    ..These new data also emphasize the central role of alanine aminotransferase in the coupling of glutamine and glucose metabolisms in the small intestine...
  13. ncbi request reprint Glycogen storage disease type 1 and diabetes: learning by comparing and contrasting the two disorders
    F Rajas
    U855, Institut National de la Sante et de la Recherche Medicale, 69008 Lyon, France Université de Lyon, 69008 Lyon, France Université Lyon 1, 69622 Villeurbanne, France Electronic address
    Diabetes Metab 39:377-87. 2013
    ..Moreover, it may highlight similar therapeutic targets for the two disorders. Thus, this review suggests that the treatment of adult patients with either GSD1 or diabetes could be carried out by the same specialists-diabetologists. ..
  14. ncbi request reprint Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase
    G Mithieux
    Institut National de la Sante et de la Recherche Medicale, Unit 449, Faculty of Medicine R T H Laennec, 69372 Lyon Cedex 08, France
    J Biol Chem 273:17-9. 1998
    ..3 +/- 0.8, 11.1 +/- 0.5 and 8.9 +/- 0.4 microM for PI3,4,5P3, PI3,4P2, and PI4,5P2, respectively. This inhibition phenomenon might be of special importance with regards to the insulin's inhibition of hepatic glucose production...
  15. ncbi request reprint The liver glucose-6-phosphatase of intact microsomes is inhibited and displays sigmoid kinetics in the presence of alpha-ketoglutarate-magnesium and oxaloacetate-magnesium chelates
    G Mithieux
    Institut National de la Sante et de la Recherche Medicale, Unité 197, Faculte de Medecine Alexis Carrel, Lyon, France
    J Biol Chem 265:20364-8. 1990
    ..The disruption of microsomal integrity by detergents abolishes the effect of Mg.alpha-KG and Mg.OAA, suggesting that the magnesium chelates inhibit the translocase component of the glucose-6-phosphatase system...
  16. ncbi request reprint Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element
    J C Gevrey
    INSERM Unité 45, IFR 62, Faculté de médecine RTH Laennec, Lyon, France
    Diabetologia 47:926-36. 2004
    ..We aimed to investigate the molecular mechanisms involved in this nutrient- PG gene interaction...
  17. ncbi request reprint Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-sensitive manner
    C Ichai
    , , Grenoble 38041, France
    J Biol Chem 276:28126-33. 2001
    ....