Mikael Mazighi

Summary

Country: France

Publications

  1. pmc The Basilar Artery International Cooperation Study (BASICS): study protocol for a randomised controlled trial
    Erik J R J van der Hoeven
    Department of Radiology, St Antonius Hospital, PO Box 2500, Nieuwegein EM 3430, The Netherlands
    Trials 14:200. 2013
  2. doi request reprint Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, 46, rue Henri Huchard, 75018 Paris, France
    Circulation 127:1980-5. 2013
  3. doi request reprint Dramatic recovery in acute ischemic stroke is associated with arterial recanalization grade and speed
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, INSERM U 698, Paris Diderot University, 46, rue Henri Huchard, 75018 Paris, France
    Stroke 43:2998-3002. 2012
  4. doi request reprint Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 43:1302-8. 2012
  5. doi request reprint Reperfusion therapy in acute cerebrovascular syndrome
    Mikael Mazighi
    Neurology and Stroke Departments, Paris 7 Denis Diderot University, Unité INSERM 698 Recherche Clinique en Athérothrombose, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Curr Opin Neurol 24:59-62. 2011
  6. doi request reprint Coronary artery disease and risk of major vascular events after cerebral infarction
    Pierre Amarenco
    INSERM U 698, Paris, France
    Stroke 44:1505-11. 2013
  7. doi request reprint Impact of a combined intravenous/intra-arterial approach in octogenarians
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Cerebrovasc Dis 31:559-65. 2011
  8. doi request reprint Yield of systematic transcranial Doppler in patients with transient ischemic attack
    Elena Meseguer
    INSERM U698 and Denis Diderot University and Medical School, Paris, France
    Ann Neurol 68:9-17. 2010
  9. doi request reprint Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France Diderot University, Paris, France
    Lancet Neurol 8:802-9. 2009
  10. ncbi request reprint Is intracerebral hemorrhage a time-dependent phenomenon after successful combined intravenous and intra-arterial therapy?
    Pascal J Mosimann
    Department of Neurology, Bichat University Hospital, Paris, France
    Stroke 44:806-8. 2013

Collaborators

Detail Information

Publications36

  1. pmc The Basilar Artery International Cooperation Study (BASICS): study protocol for a randomised controlled trial
    Erik J R J van der Hoeven
    Department of Radiology, St Antonius Hospital, PO Box 2500, Nieuwegein EM 3430, The Netherlands
    Trials 14:200. 2013
    ..Our observations in the BASICS registry underscore that we continue to lack a proven treatment modality for patients with an acute BAO and that current clinical practice varies widely...
  2. doi request reprint Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, 46, rue Henri Huchard, 75018 Paris, France
    Circulation 127:1980-5. 2013
    ..However, its impact on mortality remained to be assessed. Using a collaborative pooled analysis, we examined whether early mortality after successful endovascular treatment is time dependent...
  3. doi request reprint Dramatic recovery in acute ischemic stroke is associated with arterial recanalization grade and speed
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, INSERM U 698, Paris Diderot University, 46, rue Henri Huchard, 75018 Paris, France
    Stroke 43:2998-3002. 2012
    ..We sought to analyze the impact of recanalization on DR in patients with acute ischemic stroke eligible for any revascularization strategies (either intravenous or endovascular)...
  4. doi request reprint Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 43:1302-8. 2012
    ..The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy...
  5. doi request reprint Reperfusion therapy in acute cerebrovascular syndrome
    Mikael Mazighi
    Neurology and Stroke Departments, Paris 7 Denis Diderot University, Unité INSERM 698 Recherche Clinique en Athérothrombose, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Curr Opin Neurol 24:59-62. 2011
    ..However, arterial recanalization may be achieved without favorable clinical outcome, raising the question of the target population to be treated. We outline key issues that underline acute revascularization therapies...
  6. doi request reprint Coronary artery disease and risk of major vascular events after cerebral infarction
    Pierre Amarenco
    INSERM U 698, Paris, France
    Stroke 44:1505-11. 2013
    ..The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown...
  7. doi request reprint Impact of a combined intravenous/intra-arterial approach in octogenarians
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Cerebrovasc Dis 31:559-65. 2011
    ..The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians...
  8. doi request reprint Yield of systematic transcranial Doppler in patients with transient ischemic attack
    Elena Meseguer
    INSERM U698 and Denis Diderot University and Medical School, Paris, France
    Ann Neurol 68:9-17. 2010
    ..Our aim was to determine whether the use of transcranial Doppler (TCD) examination on arrival at the TIA clinic yields additional information that facilitates the identification of patients at high risk of stroke recurrence...
  9. doi request reprint Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France Diderot University, Paris, France
    Lancet Neurol 8:802-9. 2009
    ..The aim of this study was to ascertain the effect of a combined IV-endovascular approach (intra-arterial alteplase and, if required, additional thrombectomy) in patients with stroke due to arterial occlusion...
  10. ncbi request reprint Is intracerebral hemorrhage a time-dependent phenomenon after successful combined intravenous and intra-arterial therapy?
    Pascal J Mosimann
    Department of Neurology, Bichat University Hospital, Paris, France
    Stroke 44:806-8. 2013
    ..We therefore sought to determine whether ORT influenced the risk and volume of intracerebral hemorrhage (ICH) after combined intravenous and intra-arterial therapy...
  11. ncbi request reprint Blood-brain barrier disruption is associated with increased mortality after endovascular therapy
    Jean Philippe Desilles
    Department of Neurology and Stroke Centre, Bichat University Hospital
    Neurology 80:844-51. 2013
    ..To evaluate the incidence, baseline characteristics, and clinical prognosis of blood-brain barrier (BBB) disruption after endovascular therapy in acute ischemic stroke patients...
  12. doi request reprint Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review
    Elena Meseguer
    INSERM U 698 and Paris Diderot University, Paris, France
    Stroke 40:2104-10. 2009
    ..We evaluated gender differences in the efficacy and safety outcomes of intravenous rtPA using a clinical registry and systematic review...
  13. doi request reprint Overlap of diseases underlying ischemic stroke: the ASCOD phenotyping
    Gaia Sirimarco
    Paris Diderot University, Sorbonne Paris Cité, Paris, France
    Stroke 44:2427-33. 2013
    ..We used ASCOD to investigate the overlap of underlying vascular diseases and their prognostic implication...
  14. doi request reprint Carotid endarterectomy in the acute phase of stroke-in-evolution is safe and effective in selected patients
    Guy Leseche
    Department of Vascular and Thoracic Surgery, Bichat Claude Bernard University Hospital, Denis Diderot University and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
    J Vasc Surg 55:701-7. 2012
    ....
  15. ncbi request reprint Determinants of outcome and safety of intravenous rt-PA therapy in the very old: a clinical registry study and systematic review
    Elena Meseguer
    Department of Neurology and Stroke Centre, Bichat University Hospital, 46, rue Henri Huchard, 75018 Paris, France
    Age Ageing 37:107-11. 2008
  16. doi request reprint Diabetes mellitus, admission glucose, and outcomes after stroke thrombolysis: a registry and systematic review
    Jean Philippe Desilles
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 44:1915-23. 2013
    ..We evaluated outcomes of patients treated by intravenous and/or intra-arterial therapy, according to diabetes mellitus and AGL...
  17. doi request reprint Outcomes after thrombolysis in AIS according to prior statin use: a registry and review
    Elena Meseguer
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Neurology 79:1817-23. 2012
    ..The impact of prior statin use on outcomes after thrombolysis is unclear. We evaluated outcomes of patients treated by IV, intra-arterial (IA) thrombolysis, or combined therapy, according to prior statin use...
  18. doi request reprint Spectrum of transient visual symptoms in a transient ischemic attack cohort
    Philippa C Lavallee
    From INSERM U 698 and Paris Diderot University, Sorbonne Paris Cité, Paris, France P C L, L C, J L, M M, E M, C G, I F K, G S, J G V, P J T, P A and Department of Neurology and Stroke Centre P C L, L C, M M, E M, C G, H A, B L, J M O, G S, J G V, P J T, P A and Department of Radiology I F K, Bichat University Hospital, Paris France
    Stroke 44:3312-7. 2013
    ..We studied the prevalence, presentation, and effect of different types of TVS, paying particular attention to the association with high-risk pathology of embolism...
  19. doi request reprint Does ABCD2 score below 4 allow more time to evaluate patients with a transient ischemic attack?
    Pierre Amarenco
    Department of Neurology and Stroke Center, Paris, France
    Stroke 40:3091-5. 2009
    ....
  20. doi request reprint Outcomes of mechanical endovascular therapy for acute ischemic stroke: a clinical registry study and systematic review
    Aymeric Rouchaud
    Department of Neurology and Stroke Centre, Bichat University Hospital, INSERM U 698 and Paris Diderot University, 46, rue Henri Huchard, 75018 Paris, France
    Stroke 42:1289-94. 2011
    ..However, the benefit and safety of MET remain to be determined. The aim of this study was to give reliable estimates of efficacy and safety outcomes of MET...
  21. doi request reprint Atherogenic dyslipidemia in patients with transient ischemic attack
    Gaia Sirimarco
    INSERM U 698 and Paris Diderot University, Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 42:2131-7. 2011
    ..There is mounting evidence that atherogenic dyslipidemia (ie, low high-density lipoprotein cholesterol combined with high triglyceride concentrations) is an independent predictor of high cardiovascular risk and possibly of stroke...
  22. ncbi request reprint A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects
    Philippa C Lavallee
    Department of Neurology and Stroke Centre, Bichat Claude Bernard University Hospital, Denis Diderot University and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet Neurol 6:953-60. 2007
    ..We evaluated the effects of rapid assessment of patients with TIA on clinical decision making, length of hospital stay, and subsequent stroke rates...
  23. ncbi request reprint Aortic arch atheroma in transient ischemic attack patients
    Celine Guidoux
    Department of Neurology and Stroke Centre, Bichat University Hospital, INSERM U 698 and Paris Diderot University, Paris, France Electronic address
    Atherosclerosis 231:124-8. 2013
    ..Aortic arch atheroma (AAA) is associated with vascular risk factors and with stroke risk. Its prevalence and prognosis remain to be defined in patients with transient ischemic attack (TIA)...
  24. ncbi request reprint High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke
    Bertrand Lapergue
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 44:699-707. 2013
    ..We hypothesized that HDL vasculoprotective actions on the blood-brain barrier (BBB) may decrease hemorrhagic transformation-associated with tissue plasminogen activator (tPA) administration in acute stroke...
  25. doi request reprint Prevalence of coronary atherosclerosis in patients with cerebral infarction
    Pierre Amarenco
    INSERM U 698 and Paris Diderot University, Paris, France
    Stroke 42:22-9. 2011
    ....
  26. doi request reprint Is moderate atherosclerotic stenosis in the middle cerebral artery a cause of or a coincidental finding in ischemic stroke?
    Isabelle F Klein
    INSERM U 698 and Denis Diderot University, Paris, France
    Cerebrovasc Dis 29:140-5. 2010
    ..The objective of this study was to investigate the cause of middle cerebral artery (MCA) atherosclerotic disease in patients with fatal stroke...
  27. pmc High-density lipoproteins limit neutrophil-induced damage to the blood-brain barrier in vitro
    Quoc Bao Dang
    Inserm UMR698, Paris, France
    J Cereb Blood Flow Metab 33:575-82. 2013
    ..Our results suggest a deleterious, elastase-mediated role of activated PMNs under OGD conditions leading to BBB disruption that could be inhibited by HDLs...
  28. doi request reprint Carotid endarterectomy in the acute phase of crescendo cerebral transient ischemic attacks is safe and effective
    Guy Leseche
    Department of Vascular and Thoracic Surgery, Bichat Claude Bernard University Hospital, Denis Diderot University, and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
    J Vasc Surg 53:637-42. 2011
    ..To document the 30- and 90-day outcomes in patients with severe internal carotid artery stenosis who underwent carotid endarterectomy in the acute phase of crescendo cerebral transient ischemic attacks (CcTIAs)...
  29. doi request reprint Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study
    Isabelle F Klein
    Department of Neurology, Bichat University Hospital and Medical School, Paris, France
    Stroke 41:1405-9. 2010
    ....
  30. ncbi request reprint Impact of diffusion-weighted imaging alberta stroke program early computed tomography score on the success of endovascular reperfusion therapy
    Manabu Inoue
    From the Department of Neurology, Stanford Stroke Center, Stanford University Medical Center, CA M I, J M O, M Mlynash Department of Neurology, Purpan University Hospital, Toulouse, France J M O, J F A Department of Neurology and Stroke Centre, Bichat University Hospital, APHP, Paris, France E M, P A, M Mazighi INSERM U 1148, Laboratory of Vascular Translational Science and Paris Diderot University, Paris, France J L, E M, P A, M Mazighi and Department of Biostatistics, EA2694, UDSL, Universite Lille Nord de France, CHU Lille, France J L
    Stroke 45:1992-8. 2014
    ..Our aim was to assess the impact of pretreatment DWI-ASPECTS on outcomes after endovascular therapy, with a specific emphasis on recanalization...
  31. doi request reprint Autologous mesenchymal stem cell endografting in experimental cerebrovascular aneurysms
    Aymeric Rouchaud
    INSERM Research Unit 698, Inserm Paris 7 Denis Diderot University, Paris, France
    Neuroradiology 55:741-9. 2013
    ..In the present study, we have percutaneously delivered autologous bone marrow mesenchymal stem cells (BMSCs) to an elastase-induced rabbit carotid aneurysm model in vivo...
  32. ncbi request reprint Statin therapy and stroke prevention: what was known, what is new and what is next?
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat Hospital, Denis Diderot University and Medical School, Paris, France
    Curr Opin Lipidol 18:622-5. 2007
    ..Randomized trials have shown that statins may reduce the risk of primary stroke. There is no evidence however that statins can reduce recurrent stroke incidence...
  33. ncbi request reprint Ischemia-modified albumin in acute stroke
    Halim Abboud
    Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Cerebrovasc Dis 23:216-20. 2007
    ..Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels...
  34. doi request reprint Prehospital stroke care: potential, pitfalls, and future
    Mikael Mazighi
    INSERM U 698, Clinical Research in Atherothrombosis and Denis Diderot University, France
    Curr Opin Neurol 23:31-5. 2010
    ..New strategies are being developed and evaluated to increase the number of tissue-type plasminogen activator-treated patients...
  35. ncbi request reprint Extracranial vertebral and carotid dissection occurring in the course of subarachnoid hemorrhage
    Mikael Mazighi
    Department of Neuroradiology, Hopital Lariboisiere, Paris, France
    Neurology 65:1471-3. 2005
    ..Seven cases of spontaneous cervical artery dissection in the course of ruptured berry aneurysms are reported here...
  36. doi request reprint Protective effect of high-density lipoprotein-based therapy in a model of embolic stroke
    Bertrand Lapergue
    INSERM U 698, Paris, France
    Stroke 41:1536-42. 2010
    ..Using a rat model, we tested the hypothesis that HDL exerts direct vasculo-/neuroprotective effects when administered during the acute phase of embolic stroke...