Bruno Megarbane

Summary

Country: France

Publications

  1. ncbi request reprint Does high-dose buprenorphine cause respiratory depression?: possible mechanisms and therapeutic consequences
    Bruno Megarbane
    INSERM U705, CNRS, UMR 7157, Universite Paris 7, Universite Paris 5, Hopital Fernand Widal, Paris, France
    Toxicol Rev 25:79-85. 2006
  2. doi request reprint Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats
    Lucie Chevillard
    Universite Paris Descartes, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, CNRS, UMR7157, 75010 Paris, France
    Toxicol Lett 191:327-40. 2009
  3. doi request reprint The large spectrum of pulmonary complications following illicit drug use: features and mechanisms
    Bruno Megarbane
    Department of Medical and Toxicological Critical Care, Lariboisiere Hospital, Paris Diderot University, Paris, France INSERM U1144, Paris Descartes University, Variability of the response to psychotropic drugs, Paris, France Electronic address
    Chem Biol Interact 206:444-51. 2013
  4. ncbi request reprint [Lactic acidosis and multi-organ failure secondary to anti-retroviral therapy in HIV-infected patients]
    B Megarbane
    Service de Réanimation médicale et des Urgences médicales, Hopital Antoine Beclere, Clamart
    Presse Med 28:2257-64. 1999
  5. ncbi request reprint Cerebral and plasma kinetics of a high dose of midazolam and correlations with its respiratory effects in rats
    Bruno Megarbane
    INSERM U705, CNRS, UMR 7157 Université Paris VII, Hopital Fernand Widal, Paris, France
    Toxicol Lett 159:22-31. 2005
  6. ncbi request reprint Flunitrazepam does not alter cerebral distribution of buprenorphine in the rat
    Bruno Megarbane
    INSERM U26, Universite Paris VII, Hopital Fernand Widal, Réanimation Médicale et Toxicologique INSERM U26, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Toxicol Lett 157:211-9. 2005
  7. ncbi request reprint [Acute hydroxychloroquine poisoning. The danger of rapid or excessive correction of initial hypokalemia]
    Bruno Megarbane
    Service de réanimation médicale et toxicologique, Hopital Lariboisiere, Paris
    Presse Med 34:933-4. 2005
  8. ncbi request reprint Buprenorphine is protective against the depressive effects of norbuprenorphine on ventilation
    Bruno Megarbane
    INSERM U705, CNRS UMR 7157, Universite Paris VII, Hopital Fernand Widal, Paris, France
    Toxicol Appl Pharmacol 212:256-67. 2006
  9. doi request reprint Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationships
    Bruno Megarbane
    Medical and Toxicological Critical Care Department Paris Diderot University, Lariboisiere Hospital, Paris, France
    Clin Toxicol (Phila) 48:904-15. 2010
  10. doi request reprint Early laryngeal injury and complications because of endotracheal intubation in acutely poisoned patients: a prospective observational study
    Bruno Megarbane
    Department of Toxicological and Medical Critical Care, Lariboisiere Hospital, Paris Diderot University, France
    Clin Toxicol (Phila) 48:331-6. 2010

Detail Information

Publications66

  1. ncbi request reprint Does high-dose buprenorphine cause respiratory depression?: possible mechanisms and therapeutic consequences
    Bruno Megarbane
    INSERM U705, CNRS, UMR 7157, Universite Paris 7, Universite Paris 5, Hopital Fernand Widal, Paris, France
    Toxicol Rev 25:79-85. 2006
    ....
  2. doi request reprint Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats
    Lucie Chevillard
    Universite Paris Descartes, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, CNRS, UMR7157, 75010 Paris, France
    Toxicol Lett 191:327-40. 2009
    ..Methadone and fentanyl induced hypoxemia, hypercapnia, and T(E) increases, morphine caused both hypoxemia and hypercapnia while buprenorphine caused only hypoxemia...
  3. doi request reprint The large spectrum of pulmonary complications following illicit drug use: features and mechanisms
    Bruno Megarbane
    Department of Medical and Toxicological Critical Care, Lariboisiere Hospital, Paris Diderot University, Paris, France INSERM U1144, Paris Descartes University, Variability of the response to psychotropic drugs, Paris, France Electronic address
    Chem Biol Interact 206:444-51. 2013
    ..A better understanding of their spectrum and the implicated mechanisms of injury should help to improve patient management. ..
  4. ncbi request reprint [Lactic acidosis and multi-organ failure secondary to anti-retroviral therapy in HIV-infected patients]
    B Megarbane
    Service de Réanimation médicale et des Urgences médicales, Hopital Antoine Beclere, Clamart
    Presse Med 28:2257-64. 1999
    ..A SERIOUS COMPLICATION: Antiretroviral therapy may induce severe lactic acidosis with multiorgan failure in HIV-infected patients...
  5. ncbi request reprint Cerebral and plasma kinetics of a high dose of midazolam and correlations with its respiratory effects in rats
    Bruno Megarbane
    INSERM U705, CNRS, UMR 7157 Université Paris VII, Hopital Fernand Widal, Paris, France
    Toxicol Lett 159:22-31. 2005
    ..This study may contribute to better understanding of benzodiazepine-induced respiratory depression in poisonings...
  6. ncbi request reprint Flunitrazepam does not alter cerebral distribution of buprenorphine in the rat
    Bruno Megarbane
    INSERM U26, Universite Paris VII, Hopital Fernand Widal, Réanimation Médicale et Toxicologique INSERM U26, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Toxicol Lett 157:211-9. 2005
    ..The adverse interaction between flunitrazepam and buprenorphine cannot be explained by a pharmacokinetic drug-drug interaction during the distribution phase of buprenorphine...
  7. ncbi request reprint [Acute hydroxychloroquine poisoning. The danger of rapid or excessive correction of initial hypokalemia]
    Bruno Megarbane
    Service de réanimation médicale et toxicologique, Hopital Lariboisiere, Paris
    Presse Med 34:933-4. 2005
    ..Correction of hypokalemia can expose patients to the risk of ventricular arrhythmia...
  8. ncbi request reprint Buprenorphine is protective against the depressive effects of norbuprenorphine on ventilation
    Bruno Megarbane
    INSERM U705, CNRS UMR 7157, Universite Paris VII, Hopital Fernand Widal, Paris, France
    Toxicol Appl Pharmacol 212:256-67. 2006
    ..However, buprenorphine protective effect calls into question the role for norbuprenorphine in respiratory toxicity associated with buprenorphine use...
  9. doi request reprint Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationships
    Bruno Megarbane
    Medical and Toxicological Critical Care Department Paris Diderot University, Lariboisiere Hospital, Paris, France
    Clin Toxicol (Phila) 48:904-15. 2010
    ..We investigated the hypothesis that blood chloroquine concentrations better predicted chloroquine poisoning severity than plasma concentrations...
  10. doi request reprint Early laryngeal injury and complications because of endotracheal intubation in acutely poisoned patients: a prospective observational study
    Bruno Megarbane
    Department of Toxicological and Medical Critical Care, Lariboisiere Hospital, Paris Diderot University, France
    Clin Toxicol (Phila) 48:331-6. 2010
    ..Although considered as a safe procedure, intubation may rapidly damage laryngeal mucosa. The incidence and nature of short-duration intubation-associated laryngeal injuries are unknown in the population of poisoned patients...
  11. pmc Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships
    Bruno Megarbane
    INSERM U705, CNRS, UMR 7157, Universite Paris 7, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Réanimation Médicale et Toxicologique, Paris, France
    Crit Care 11:R5. 2007
    ..The aim of this study was to describe the relationships between methadone-related respiratory effects and their corresponding concentrations...
  12. doi request reprint Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Universite Paris Diderot, Paris, France
    J Subst Abuse Treat 38:403-7. 2010
    ..Although mental status and respiratory depression are often unresponsive to low-dose naloxone, flumazenil may be effective in buprenorphine overdoses involving benzodiazepines...
  13. ncbi request reprint Acute lower limb ischemia is a frequent complication of severe diabetic hyperosmolarity
    B Megarbane
    Service de réanimation médicale et toxicologique, APHP, Hopital Lariboisiere, Universite Paris VII, 2 rue Ambroise Pare, 75010 Paris, France
    Diabetes Metab 33:148-52. 2007
    ..To describe the outcome of intensive care unit (ICU) patients admitted with a hyperglycaemic hyperosmolar non-ketotic syndrome (HHNS), with a specific analysis of precipitating conditions and complications including lower limb ischemia...
  14. ncbi request reprint Pharmacokinetic/pharmacodynamic modeling of cardiac toxicity in human acute overdoses: utility and limitations
    Bruno Megarbane
    Hopital Lariboisiere, Réanimation Médicale et Toxicologique, 2 rue Ambroise Pare, 75010, Paris, France
    Expert Opin Drug Metab Toxicol 4:569-79. 2008
    ..Pharmacokinetic/pharmacodynamic (PK/PD) relationships are useful to assess diagnosis, prognosis, and treatment efficacy in acute poisonings...
  15. ncbi request reprint The role of insulin and glucose (hyperinsulinaemia/euglycaemia) therapy in acute calcium channel antagonist and beta-blocker poisoning
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Hôpital Lariboisière Université Paris 7, Paris, France
    Toxicol Rev 23:215-22. 2004
    ..There is a need for large prospective clinical trials to confirm safety and efficacy of hyperinsulinaemia/euglycaemia therapy in both CCA and beta-blocker poisoning...
  16. pmc Difficulties in assessing cytomegalovirus-associated gastric perforation in an HIV-infected patient
    Bruno Megarbane
    Medical and Toxicological Intensive Care Unit, Lariboisiere Hospital, Paris, France
    BMC Infect Dis 5:28. 2005
    ..CMV-induced intestinal perforations are hard to diagnose and may be observed throughout the gastrointestinal tract. Isolated stomach perforation is exceptional...
  17. ncbi request reprint Acute pancreatitis caused by severe Legionella pneumophila infection
    B Megarbane
    Dept of Medical Intensive Care, Antoine Beclere Hospital, Clamart, France
    Infection 28:329-31. 2000
    ..We discuss the possible mechanisms of L. pneumophila associated acute pancreatitis for which the pathophysiology is still undetermined: infection, toxin release or cytokine secretion...
  18. ncbi request reprint Hypothermia with indoor occurrence is associated with a worse outcome
    B Megarbane
    Department of Medical Intensive Care Unit and Medical Emergency, Antoine Beclere Hospital, Clamart, France
    Intensive Care Med 26:1843-9. 2000
    ..To describe patients admitted to intensive care unit (ICU) for hypothermia, evaluate prognostic factors, and test the hypothesis that patients found indoors have a worse outcome...
  19. ncbi request reprint Treatment of acute methanol poisoning with fomepizole
    B Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Universite Paris VII, 2, rue Ambroise Pare, 75475 Paris Cedex 10, France
    Intensive Care Med 27:1370-8. 2001
    ..To assess the efficacy and safety of fomepizole, a competitive alcohol dehydrogenase inhibitor, in methanol poisoning and to test the hypothesis that fomepizole obviates the need for hemodialysis in selected patients...
  20. ncbi request reprint Treatment of a 1,4-butanediol poisoning with fomepizole
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Universite Paris VII, INSERM U26, Hopital Laribosiere, France
    J Toxicol Clin Toxicol 40:77-80. 2002
    ..Toxicity of 1,4-butanediol, an industrial solvent and a substance of abuse, is still misunderstood and not well documented. To date, only supportive treatments are used in this poisoning...
  21. doi request reprint Usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest with extracorporeal life support
    Bruno Megarbane
    Assistance Publique Hopitaux de Paris, Lariboisiere Hospital, Medical and Toxicological Critical Care Department, Paris Diderot University, 75010 Paris, France
    Resuscitation 82:1154-61. 2011
    ..To evaluate the usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest patients with extracorporeal life support (ECLS)...
  22. ncbi request reprint Antidotal treatment of cyanide poisoning
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Universite Paris VII, INSERM U26, Hospital Lariboisiere, Paris, France
    J Chin Med Assoc 66:193-203. 2003
    ..In massive cyanide poisoning, due to the limited potency of hydroxocobalamin, continuous infusion of sodium thiosulfate should be associated...
  23. doi request reprint Usefulness of the serum lactate concentration for predicting mortality in acute beta-blocker poisoning
    Bruno Megarbane
    Medical and Toxicological Critical Care Department, Lariboisiere Hospital, Paris Diderot University, 75010, Paris, France
    Clin Toxicol (Phila) 48:974-8. 2010
    ..0 mmol/L. However, lactate's role has never been specifically studied in beta-blocker poisonings...
  24. ncbi request reprint [Descriptive study of the patients admitted to an intensive care unit during the heat wave of August 2003 in France]
    B Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Paris
    Presse Med 32:1690-8. 2003
    ..Several thousands of deaths were attributed to heat stroke during August 2003 in France. To date, only a very few studies have analyzed the prognosis in the intensive care unit (ICU) of the most severely hyperthermic patients...
  25. ncbi request reprint [Interactions between benzodiazepines and opioids]
    Bruno Megarbane
    Service de Réanimation Médicale et Toxicologique et INSERM U26 Université Paris VII, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris
    Ann Med Interne (Paris) 154:S64-72. 2003
    ..A better understanding of the exact mechanisms implicated in these interactions would increase the safety of prescription of these drugs...
  26. ncbi request reprint Increased diffusion of soluble adhesion molecules in meningitis, severe sepsis and systemic inflammatory response without neurological infection is associated with intrathecal shedding in cases of meningitis
    Bruno Megarbane
    Department of Medical Intensive Care Unit and Medical Emergency, AP HP Antoine Béclère Hospital, Clamart, France
    Intensive Care Med 30:867-74. 2004
    ....
  27. ncbi request reprint [Surgery to save body-packers]
    B Megarbane
    Service de réanimation médicale et toxicologique, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, France
    Ann Fr Anesth Reanim 23:495-8. 2004
    ..Adrenaline and labetalol-combined therapy as well as gastric incision to recover the bullets were needed to allow cardiovascular stabilization. In these three cases, the surgical treatment allowed patient survival...
  28. ncbi request reprint Current recommendations for treatment of severe toxic alcohol poisonings
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, 2 rue Ambroise Pare, 5010 Paris, France
    Intensive Care Med 31:189-95. 2005
    ..S. trials definitively established its efficacy. Fomepizole appears safer than ethanol and while no comparative study of efficacy exists, fomepizole is recommended as the first-line antidote...
  29. ncbi request reprint A possible hypophosphatemia-induced, life-threatening encephalopathy in diabetic ketoacidosis: a case report
    Bruno Megarbane
    Medical Critical Care Department, Lariboisiere Hospital, Paris, France
    Am J Med Sci 333:384-6. 2007
    ..Our data strongly suggest that phosphate depletion-induced encephalopathy probably originates from direct impairment of cerebral electrophysiological activity rather than from cardiac flow alteration...
  30. doi request reprint Role of cardiac troponin in the diagnosis of acute myocardial infarction in comatose patients resuscitated from out-of-hospital cardiac arrest
    Sébastian Voicu
    Cardiology Department, Lariboisiere Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Resuscitation 83:452-8. 2012
    ..Troponin is a major diagnostic criterion of acute myocardial infarction (AMI) but in out-of-hospital cardiac arrest (OHCA) patients, its diagnostic value may be altered by cardiopulmonary resuscitation...
  31. doi request reprint Effects of various combinations of benzodiazepines with buprenorphine on arterial blood gases in rats
    Stephane O Pirnay
    INSERM U705, CNRS UMR 7157, Paris Diderot and Paris Descartes University, Paris, France
    Basic Clin Pharmacol Toxicol 103:228-39. 2008
    ..Our results may suggest that effects of these combinations are rather mild. Respiratory failure may, however, result from the association of buprenorphine with elevated doses of benzodiazepines...
  32. ncbi request reprint Dexamethasone hepatic induction in rats subsequently treated with high dose buprenorphine does not lead to respiratory depression
    Raymond Hreiche
    INSERM U705, CNRS UMR 7157, Universite Paris 7, Universite Paris 5, Hopital Fernand Widal, 75010 Paris, France
    Toxicol Appl Pharmacol 217:352-62. 2006
    ..Our results suggest a limited role of drug-mediated CYP3A induction in the occurrence of buprenorphine-attributed respiratory depression in addicts...
  33. doi request reprint Buprenorphine alters desmethylflunitrazepam disposition and flunitrazepam toxicity in rats
    Stephane Pirnay
    INSERM U705, CNRS, UMR7157, Universite Paris Descartes, Paris F 75018, France
    Toxicol Sci 106:64-73. 2008
    ..We conclude that combined high-dosage BUP and FZ is responsible for increased respiratory toxicity in which BUP-mediated alteration in DMFZ disposition may play a significant role...
  34. doi request reprint Mechanisms of respiratory insufficiency induced by methadone overdose in rats
    Lucie Chevillard
    Universite Paris Descartes, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, CNRS, UMR 7157, Paris, France
    Addict Biol 15:62-80. 2010
    ..83 microg/ml). Methadone-induced hypoxemia is caused by mu-ORs and modulated by kappa-ORs. Additionally, methadone-induced increase in T(E) is caused by mu1- and delta-opioid receptors while increase in T(I) is caused by mu-ORs...
  35. ncbi request reprint Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest
    Bruno Megarbane
    Lariboisiere Hospital, Assistance Publique Hopitaux de Paris, Medical and Toxicological Critical Care Department, University of Paris 7, 2 rue Ambroise Pare, 75010, Paris, France
    Intensive Care Med 33:758-64. 2007
    ..To report the feasibility, complications, and outcomes of emergency extracorporeal life support (ECLS) in refractory cardiac arrests in medical intensive care unit (ICU)...
  36. ncbi request reprint [Acute poisoning: general management and main causes]
    Bruno Megarbane
    Service réanimation médicale et toxicologique, Hopital Lariboisiere, 75010 Paris
    Rev Prat 56:1603-13. 2006
  37. ncbi request reprint Toxic doses of paraoxon alter the respiratory pattern without causing respiratory failure in rats
    Antoine F Villa
    INSERM U705, CNRS UMR 7157, Universite Paris 5, Hopital Fernand Widal, 75010 Paris, France
    Toxicology 232:37-49. 2007
    ..Atropine completely reversed the paraoxon-induced respiratory alterations. We conclude that paraoxon, at doses equal to 50 and 75% of the LD(50), alters ventilation at rest without inducing respiratory failure during the study period...
  38. doi request reprint Respiratory effects of diazepam/methadone combination in rats: a study based on concentration/effect relationships
    Lucie Chevillard
    INSERM U705, CNRS UMR8206, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, Paris, France
    Drug Alcohol Depend 131:298-307. 2013
    ..However, the exact contribution of benzodiazepines to methadone-induced respiratory toxicity remains debatable...
  39. doi request reprint Gender and strain contributions to the variability of buprenorphine-related respiratory toxicity in mice
    Hisham Alhaddad
    INSERM U705, CNRS UMR8206, Neuropsychopharmacologie des Addictions, Faculte des Sciences Pharmaceutiques et Biologiques, Paris, France
    Toxicology 305:99-108. 2013
    ..Both gender- and strain-related differences in respiratory effects of BUP could be attributed to BUP itself rather than to its metabolite, NBUP...
  40. doi request reprint Postintensive care unit psychological burden in patients with chronic obstructive pulmonary disease and informal caregivers: A multicenter study
    Sandra De Miranda
    AP HP, Hopital Saint Louis, Medical ICU and Biostatistics Department, Paris, France
    Crit Care Med 39:112-8. 2011
    ....
  41. ncbi request reprint Extracorporeal life support in a case of acute carbamazepine poisoning with life-threatening refractory myocardial failure
    Bruno Megarbane
    AP HP, Hopital Lariboisiere, Réanimation Médicale et Toxicologique, INSERM U705, CNRS, UMR 7157, Universite Paris VII, 2 rue Ambroise Pare, 75010 Paris, France
    Intensive Care Med 32:1409-13. 2006
    ..To report the efficacy of extracorporeal life support (ECLS) in acute carbamazepine poisoning with sustained refractory myocardial failure and a high degree of conductance disturbances...
  42. ncbi request reprint Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning
    Frederic J Baud
    Réanimation Médicale et Toxicologique and Inserm U26, Universite Paris 7, France
    Crit Care Med 30:2044-50. 2002
    ....
  43. doi request reprint Poisoning-related bowel infarction: characteristics and outcomes
    Jean Charles Nault
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Réanimation Médicale et Toxicologique, Universite Paris Diderot, Paris, France
    Clin Toxicol (Phila) 47:412-8. 2009
    ..Bowel infarction (BI) is a rare complication of poisoning. We aimed to describe the characteristics of BI in poisoned patients compared to nonpoisoned patients...
  44. doi request reprint Value of post-resuscitation electrocardiogram in the diagnosis of acute myocardial infarction in out-of-hospital cardiac arrest patients
    Georgios Sideris
    Cardiology Department, Assistance Publique Hopitaux de Paris, Lariboisiere Hospital, Paris, France
    Resuscitation 82:1148-53. 2011
    ..However, the value of acute post-resuscitation electrocardiographic (ECG) data for the detection of AMI is debatable...
  45. doi request reprint Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice
    Wasseem Mohammed
    Neuropsychopharmacologie des Addictions, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    Toxicol Lett 217:251-9. 2013
    ..The difference in morphine-induced AC activation between the brainstem and the PAG contributes to the observed difference in tolerance between both morphine effects...
  46. doi request reprint Predictors of mortality in verapamil overdose: usefulness of serum verapamil concentrations
    Bruno Megarbane
    Medical and Toxicological Critical Care Department, Lariboisiere Hospital, Paris Diderot University, France
    Basic Clin Pharmacol Toxicol 108:385-9. 2011
    ..In conclusion, cardiovascular monitoring and assessment of organ failure are vital in symptomatic verapamil poisonings. The serum verapamil concentration has excellent prognostic ability for predicting fatality in verapamil overdose...
  47. doi request reprint Important questions asked by family members of intensive care unit patients
    Vincent Peigne
    AP HP, Hopital Saint Louis, Medical ICU, Paris, France
    Crit Care Med 39:1365-71. 2011
    ..We aimed to develop a list of questions important for relatives of patients in the intensive care unit...
  48. doi request reprint Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)
    Nicolas Tournier
    Unité INSERM U705, CNRS, UMR 7157, Universite Paris Descartes, France
    Int J Neuropsychopharmacol 13:905-15. 2010
    ..BCRP did not transport any of the tested compounds. However, the clinical significance of the interaction of norbuprenorphine with P-gp remains to be evaluated...
  49. ncbi request reprint Is elevated plasma lactate a useful marker in the evaluation of pure carbon monoxide poisoning?
    M Lamine Benaissa
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Université Paris VII INSERM U26, 2 rue Ambroise Pare, 5010, Paris, France
    Intensive Care Med 29:1372-5. 2003
    ..To examine whether CO poisoning induces a significant increase in plasma lactate concentration...
  50. doi request reprint Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice
    Hisham Alhaddad
    INSERM U705, CNRS UMR8206, Universite Paris Descartes, Universite Paris Diderot, Sorbonne Paris Cité, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, Paris, France
    Crit Care Med 40:3215-23. 2012
    ..Our objectives were to assess P-glycoprotein involvement in norbuprenorphine transport in vivo and study its role in the modulation of buprenorphine-related respiratory effects in mice...
  51. doi request reprint Serum sodium abnormalities during nonexertional heatstroke: incidence and prognostic values
    Pierre Hausfater
    Emergency Department, Centre Hospitalo Universitaire Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, and UPMC Univ Paris 06 France
    Am J Emerg Med 30:741-8. 2012
    ..Although heatstroke is often associated with dehydration, the clinical significance of serum sodium abnormalities in patients with heat-related illness during heat wave has been poorly documented...
  52. doi request reprint Blood cocaine and metabolite pharmacokinetics after cardiac arrest in a body-packer case
    Nicolas de Prost
    Service de Pneumologie et Reanimation, Hotel Dieu, Assistance Publique Hôpitaux de Paris and Université Paris Descartes, Paris, France
    Hum Exp Toxicol 29:49-53. 2010
    ..No data is currently available on the pharmacokinetics of cocaine and its metabolites when a packet rupture occurs in a body packer...
  53. pmc Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles
    Bruno Megarbane
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Réanimation Médicale et Toxicologique, INSERM U705, CNRS, UMR 7157, Universite Paris 7, 2 rue Ambroise Pare, 75010, Paris, France
    Crit Care 11:R115. 2007
    ..We therefore conducted this study to investigate prognostic factors in insulin poisoning, in relation to the value of plasma insulin concentration...
  54. doi request reprint Mechanisms of high-dose citalopram-induced death in a rat model
    Sébastien Beaune
    INSERM U705, CNRS UMR8206, Neuropsychopharmacologie des Addictions, Faculte des Sciences, Pharmaceutiques et Biologiques, Paris, France
    Toxicology 302:248-54. 2012
    ..Our observations support the role of serotonin-induced neurotoxicity in citalopram overdose and suggest that cyproheptadine and benzodiazepines, but not beta-blockers, may have a role in the management of citalopram toxicity...
  55. pmc A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype
    Didier Payen
    Department of Anesthesiology and Critical Care, Lariboisiere Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 7:e35838. 2012
    ..To investigate the association between severity of acute kidney injury (AKI) and outcome, systemic inflammatory phenotype and HLA genotype in severe sepsis...
  56. doi request reprint Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: a case report
    Alexis Soummer
    Department of Anesthesiology and Critical Care, Multidisciplinary Intensive Care Unit, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, UPMC University Pierre et Marie Curie, Paris 6, France
    Clin Toxicol (Phila) 49:124-7. 2011
    ..Organophosphate poisoning by oral or inhalation routes is characterized by a typical time-course of clinical features...
  57. pmc Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity
    Frederic J Baud
    Medical and Toxicological Intensive Care Unit, Assistance Publique Hopitaux de Paris, University Paris 7, Hopital Lariboisiere, 75010 Paris, France
    Crit Care 11:207. 2007
    ..These prognostic factors are specific for a toxicant or a class of toxicants. Knowledge of them will result in clarification of the indications for cardiopulmonary bypass in poisonings...
  58. doi request reprint Prognostic factors in non-exertional heatstroke
    Pierre Hausfater
    Emergency Department, Centre Hospitalo Universitaire CHU Pitié Salpêtrière Assistance Publique Hôpitaux de Paris, UPMC Univ Paris 06, Paris, France
    Intensive Care Med 36:272-80. 2010
    ..To identify the prognostic factors associated with mortality in heat-related illness...
  59. doi request reprint Extracorporeal life support in a case of fatal flecainide and betaxolol poisoning allowing successful cardiac allograft
    Benoit Vivien
    Departement d Anesthesie Reanimation, Hopital Necker Enfants Malades, Paris, France
    Ann Emerg Med 56:409-12. 2010
    ..Forty-five months later, each organ recipient was alive, with normal graft function...
  60. pmc Delayed immunosuppressive treatment in life-threatening paraquat ingestion: a case report
    Alexis Descatha
    Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Réanimation Médicale et Toxicologique, Paris, France
    J Med Toxicol 5:76-9. 2009
    ..Its benefit has been observed when given early in the course of poisoning; however, whether its delayed administration remains beneficial is unknown...
  61. ncbi request reprint Swallowing disorders as a predictor of unsuccessful extubation: a clinical evaluation
    Philippe Colonel
    Service de Medecine Physique et de Readaptation, l Hôpital Lariboisière Fernand Widal, Universite Paris VII, Paris, France
    Am J Crit Care 17:504-10. 2008
    ..Unsuccessful extubation may be due to swallowing dysfunction that causes airway obstruction and impairs patients' ability to cough and expectorate...
  62. doi request reprint Impaired plasma B-type natriuretic peptide clearance in human septic shock
    Romain Pirracchio
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, APHP, University Paris 7 Diderot, Paris, France
    Crit Care Med 36:2542-6. 2008
    ..We further evaluated whether baseline plasma BNP can predict fluid responsiveness and whether BNP can still be released in plasma despite high initial BNP levels, in response to overloading...
  63. ncbi request reprint [Extracorporeal life support for poisonings with cardiotoxicants]
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Universite Paris VII, 75475 Paris Cedex 10
    Rev Prat 58:855-60. 2008
    ..Several cases of survival using this exceptional technique were reported in the literature. Thus, based on these reports, extracorporeal life support has gained a recognized place in the therapeutic arsenal of acute poisonings...
  64. doi request reprint Lithium poisoning: is determination of the red blood cell lithium concentration useful?
    Souleiman El Balkhi
    Laboratoire de Toxicologie Biologique, Hopital Lariboisiere, Paris, France
    Clin Toxicol (Phila) 47:8-13. 2009
    ..Therefore, more reliable indicators have been proposed, including measurement of the red blood cell (RBC) lithium concentration and the RBC-to-plasma lithium ratio...
  65. ncbi request reprint A communication strategy and brochure for relatives of patients dying in the ICU
    Alexandre Lautrette
    Saint Louis Hospital and Paris 7 University, Assistance Publique Hopitaux de Paris, France
    N Engl J Med 356:469-78. 2007
    ..We evaluated a format that included a proactive end-of-life conference and a brochure to see whether it could lessen the effects of bereavement...
  66. doi request reprint Prevalence and factors of intensive care unit conflicts: the conflicus study
    Elie Azoulay
    AP HP, Hopital Saint Louis, Medical ICU, University Paris 7 Paris Diderot, UFR de Medecine, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Respir Crit Care Med 180:853-60. 2009
    ..Many sources of conflict exist in intensive care units (ICUs). Few studies recorded the prevalence, characteristics, and risk factors for conflicts in ICUs...