Dorothée Missé


Country: France


  1. Wichit S, Hamel R, Zanzoni A, Diop F, Cribier A, Talignani L, et al. SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts. Int J Mol Sci. 2019;20: pubmed publisher
    ..Together, these results suggest that IFITs are involved in the restriction of replication of CHIKV and ZIKV and provide, as yet unreported, evidence for a proviral role of SAMHD1 in arbovirus infection of human skin cells. ..
  2. Surasombatpattana P, Ekchariyawat P, Hamel R, Patramool S, Thongrungkiat S, Denizot M, et al. Aedes aegypti saliva contains a prominent 34-kDa protein that strongly enhances dengue virus replication in human keratinocytes. J Invest Dermatol. 2014;134:281-284 pubmed publisher
  3. Thomas F, Doyon J, Elguero E, Dujardin J, Brodeur J, Roucher C, et al. Plasmodium infections and fluctuating asymmetry among children and teenagers from Senegal. Infect Genet Evol. 2015;32:97-101 pubmed publisher
    ..Depending on traits considered, associations were not significant, or (marginally) significant but not in the same directions. We discuss the possible reasons for the global weakness of the signals detected in this study. ..
  4. Ekchariyawat P, Hamel R, Bernard E, Wichit S, Surasombatpattana P, Talignani L, et al. Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts. Infect Genet Evol. 2015;32:401-8 pubmed publisher
    ..Together, these results indicate that the skin contributes to the pro-inflammatory and anti-viral microenvironment via the activation of the inflammasome in the early stages following infection with arboviruses. ..
  5. Hamel R, Liégeois F, Wichit S, Pompon J, Diop F, Talignani L, et al. Zika virus: epidemiology, clinical features and host-virus interactions. Microbes Infect. 2016;18:441-9 pubmed publisher
    ..This paper reviews information on the epidemiology and clinical features of Zika disease with a particular emphasis on the host-virus interactions that contribute to the pathogenicity of ZIKV in humans. ..
  6. Wichit S, Ferraris P, Choumet V, Missé D. The effects of mosquito saliva on dengue virus infectivity in humans. Curr Opin Virol. 2016;21:139-145 pubmed publisher
    ..Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors. ..
  7. Bourgarel M, Pfukenyi D, Boué V, Talignani L, Chiweshe N, Diop F, et al. Circulation of Alphacoronavirus, Betacoronavirus and Paramyxovirus in Hipposideros bat species in Zimbabwe. Infect Genet Evol. 2018;58:253-257 pubmed publisher
  8. Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol. 2015;89:8880-96 pubmed publisher
    ..Taken together, these results provide the first general insights into the interaction between ZIKV and its mammalian host. ..
  9. Hamel R, Ferraris P, Wichit S, Diop F, Talignani L, Pompon J, et al. African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes. Infect Genet Evol. 2017;49:134-137 pubmed publisher
    ..This study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system. ..

More Information


  1. Wichit S, Hamel R, Bernard E, Talignani L, Diop F, Ferraris P, et al. Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking. Sci Rep. 2017;7:3145 pubmed publisher
    ..Together, these data show that this compound is a potential drug candidate for anti-arboviral treatment. ..
  2. Le Coupanec A, Tchankouo Nguetcheu S, Roux P, Khun H, Huerre M, Morales Vargas R, et al. Co-Infection of Mosquitoes with Chikungunya and Dengue Viruses Reveals Modulation of the Replication of Both Viruses in Midguts and Salivary Glands of Aedes aegypti Mosquitoes. Int J Mol Sci. 2017;18: pubmed publisher
    ..aegypti. The outcome of these mixed infections must be further studied to increase our understanding of pathogen-pathogen interactions in host cells. ..
  3. Wichit S, Diop F, Hamel R, Talignani L, Ferraris P, Cornelie S, et al. Aedes Aegypti saliva enhances chikungunya virus replication in human skin fibroblasts via inhibition of the type I interferon signaling pathway. Infect Genet Evol. 2017;55:68-70 pubmed publisher
  4. Ryckebusch F, Berthet M, Missé D, Choumet V. Infection of a French Population of Aedes albopictus and of Aedes aegypti (Paea Strain) with Zika Virus Reveals Low Transmission Rates to These Vectors' Saliva. Int J Mol Sci. 2017;18: pubmed publisher
    ..albopictus. Although the salivary glands of both vectors are highly infected, transmission rates of ZIKV to saliva remain relatively low. These observations may suggest that the risk of emergence of ZIKV in Europe could be low. ..
  5. Pompon J, Morales Vargas R, Manuel M, Huat Tan C, Vial T, Hao Tan J, et al. A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia. Sci Rep. 2017;7:1215 pubmed publisher
    ..aegypti from 3 to 14 days post-infection than the Asian strain. Our data suggests that American strains are more efficiently transmitted than Asian strains, which raises concerns about the introduction of American strains in Asia. ..
  6. Jacqueline C, Tasiemski A, Sorci G, Ujvari B, Maachi F, Missé D, et al. Infections and cancer: the "fifty shades of immunity" hypothesis. BMC Cancer. 2017;17:257 pubmed publisher
    ..Infectious organisms, that are not oncogenic neither oncolytic, may play a significant role in carcinogenesis, suggesting the need to increase our knowledge about immune interactions between infections and cancer. ..
  7. Roche B, Hochberg M, Caulin A, Maley C, Gatenby R, Missé D, et al. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 2012;12:387 pubmed publisher
    ..This will provide important insights into mechanisms of cancer resistance. ..