Pierre Marie

Summary

Country: France

Publications

  1. doi request reprint Transcription factors controlling osteoblastogenesis
    Pierre J Marie
    INSERM U606 and University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Arch Biochem Biophys 473:98-105. 2008
  2. ncbi request reprint Strontium ranelate: a physiological approach for optimizing bone formation and resorption
    P J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Bone 38:S10-4. 2006
  3. doi request reprint Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts
    Pierre J Marie
    INSERM U 606 and University Paris 7, Hopital Lariboisiere, Paris, France
    Front Oral Biol 12:144-59. 2008
  4. ncbi request reprint Fibroblast growth factor signaling controlling osteoblast differentiation
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM U 349 affiliated to CNRS, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Cedex 10, Paris, France
    Gene 316:23-32. 2003
  5. ncbi request reprint Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation
    Pierre J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 75475 Paris Cedex 10, France
    Curr Opin Rheumatol 18:S11-5. 2006
  6. doi request reprint [OPG/RANKL: role and therapeutic target in osteoporosis]
    Pierre Marie
    Directeur de Recherche au CNRS, INSERM U606 et Université Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, Paris Cedex 10, France
    Med Sci (Paris) 24:105-10. 2008
  7. ncbi request reprint Strontium ranelate: a novel mode of action optimizing bone formation and resorption
    P J Marie
    INSERM U606, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris, France
    Osteoporos Int 16:S7-10. 2005
  8. ncbi request reprint Osteogenic differentiation of human marrow-derived mesenchymal stem cells
    Pierre J Marie
    Laboratory of Osteoblast Biology and Pathology Unité 606 INSERM, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Regen Med 1:539-48. 2006
  9. ncbi request reprint Strontium as therapy for osteoporosis
    Pierre J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Curr Opin Pharmacol 5:633-6. 2005
  10. ncbi request reprint Optimizing bone metabolism in osteoporosis: insight into the pharmacologic profile of strontium ranelate
    P J Marie
    INSERM U349 affiliated CNRS, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475, Paris Cedex 10, France
    Osteoporos Int 14:S9-12. 2003

Collaborators

Detail Information

Publications63

  1. doi request reprint Transcription factors controlling osteoblastogenesis
    Pierre J Marie
    INSERM U606 and University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Arch Biochem Biophys 473:98-105. 2008
    ..This review also updates the regulation of transcription factor expression by signaling factors and hormones that control osteoblastogenesis...
  2. ncbi request reprint Strontium ranelate: a physiological approach for optimizing bone formation and resorption
    P J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Bone 38:S10-4. 2006
    ..These pharmacological and clinical studies suggest that strontium ranelate acts by increasing bone formation and decreasing bone resorption and that these effects result in improved bone mass in vivo...
  3. doi request reprint Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts
    Pierre J Marie
    INSERM U 606 and University Paris 7, Hopital Lariboisiere, Paris, France
    Front Oral Biol 12:144-59. 2008
    ..In this review paper, we summarize the effects of FGFR2 and Twist genetic mutations resulting in altered osteoblast phenotype and premature cranial fusion based on our analysis in human syndromic craniosynostosis...
  4. ncbi request reprint Fibroblast growth factor signaling controlling osteoblast differentiation
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM U 349 affiliated to CNRS, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Cedex 10, Paris, France
    Gene 316:23-32. 2003
    ....
  5. ncbi request reprint Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation
    Pierre J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 75475 Paris Cedex 10, France
    Curr Opin Rheumatol 18:S11-5. 2006
    ....
  6. doi request reprint [OPG/RANKL: role and therapeutic target in osteoporosis]
    Pierre Marie
    Directeur de Recherche au CNRS, INSERM U606 et Université Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, Paris Cedex 10, France
    Med Sci (Paris) 24:105-10. 2008
    ..This opens the way for novel therapeutic strategies for correcting bone metabolism in various pathologic disorders characterized by increased bone remodelling and bone loss...
  7. ncbi request reprint Strontium ranelate: a novel mode of action optimizing bone formation and resorption
    P J Marie
    INSERM U606, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris, France
    Osteoporos Int 16:S7-10. 2005
    ..Thus, pharmacological and clinical studies suggest that strontium ranelate optimizes bone resorption and bone formation, resulting in increased bone mass, which may be of great value in the treatment of osteoporosis...
  8. ncbi request reprint Osteogenic differentiation of human marrow-derived mesenchymal stem cells
    Pierre J Marie
    Laboratory of Osteoblast Biology and Pathology Unité 606 INSERM, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Regen Med 1:539-48. 2006
    ..In the future this may lead to selective therapeutic strategies for tissue engineering application in bone regeneration and repair in humans...
  9. ncbi request reprint Strontium as therapy for osteoporosis
    Pierre J Marie
    INSERM U606 and University Paris 7, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Curr Opin Pharmacol 5:633-6. 2005
    ..Together, these recent advances point to unique effects of strontium ranelate on bone cells and show that strontium ranelate has significant clinical benefits in the treatment of postmenopausal osteoporosis...
  10. ncbi request reprint Optimizing bone metabolism in osteoporosis: insight into the pharmacologic profile of strontium ranelate
    P J Marie
    INSERM U349 affiliated CNRS, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475, Paris Cedex 10, France
    Osteoporos Int 14:S9-12. 2003
    ..Altogether, these pharmacologic results suggest that SR optimizes bone metabolism by decreasing bone resorption and promoting bone formation, which may be of potential value in the treatment of osteoporosis...
  11. ncbi request reprint Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells
    A Barbara
    INSERM U349 affiliated to CNRS, Lariboisiere Hospital, Paris, France
    Metabolism 53:532-7. 2004
    ..These results show that long-term treatment with SR increases collagenous matrix formation by MC3T3-E1 osteoblasts without inducing deleterious effect on matrix mineralization...
  12. ncbi request reprint Role of N-cadherin and protein kinase C in osteoblast gene activation induced by the S252W fibroblast growth factor receptor 2 mutation in Apert craniosynostosis
    J Lemonnier
    , Centre National de la Recherche Scientifique, , Paris, France
    J Bone Miner Res 16:832-45. 2001
    ....
  13. doi request reprint [Implication of the ubiquitin ligase c-Cbl in bone formation and tumorigenesis]
    Nicolas Severe
    Université Paris Diderot Sorbonne Paris Cité, Paris, France
    Med Sci (Paris) 28:970-5. 2012
    ..Thus, the use of pharmacological agents capable of modulating c-Cbl activity may be of therapeutic interest for promoting bone formation in normal bone, or to reduce tumorigenesis in primary bone cancer...
  14. doi request reprint Characterization of distinct mesenchymal-like cell populations from human skeletal muscle in situ and in vitro
    Séverine Lecourt
    UPMC AIM UMR S 974, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Exp Cell Res 316:2513-26. 2010
    ..These results underline the diversity of human muscle cells, and the shared or restricted commitment abilities of the main lineages under defined conditions...
  15. ncbi request reprint FGF and FGFR signaling in chondrodysplasias and craniosynostosis
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM Unite 606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    J Cell Biochem 96:888-96. 2005
    ..These issues need to be addressed in future in in vitro and in vivo approaches to better understand the molecular mechanisms of action of FGFR signaling in osteoblasts that result in anabolic effects in bone formation...
  16. doi request reprint How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM, U606, Paris 75475, France
    Osteoporos Int 22:1659-67. 2011
    ....
  17. doi request reprint Cell and gene therapy for bone repair
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, Inserm UMR606 and University Paris Diderot, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Osteoporos Int 22:2023-6. 2011
    ..We identified genes that promote human mesenchymal cell differentiation and bone formation. Targeting these or other genes may improve the efficacy of cell therapy for bone repair...
  18. ncbi request reprint S12911-2 reduces bone loss induced by short-term immobilization in rats
    M Hott
    INSERM Unit 349 Affiliated CNRS, Hopital Lariboisiere, Paris, France
    Bone 33:115-23. 2003
    ..This study shows that the bone resorption induced by immobilization in rats can be suppressed by treatment with S12911-2, resulting in partial reduction of the bone loss...
  19. ncbi request reprint Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation
    O Fromigue
    INSERM Unit 349, Cell and Molecular Biology of Bone and Cartilage, Lariboisiere Hospital, Paris, France
    J Cell Biochem 68:411-26. 1998
    ..These observations suggest that TGF-beta2 and BMP-2 may act in a sequential manner at different stages to promote human bone marrow stromal cell differentiation towards the osteoblast phenotype...
  20. pmc Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome
    M Yousfi
    Laboratory on Osteoblast Biology and Pathology, , Affiliated Centre National de la Recherche Scientifique, , Paris, France
    J Clin Invest 107:1153-61. 2001
    ..This provides one mechanism that may contribute to the premature cranial ossification induced by deletion of the bHLH Twist domain in Saethre-Chotzen syndrome...
  21. ncbi request reprint Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling
    P J Marie
    INSERM U349, Hopital Lariboisiere, Paris, France
    Histol Histopathol 17:877-85. 2002
    ....
  22. ncbi request reprint N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2
    E Hay
    INSERM U 349, Affiliated CNRS, Cell and Molecular Biology of Bone and Cartilage, Paris, France
    J Cell Physiol 183:117-28. 2000
    ..We conclude that rhBMP-2 rapidly and transiently increases N- and E-cadherin expression, and this effect mediates the rhBMP-2-induced early promotion of cell-cell adhesion and osteoblast marker gene expression in human calvaria cells...
  23. ncbi request reprint Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice
    P Delannoy
    INSERM U349 affiliated CNRS, Lariboisiere Hospital, Paris, France
    Metabolism 51:906-11. 2002
    ....
  24. ncbi request reprint Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts
    S Le Mee
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Lariboisiere Hospital, 75475 Cedex 10 Paris, France
    Exp Cell Res 302:129-42. 2005
    ..These results indicate that Sp1/Sp3 and MZF1 are important transcription factors regulating N-cadherin promoter activity and expression in osteoblasts...
  25. ncbi request reprint Plasticity and regulation of human bone marrow stromal osteoprogenitor cells: potential implication in the treatment of age-related bone loss
    S Ahdjoudj
    Laboratory of Osteoblast Biology and Pathology, INSERM Unité 349 affiliated to CNRS, Paris Cedex 10, France
    Histol Histopathol 19:151-7. 2004
    ..This may result in the development of therapeutic strategies to promote the differentiation of these cells towards the osteoblast lineage and to inhibit excessive bone marrow adipogenesis associated with aging...
  26. ncbi request reprint Increased expression of protein kinase Calpha, interleukin-1alpha, and RhoA guanosine 5'-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 receptor Apert mutation: identification by analysis of complementary DNA microarray
    A Lomri
    , Lariboisiere Hospital, Paris, France
    J Bone Miner Res 16:705-12. 2001
    ..The cDNA microarray technology appears to be a useful tool to gain information on abnormal gene expression and molecular pathways induced by genetic mutations in bone cells...
  27. ncbi request reprint Protein kinase C-dependent upregulation of N-cadherin expression by phorbol ester in human calvaria osteoblasts
    P Delannoy
    INSERM U 349 Affiliated CNRS, , Paris, France
    Exp Cell Res 269:154-61. 2001
    ....
  28. ncbi request reprint Mechanisms of action and therapeutic potential of strontium in bone
    P J Marie
    INSERM U349, , Paris, France
    Calcif Tissue Int 69:121-9. 2001
    ..This review summarizes the mechanisms of action of strontium on bone cells, the evidence for its beneficial effects on bone mass in vivo, and its potential therapeutic effects in osteopenic disorders...
  29. ncbi request reprint Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway
    E Hay
    Laboratory of Osteoblast Biology and Pathology, INSERM U 349, Affiliated CNRS, Lariboisiere Hospital, 75475 Cedex 10 Paris, France
    J Biol Chem 276:29028-36. 2001
    ..The results show that BMP-2 uses a Smad-independent, PKC-dependent pathway to promote apoptosis via a Bax/Bcl-2 and cytochrome c-caspase-9-caspase-3, -6, -7 cascade in human osteoblasts...
  30. ncbi request reprint Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts
    D Modrowski
    INSERM, Unité 349, affiliated to CNRS, Hopital Lariboisiere, 75475 Paris Cedex 10, France
    J Biol Chem 275:9178-85. 2000
    ..Our results indicate functional interactions between syndecan-2 and GM-CSF in osteoblasts, and we propose that syndecan-2 plays a role as a co-receptor for this cytokine...
  31. ncbi request reprint Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells
    S Ahdjoudj
    Unit 606 INSERM, Laboratory of Osteoblast Biology and Pathology, Paris, France
    Exp Cell Res 303:138-47. 2005
    ....
  32. ncbi request reprint The molecular genetics of bone formation: implications for therapeutic interventions in bone disorders
    P J Marie
    Laboratory on Osteoblast Biology and Pathology, INSERM U349, Affiliated CNRS, Hopital Lariboisiere, Paris, France
    Am J Pharmacogenomics 1:175-87. 2001
    ....
  33. ncbi request reprint Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts
    F Debiais
    INSERM Unit 349 Affiliated CNRS, Lariboisiere Hospital, , 75475 Paris Cedex 10, France
    J Cell Biochem 81:68-81. 2001
    ..This study identifies N-cadherin as a previously unrecognized target gene for FGF-2 signaling pathway that regulates cell-cell adhesion in human osteoblasts...
  34. ncbi request reprint Reciprocal control of osteoblast/chondroblast and osteoblast/adipocyte differentiation of multipotential clonal human marrow stromal F/STRO-1(+) cells
    S Ahdjoudj
    , , , 75475 Paris Cedex 10, France
    J Cell Biochem 81:23-38. 2001
    ....
  35. ncbi request reprint Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway
    F Debiais
    INSERM U 606, Lariboisiere Hospital, Paris, France
    Exp Cell Res 297:235-46. 2004
    ..The results indicate that the immediate protective effect of FGF-2 on human osteoblastic cell apoptosis involves PI3K and inhibition of downstream caspases, independently of GSK-3 and beta-catenin-Lef/Tcf-mediated transcription...
  36. ncbi request reprint Cellular and molecular alterations of osteoblasts in human disorders of bone formation
    P J Marie
    U 349 INSERM, Cell and Molecular Biology of Bone and Cartilage, Hopital Lariboisiere, Paris, France
    Histol Histopathol 14:525-38. 1999
    ....
  37. pmc Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1
    J Lemonnier
    INSERM U 349 Affiliated CNRS, , Paris, France
    Am J Pathol 158:1833-42. 2001
    ..This identifies a complex FGFR-2 signaling pathway involved in the premature apoptosis induced by the Apert S252W FGFR-2 mutation in human calvaria osteoblasts...
  38. ncbi request reprint RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation
    O Fromigue
    INSERM U606, University Paris 7, IFR 139, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Cell Death Differ 13:1845-56. 2006
    ..Thus, lipophilic statins induce caspase-dependent osteosarcoma cell apoptosis by a RhoA-p42/p44 MAPKs-Bcl-2-mediated mechanism, independently of BMP-2 signaling and cell differentiation...
  39. ncbi request reprint Skeletal unloading induces osteoblast apoptosis and targets alpha5beta1-PI3K-Bcl-2 signaling in rat bone
    C Dufour
    Unit 606 INSERM, Laboratory of Osteoblast Biology and Pathology, University Paris 7, France
    Exp Cell Res 313:394-403. 2007
    ....
  40. ncbi request reprint Cellular and molecular basis of fibrous dysplasia
    P J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM Unite 349, CNRS, Hopital Lariboisiere, Paris, France
    Histol Histopathol 16:981-8. 2001
    ..These mechanisms provide a cellular and molecular basis for the alterations in bone cells and bone matrix in fibrous dysplasia...
  41. ncbi request reprint Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma
    Armelle Orosco
    INSERM U606 and Université Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Cancer Res 67:3708-15. 2007
    ..Moreover, our data identify syndecan-2 as a new factor mediating the antioncogenic effect of chemotherapeutic drugs...
  42. ncbi request reprint Distinct osteoblastic differentiation potential of murine fetal liver and bone marrow stroma-derived mesenchymal stem cells
    Olivia Fromigue
    INSERM U606, Universite Paris 7, Hopital Lariboisiere, Paris, France
    J Cell Biochem 104:620-8. 2008
    ....
  43. doi request reprint Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs
    Olivia Fromigue
    Institut National de la Santé et de la Recherche Médicale U606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    J Pharmacol Exp Ther 325:595-600. 2008
    ....
  44. pmc Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation
    Hind Guenou
    Laboratory of Osteoblast Biology and Pathology, INSERM U 606, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Am J Pathol 169:1303-11. 2006
    ..This provides genetic and biochemical evidence for a role for Cbl-mediated PI3K signaling in the altered osteoblast phenotype induced by Twist haploinsufficiency in SCS...
  45. doi request reprint FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival
    Cecilie Dufour
    INSERM U606 and University Paris 7, Paris, France
    Bone 42:1032-9. 2008
    ....
  46. doi request reprint FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression
    Zahia Hamidouche
    INSERM U606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    FASEB J 22:3813-22. 2008
    ....
  47. ncbi request reprint Dual involvement of protein kinase C delta in apoptosis induced by syndecan-2 in osteoblasts
    Armelle Orosco
    Laboratory of Osteoblast Biology and Pathology, INSERM, Lariboisiere Hospital, University Paris 7, Paris, France
    J Cell Biochem 98:838-50. 2006
    ..This establishes a functional interaction between SYND2 and PKCdelta in osteoblasts...
  48. ncbi request reprint Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation
    Malika Yousfi
    Laboratory of Osteoblast Biology and Pathology, INSERM U349 affiliated CNRS, Hopital Lariboisiere, 2 rue Ambroise Pare 75475 Paris cedex 10, France
    Hum Mol Genet 11:359-69. 2002
    ....
  49. ncbi request reprint Role of N-cadherin in bone formation
    Pierre J Marie
    INSERM U 349, Affiliated CNRS, Biology and Pathology of Osteoblast, Lariboisiere Hospital, Paris, France
    J Cell Physiol 190:297-305. 2002
    ..These findings indicate that N-cadherin plays a role in normal and pathological bone formation and provide some insight into the process involved in N-cadherin-mediated cell-cell adhesion and differentiation in osteoblasts...
  50. ncbi request reprint Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma
    Souhila Ahdjoudj
    Unit 349 INSERM, CNRS, Laboratory of Osteoblast Biology and Pathology, Lariboisiere Hospital, Paris, France
    J Bone Miner Res 17:668-77. 2002
    ..These abnormalities are prevented and reversed by TGF-beta2, suggesting a role for TGF-beta in the control of adipogenic differentiation in the bone marrow stroma...
  51. ncbi request reprint FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  52. ncbi request reprint Spaceflight affects bone formation in rhesus monkeys: a histological and cell culture study
    Erik Zerath
    Department of Aerospace Physiology, IMASSA, 91223 Brétigny sur Orge, France
    J Appl Physiol 93:1047-56. 2002
    ..This study suggests that a 14-day spaceflight reduces iliac bone formation, osteoblastic activity, and/or recruitment in young rhesus monkeys, resulting in decreased trabecular bone volume...
  53. ncbi request reprint TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts
    Malika Yousfi
    INSERM Unit 349 Affiliated CNRS, Lariboisiere Hospital, 2 rue Ambroise Pare, 75475 10, Paris Cedex, France
    Biochem Biophys Res Commun 297:641-4. 2002
    ..This provides the first evidence that TWIST inactivation alters CBFA1/RUNX2 expression and Cbfa1 binding ability to the osteocalcin promoter, indicating that CBFA1/RUNX2 is a target gene for TWIST in human osteoblasts...
  54. ncbi request reprint Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells
    Eric Hay
    Laboratory of Osteoblast Biology and Pathology, INSERM U 349, CNRS, Lariboisiere Hospital, 75475 Cedex 10 Paris, France
    J Biol Chem 279:1650-8. 2004
    ....
  55. ncbi request reprint Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation
    Karim Kaabeche
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    J Biol Chem 279:36259-67. 2004
    ....
  56. ncbi request reprint A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome
    Yukiho Tanimoto
    Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8504, Japan
    J Biol Chem 279:45926-34. 2004
    ....
  57. ncbi request reprint Growth factors and bone formation in osteoporosis: roles for fibroblast growth factor and transforming growth factor beta
    Olivia Fromigue
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris, France
    Curr Pharm Des 10:2593-603. 2004
    ....
  58. ncbi request reprint Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation
    Karim Kaabeche
    INSERM U 606, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, Universite Paris 7, Paris, France
    J Cell Sci 118:1223-32. 2005
    ....
  59. ncbi request reprint A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome
    Hind Guenou
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris, University Paris 7, Hopital Lariboisiere, Paris, France
    Hum Mol Genet 14:1429-39. 2005
    ..This provides genetic and biochemical evidence for a role of Fgfr2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the SCS...
  60. ncbi request reprint Apoptosis in membranous bone formation: role of fibroblast growth factor and bone morphogenetic protein signaling
    Olivia Fromigue
    Laboratory of Osteoblast Biology and Pathology, INSERM Unite 606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Crit Rev Eukaryot Gene Expr 15:75-92. 2005
    ..These mechanisms allow a fine control of the number of functional bone-forming cells and, thereby, the normal progression of membranous bone formation...
  61. ncbi request reprint Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling
    Dominique Modrowski
    Laboratory of Osteoblast Biology and Pathology, Unité 606, INSERM, Lariboisiere Hospital, Universite Paris 7, 2 rue Ambroise Pare, 75475 Cedex 10 Paris, France
    Bone 37:180-9. 2005
    ..This supports a role for syndecan-2 in the regulation of osteosarcoma cell fate and identifies one signaling pathway by which syndecan-2 induces apoptosis in osteosarcoma cells...
  62. doi request reprint Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling
    Cecilie Dufour
    Unit 606 Institut National de la Santé et de la Recherche Médicale, Paris, France
    Am J Physiol Endocrinol Metab 294:E794-801. 2008
    ..We thus propose a novel role for TGF-beta2 in protection from unloading-induced apoptosis in vivo...
  63. ncbi request reprint The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells
    Kimberly M Rieger-Christ
    Cell and Molecular Biology Laboratory, Robert E Wise Research and Education Institute, Lahey Clinic Medical Center, 31 Mall Road, Burlington, Massachusetts 01805, USA
    J Cell Biochem 102:377-88. 2007
    ..Continuous administration of EGCG to mice revealed significant inhibition of tumor growth in vivo indicating a possible preventative role for green tea in bladder cancer...