Philippe Metellus

Summary

Country: France

Publications

  1. doi request reprint [Place of surgery in brain metastases]
    Philippe Metellus
    AP HM, CHU Timone, Aix Marseille Universite, Departement de Neurochirurgie, Marseille, France
    Bull Cancer 100:51-6. 2013
  2. doi request reprint Molecular genetics of adult grade II gliomas: towards a comprehensive tumor classification system
    Dominique Figarella-Branger
    Service d anatomie pathologique et de neuropathologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, 13000, Marseille, France
    J Neurooncol 110:205-13. 2012
  3. ncbi request reprint Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Cancer 115:4783-94. 2009
  4. doi request reprint Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution
    Philippe Metellus
    Service de Neurochirurgie, Hopital de la Timone, Marseille, France
    Ann Surg Oncol 18:2937-45. 2011
  5. pmc Adult intracranial WHO grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Neuro Oncol 12:976-84. 2010
  6. doi request reprint [Management of brain metastases for lung cancer patients]
    Fabrice Barlesi
    Aix Marseille Universite, Assistance Publique Hopitaux de Marseille, Service d Oncologie Multidisciplinaire et Innovations Thérapeutiques, Hopital Nord, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Bull Cancer 100:303-8. 2013
  7. pmc Gene expression profiling of solitary fibrous tumors
    Francois Bertucci
    Département d Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille CRCM, Institut Paoli Calmettes IPC, UMR1068 Inserm, Marseille, France
    PLoS ONE 8:e64497. 2013
  8. doi request reprint Solitary fibrous tumors and hemangiopericytomas of the meninges: overlapping pathological features and common prognostic factors suggest the same spectrum of tumors
    Corinne Bouvier
    Department of Pathology and Neuropathology, Timone Hospital, Marseille, France
    Brain Pathol 22:511-21. 2012
  9. doi request reprint Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties
    Aurelie Tchoghandjian
    INSERM U911, Marseille, France
    Ann Surg Oncol 19:S608-19. 2012
  10. doi request reprint Supratentorial ependymomas: prognostic factors and outcome analysis in a retrospective series of 46 adult patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Cancer 113:175-85. 2008

Collaborators

Detail Information

Publications37

  1. doi request reprint [Place of surgery in brain metastases]
    Philippe Metellus
    AP HM, CHU Timone, Aix Marseille Universite, Departement de Neurochirurgie, Marseille, France
    Bull Cancer 100:51-6. 2013
    ..Surgical resection currently represents a valuable tool in the armamentarium of brain metastases but has also become a diagnostic and decision tool that can affect therapeutic strategies in these patients...
  2. doi request reprint Molecular genetics of adult grade II gliomas: towards a comprehensive tumor classification system
    Dominique Figarella-Branger
    Service d anatomie pathologique et de neuropathologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, 13000, Marseille, France
    J Neurooncol 110:205-13. 2012
    ..Moreover, immunohistochemical detection of p53, INA and mR132H IDH1 expression could represent an interesting prescreening test to be performed before 1p19q codeletion, IDH1 minor mutation and IDH2 mutation detection...
  3. ncbi request reprint Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Cancer 115:4783-94. 2009
    ..In this study, the authors evaluated the prognostic value of different biomarkers in recurrent GBM and analyzed the changes in MGMT status between primary tumors and recurrent tumors...
  4. doi request reprint Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution
    Philippe Metellus
    Service de Neurochirurgie, Hopital de la Timone, Marseille, France
    Ann Surg Oncol 18:2937-45. 2011
    ..To address this question we investigated the relationship between CD133 mRNA expression and patient outcome in a glioblastoma patient cohort...
  5. pmc Adult intracranial WHO grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Neuro Oncol 12:976-84. 2010
    ..Interestingly, tumor location also seems to have an actual impact on both OS and PFS. Finally, the prognostic impact of RT was found to be beneficial for incompletely resected tumors...
  6. doi request reprint [Management of brain metastases for lung cancer patients]
    Fabrice Barlesi
    Aix Marseille Universite, Assistance Publique Hopitaux de Marseille, Service d Oncologie Multidisciplinaire et Innovations Thérapeutiques, Hopital Nord, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Bull Cancer 100:303-8. 2013
    ..The management will depend on the circumstances of diagnosis (symptomatic or not), the cancer history (synchronous or metachronous brain metastases), the histology and the number of lesions...
  7. pmc Gene expression profiling of solitary fibrous tumors
    Francois Bertucci
    Département d Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille CRCM, Institut Paoli Calmettes IPC, UMR1068 Inserm, Marseille, France
    PLoS ONE 8:e64497. 2013
    ..They raise several clinical problems. Differential diagnosis may be difficult, prognosis is poorly apprehended by histoclinical features, and no effective therapy exists for advanced stages...
  8. doi request reprint Solitary fibrous tumors and hemangiopericytomas of the meninges: overlapping pathological features and common prognostic factors suggest the same spectrum of tumors
    Corinne Bouvier
    Department of Pathology and Neuropathology, Timone Hospital, Marseille, France
    Brain Pathol 22:511-21. 2012
    ..As extent of surgery was also a prognostic factor for both PFS and OS in univariate analysis, we propose that management of SFT/HPC might be based both on quality of removal and histological grade...
  9. doi request reprint Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties
    Aurelie Tchoghandjian
    INSERM U911, Marseille, France
    Ann Surg Oncol 19:S608-19. 2012
    ..These cells generate a specific tumor phenotype, but no link with tumor location or molecular characteristics has ever been made...
  10. doi request reprint Supratentorial ependymomas: prognostic factors and outcome analysis in a retrospective series of 46 adult patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Cancer 113:175-85. 2008
    ..The authors report a series of adult patients with supratentorial ependymomas to characterize the roles of surgery and histology in tumor control...
  11. ncbi request reprint Surgical resection of brain metastases from breast cancer in the modern era: clinical outcome and prognostic factors
    Emeline Tabouret
    Departements of Medical Oncology, Paoli Calmettes Institut, Marseille, France
    Anticancer Res 33:2159-67. 2013
    ..Aim: To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific population...
  12. doi request reprint Biodegradable carmustine wafers (Gliadel) alone or in combination with chemoradiotherapy: the French experience
    Philippe Menei
    Departement de Neurochirurgie, Inserm U646, CHU d Angers, Angers, France
    Ann Surg Oncol 17:1740-6. 2010
    ..Carmustine-releasing wafers (Gliadel have been available and reimbursed in France since 2005...
  13. pmc FDG-PET predicts survival in recurrent high-grade gliomas treated with bevacizumab and irinotecan
    Cecile Colavolpe
    Service Central de Biophysique et Médecine Nucléaire, Assistance Publique des Hopitaux de Marseille, CHU Timone, Aix Marseille University, Marseille, France
    Neuro Oncol 14:649-57. 2012
    ..This study provides the first evidence that pretreatment FDG-PET can serve as an imaging biomarker in recurrent HGG for predicting survival following anti-angiogenic therapy with bevacizumab...
  14. pmc Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines
    Marie Claude Amoureux
    Université de la Méditerranée CNRS UMR6216, Institut de Biologie du Developpement de Marseille Luminy, Marseille, France
    BMC Cancer 10:91. 2010
    ..Here, we studied its expression in GBM and evaluated its prognosis value for overall survival (OS) and disease free survival (DFS)...
  15. ncbi request reprint Meningeal Rosai-Dorfman disease mimicking meningioma
    Fabien Forest
    Department of Pathology and Neuropathology, Timone Hospital, 264 rue Saint Pierre, 18285 CEDEX 5, Marseille, France
    Ann Hematol 93:937-40. 2014
    ....
  16. pmc Assessment of prognostic scores in brain metastases from breast cancer
    Emeline Tabouret
    APHM, Timone Hospital, Departement of Neuro Oncology, Marseille, France E T L institut Paoli Calmettes, Department of Medical Oncology, Marseille, France E T, A G APHM, Timone Hospital, Department of Neurosurgery, Marseille, France P M L institut Paoli Calmettes, Department of Biostatistics, Marseille, France B E UMR911, CRO2, Aix Marseille Universite, Marseille, France P M L institut Paoli Calmettes, Department of Anatomic Pathology, Marseille, France E C J L institut Paoli Calmettes, Department of Radiotherapy, Marseille, France A T
    Neuro Oncol 16:421-8. 2014
    ..We evaluated the prognostic value and validity of the 6 proposed scoring systems in an independent population of BC patients with BM...
  17. doi request reprint Comprehensive genome characterization of solitary fibrous tumors using high-resolution array-based comparative genomic hybridization
    Francois Bertucci
    Département d Oncologie Moléculaire, Institut Paoli Calmettes, CRCM, UMR1068 Inserm, Marseille, France
    Genes Chromosomes Cancer 52:156-64. 2013
    ..A total of 425 genes without CNV showed copy number transition in at least one sample, but only but only 1 in at least 10% of samples. The genomic profiles of meningeal and extra-meningeal cases did not show any differences...
  18. doi request reprint Cervicosternotomy as an anterior approach to the upper thoracic and cervicothoracic spinal junction
    Stephane Fuentes
    Department of Neurosurgery, Centre Hospitalier Regional Universitaire, Timone, Marseille, France
    J Neurosurg Spine 12:160-4. 2010
    ..When operating on this specific area (for tumor or trauma), the aim is generally to decompress and stabilize the spine. The authors describe an improved median sternotomy method for reaching the anterior aspect of the spine down to T-5...
  19. pmc Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma
    Emeline Tabouret
    Aix Marseille Universite, Inserm CRO2, Marseille, France E T, F B, D F B, L O, O C Assistance Publique Hôpitaux de Marseille AP HM, CHU Timone, Service de Neuro Oncologie, Marseille, France E T, M B, M M, C B Aix Marseille Université, Public Health Research Unit EA3279 AP HM, Marseille, France A L Assistance Publique Hôpitaux de Paris AP HP, Hopital Avicenne, Service de Neurologie, Bobigny, France A C Université Paris Descartes, Laboratoire de Recherches Biochirurgicales, Hopital Europeen Georges Pompidou, Paris, France A C INSERM U 975, CNRS UMR 7225, Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moëlle épinière UMR S975, Paris, France M S AP HP, Service Neurologie 2, Groupe Hospitalier Pitie Salpetriere, Paris, France M S AP HM, CHU Timone, Service de Neurochirurgie
    Neuro Oncol 16:392-9. 2014
    ..We evaluated the predictive value of selected circulating prebiomarkers involved in neoangiogenesis and invasion on patient outcome in recurrent high-grade glioma treated with bevacizumab...
  20. doi request reprint Multidisciplinary management of giant functional petrous bone paraganglioma
    Thomas Graillon
    Department of Neurosurgery, Hopital La Timone, 264 rue Saint Pierre 13385 Marseille cedex 05, Marseille, France
    Acta Neurochir (Wien) 153:85-9; discussion 89. 2011
    ..Tumour residue was treated by gamma knife radiosurgery, without additional growth at the last follow-up. This case illustrates the interest of multidisciplinary management of giant skull base paragangliomas...
  21. doi request reprint Systems for long-segment percutaneous spinal fixation: technical feasibility for various indications
    Benjamin Blondel
    Universite de la Mediterranee, Service d Orthopedie, CHU Nord, Marseille, France
    Acta Neurochir (Wien) 153:985-91. 2011
    ..New methods of spinal percutaneous fixation are developing very rapidly. However, few studies to date have focused on long-segment methods of instrumentation...
  22. doi request reprint Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis
    Philippe Metellus
    Assistance Publique Hopitaux de Marseille, Hopital de la Timone, Marseille, France
    Acta Neuropathol 120:719-29. 2010
    ..These findings could significantly modify the LGG classification and may represent a new tool to guide patient-tailored therapy...
  23. ncbi request reprint 18F-DOPA, a clinically available PET tracer to study brain inflammation?
    Quentin Sala
    From the APHM, Hopital de la Timone, Service Central de Biophysique et Médecine Nucléaire, Marseille Aix Marseille Univ, CERIMED, Marseille APHM, Hopital de la Timone, Service de Neurochirurgie, Marseille APHM, Hopital de la Timone, Service de Neurologie, Marseille APHM, Hopital de la Timone, Service d anatomie pathologique et neuropathologie, Marseille and Aix Marseille Univ, CNRS, UMR7289, INT, Marseille, France
    Clin Nucl Med 39:e283-5. 2014
    ..This report suggests it may serve to study brain inflammation...
  24. ncbi request reprint Prospective controlled trial of gamma knife surgery for essential trigeminal neuralgia
    Jean Regis
    Departments of Functional Neurosurgery and Neurology, Timone University Hospital, Marseille, France
    J Neurosurg 104:913-24. 2006
    ..Stereotactic radiosurgery is an alternative to conventional surgery for the treatment of trigeminal neuralgia. The authors conducted a prospective evaluation of the safety and efficacy of this method in a large series of patients...
  25. ncbi request reprint Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide
    Olivier L Chinot
    Unité de Neuro Oncologie, Service de Neurochirurgie, Centre Hospitalier Universitaire Timone, Assistance Publique Hopitaux de Marseille, and Université de la Méditerranée, Faculte de Medecine de Marseille, Marseille, France
    J Clin Oncol 25:1470-5. 2007
    ..This phase II study evaluated the efficacy and safety of a 7-day on/7-day off regimen of temozolomide before radiotherapy (RT) in patients with inoperable newly diagnosed glioblastoma...
  26. ncbi request reprint Multicentric French study on adult intracranial ependymomas: prognostic factors analysis and therapeutic considerations from a cohort of 152 patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Brain 130:1338-49. 2007
    ..The role of adjuvant radiotherapy for patients with incompletely resected low-grade ependymomas seems to be beneficial but remains to be addressed for high-grade tumours...
  27. ncbi request reprint Successful treatment of a giant isolated cerebral mucormycotic (zygomycotic) abscess using endoscopic debridement: case report and therapeutic considerations
    Philippe Metellus
    Départamentes de Neurochirurgie, Hopital Timone, Marseille, France
    Surg Neurol 69:510-5; discussion 515. 2008
    ..Cerebral mucormycosis without rhino-orbital or systemic involvement is an extremely rare condition mostly associated with parenteral drug abuse...
  28. doi request reprint High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas
    Carole Colin
    INSERM U911, Centre de Recherche en Oncologie et Oncopharmacologie CRO2, Angiogenèse, Invasivité et Microenvironnement Tumoral, Faculte de Medecine Timone, 27, Bd Jean Moulin, 13005, Marseille, France
    Acta Neuropathol 118:745-54. 2009
    ..These results suggest that cathepsin B and PAI-1 are important biomarkers for the stratification of glioblastoma patients with respect to survival...
  29. ncbi request reprint Recent trends in epidemiology of brain metastases: an overview
    Emeline Tabouret
    AP HM, Timone Hospital, Departement of Neuro oncology and Neuro surgery, Marseille, France
    Anticancer Res 32:4655-62. 2012
    ..The recent emergence of targeted therapies and growing knowledge regarding the specific biology of BM should allow further improvements in prognosis of this devastating disease...
  30. ncbi request reprint Patients with brain metastases from colorectal cancer are not condemned
    Diane Mege
    Department of Digestive and Oncological Surgery, Timone Hospital, Aix Marseille University, Marseille, France
    Anticancer Res 33:5645-8. 2013
    ..They usually occur in advanced stages of the disease and their prognosis is poor. The aim of this study was to assess the impact of surgical resection of BMs from colorectal cancer in terms of overall survival...
  31. doi request reprint Linezolid for treatment of subdural empyema due to Streptococcus: case reports
    Laurent Lefebvre
    Department of Anesthesiology and Intensive Care, CHU Timone, Universite de la Mediterranee, Marseille, France
    Surg Neurol 71:89-91; discussion 91. 2009
    ..Recurring subdural empyema despite adequate surgical drainage and antibiotic treatment is still a life-threatening disease. This is mainly due to poor diffusion of the antibiotic into the subdural space...
  32. ncbi request reprint Use of a self-expanding stent with balloon angioplasty in the treatment of dural arteriovenous fistulas involving the transverse and/or sigmoid sinus: functional and neuroimaging-based outcome in 10 patients
    Olivier Levrier
    Department of Neuroradiology, Timone Hospital, University of Aix Marseille II, Marseille, France
    J Neurosurg 104:254-63. 2006
    ..The goal of this study was to evaluate the clinical and angiography results in 10 patients with transverse-sigmoid dural arteriovenous fistulas (DAVFs) treated using sinus angioplasty and dural sinus stent insertion...
  33. ncbi request reprint Correlations between MR and endothelial hyperplasia in low-grade gliomas
    Virginie Callot
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Faculte de Medecine de Marseille, Universite de la Mediterranee, Marseille, France
    J Magn Reson Imaging 26:52-60. 2007
    ....
  34. doi request reprint Single anterior procedure for stabilization of a three-part fracture of the axis (odontoid dens and hangman fracture): case report
    Benjamin Blondel
    Department of Neurosurgery, CHU Timone, Marseille, France
    Spine (Phila Pa 1976) 34:E255-7. 2009
    ..A case of a 3-part fracture of the axis combining an odontoid dens and a hangman fracture is reported...
  35. pmc Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment
    Agnès V Tallet
    Department of Radiation Oncology, Institut Paoli Calmettes, Marseille, France
    Radiat Oncol 7:77. 2012
    ....
  36. doi request reprint Functional cerebral venous outflow in swine and baboon: feasibility of an intracranial venous hypertension model
    Pascale Lavoie
    L2PTV Laboratoire de Physiopathologie et de Therapeutique Vasculaire, Faculté de médecine AIX Marseille, Marseille, France
    J Invest Surg 21:323-9. 2008
    ..To evaluate the feasibility of performing a functional cerebral venous outflow blockage in two large animals species, the swine and the baboon, for elaboration of venous hypertension models...
  37. ncbi request reprint Brainstem metastases: management using gamma knife radiosurgery
    Stephane Fuentes
    Neurosurgical Service, Timone University Hospital Center, Marseille, France
    Neurosurgery 58:37-42; discussion 37-42. 2006
    ..Surgical risks are high and standard radiation or chemotherapy have little effect. The purpose of this study is to evaluate our experience using Gamma Knife radiosurgery (GKRS) for the management of brainstem metastasis...