P J Meunier

Summary

Country: France

Publications

  1. ncbi request reprint Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
    P J Meunier
    Department of Rheumatology and Bone Diseases, Pavillon F, Hopital Edouard Herriot, 69437, Lyon Cedex 3, France
    Osteoporos Int 14:S66-76. 2003
  2. ncbi request reprint Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial
    Guillaume Chevrel
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyon France
    J Bone Miner Res 21:300-6. 2006
  3. ncbi request reprint Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate
    Monique E Arlot
    INSERM, Universite Lyon 1, Lyon, France
    J Bone Miner Res 23:215-22. 2008
  4. ncbi request reprint Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake
    Pierre J Meunier
    Faculty of Medicine RTH, Laennec INSERM Unit 403, Rue G Paradin, 69372 Lyon Cedex 08, France
    Osteoporos Int 16:1203-9. 2005
  5. pmc Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis
    P J Meunier
    Faculty Laennec, Claude Bernard University, Rue G Paradin, 69437, Lyon Cedex 03, France
    Osteoporos Int 20:1663-73. 2009
  6. ncbi request reprint Which screening strategy using BMD measurements would be most cost effective for hip fracture prevention in elderly women? A decision analysis based on a Markov model
    A M Schott
    Epidemiology Unit, Département d information médicale des Hospices Civils de Lyon, 162 Avenue Lacassagne, 69424, Lyon Cedex 03, France
    Osteoporos Int 18:143-51. 2007
  7. ncbi request reprint Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study
    P Szulc
    INSERM 403 Research Unit, Hopital Edouard Herriot, Pavillon F Place d Arsonval, 69437, Lyon, France
    Osteoporos Int 17:231-6. 2006
  8. ncbi request reprint Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women
    G Boivin
    Institut National de la Santé et de la Recherche Médicale Unité 403, Faculté de Médecine R Laennec, 69372 Lyon Cedex 08, France
    J Clin Endocrinol Metab 88:4199-205. 2003
  9. ncbi request reprint Should age influence the choice of quantitative bone assessment technique in elderly women? The EPIDOS study
    A M Schott
    INSERM U 403, Hopital Edouard Herriot, 5 Place d Arsonval, Cedex 03, 69437, Lyon, France
    Osteoporos Int 15:196-203. 2004
  10. doi request reprint The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients
    G Boivin
    INSERM Unité 831, Universite de Lyon, Faculté de Médecine R Laennec, Lyon, France
    Bone 43:532-8. 2008

Detail Information

Publications36

  1. ncbi request reprint Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
    P J Meunier
    Department of Rheumatology and Bone Diseases, Pavillon F, Hopital Edouard Herriot, 69437, Lyon Cedex 3, France
    Osteoporos Int 14:S66-76. 2003
    ..Its aim is to demonstrate the effect of strontium ranelate on the axial and appendicular skeleton as well as its tolerability in osteoporotic patients with replete calcium and vitamin D stores...
  2. ncbi request reprint Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial
    Guillaume Chevrel
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyon France
    J Bone Miner Res 21:300-6. 2006
    ..The mean increases in the lumbar spine BMD were 10.1 +/- 9.8% (p < 0.001) and 0.7 +/- 5.7% in the alendronate and placebo groups, respectively. Oral alendronate increases BMD in adult patients with osteogenesis imperfecta...
  3. ncbi request reprint Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate
    Monique E Arlot
    INSERM, Universite Lyon 1, Lyon, France
    J Bone Miner Res 23:215-22. 2008
    ..Hence, these effects may explain the decreased fracture rate...
  4. ncbi request reprint Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake
    Pierre J Meunier
    Faculty of Medicine RTH, Laennec INSERM Unit 403, Rue G Paradin, 69372 Lyon Cedex 08, France
    Osteoporos Int 16:1203-9. 2005
    ..This could contribute to the repair of calcium deficiency and to the reduction of age-related bone loss in this population...
  5. pmc Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis
    P J Meunier
    Faculty Laennec, Claude Bernard University, Rue G Paradin, 69437, Lyon Cedex 03, France
    Osteoporos Int 20:1663-73. 2009
    ....
  6. ncbi request reprint Which screening strategy using BMD measurements would be most cost effective for hip fracture prevention in elderly women? A decision analysis based on a Markov model
    A M Schott
    Epidemiology Unit, Département d information médicale des Hospices Civils de Lyon, 162 Avenue Lacassagne, 69424, Lyon Cedex 03, France
    Osteoporos Int 18:143-51. 2007
    ....
  7. ncbi request reprint Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study
    P Szulc
    INSERM 403 Research Unit, Hopital Edouard Herriot, Pavillon F Place d Arsonval, 69437, Lyon, France
    Osteoporos Int 17:231-6. 2006
    ..Thus, the independent contribution of the external diameter of the femoral neck to the risk of hip fracture cannot be reliably estimated by this technique...
  8. ncbi request reprint Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women
    G Boivin
    Institut National de la Santé et de la Recherche Médicale Unité 403, Faculté de Médecine R Laennec, 69372 Lyon Cedex 08, France
    J Clin Endocrinol Metab 88:4199-205. 2003
    ..The profile of MDMB observed in biopsies after treatment with placebo and raloxifene, compared with baseline, closely resembles physiological premenopausal bone...
  9. ncbi request reprint Should age influence the choice of quantitative bone assessment technique in elderly women? The EPIDOS study
    A M Schott
    INSERM U 403, Hopital Edouard Herriot, 5 Place d Arsonval, Cedex 03, 69437, Lyon, France
    Osteoporos Int 15:196-203. 2004
    ..75 [0.73-0.76], BUA 0.67 [0.66-0.69], SOS 0.67 [0.65-0.69]). For patients older than 80, we did not observe significant differences in AUC between DXA and QUS to predict hip fracture...
  10. doi request reprint The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients
    G Boivin
    INSERM Unité 831, Universite de Lyon, Faculté de Médecine R Laennec, Lyon, France
    Bone 43:532-8. 2008
    ..Bone microhardness is linked to Young's modulus of bone and is strongly correlated to mineralization, but the organic matrix accounts for about one third of its variance...
  11. ncbi request reprint Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women
    G Y Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, Lyon, France
    Bone 27:687-94. 2000
    ..That these effects contribute to improved bone strength is demonstrated by the reduction in fracture incidence previously demonstrated in these patients...
  12. ncbi request reprint Osteogenesis imperfecta: lifelong management is imperative and feasible
    G Chevrel
    Service de Rhumatologie et de Pathologie Osseuse, H pital Edouard Herriot, Lyon, France
    Joint Bone Spine 68:125-9. 2001
    ..Other bisphosphonates are being evaluated, particularly in adults. Prevention of vitamin D and calcium deficiency is essential throughout life. Pain is common and should be given adequate attention...
  13. ncbi request reprint Intrinsic mechanical properties of trabecular calcaneus determined by finite-element models using 3D synchrotron microtomography
    H Follet
    Laboratoire de Mécanique des Contacts et des Solides LaMCoS UMR CNRS 5514, INSA, Bât Coulomb, Lyon, France
    J Biomech 40:2174-83. 2007
    ..Those results show the limitation of hexahedral finite elements at 40 microm, mostly used, for thin trabecular structures...
  14. doi request reprint In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization
    G Boivin
    INSERM Unité 831, Faculté de Médecine R Laennec, Universite de Lyon, Lyon, France
    Osteoporos Int 21:667-77. 2010
    ..Strontium was shown to be dose-dependently deposited into this newly formed bone with preservation of the mineralization...
  15. ncbi request reprint The mineralization of bone tissue: a forgotten dimension in osteoporosis research
    G Boivin
    Laboratoire d Histodynamique Osseuse, Faculté de Médecine R Laennec, 69372, Lyon Cedex 08, France
    Osteoporos Int 14:S19-24. 2003
    ..This emphasizes the value, as antiosteoporotic treatment, of SR, which is safe at the bone mineral level...
  16. ncbi request reprint Role of polyunsaturated fatty acids in the inhibitory effect of human adipocytes on osteoblastic proliferation
    A C Maurin
    Inserm Unite 403, Faculté de Médecine R T H Laënnec, Lyon, France
    Bone 31:260-6. 2002
    ..In vitro results indicate that mature adipocytes may contribute to age-related bone loss through the release of polyunsaturated fatty acids, which impair osteoblastic proliferation...
  17. ncbi request reprint Changes in bone remodeling rate influence the degree of mineralization of bone
    G Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, Hopital Edouard Herriot, Lyon, France
    Connect Tissue Res 43:535-7. 2002
    ..In contrast, an activation of bone remodeling as in primary hyperparathyroidism lowered the mean DMB...
  18. ncbi request reprint Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    Osteoporos Int 8:563-9. 1998
    ..If DXA is not available, the combination of history of fracture and urinary CTX performs as well as hip BMD to assess hip fracture risk in elderly women...
  19. ncbi request reprint Euler(strut.cavity), a new histomorphometric parameter of connectivity reflects bone strength and speed of sound in trabecular bone from human os calcis
    Nathalie R Portero-Muzy
    INSERM Unité 831, Faculte de Medecine Laennec, Universite de Lyon, 69372, Lyon Cedex 08, France
    Calcif Tissue Int 81:92-8. 2007
    ..cavity ) and TBPf contribute to bone strength, independently of the bone quantity. The bone mechanical properties may be assessed, in os calcis, in the elastic domain by SOS and in the plastic domain by BUA...
  20. ncbi request reprint Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters
    Monique Arlot
    Laboratoire d Histodynamique Osseuse and INSERM Unit 403, Faculty of Medicine R Laennec, Lyon, France
    J Bone Miner Res 20:1244-53. 2005
    ..Biopsies were obtained from 42 patients. Indices of bone formation were significantly higher after 6 or 18 months of teriparatide compared with alendronate treatment...
  21. ncbi request reprint Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women
    Georges Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, Université C Bernard Lyon 1, 69372 Lyon Cedex 08, France
    Bone 36:562-7. 2005
    ..However, this increase was about two-fold lower than that observed after alendronate therapy (10 mg/day/3 years) in postmenopausal osteoporotic women...
  22. doi request reprint Time sequence of secondary mineralization and microhardness in cortical and cancellous bone from ewes
    Yohann Bala
    INSERM Unité 831, Faculte de Medecine Laennec, 69372 Lyon Cedex 08, France
    Bone 46:1204-12. 2010
    ..Finally, secondary mineralization in BSUs is completed after a period of 30 months. This observation should be taken into account for understanding the effects of long-term treatments of bone diseases...
  23. ncbi request reprint [Comparison of early bone histomorphometric effects of parathormone and alendronate in osteoporotic women]
    Monique Arlot
    INSERM U 403, Laboratoire d histodynamique Faculté Laennec Rue Paradin F 69008 Lyon
    Rev Med Suisse Romande 124:91-2. 2004
    ..Theses effects are present at the sixth month...
  24. ncbi request reprint [New methods to measure bone quality]
    Jean Paul Roux
    INSERM U 403 Faculté de médecine Laennec Rue G Paradin, F 69372 Lyon
    Rev Med Suisse Romande 124:71-2. 2004
    ..These determinants are more or less linked to bone turnover, an absence or excessive one increasing bone fragility. Consequently, a minimum but not excessive level of bone turnover must be preserved in osteoporosis treatment...
  25. ncbi request reprint The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  26. ncbi request reprint Effect of cyclical intravenous pamidronate therapy in children with osteogenesis imperfecta. Open-label study in seven patients
    Francoise Giraud
    Rheumatology Department, Pavillon F, Hĵpital Edouard Heriot, Lyon Cedex 03, France
    Joint Bone Spine 69:486-90. 2002
    ..To evaluate the efficacy of pamidronate in protecting against fractures, increasing bone mineral density (BMD), and decreasing bone remodeling marker levels in children with osteogenesis imperFecta...
  27. ncbi request reprint The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography
    G Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, 69372 Lyon Cedex 08, France
    Calcif Tissue Int 70:503-11. 2002
    ..A control MDMB, which does not change with age, and a control distribution of these values are thus established. These control values are necessary for interpreting the changes in MDMB observed in bone conditions untreated or treated...
  28. ncbi request reprint Estimates of optimal vitamin D status
    Bess Dawson-Hughes
    Osteoporos Int 16:713-6. 2005
    ..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture...
  29. ncbi request reprint Intravenous zoledronic acid in postmenopausal women with low bone mineral density
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Engl J Med 346:653-61. 2002
    ..Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored...
  30. doi request reprint Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial
    Jean Yves Reginster
    University of Liege, Liege, Belgium
    Arthritis Rheum 58:1687-95. 2008
    ..This study was undertaken to assess the effect of strontium ranelate on nonvertebral and vertebral fractures in postmenopausal women with osteoporosis in a 5-year, double-blind, placebo-controlled trial...
  31. ncbi request reprint Methodological considerations in measurement of bone mineral content
    Georges Boivin
    Osteoporos Int 14:S22-7; discussion S27-8. 2003
  32. ncbi request reprint Evaluation and development of automatic two-dimensional measurements of histomorphometric parameters reflecting trabecular bone connectivity: correlations with dual-energy x-ray absorptiometry and quantitative ultrasound in human calcaneum
    Nathalie R Portero
    Inserm Unite 403, Faculté de Médecine R Laennec, Universite Claude Bernard, Lyon, France
    Calcif Tissue Int 77:195-204. 2005
    ..These new parameters were significantly correlated to the established trabecular structure parameters: trabecular thickness or trabecular spacing, being weakly correlated with SOS...
  33. ncbi request reprint Predictive value of BMD for hip and other fractures
    Olof Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    J Bone Miner Res 20:1185-94. 2005
    ..Low hip BMD was an important predictor of fracture risk. The prediction of hip fracture with hip BMD also depended on age and z score...
  34. ncbi request reprint [Strontium ranelate: new therapeutic agent for postmenopausal osteoporosis]
    Pierre J Meunier
    Med Sci (Paris) 20:631-3. 2004
  35. ncbi request reprint Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review
    Florent Richy
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
    Osteoporos Int 14:179-90. 2003
    ..These findings could have practical implication in the long-term management of asthmatic and COPD patients...
  36. ncbi request reprint Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention
    Hervé Lilliu
    CLP Santé, 9 11 rue du Mont Aigoual, F 75015 Paris, France
    Maturitas 44:299-305. 2003
    ..To assess the cost implications for a preventive treatment strategy for institutionalised elderly women with a combined 1200 mg/day calcium and 800 IU/day vitamin D(3) supplementation in seven European countries...