Research Topics
| Karin L MeibomSummaryCountry: France Publications
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Publications
The Vibrio cholerae chitin utilization programKarin L Meibom
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 101:2524-9. 2004..Collectively, these results provide a global portrait of a complex, multistage V. cholerae program for the efficient utilization of chitin...
Chitin induces natural competence in Vibrio choleraeKarin L Meibom
Division of Infectious Diseases and Geographic Medicine, Department of Microbiology and Immunology, and Stanford Institute for the Environment, Stanford University, Stanford, CA 94305, USA
Science 310:1824-7. 2005....
The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected miceKarin L Meibom
Universite Paris Descartes, Faculté de Médecine René Descartes, Paris F 75015, France
Mol Microbiol 67:1384-401. 2008..The crucial role of ClpB for in vivo persistence of Francisella may be linked to its assumed function in reactivation of aggregated proteins under in vivo stress conditions...
Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensisKhaled Alkhuder
Universite Paris Descartes, France
PLoS Pathog 5:e1000284. 2009..Thus, the capacity this intracellular bacterial pathogen has evolved to utilize the available GSH, as a source of cysteine in the host cytosol, constitutes a paradigm of bacteria-host adaptation...
Identification of trkH, encoding a potassium uptake protein required for Francisella tularensis systemic dissemination in miceKhaled Alkhuder
Universite Paris Descartes, Faculte de Medecine Necker Enfants Malades, Paris, France
PLoS ONE 5:e8966. 2010..tularensis infectious cycle. More generally, potassium could constitute an important mineral nutrient involved in other diseases linked to systemic dissemination of bacterial pathogens...
Pivotal role of the Francisella tularensis heat-shock sigma factor RpoHNathalie Grall
Universite Paris Descartes, Faculte de Medecine Necker Enfants Malades, F 75015 Paris, France
Microbiology 155:2560-72. 2009..Our results suggest that RpoH is an essential protein of F. tularensis, and positively regulates a subset of genes involved in the heat-shock response...
Loops and networks in control of Francisella tularensis virulenceKarin L Meibom
INSERM U570, Universite Paris Descartes, Faculte de Medecine Necker Enfants Malades, 75730, Paris Cedex 15, France
Future Microbiol 4:713-29. 2009..The unraveling secrets of the regulatory cascades governing the regulation of virulence of F. tularensis will be discussed along with future challenges yet to be solved...
Identification of a novel small RNA modulating Francisella tularensis pathogenicityGuillaume Postic
INSERM U1002, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
PLoS ONE 7:e41999. 2012..We further show that gene FTL_1293 is not required for F. tularensis virulence in vitro or in vivo, which indicates that another unidentified FtrC target modulates the virulence capacity of the bacterium...
Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicityCatherine Raynaud
Universite Paris Descartes, Faculté de Médecine René Descartes, Paris F 75015, France
Infect Immun 75:536-41. 2007..Notably, this mutant afforded protection against a challenge against virulent LVS...
The unraveling panoply of Francisella tularensis virulence attributesKarin L Meibom
Universite Paris Descartes, Faculte de Medecine Necker Enfants Malades, Paris, France
Curr Opin Microbiol 13:11-7. 2010..In this review, we will try to provide a comprehensive overview of the bacterial attributes, currently known-or suspected-to participate in F. tularensis virulence and will highlight the future challenges in F. tularensis research...
