M Mechali

Summary

Country: France

Publications

  1. doi request reprint Eukaryotic DNA replication origins: many choices for appropriate answers
    Marcel Mechali
    Institute of Human Genetics, CNRS, Montpellier, France
    Nat Rev Mol Cell Biol 11:728-38. 2010
  2. doi request reprint Genetic and epigenetic determinants of DNA replication origins, position and activation
    Marcel Mechali
    Institute of Human Genetics, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Curr Opin Genet Dev 23:124-31. 2013
  3. ncbi request reprint MCM proteins and DNA replication
    Domenico Maiorano
    Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Curr Opin Cell Biol 18:130-6. 2006
  4. ncbi request reprint DNA replication origins: from sequence specificity to epigenetics
    M Mechali
    Marcel Méchali is at the Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier, France
    Nat Rev Genet 2:640-5. 2001
  5. ncbi request reprint XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, Montpellier, France
    Nature 404:622-5. 2000
  6. ncbi request reprint Stepwise regulated chromatin assembly of MCM2-7 proteins
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, Montpellier, Cedex 5, France
    J Biol Chem 275:8426-31. 2000
  7. pmc A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats
    S Cohen
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:2542-8. 2001
  8. ncbi request reprint Characterization of Xenopus RalB and its involvement in F-actin control during early development
    J Moreau
    Laboratoire d Etude des Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, Université Paris VI VII, 2 place Jussieu, Paris Cedex 05, 75251, France
    Dev Biol 209:268-81. 1999
  9. ncbi request reprint Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus
    M Coue
    Institut Jacques Monod, CNRS, Universite Paris 7, 2 place Jussieu, Paris Cedex 05, 75251, France
    Exp Cell Res 245:282-9. 1998
  10. ncbi request reprint Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA)
    M Leibovici
    CNRS, Institut Jacques Momod, Laboratoire d Embryologie Moleculaire, Paris, France
    Dev Biol 141:183-92. 1990

Collaborators

  • J Moreau
  • D Maiorano
  • Domenico Maiorano
  • S Cohen
  • C Demeret
  • M Coue
  • Malik Lutzmann
  • Y Vassetzky
  • J M Lemaitre
  • F Amariglio
  • S Bocquet
  • M Leibovici
  • M Gusse
  • R Bravo

Detail Information

Publications11

  1. doi request reprint Eukaryotic DNA replication origins: many choices for appropriate answers
    Marcel Mechali
    Institute of Human Genetics, CNRS, Montpellier, France
    Nat Rev Mol Cell Biol 11:728-38. 2010
    ..This suggests that during evolution, the use of replication origins became more controlled by epigenetic mechanisms affecting chromosome dynamics and expression than by DNA synthesis per se...
  2. doi request reprint Genetic and epigenetic determinants of DNA replication origins, position and activation
    Marcel Mechali
    Institute of Human Genetics, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Curr Opin Genet Dev 23:124-31. 2013
    ..This view is supported by recent genome-wide studies showing that DNA replication profiles are shaped by genetic and epigenetic processes that act both at the local and global levels to regulate origin function in eukaryotic cells...
  3. ncbi request reprint MCM proteins and DNA replication
    Domenico Maiorano
    Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Curr Opin Cell Biol 18:130-6. 2006
    ..The function of MCM8 is distinct from that of MCM2-7 proteins, while the function of MCM9 is unknown. MCM1 and MCM10 are not related to this family, nor to each other, but also function in DNA synthesis...
  4. ncbi request reprint DNA replication origins: from sequence specificity to epigenetics
    M Mechali
    Marcel Méchali is at the Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier, France
    Nat Rev Genet 2:640-5. 2001
    ..According to this model, origins of DNA replication help to establish domains of gene expression for the generation of cell diversity...
  5. ncbi request reprint XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, Montpellier, France
    Nature 404:622-5. 2000
    ..These findings indicate that XCDT1 is an essential component of the system that regulates origins firing during S phase...
  6. ncbi request reprint Stepwise regulated chromatin assembly of MCM2-7 proteins
    D Maiorano
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, Montpellier, Cedex 5, France
    J Biol Chem 275:8426-31. 2000
    ..These results indicate that the assembly of the MCM complex onto pre-replicative chromatin is regulated at the level of distinct subunits, suggesting an additional regulatory step in the formation of pre-replication complexes...
  7. pmc A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats
    S Cohen
    Institute of Human Genetics, CNRS, Genome Dynamics and Development, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:2542-8. 2001
    ....
  8. ncbi request reprint Characterization of Xenopus RalB and its involvement in F-actin control during early development
    J Moreau
    Laboratoire d Etude des Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, Université Paris VI VII, 2 place Jussieu, Paris Cedex 05, 75251, France
    Dev Biol 209:268-81. 1999
    ..In contrast, the inactivated form blocks only the closing of neural tube. Altogether, these observations suggest that RalB is part of a regulatory pathway that may affect the blastomere cytoskeleton and take part in early development...
  9. ncbi request reprint Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus
    M Coue
    Institut Jacques Monod, CNRS, Universite Paris 7, 2 place Jussieu, Paris Cedex 05, 75251, France
    Exp Cell Res 245:282-9. 1998
    ..Altogether, these data suggest that licensing of chromatin by MCMs occurs in an ordered fashion involving discrete subcomplexes...
  10. ncbi request reprint Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA)
    M Leibovici
    CNRS, Institut Jacques Momod, Laboratoire d Embryologie Moleculaire, Paris, France
    Dev Biol 141:183-92. 1990
    ..The maternal protein is maintained at a constant level during embryonic development at least until the swimming tadpole stage. The protein is localized in the nuclei at all stages of oogenesis and development that were examined...
  11. ncbi request reprint Chromatin remodelling and DNA replication: from nucleosomes to loop domains
    C Demeret
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Oncogene 20:3086-93. 2001
    ..The present review considers the effects of chromatin remodelling on replication and vice versa...