Genomes and Genes


Alexandre Mebazaa


Country: France


  1. Hollinger A, Gayat E, Feliot E, Paugam Burtz C, Fournier M, Duranteau J, et al. Gender and survival of critically ill patients: results from the FROG-ICU study. Ann Intensive Care. 2019;9:43 pubmed publisher
    ..Trial registration NCT01367093; registered on June 6, 2011. ..
  2. Mebazaa A, Combes A, van Diepen S, Hollinger A, Katz J, Landoni G, et al. Management of cardiogenic shock complicating myocardial infarction. Intensive Care Med. 2018;44:760-773 pubmed publisher
  3. Léopold V, Gayat E, Pirracchio R, Spinar J, Parenica J, Tarvasmäki T, et al. Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients. Intensive Care Med. 2018;44:847-856 pubmed publisher
    ..2 [3.0-6.0]). In this very large cohort, epinephrine use for hemodynamic management of CS patients is associated with a threefold increase of risk of death. ..
  4. Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, et al. New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Int J Cardiol. 2018;266:95-99 pubmed publisher
    ..6, P = 0.03). New-onset AFib is independently associated with in-hospital and post-ICU risk of death in critically ill patients. ..
  5. Mebazaa A, Tolppanen H, Mueller C, Lassus J, Disomma S, Baksyte G, et al. Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance. Intensive Care Med. 2016;42:147-63 pubmed publisher
    ..Medical management should be planned according to the underlying mechanisms of various clinical scenarios of AHF. ..
  6. Ganovska E, Arrigo M, Helanova K, Littnerova S, Sadoune M, Kubena P, et al. Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: A prospective observational cohort study. Int J Cardiol. 2016;215:527-31 pubmed publisher
    ..Hence, using the rule of "low-Zwolle or low-BNP" might increase the number of STEMI patients that might be eligible for early discharge. ..
  7. request reprint
    Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, et al. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Clin Res Cardiol. 2016;105:971-980 pubmed
    ..90, p < 0.001). Vasodilators and inotropes had no short-term effect of renal function. The left- and right-sided filling pressures are similarly improved by vasodilators or inotropes, in AHF with reduced LVEF. ..
  8. Labbene I, Arrigo M, Tavares M, Hajjej Z, Brandão J, Tolppanen H, et al. Decongestive effects of levosimendan in cardiogenic shock induced by postpartum cardiomyopathy. Anaesth Crit Care Pain Med. 2017;36:39-42 pubmed publisher
    ..Haemodynamics and left-ventricular ejection fraction rapidly improved after treatment with levosimendan. In patients with PPCM-induced CS, a more profound reduction of congestion was observed. ..
  9. Arrigo M, Truong Q, Onat D, Szymonifka J, Gayat E, Tolppanen H, et al. Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study. Clin Chem. 2017;63:386-393 pubmed publisher
    ..Soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic HF patients. ..