Genomes and Genes
- Eukaryotic DNA replication origins: many choices for appropriate answersMarcel Mechali
Institute of Human Genetics, CNRS, Montpellier, France
Nat Rev Mol Cell Biol 11:728-38. 2010..This suggests that during evolution, the use of replication origins became more controlled by epigenetic mechanisms affecting chromosome dynamics and expression than by DNA synthesis per se...
- Genetic and epigenetic determinants of DNA replication origins, position and activationMarcel Mechali
Institute of Human Genetics, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Curr Opin Genet Dev 23:124-31. 2013..This view is supported by recent genome-wide studies showing that DNA replication profiles are shaped by genetic and epigenetic processes that act both at the local and global levels to regulate origin function in eukaryotic cells...
- MCM proteins and DNA replicationDomenico Maiorano
Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
Curr Opin Cell Biol 18:130-6. 2006..The function of MCM8 is distinct from that of MCM2-7 proteins, while the function of MCM9 is unknown. MCM1 and MCM10 are not related to this family, nor to each other, but also function in DNA synthesis...
- DNA replication origins: from sequence specificity to epigeneticsM Mechali
Marcel Méchali is at the Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier, France
Nat Rev Genet 2:640-5. 2001..According to this model, origins of DNA replication help to establish domains of gene expression for the generation of cell diversity...
- XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevisD Maiorano
Institute of Human Genetics, CNRS, Genome Dynamics and Development, Montpellier, France
Nature 404:622-5. 2000..These findings indicate that XCDT1 is an essential component of the system that regulates origins firing during S phase...
- Stepwise regulated chromatin assembly of MCM2-7 proteinsD Maiorano
Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, Montpellier, Cedex 5, France
J Biol Chem 275:8426-31. 2000..These results indicate that the assembly of the MCM complex onto pre-replicative chromatin is regulated at the level of distinct subunits, suggesting an additional regulatory step in the formation of pre-replication complexes...
- A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeatsS Cohen
Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Nucleic Acids Res 29:2542-8. 2001....
- Characterization of Xenopus RalB and its involvement in F-actin control during early developmentJ Moreau
Laboratoire d Etude des Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, Université Paris VI VII, 2 place Jussieu, Paris Cedex 05, 75251, France
Dev Biol 209:268-81. 1999..In contrast, the inactivated form blocks only the closing of neural tube. Altogether, these observations suggest that RalB is part of a regulatory pathway that may affect the blastomere cytoskeleton and take part in early development...
- Evidence for different MCM subcomplexes with differential binding to chromatin in XenopusM Coue
Institut Jacques Monod, CNRS, Universite Paris 7, 2 place Jussieu, Paris Cedex 05, 75251, France
Exp Cell Res 245:282-9. 1998..Altogether, these data suggest that licensing of chromatin by MCMs occurs in an ordered fashion involving discrete subcomplexes...
- Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA)M Leibovici
CNRS, Institut Jacques Momod, Laboratoire d Embryologie Moleculaire, Paris, France
Dev Biol 141:183-92. 1990..The maternal protein is maintained at a constant level during embryonic development at least until the swimming tadpole stage. The protein is localized in the nuclei at all stages of oogenesis and development that were examined...
- Chromatin remodelling and DNA replication: from nucleosomes to loop domainsC Demeret
Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
Oncogene 20:3086-93. 2001..The present review considers the effects of chromatin remodelling on replication and vice versa...