Tangui Maurice

Summary

Country: France

Publications

  1. pmc Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice
    Tangui Maurice
    Universite Montpellier II, Montpellier, France
    Neuropsychopharmacology 33:1584-602. 2008
  2. ncbi request reprint Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection
    Tangui Maurice
    INSERM U 710, Montpellier, F 34095 France University of Montpellier II, Montpellier, F 34095 France c EPHE, Paris, F 75007 France
    Pharmacol Biochem Behav 84:581-97. 2006
  3. pmc The pharmacology of sigma-1 receptors
    Tangui Maurice
    Team II Endogenous Neuroprotection in Neurodegenerative Diseases, INSERM U 710, 34095 Montpellier Cedex 5, France
    Pharmacol Ther 124:195-206. 2009
  4. doi request reprint Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation
    Fabien Lanté
    Oxidative Stress and Neuroprotection, IBMM, CNRS UMR 5247, UM 1 and UM 2, Place E Bataillon, 34095 Montpellier Cedex 5, France
    Hippocampus 18:602-9. 2008
  5. doi request reprint Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations
    Nathalie Chevallier
    INSERM, EPHE, University of Montpellier II, Montpellier, France
    J Psychopharmacol 25:960-75. 2011
  6. doi request reprint Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs
    Julie Espallergues
    INSERM U 710, EPHE, University of Montpellier 2, 34095 Montpellier, France
    Behav Brain Res 206:263-73. 2010
  7. pmc Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease
    Valentine Lahmy
    INSERM U710, Montpellier, France
    Neuropsychopharmacology 38:1706-23. 2013
  8. ncbi request reprint Compensatory effect by sigma1 (sigma1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task
    Johann Meunier
    CNRS FRE 2693, Universite de Montpellier II, CC 090, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Behav Brain Res 166:166-76. 2006
  9. pmc Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats
    Charleine Zussy
    Molecular Mechanisms in Neurodegenerative Dementia Laboratory, INSERM U710, Montpellier, France
    PLoS ONE 8:e53117. 2013
  10. doi request reprint Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background
    Florian Duclot
    INSERM U 710, 34095 Montpellier, France
    Neurosci Lett 475:179-83. 2010

Collaborators

Detail Information

Publications47

  1. pmc Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice
    Tangui Maurice
    Universite Montpellier II, Montpellier, France
    Neuropsychopharmacology 33:1584-602. 2008
    ..These observations demonstrate that PCAF histone acetylase is involved lifelong in the chromatin remodeling necessary for memory formation and response to stress...
  2. ncbi request reprint Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection
    Tangui Maurice
    INSERM U 710, Montpellier, F 34095 France University of Montpellier II, Montpellier, F 34095 France c EPHE, Paris, F 75007 France
    Pharmacol Biochem Behav 84:581-97. 2006
    ..Biochemical and physiological arguments for an interaction of neuro(active)steroids with the sigma(1) receptor are analyzed and the impact on physiopathological outcomes in neuroprotection is illustrated...
  3. pmc The pharmacology of sigma-1 receptors
    Tangui Maurice
    Team II Endogenous Neuroprotection in Neurodegenerative Diseases, INSERM U 710, 34095 Montpellier Cedex 5, France
    Pharmacol Ther 124:195-206. 2009
    ..We conclude that the sigma-1 and sigma-2 receptors represent potential fruitful targets for therapeutic developments in combating many human diseases...
  4. doi request reprint Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation
    Fabien Lanté
    Oxidative Stress and Neuroprotection, IBMM, CNRS UMR 5247, UM 1 and UM 2, Place E Bataillon, 34095 Montpellier Cedex 5, France
    Hippocampus 18:602-9. 2008
    ..The therapeutic window of NAC extends up to birth, suggesting that this drug might be clinically useful even after an immuno-inflammatory episode...
  5. doi request reprint Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations
    Nathalie Chevallier
    INSERM, EPHE, University of Montpellier II, Montpellier, France
    J Psychopharmacol 25:960-75. 2011
    ..protein invalidation therefore affected stress or anxiety response but not memory in males. Changes in steroid tonus in female animals led, however, to memory impairments that increased with age...
  6. doi request reprint Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs
    Julie Espallergues
    INSERM U 710, EPHE, University of Montpellier 2, 34095 Montpellier, France
    Behav Brain Res 206:263-73. 2010
    ..We conclude that the increase in cholinergic tonus observed in AChE+/- mice did not result in increased memory functions but allowed a significant prevention of the deleterious effects of muscarinic blockade or amyloid toxicity...
  7. pmc Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease
    Valentine Lahmy
    INSERM U710, Montpellier, France
    Neuropsychopharmacology 38:1706-23. 2013
    ..The drug, acting synergistically on both targets, but with moderate affinity, presents a promising pharmacological profile...
  8. ncbi request reprint Compensatory effect by sigma1 (sigma1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task
    Johann Meunier
    CNRS FRE 2693, Universite de Montpellier II, CC 090, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Behav Brain Res 166:166-76. 2006
    ..Regulation of its expression during withdrawal, notably using a selective agonist, allowed not only to attenuate the CAC-induced hyper-responsiveness, but also to restore correct cognitive abilities...
  9. pmc Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats
    Charleine Zussy
    Molecular Mechanisms in Neurodegenerative Dementia Laboratory, INSERM U710, Montpellier, France
    PLoS ONE 8:e53117. 2013
    ....
  10. doi request reprint Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background
    Florian Duclot
    INSERM U 710, 34095 Montpellier, France
    Neurosci Lett 475:179-83. 2010
    ....
  11. ncbi request reprint Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas
    Johann Meunier
    INSERM U 710, EPHE, University of Montpellier II, c c 105, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    J Pharmacol Exp Ther 317:1307-19. 2006
    ..In particular, the drug is a more potent postinsult protecting agent compared with more selective cholinesterase inhibitors...
  12. doi request reprint Antiamnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid beta(25-35)-induced toxicity in mice
    Vanessa Villard
    INSERM U 710, University of Montpellier 2, Montpellier, France
    Neuropsychopharmacology 34:1552-66. 2009
    ..A synergic effect could indeed account for the very low active doses measured in vivo. These data outline the therapeutic potential of ANAVEX1-41 as a neuroprotective agent in Alzheimer's disease...
  13. ncbi request reprint Sigma1 receptor ligands and related neuroactive steroids interfere with the cocaine-induced state of memory
    Pascal Romieu
    Behavioral Neuropharmacology Group, INSERM U 336, Institut de Biologie, Montpellier, France
    Neuropsychopharmacology 31:1431-43. 2006
    ....
  14. ncbi request reprint Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ₂₅₋₃₅ non-transgenic mouse model of Alzheimer's disease
    Tangui Maurice
    1University of Montpellier 2, Montpellier, France
    J Psychopharmacol 27:1044-57. 2013
    ..We here identified a new IN formulation of EPO showing high neuroprotective activity. Considering its efficacy, ease and safety, IN Neuro-EPO is a new promising therapeutic agent in AD...
  15. ncbi request reprint Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG)
    Michel Vignes
    Laboratory Oxidative Stress and Neuroprotection, University of Montpellier II, Montpellier, France
    Brain Res 1110:102-15. 2006
    ..Therefore, our data support that EGCG can induce anxiolytic activity which could result from an interaction with GABA(A) receptors...
  16. ncbi request reprint Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse
    Vân Ly Phan
    INSERM U 336, Behavioral Neuropharmacology Group, Montpellier, France
    J Neurosci Res 79:561-72. 2005
    ..Preserved sigma1 receptor expression and enhanced behavioral efficacy of sigma1 agonists were measured in SAM animals, confirming the therapeutic opportunities for selective ligands against age-related mood disorders...
  17. pmc Attenuation by a sigma1 (sigma1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats
    Johann Meunier
    Laboratoire de Plasticite Cerebrale, CNRS FRE 2693, Universite de Montpellier II, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Br J Pharmacol 142:689-700. 2004
    ..Activation of the sigma(1) neuromodulatory receptor allows a significant recovery of the memory functions in PS rats...
  18. ncbi request reprint The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects
    François P Monnet
    Unité 705 de l Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 7157 du Centre National de la Recherche Scientifique, Université de Paris V et VII, Hôpital Lariboisière Fernand Widal, Paris, France
    J Pharmacol Sci 100:93-118. 2006
    ....
  19. pmc Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats
    Charleine Zussy
    Molecular Mechanisms in Neurodegenerative Dementia Laboratory, INSERM U710, Montpellier, France
    Am J Pathol 179:315-34. 2011
    ....
  20. ncbi request reprint Interaction with sigma(1) protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil
    Tangui Maurice
    Unité 710 de l Institut National de la Santé et de la Recherche Médicale, Ecole Pratique des Hautes Etudes, Universite de Montpellier II, Montpellier, France
    J Pharmacol Exp Ther 317:606-14. 2006
    ..Therefore, donepezil behaved as an effective sigma(1) receptor agonist on these behavioral responses, and an interaction of the drug with the sigma(1) receptor must be considered in its pharmacological actions...
  21. doi request reprint The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors
    Julie Espallergues
    INSERM U 710, Université de Montpellier 2, 34095, Montpellier, France
    Psychopharmacology (Berl) 214:455-63. 2011
    ..Trilostane shows antidepressant-like properties in the forced swimming test (FST). The compound, however, induced only moderate effects on neuroactive steroid levels that could be related to its behavioral efficacy...
  22. doi request reprint Hyposensitivity to the amnesic effects of scopolamine or amyloid beta(25-35) peptide in heterozygous acetylcholinesterase knockout (AChE(+/-)) mice
    Julie Espallergues
    INSERM U 710, Montpellier, France
    Chem Biol Interact 175:131-4. 2008
    ..Therefore, the hyper-activity of cholinergic systems in AChE(+/-) mice did not result in increased memory abilities, but prevented the deleterious effects of muscarinic blockade or amyloid toxicity...
  23. ncbi request reprint Neurodevelopmental damage after prenatal infection: role of oxidative stress in the fetal brain
    Fabien Lanté
    Oxidative Stress and Neuroprotection, IBMM, CNRS UMR 5247, University of Montpellier II, Place E Bataillon, 34095 Montpellier Cedex 5, France
    Free Radic Biol Med 42:1231-45. 2007
    ..Oxidative stress in the hippocampus of male fetuses may thus participate in the neurodevelopmental damage induced by a prenatal LPS challenge...
  24. ncbi request reprint Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer's disease rat model
    Anthony Brureau
    Molecular Mechanisms in Neurodegenerative Dementia Laboratory, INSERM U710, Montpellier, France
    Neurobiol Aging 34:1426-39. 2013
    ....
  25. ncbi request reprint Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants
    Vanessa Villard
    Institut National de la Sante et de la Recherche Medicale, Unit 710, Montpellier, France
    J Pharmacol Sci 115:279-92. 2011
    ..Moreover, the CFS appears to more reliably uncover a σ(1) pharmacological component in antidepressant screening...
  26. ncbi request reprint Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward
    Pascal Romieu
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 5102, University of Montpellier II, 34095 Montpellier Cedex 5, France
    J Neurosci 23:3572-6. 2003
    ..Therefore, neuroendocrine control of cocaine addiction may not involve solely glucocorticoids. The importance of neuroactive steroids as factors of individual vulnerability to drug addiction should, thus, be considered...
  27. ncbi request reprint Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity
    Tangui Maurice
    CNRS UMR 5102, University of Montpellier II, c c 090, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Neurosci Biobehav Rev 26:499-527. 2002
    ..The therapeutic potentials and neuropharmacological perspectives opened by the use of selective sigma(1) receptor antagonists in cocaine addiction will finally be discussed...
  28. ncbi request reprint Sex differences in learning deficits induced by prenatal stress in juvenile rats
    Michèle Gué
    CNRS UMR 5102, Laboratory of Cerebral Plasticity, University of Montpellier II, Place Eugene Bataillon, 34095 Montpellier, Cedex 5, France
    Behav Brain Res 150:149-57. 2004
    ..In addition, marked sex differences were evidenced, particularly in the passive avoidance response that may reflect differential developmental neuroadaptations in precise brain structures...
  29. ncbi request reprint Involvement of the sigma 1 receptor in the motivational effects of ethanol in mice
    Tangui Maurice
    Behavioral Neuropharmacology Group, Institut de Biologie, INSERM U 336, 4, bvd Henri IV, 34060 Montpellier, France
    Pharmacol Biochem Behav 74:869-76. 2003
    ..These observations show that activation of the sigma(1) receptor is a necessary component of ethanol-induced motivational effects and suggest a new pharmacological target for alleviating ethanol addiction...
  30. pmc Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice
    Catherine Desrumaux
    INSERM U710, Universite Montpellier 2, CC105, Place Eugene Bataillon, 34095 Montpellier, Cedex 05, France
    Neuropsychopharmacology 38:817-25. 2013
    ..We conclude that PLTP, through its ability to deliver vitamin E to the brain, constitutes an endogenous neuroprotective agent. Increasing PLTP activity may offer a new way to develop neuroprotective therapies...
  31. ncbi request reprint The antidepressant-like effect induced by the sigma(1) (sigma(1)) receptor agonist igmesine involves modulation of intracellular calcium mobilization
    Alexandre Urani
    Département de Biochimie Enzymologie, Pfizer GRD Fresnes, 3 9, rue de la Loge, BP 100, 94265 Fresnes Cedex, France
    Psychopharmacology (Berl) 163:26-35. 2002
    ..At the behavioral level, sigma(1) agonists modulate learning, response to stress and depression. In particular, the selective sigma(1) agonist igmesine reduced immobility in the forced swimming test...
  32. ncbi request reprint Enhanced antidepressant effect of sigma(1) (sigma(1)) receptor agonists in beta(25-35)-amyloid peptide-treated mice
    Alexandre Urani
    INSERM U 336, Behavioural Neuropharmacology Group, Institut de Biologie, 4, bvd Henri IV, 34060 Montpellier, France
    Behav Brain Res 134:239-47. 2002
    ..This behavioural study suggests that sigma(1) agonists, due to their enhanced efficacy, may allow to alleviate the depressive symptoms associated with Alzheimer's disease...
  33. ncbi request reprint Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels
    Vân Ly Phan
    Behavioural Neuropharmacology Group, INSERM U 336, Institut de Biologie, 4, blvd Henri IV, 34060 Montpellier, France
    Eur J Neurosci 15:1523-34. 2002
    ..Noteworthy, these observations are coherent with strain differences observed in the intensity of cocaine-induced reward properties, known to critically involve the sigma(1) receptor...
  34. ncbi request reprint Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade
    Pascal Romieu
    Behavioral Neuropharmacology Group, INSERM U 336, Institut de Biologie, 4 Blvd Henri IV, 34060 Montpellier, France
    Neuropsychopharmacology 26:444-55. 2002
    ..These results show that strategies targeting the sigma(1) receptor with selective antagonists may allow effective attenuation of cocaine's rewarding properties and, in turn, offer new treatment strategies against drug addiction...
  35. pmc Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes
    Anis Klouz
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, F 94010 Creteil, France
    Br J Pharmacol 135:1607-15. 2002
    ..The pharmacological significance of these sites and their role on mitochondrial function remain unknown...
  36. ncbi request reprint Preserved sigma1 (sigma1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse
    Vân Ly Phan
    Behavioral Neuropharmacology Group, INSERM U 336, Institut de Biologie, 4, bvd Henri IV, 34060 Montpellier, France
    Neurobiol Aging 24:865-81. 2003
    ..Targeting this unique receptor may offer an original drug strategy during aging...
  37. ncbi request reprint Memory impairments and oxidative stress in the hippocampus of in-utero cocaine-exposed rats
    Valentina Bashkatova
    Department of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315 Moscow, Russia
    Neuroreport 16:1217-21. 2005
    ..Therefore, in-utero cocaine exposure resulted in a significant oxidative stress in basal conditions, which may be related to impaired learning ability...
  38. ncbi request reprint The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming
    Pascal Romieu
    CNRS FRE 2693, University of Montpellier II, Place Eugene Bataillon, 34095, Montpellier 5, France
    Psychopharmacology (Berl) 175:154-62. 2004
    ..CPP can be extinguished and then reactivated, notably using a cocaine challenge (i.e., priming)...
  39. ncbi request reprint Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward
    Remi Martin-Fardon
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1967-73. 2007
    ..The findings support a role for sigma(1) receptors in regulating conditioned responses to cocaine-related contextual stimuli and identify this receptor as a potential treatment target for the prevention of craving and relapse...
  40. ncbi request reprint Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    Neurochem Int 50:791-9. 2007
    ..These results suggest that DM prevents TMT-induced neurotoxicity, at least in part, via sigma(1) receptor stimulation...
  41. ncbi request reprint Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein
    Alexandre Urani
    INSERM U 336, Behavioural Neuropharmacology Group, Institut de Biologie, 4, bvd Henri IV, 34060 Montpellier, France
    Eur J Pharmacol 486:151-61. 2004
    ..The present study suggests that sigma(1) receptor agonists, due to their enhanced efficacy in a nontransgenic animal model, may alleviate Alzheimer's disease-associated depressive symptoms...
  42. ncbi request reprint Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats
    Gaelle Naert
    Universite Montpellier 2, F 34095 Montpellier, France
    Psychoneuroendocrinology 32:1062-78. 2007
    ..They also suggest that neurosteroids effects on central BDNF could partially explain the trophic properties of these molecules...
  43. ncbi request reprint Beneficial effects of the sigma1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine
    Johann Meunier
    Laboratoire de Plasticite Cerebrale, CNRS FRE 2693, Universite de Montpellier II, Place Eugene Bataillon, Montpellier cedex 534095, France
    Neurotoxicol Teratol 26:783-97. 2004
    ..The activation of the sigma(1) neuromodulatory receptor allows a complete behavioral recovery of the memory functions in prenatally cocaine-exposed rats...
  44. ncbi request reprint The ocular anomalies in a cystinosis animal model mimic disease pathogenesis
    Vasiliki Kalatzis
    Institut de Genetique Moleculaire de Montpellier, France
    Pediatr Res 62:156-62. 2007
    ..This work is a prerequisite step to the testing of novel ocular cystine-depleting therapies...
  45. ncbi request reprint Nitric oxide and oxidative stress in the brain of rats exposed in utero to cocaine
    Valentina Bashkatova
    Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315, Moscow, Russia
    Ann N Y Acad Sci 1074:632-42. 2006
    ..It may probably mean that changes in intensity of LPO processes observed during prenatal cocaine exposure are not directly linked to NO pathway activation...
  46. ncbi request reprint Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine
    Magali Peeters
    Laboratoire de Pharmacologie Expérimentale FARL, Universite Catholique de Louvain, 54 10, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    Eur J Neurosci 19:2212-20. 2004
    ..Together, these data demonstrate that aminoadamantanes behave as sigma1 receptor agonists, and confirm an involvement of this receptor in modulating dopamine receptors exerted by therapeutically relevant concentrations of amantadine...
  47. ncbi request reprint Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure
    Julie Pannequin
    Laboratoire de Biochimie, Faculte de Pharmacie, Institut de Genomique Fonctionnelle, Bâtiment E, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    Mol Cancer Res 5:1147-57. 2007
    ..Our results show that phosphatidylethanol accumulation after chronic ethanol exposure disrupts signals that normally restrict proliferation in highly confluent intestinal cells, thus facilitating abnormal intestinal cell proliferation...