Otto Wilhelm Merten

Summary

Country: France

Publications

  1. ncbi Current issues in adeno-associated viral vector production
    O-W Merten
    Genethon, 1 bis, rue de l'Internationale, Evry, France
    Gene Ther 12:S51-61. 2005
  2. ncbi Comparison of different bioreactor systems for the production of high titer retroviral vectors
    O W Merten
    Genethon III, CNRS URA 1923, 1, rue de l Internationale, F 91002 Evry, France
    Biotechnol Prog 17:326-35. 2001
  3. ncbi Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application
    Otto Wilhelm Merten
    Genethon, F 91002 Evry, France
    Hum Gene Ther 22:343-56. 2011
  4. ncbi Virus contaminations of cell cultures - A biotechnological view
    O W Merten
    Genethon III, Evry Cedex, France E mail
    Cytotechnology 39:91-116. 2002
  5. ncbi Development of serum-free media for cell growth and production of viruses/viral vaccines--safety issues of animal products used in serum-free media
    O W Merten
    Genethon III, Evry, France
    Dev Biol (Basel) 111:233-57. 2002
  6. ncbi State-of-the-art of the production of retroviral vectors
    O W Merten
    Genethon, 1bis rue de l Internationale, BP 60, F 91002 Evry Cedex, France
    J Gene Med 6:S105-24. 2004
  7. ncbi Host cells and cell banking
    Glyn N Stacey
    Genethon, Evry, France
    Methods Mol Biol 737:45-88. 2011
  8. ncbi Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases
    Lionel Galibert
    Genethon, Laboratory for Applied Vectorology and Innovation, 1 rue de l Internationale, BP60, F 91002 Evry Cedex 2, France
    J Invertebr Pathol 107:S80-93. 2011
  9. ncbi Adeno-associated viruses
    Mauro Mezzina
    Genethon, Evry, France
    Methods Mol Biol 737:211-34. 2011
  10. ncbi Quantitative proteomic analysis of lentiviral vectors using 2-DE
    Jérome Denard
    Genethon, 91002 Evry, France
    Proteomics 9:3666-76. 2009

Collaborators

Detail Information

Publications14

  1. ncbi Current issues in adeno-associated viral vector production
    O-W Merten
    Genethon, 1 bis, rue de l'Internationale, Evry, France
    Gene Ther 12:S51-61. 2005
    ....
  2. ncbi Comparison of different bioreactor systems for the production of high titer retroviral vectors
    O W Merten
    Genethon III, CNRS URA 1923, 1, rue de l Internationale, F 91002 Evry, France
    Biotechnol Prog 17:326-35. 2001
    ....
  3. ncbi Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application
    Otto Wilhelm Merten
    Genethon, F 91002 Evry, France
    Hum Gene Ther 22:343-56. 2011
    ..Results obtained with the WAS vector provide the initial manufacturing and quality control benchmarking that should be helpful to further development and clinical applications...
  4. ncbi Virus contaminations of cell cultures - A biotechnological view
    O W Merten
    Genethon III, Evry Cedex, France E mail
    Cytotechnology 39:91-116. 2002
    ..In addition, ways to prevent viral contaminations as well as measures undertaken to avoid and assess risks for viral contaminations as performed in the biotech industry are briefly described...
  5. ncbi Development of serum-free media for cell growth and production of viruses/viral vaccines--safety issues of animal products used in serum-free media
    O W Merten
    Genethon III, Evry, France
    Dev Biol (Basel) 111:233-57. 2002
    ....
  6. ncbi State-of-the-art of the production of retroviral vectors
    O W Merten
    Genethon, 1bis rue de l Internationale, BP 60, F 91002 Evry Cedex, France
    J Gene Med 6:S105-24. 2004
    ..The overall optimization of the cultivation and production parameters will have a significant impact on the use of retroviral vectors for gene therapy purposes...
  7. ncbi Host cells and cell banking
    Glyn N Stacey
    Genethon, Evry, France
    Methods Mol Biol 737:45-88. 2011
    ....
  8. ncbi Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases
    Lionel Galibert
    Genethon, Laboratory for Applied Vectorology and Innovation, 1 rue de l Internationale, BP60, F 91002 Evry Cedex 2, France
    J Invertebr Pathol 107:S80-93. 2011
    ....
  9. ncbi Adeno-associated viruses
    Mauro Mezzina
    Genethon, Evry, France
    Methods Mol Biol 737:211-34. 2011
    ..In Chapter 10, the reader will find a large-scale production method based on the use of the insect cell/baculovirus system...
  10. ncbi Quantitative proteomic analysis of lentiviral vectors using 2-DE
    Jérome Denard
    Genethon, 91002 Evry, France
    Proteomics 9:3666-76. 2009
    ..This study defines for the first time, the protein stoichiometry of infectious HIV-1-derived LV particles...
  11. ncbi Large-scale production means for the manufacturing of lentiviral vectors
    M Schweizer
    Paul Ehrlich Institut, Division of Medical Biotechnology, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
    Curr Gene Ther 10:474-86. 2010
    ..Published large scale production and purification processes of lentiviral vectors and their process performances are compared...
  12. ncbi Retrovirus producer cell line metabolism: implications on viral productivity
    A S Coroadinha
    IBET/ITQB, Apartado 12, Oeiras 2781-901, Portugal
    Appl Microbiol Biotechnol 72:1125-35. 2006
    ..The synthesis of fatty acids and phospholipids were enhanced in the fructose or mixed media and are possibly key parameters in retroviral vector production...
  13. ncbi Effect of medium sugar source on the production of retroviral vectors for gene therapy
    A S Coroadinha
    IBET/ITQB, Apartado 12, P-2781-901 Oeiras, Portugal
    Biotechnol Bioeng 94:24-36. 2006
    ..This resulted in a product quality with a superior ratio of infectious to total particles, thus reducing the most problematic contaminant in the production of retroviral vectors, non-infectious retroviral particles...
  14. ncbi Relationship between retroviral vector membrane and vector stability
    M Carmo
    IBET/ITQB, Oeiras, Portugal
    J Gen Virol 87:1349-56. 2006
    ....