Jean Philippe Merlio

Summary

Country: France

Publications

  1. pmc Expression of neurotrophins and their receptors in human bone marrow
    E Labouyrie
    Laboratoire d Histologie Embryologie, Universite Victor Segalen, Bordeaux, France
    Am J Pathol 154:405-15. 1999
  2. ncbi request reprint A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas
    Marc Antoine Belaud-Rotureau
    Department of Histology and Molecular Pathology, Victor Segalen University, Bordeaux, France
    Mod Pathol 15:517-25. 2002
  3. ncbi request reprint Chromosomal imbalances: a hallmark of tumour relapse in primary cutaneous CD30+ T-cell lymphoma
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory, EA2406, V Segalen University, Bordeaux, France
    J Pathol 201:421-9. 2003
  4. doi request reprint CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma
    Elodie Laharanne
    EA 2406 Histology and Molecular Pathology, University of Bordeaux, Bordeaux, France
    Mod Pathol 23:547-58. 2010
  5. ncbi request reprint Large cell transformation of mycosis fungoides: tetraploidization within skin tumor large cells
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory EA 2406, Victor Segalen University, 33076 Bordeaux, France
    Cancer Genet Cytogenet 163:1-6. 2005
  6. ncbi request reprint Common chromosomal abnormalities in mycosis fungoides transformation
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory EA2406, Victor Segalen University, Bordeaux, France
    Genes Chromosomes Cancer 46:828-38. 2007
  7. ncbi request reprint Neoplastic cells do not carry bcl2-JH rearrangements detected in a subset of primary cutaneous follicle center B-cell lymphomas
    Beatrice Vergier
    Equipe Histologie et Pathologie Moléculaire, Universite Victor Segalen, Bordeaux, France
    Am J Surg Pathol 28:748-55. 2004
  8. doi request reprint Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes
    Elodie Laharanne
    Histology and Molecular Pathology EA 2406, University Bordeaux 2, 146 rue Leo Saignat, Bordeaux, France
    J Invest Dermatol 130:1707-18. 2010
  9. doi request reprint IRF4 gene rearrangements define a subgroup of CD30-positive cutaneous T-cell lymphoma: a study of 54 cases
    Anne Pham-Ledard
    Department of Histology and Molecular Pathology of Tumors, University Bordeaux 2, and Department of Dermatology, Hôpital Saint André, Bordeaux, France
    J Invest Dermatol 130:816-25. 2010
  10. doi request reprint Inactivation of p16INK4a/CDKN2A gene may be a diagnostic feature of large B cell lymphoma leg type among cutaneous B cell lymphomas
    Marc Antoine Belaud-Rotureau
    EA 2406 Histologie et Pathologie Moléculaire des Tumeurs, Universite Victor Segalen, Batiment 3B, 2eme etage, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Virchows Arch 452:607-20. 2008

Collaborators

Detail Information

Publications25

  1. pmc Expression of neurotrophins and their receptors in human bone marrow
    E Labouyrie
    Laboratoire d Histologie Embryologie, Universite Victor Segalen, Bordeaux, France
    Am J Pathol 154:405-15. 1999
    ..The local expression of neurotrophin genes suggests a wide range of paracrine and/or autocrine mode of action through their corresponding receptors within the bone marrow...
  2. ncbi request reprint A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas
    Marc Antoine Belaud-Rotureau
    Department of Histology and Molecular Pathology, Victor Segalen University, Bordeaux, France
    Mod Pathol 15:517-25. 2002
    ..It may also provide some informations on secondary cytogenetic changes of potential clinical relevance...
  3. ncbi request reprint Chromosomal imbalances: a hallmark of tumour relapse in primary cutaneous CD30+ T-cell lymphoma
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory, EA2406, V Segalen University, Bordeaux, France
    J Pathol 201:421-9. 2003
    ..Although further studies are required to strengthen these data, this CGH analysis demonstrates chromosomal imbalances that may be involved in the pathogenesis of relapsing CD30+ CTCL...
  4. doi request reprint CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma
    Elodie Laharanne
    EA 2406 Histology and Molecular Pathology, University of Bordeaux, Bordeaux, France
    Mod Pathol 23:547-58. 2010
    ....
  5. ncbi request reprint Large cell transformation of mycosis fungoides: tetraploidization within skin tumor large cells
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory EA 2406, Victor Segalen University, 33076 Bordeaux, France
    Cancer Genet Cytogenet 163:1-6. 2005
    ..Accordingly, additional parallel blood and skin tumor cytogenetic studies are required to further identify the recurrent cytogenetic changes associated with the aggressiveness of the disease after large cell transformation...
  6. ncbi request reprint Common chromosomal abnormalities in mycosis fungoides transformation
    Martina Prochazkova
    Histology and Molecular Pathology Laboratory EA2406, Victor Segalen University, Bordeaux, France
    Genes Chromosomes Cancer 46:828-38. 2007
    ..78) to hypotetraploid (3.69) (mean 3.14+/-0.38). Thus, T-MF displayed frequent chromosomal imbalances associated with hypotetraploidy...
  7. ncbi request reprint Neoplastic cells do not carry bcl2-JH rearrangements detected in a subset of primary cutaneous follicle center B-cell lymphomas
    Beatrice Vergier
    Equipe Histologie et Pathologie Moléculaire, Universite Victor Segalen, Bordeaux, France
    Am J Surg Pathol 28:748-55. 2004
    ..Our study also underlines the diagnostic value of interphase fluorescence in situ hybridization to discriminate between t(14;18)-negative PCFL and extracutaneous FL involving the skin...
  8. doi request reprint Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes
    Elodie Laharanne
    Histology and Molecular Pathology EA 2406, University Bordeaux 2, 146 rue Leo Saignat, Bordeaux, France
    J Invest Dermatol 130:1707-18. 2010
    ..Finally, different samples in the same patient clustered together, showing reproducibility of such a classifier...
  9. doi request reprint IRF4 gene rearrangements define a subgroup of CD30-positive cutaneous T-cell lymphoma: a study of 54 cases
    Anne Pham-Ledard
    Department of Histology and Molecular Pathology of Tumors, University Bordeaux 2, and Department of Dermatology, Hôpital Saint André, Bordeaux, France
    J Invest Dermatol 130:816-25. 2010
    ..Investigation of the biological pathways triggered by IRF4 rearrangements and/or expression in CTCL will provide a biological basis for IRF4-directed therapy...
  10. doi request reprint Inactivation of p16INK4a/CDKN2A gene may be a diagnostic feature of large B cell lymphoma leg type among cutaneous B cell lymphomas
    Marc Antoine Belaud-Rotureau
    EA 2406 Histologie et Pathologie Moléculaire des Tumeurs, Universite Victor Segalen, Batiment 3B, 2eme etage, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Virchows Arch 452:607-20. 2008
    ..The diagnostic and prognostic impact of the p16(INK4a)CDKN2A gene status in PCBCL should therefore be confirmed on a larger series...
  11. pmc Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing
    Lucile Boursault
    Department of Dermatology, CHU Bordeaux, Bordeaux, France
    PLoS ONE 8:e70826. 2013
    ..This study also provides evidence that IHC may be a cost-effective first-line method for BRAF(V600E) detection. Thereafter, molecular techniques should be used in negative, ambiguous or non-contributive cases. ..
  12. ncbi request reprint Automatized assessment of 1p36-19q13 status in gliomas by interphase FISH assay on touch imprints of frozen tumours
    Marc Antoine Belaud-Rotureau
    EA 2406 Histology and Molecular Pathology of Tumours, Victor Segalen University, 146 rue Leo Saignat, 33076, Bordeaux, Cedex, France
    Acta Neuropathol 111:255-63. 2006
    ..The recently developed probes together with automatic counting may facilitate multicentric evaluation and standardization of 1p-19q assessment in gliomas...
  13. doi request reprint Primary cutaneous T-cell lymphomas do not show specific NAV3 gene deletion or translocation
    Marion Marty
    Histology and Molecular Pathology Laboratory, University Bordeaux, Bordeaux, France
    J Invest Dermatol 128:2458-66. 2008
    ..No NAV3 specific breakpoint or partial deletion was detected...
  14. ncbi request reprint Multiple genetic alterations in primary cutaneous large B-cell lymphoma, leg type support a common lymphomagenesis with activated B-cell-like diffuse large B-cell lymphoma
    Anne Pham-Ledard
    1 EA2406 Histology and Molecular Pathology of Tumors, University of Bordeaux, Bordeaux, France 2 Dermatology Department, CHU Bordeaux, Bordeaux, France
    Mod Pathol 27:402-11. 2014
    ..Our data support the use of therapies targeting NF-κB, as most patients displayed disease progression and resistance to conventional therapies. ..
  15. ncbi request reprint Bone marrow histopathologic and molecular staging in epidermotropic T-cell lymphomas
    Vincent Sibaud
    Oncodermatology Unit, Dermatology Department, Saint André University Hospital of Bordeaux, Bordeaux, France
    Am J Clin Pathol 119:414-23. 2003
    ..No further prognostic value was observed for the presence of a T-cell clone in bone marrow specimens. Our data do not support the need for bone marrow examination in patients with mycosis fungoides/Sézary syndrome...
  16. pmc Reduced placental telomere length during pregnancies complicated by intrauterine growth restriction
    Jerome Toutain
    EA 2406 Histologie et Pathologie Moléculaire des Tumeurs, Université Bordeaux Segalen, Bordeaux, France
    PLoS ONE 8:e54013. 2013
    ..Placental telomere length measurement during ongoing pregnancies complicated by intrauterine growth restriction has never been reported. This was the main objective of our study...
  17. doi request reprint Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases
    Beatrice Vergier
    Département de Pathologie et Biologie des Tumeurs, CHU Bordeaux Université Victor Segalen Bordeaux 2, Hopital Haut Leveque, CHU Pessac Bordeaux, Avenue de Magellan, Bordeaux, France
    Mod Pathol 24:613-23. 2011
    ..A positive FISH test reinforces the diagnosis of melanoma, allowing such tumors (particularly thick tumors) to be managed as melanomas...
  18. ncbi request reprint Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death
    Sandrine Eimer
    Histology and Molecular Pathology of Tumors Laboratory, Victor Segalen University, Bordeaux, France
    Cancer Biol Ther 11:1017-27. 2011
    ..These results confirm that glioblastoma cell lines exhibit several anti-apoptotic mechanisms, and underline that EGFR targeted therapy must be associated to other inhibitors to achieve an antitumoral effect...
  19. ncbi request reprint Primary Lung Small B-Cell Lymphoma versus Lymphoid Hyperplasia: Evaluation of Diagnostic Criteria in 26 Cases
    Hugues Begueret
    Department of Pathology and Molecular Biology, Universite de Bordeaux, Bordeaux, France
    Am J Surg Pathol 26:76-81. 2002
    ..4% of the mucosa-associated lymphoid tissue-type lymphoma specimens. Investigation of H. pylori by polymerase chain reaction detection was negative, even for the two cases associated with H. pylori gastritis...
  20. ncbi request reprint The relative levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism
    Nathalie Carrere
    Haematologica 90:854-6. 2005
    ..No correlation was observed between expression of cyclin D1 isoforms and CCND1 genotype at position 870...
  21. ncbi request reprint Interphase fluorescence in situ hybridization is more sensitive than BIOMED-2 polymerase chain reaction protocol in detecting IGH-BCL2 rearrangement in both fixed and frozen lymph node with follicular lymphoma
    Marc Antoine Belaud-Rotureau
    Pathology Laboratory, CHU Bordeaux, 33604 Pessac, France
    Hum Pathol 38:365-72. 2007
    ..Whether such IGH-BCL2-negative cases are characterized by alternative oncogenetic pathways remains to be determined...
  22. doi request reprint Mucosal intraepithelial T-lymphocytes in refractory celiac disease: a neoplastic population with a variable CD8 phenotype
    Antoine de Mascarel
    Department of Pathology, CHU de Bordeaux, Hopital Haut Leveque, 33604 Pessac EA2406 Histology and Pathology, University of Bordeaux 2, 33076 Bordeaux, France
    Am J Surg Pathol 32:744-51. 2008
    ..However, cases with a normal CD3 CD8 IEL phenotype may correspond to RCD. In such cases, we suggest that molecular analysis of TCR-gamma genes is a useful method for identifying cases with RCD...
  23. ncbi request reprint A suggested protocol for obtaining high-quality skin metaphases from primary cutaneous T-cell lymphoma
    Edith Chevret
    Cancer Genet Cytogenet 167:89-91. 2006
  24. doi request reprint [Composite lymphoma: association of a follicular lymphoma and a chronic lymphocytic leukemia]
    Florian Rabiller
    Service d anatomie et cytopathologie, département de pathologie et biologie moléculaire, Hopital du Haut leveque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France
    Ann Pathol 28:41-4. 2008
    ..Routinely, CL must not be misdiagnosed because of its prognosis and treatment implication...
  25. ncbi request reprint Clinical, histological and molecular follow-up of 60 patients with gastric marginal zone lymphoma of mucosa-associated lymphoid tissue
    Antoine de Mascarel
    Department of Pathology, University Victor Segalen Bordeaux 2, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Virchows Arch 446:219-24. 2005
    ..The presence of monoclonal B cells at both infiltrated and normal sites may therefore identify patients with a longer delay to achieve complete response, suggesting that molecular dissemination may require therapeutic intensification...