M Mechali

Summary

Country: France

Publications

  1. ncbi Eukaryotic DNA replication origins: many choices for appropriate answers
    Marcel Mechali
    Institute of Human Genetics, CNRS, Montpellier, France
    Nat Rev Mol Cell Biol 11:728-38. 2010
  2. ncbi MCM proteins and DNA replication
    Domenico Maiorano
    Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Curr Opin Cell Biol 18:130-6. 2006
  3. ncbi DNA replication origins: from sequence specificity to epigenetics
    M Mechali
    Marcel Méchali is at the Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier, France
    Nat Rev Genet 2:640-5. 2001
  4. ncbi XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, Montpellier, France
    Nature 404:622-5. 2000
  5. ncbi Stepwise regulated chromatin assembly of MCM2-7 proteins
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, Montpellier, Cedex 5, France
    J Biol Chem 275:8426-31. 2000
  6. ncbi A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats
    S Cohen
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:2542-8. 2001
  7. ncbi Characterization of Xenopus RalB and its involvement in F-actin control during early development
    J Moreau
    Laboratoire d Etude des Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, Université Paris VI VII, 2 place Jussieu, Paris Cedex 05, 75251, France
    Dev Biol 209:268-81. 1999
  8. ncbi Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus
    M Coue
    Institut Jacques Monod, CNRS, Universite Paris 7, 2 place Jussieu, Paris Cedex 05, 75251, France
    Exp Cell Res 245:282-9. 1998
  9. ncbi Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA)
    M Leibovici
    CNRS, Institut Jacques Momod, Laboratoire d Embryologie Moleculaire, Paris, France
    Dev Biol 141:183-92. 1990
  10. ncbi Chromatin remodelling and DNA replication: from nucleosomes to loop domains
    C Demeret
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Oncogene 20:3086-93. 2001

Collaborators

  • J Moreau
  • D Maiorano
  • Domenico Maiorano
  • C Demeret
  • S Cohen
  • Malik Lutzmann
  • M Coue
  • Y Vassetzky
  • J M Lemaitre
  • S Bocquet
  • F Amariglio
  • M Leibovici
  • M Gusse
  • R Bravo

Detail Information

Publications10

  1. ncbi Eukaryotic DNA replication origins: many choices for appropriate answers
    Marcel Mechali
    Institute of Human Genetics, CNRS, Montpellier, France
    Nat Rev Mol Cell Biol 11:728-38. 2010
    ..This suggests that during evolution, the use of replication origins became more controlled by epigenetic mechanisms affecting chromosome dynamics and expression than by DNA synthesis per se...
  2. ncbi MCM proteins and DNA replication
    Domenico Maiorano
    Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Curr Opin Cell Biol 18:130-6. 2006
    ..The function of MCM8 is distinct from that of MCM2-7 proteins, while the function of MCM9 is unknown. MCM1 and MCM10 are not related to this family, nor to each other, but also function in DNA synthesis...
  3. ncbi DNA replication origins: from sequence specificity to epigenetics
    M Mechali
    Marcel Méchali is at the Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier, France
    Nat Rev Genet 2:640-5. 2001
    ..According to this model, origins of DNA replication help to establish domains of gene expression for the generation of cell diversity...
  4. ncbi XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, Montpellier, France
    Nature 404:622-5. 2000
    ..These findings indicate that XCDT1 is an essential component of the system that regulates origins firing during S phase...
  5. ncbi Stepwise regulated chromatin assembly of MCM2-7 proteins
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, Montpellier, Cedex 5, France
    J Biol Chem 275:8426-31. 2000
    ..These results indicate that the assembly of the MCM complex onto pre-replicative chromatin is regulated at the level of distinct subunits, suggesting an additional regulatory step in the formation of pre-replication complexes...
  6. ncbi A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats
    S Cohen
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:2542-8. 2001
    ....
  7. ncbi Characterization of Xenopus RalB and its involvement in F-actin control during early development
    J Moreau
    Laboratoire d Etude des Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, Université Paris VI VII, 2 place Jussieu, Paris Cedex 05, 75251, France
    Dev Biol 209:268-81. 1999
    ..In contrast, the inactivated form blocks only the closing of neural tube. Altogether, these observations suggest that RalB is part of a regulatory pathway that may affect the blastomere cytoskeleton and take part in early development...
  8. ncbi Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus
    M Coue
    Institut Jacques Monod, CNRS, Universite Paris 7, 2 place Jussieu, Paris Cedex 05, 75251, France
    Exp Cell Res 245:282-9. 1998
    ..Altogether, these data suggest that licensing of chromatin by MCMs occurs in an ordered fashion involving discrete subcomplexes...
  9. ncbi Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA)
    M Leibovici
    CNRS, Institut Jacques Momod, Laboratoire d Embryologie Moleculaire, Paris, France
    Dev Biol 141:183-92. 1990
    ..The maternal protein is maintained at a constant level during embryonic development at least until the swimming tadpole stage. The protein is localized in the nuclei at all stages of oogenesis and development that were examined...
  10. ncbi Chromatin remodelling and DNA replication: from nucleosomes to loop domains
    C Demeret
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Oncogene 20:3086-93. 2001
    ..The present review considers the effects of chromatin remodelling on replication and vice versa...