Laurent Marrot

Summary

Country: France

Publications

  1. ncbi request reprint Photogenotoxicity of mammalian cells: a review of the different assays for in vitro testing
    Jean Roch Meunier
    L OREAL Advanced Research, Life Sciences Research, Aulnay sous Bois, France
    Photochem Photobiol 75:437-47. 2002
  2. ncbi request reprint Importance of UVA photoprotection as shown by genotoxic related endpoints: DNA damage and p53 status
    Laurent Marrot
    L OREAL Research, Life Sciences Research, Phototoxicology Unit, Genotoxicity Group 1, av E Schueller, 93600 Aulnay sous Bois, France
    Mutat Res 571:175-84. 2005
  3. doi request reprint TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress
    Quentin Michard
    L Oreal Recherche, 90 rue du General Roguet, 92583 Clichy Cedex, France
    Free Radic Biol Med 44:1023-31. 2008
  4. ncbi request reprint Comet assay combined with p53 detection as a sensitive approach for DNA photoprotection assessment in vitro
    Laurent Marrot
    Genotoxicity Group, L OREAL Research, 1 Avenue E Schueller, 96300 Aulnay sous Bois, France
    Exp Dermatol 11:33-6. 2002
  5. doi request reprint The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis
    Laurent Marrot
    Department of Safety Research, Phototoxicity Unit, L OREAL Research, Aulnay sous Bois, France
    Pigment Cell Melanoma Res 21:79-88. 2008
  6. ncbi request reprint Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis
    Laurent Marrot
    Genotoxicity Group, L OREAL Research, 1 avenue Eugene Schueller, 93600 Aulnay sous Bois, France
    J Invest Dermatol 121:596-606. 2003
  7. ncbi request reprint Molecular responses to stress induced in normal human caucasian melanocytes in culture by exposure to simulated solar UV
    Laurent Marrot
    L Oreal Recherche, Aulnay sous Bois, France
    Photochem Photobiol 81:367-75. 2005
  8. doi request reprint Skin DNA photodamage and its biological consequences
    Laurent Marrot
    L OREAL Advanced Research, Life Science Research, Investigative Toxicology Department, Genotoxicity Group, Aulnay sous Bois, France
    J Am Acad Dermatol 58:S139-48. 2008
  9. ncbi request reprint The EpiSkin phototoxicity assay (EPA): development of an in vitro tiered strategy using 17 reference chemicals to predict phototoxic potency
    Damien Lelièvre
    L OREAL Research, Life Sciences, 1 avenue Eugene Schueller, 93 600 Aulnay Sous Bois, France
    Toxicol In Vitro 21:977-95. 2007
  10. ncbi request reprint Development of genotoxicity test procedures with Episkin, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds?
    Nicole Flamand
    L Oreal, Advanced Research, Life Sciences, Safety Research Department, Phototoxicity Genotoxicity Carcinogenicity Group, 1, avenue E Schueller, F 93600 Aulnay Sous Bois, France
    Mutat Res 606:39-51. 2006

Collaborators

  • Alain Sarasin
  • Jose Cotovio
  • Stan Pavel
  • Nico P M Smit
  • Jean Roch Meunier
  • Quentin Michard
  • Damien Lelièvre
  • Jean Philippe Belaidi
  • Nicole Flamand
  • Joan Eilstein
  • Stephane Commo
  • Bruno Alain Bernard
  • Anne Marie Alleaume
  • Edwige Daronnat
  • Jean Francois Michelet
  • Daniel Duche
  • Pascale Justine
  • Nicole Bonaventure
  • François Christiaens
  • Julie Coutet
  • Linda Bourouf
  • Michèle Feltes
  • Emilie Dourille

Detail Information

Publications11

  1. ncbi request reprint Photogenotoxicity of mammalian cells: a review of the different assays for in vitro testing
    Jean Roch Meunier
    L OREAL Advanced Research, Life Sciences Research, Aulnay sous Bois, France
    Photochem Photobiol 75:437-47. 2002
    ..Ultimately, it can lead to the induction of hereditary DNA modification. A variety of assays are proposed to specifically address all these particular consequences of UV-induced toxicity...
  2. ncbi request reprint Importance of UVA photoprotection as shown by genotoxic related endpoints: DNA damage and p53 status
    Laurent Marrot
    L OREAL Research, Life Sciences Research, Phototoxicology Unit, Genotoxicity Group 1, av E Schueller, 93600 Aulnay sous Bois, France
    Mutat Res 571:175-84. 2005
    ..These data demonstrate that the loss of absorbing efficiency within UVA wavelengths due to photounstability may have detrimental consequences leading to impairments implicated in genotoxic events...
  3. doi request reprint TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress
    Quentin Michard
    L Oreal Recherche, 90 rue du General Roguet, 92583 Clichy Cedex, France
    Free Radic Biol Med 44:1023-31. 2008
    ..Nevertheless, these properties appeared to depend on a particular cell environment because expression of TRP-2 failed to rescue HEK epithelial cells exposed to similar treatments...
  4. ncbi request reprint Comet assay combined with p53 detection as a sensitive approach for DNA photoprotection assessment in vitro
    Laurent Marrot
    Genotoxicity Group, L OREAL Research, 1 Avenue E Schueller, 96300 Aulnay sous Bois, France
    Exp Dermatol 11:33-6. 2002
    ..As a consequence, such a formulation was not as protective as a photostable one at the genomic level...
  5. doi request reprint The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis
    Laurent Marrot
    Department of Safety Research, Phototoxicity Unit, L OREAL Research, Aulnay sous Bois, France
    Pigment Cell Melanoma Res 21:79-88. 2008
    ..The results hereby presented should contribute to a better understanding of the molecular mechanisms involved in skin adaptation to environmental stress...
  6. ncbi request reprint Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis
    Laurent Marrot
    Genotoxicity Group, L OREAL Research, 1 avenue Eugene Schueller, 93600 Aulnay sous Bois, France
    J Invest Dermatol 121:596-606. 2003
    ..These data show that the phototoxicity of a given drug can be driven by different mechanisms and that its biologic impact varies according to cell type...
  7. ncbi request reprint Molecular responses to stress induced in normal human caucasian melanocytes in culture by exposure to simulated solar UV
    Laurent Marrot
    L Oreal Recherche, Aulnay sous Bois, France
    Photochem Photobiol 81:367-75. 2005
    ..They provide new data related to gene expression and suggest that melanin in light skin could contribute to sunlight-induced genotoxicity and maybe to melanocyte transformation...
  8. doi request reprint Skin DNA photodamage and its biological consequences
    Laurent Marrot
    L OREAL Advanced Research, Life Science Research, Investigative Toxicology Department, Genotoxicity Group, Aulnay sous Bois, France
    J Am Acad Dermatol 58:S139-48. 2008
    ..Besides the biological consequences of DNA photolesions, this article also deals with technologies used for their detection and shows how helpful such approaches can be to assess photoprotection provided by sunscreens...
  9. ncbi request reprint The EpiSkin phototoxicity assay (EPA): development of an in vitro tiered strategy using 17 reference chemicals to predict phototoxic potency
    Damien Lelièvre
    L OREAL Research, Life Sciences, 1 avenue Eugene Schueller, 93 600 Aulnay Sous Bois, France
    Toxicol In Vitro 21:977-95. 2007
    ..1%. The performances of the EPA showed that the EpiSkin(LM) model is an interesting tool able to integrate decision-making processes to address the question of phototoxicity linked to the application site...
  10. ncbi request reprint Development of genotoxicity test procedures with Episkin, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds?
    Nicole Flamand
    L Oreal, Advanced Research, Life Sciences, Safety Research Department, Phototoxicity Genotoxicity Carcinogenicity Group, 1, avenue E Schueller, F 93600 Aulnay Sous Bois, France
    Mutat Res 606:39-51. 2006
    ..This second way of using human reconstructed skin for genotoxicity testing aims at improving the relevance of exposure conditions in in vitro genotoxicity assays for dermally applied compounds...
  11. doi request reprint Increased melanogenesis is a risk factor for oxidative DNA damage--study on cultured melanocytes and atypical nevus cells
    Nico P M Smit
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Photochem Photobiol 84:550-5. 2008
    ....