Eric Maréchal

Summary

Country: France

Publications

  1. pmc Fitting hidden Markov models of protein domains to a target species: application to Plasmodium falciparum
    Nicolas Terrapon
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Universite Montpellier 2, France
    BMC Bioinformatics 13:67. 2012
  2. doi request reprint Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells
    Laurence Boudière
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168 CNRS CEA INRA Université J Fourier Grenoble 1, Grenoble, France
    Mol Biosyst 8:2023-35, 2014. 2012
  3. pmc Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    Lyn Marie Birkholtz
    Department of Biochemistry and African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences, University of Pretoria, 0002, Pretoria, South Africa
    Malar J 5:110. 2006
  4. pmc Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum
    Laurent Bréhélin
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Univ, Montpellier 2, CNRS 161 rue Ada, 34392 Montpellier, France
    BMC Genomics 11:35. 2010
  5. pmc A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism
    Isabelle Florent
    FRE3206 CNRS MNHN, USM504, Biologie Fonctionnelle des Protozoaires, RDDM, Museum national d histoire naturelle, Paris, France
    BMC Genomics 10:235. 2009
  6. ncbi request reprint Chemogenomics: a discipline at the crossroad of high throughput technologies, biomarker research, combinatorial chemistry, genomics, cheminformatics, bioinformatics and artificial intelligence
    Eric Maréchal
    Unité mixte de recherche 5168 CNRS CEA INRA Université Joseph Fourier, Institut de Recherches en Technologies et Sciences pour le Vivant, 17 Avenue des Martyrs, France
    Comb Chem High Throughput Screen 11:583-6. 2008
  7. doi request reprint Membrane lipidomics for the discovery of new antiparasitic drug targets
    Eric Maréchal
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, CNRS CEA INRA Université Joseph Fourier, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, 17 rue des Martyrs, Grenoble, France
    Trends Parasitol 27:496-504. 2011
  8. ncbi request reprint Refolding from denatured inclusion bodies, purification to homogeneity and simplified assay of MGDG synthases from land plants
    Yoshitaka Nishiyama
    UMR 5019 CNRS CEA INRA Université Joseph Fourier, Laboratoire de Physiologie Cellulaire Végétale, Département de Recherche et Dynamique Cellulaire, CEA Grenoble, 17 rue des Martyrs, F 38054, 09, Grenoble Cedex, France
    Protein Expr Purif 31:79-87. 2003
  9. ncbi request reprint Transient increase of phosphatidylcholine in plant cells in response to phosphate deprivation
    Juliette Jouhet
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5019 CNRS CEA Université Joseph Fourier, DRDC PCV, CEA Grenoble, 17 rue des Martyrs, France
    FEBS Lett 544:63-8. 2003
  10. ncbi request reprint Molecular modeling and site-directed mutagenesis of plant chloroplast monogalactosyldiacylglycerol synthase reveal critical residues for activity
    Cyrille Botté
    UMR 5168 CNRS Commissariat à l Energie Atomique Institut National de la Recherche Agronomique, Universite Joseph Fourier, Departement Reponse et Dynamique Cellulaires, 17 rue des Martyrs, Commissariat a l Energie Atomique, 38054 Grenoble Cedex 9, France
    J Biol Chem 280:34691-701. 2005

Collaborators

Detail Information

Publications29

  1. pmc Fitting hidden Markov models of protein domains to a target species: application to Plasmodium falciparum
    Nicolas Terrapon
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Universite Montpellier 2, France
    BMC Bioinformatics 13:67. 2012
    ..falciparum, the main causal agent of human malaria. In this context, fitting HMMs to the specificities of the target proteome can help identify additional domains...
  2. doi request reprint Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells
    Laurence Boudière
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168 CNRS CEA INRA Université J Fourier Grenoble 1, Grenoble, France
    Mol Biosyst 8:2023-35, 2014. 2012
    ..This review details how this probe could be beneficial to study the lipid homeostasis system at the whole cell level and highlights connections between MGDG synthesis and Arabidopsis flower development...
  3. pmc Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    Lyn Marie Birkholtz
    Department of Biochemistry and African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences, University of Pretoria, 0002, Pretoria, South Africa
    Malar J 5:110. 2006
    ..Recent progress towards a grid-enabled chemogenomic knowledge space is discussed...
  4. pmc Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum
    Laurent Bréhélin
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Univ, Montpellier 2, CNRS 161 rue Ada, 34392 Montpellier, France
    BMC Genomics 11:35. 2010
    ..Gene expression data have been widely used in the recent years to help functional annotation in an intra-species way via the so-called Guilt By Association (GBA) principle...
  5. pmc A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism
    Isabelle Florent
    FRE3206 CNRS MNHN, USM504, Biologie Fonctionnelle des Protozoaires, RDDM, Museum national d histoire naturelle, Paris, France
    BMC Genomics 10:235. 2009
    ..falciparum gene models and 3) pinpointing genes displaying protein polymorphism between the FcB1 and 3D7 strains...
  6. ncbi request reprint Chemogenomics: a discipline at the crossroad of high throughput technologies, biomarker research, combinatorial chemistry, genomics, cheminformatics, bioinformatics and artificial intelligence
    Eric Maréchal
    Unité mixte de recherche 5168 CNRS CEA INRA Université Joseph Fourier, Institut de Recherches en Technologies et Sciences pour le Vivant, 17 Avenue des Martyrs, France
    Comb Chem High Throughput Screen 11:583-6. 2008
    ..Concerns about the environmental impact of chemical industry open new fields of research for chemogenomics...
  7. doi request reprint Membrane lipidomics for the discovery of new antiparasitic drug targets
    Eric Maréchal
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, CNRS CEA INRA Université Joseph Fourier, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, 17 rue des Martyrs, Grenoble, France
    Trends Parasitol 27:496-504. 2011
    ..This review highlights recent trends in parasite lipidomics, combined with functional analyses, for the discovery of novel targets and the development of novel drugs...
  8. ncbi request reprint Refolding from denatured inclusion bodies, purification to homogeneity and simplified assay of MGDG synthases from land plants
    Yoshitaka Nishiyama
    UMR 5019 CNRS CEA INRA Université Joseph Fourier, Laboratoire de Physiologie Cellulaire Végétale, Département de Recherche et Dynamique Cellulaire, CEA Grenoble, 17 rue des Martyrs, F 38054, 09, Grenoble Cedex, France
    Protein Expr Purif 31:79-87. 2003
    ..Additionally, using the portion of recombinant enzyme that accumulates in an active form in bacterial membranes, we developed a miniature assay for high-throughput screening for inhibitors...
  9. ncbi request reprint Transient increase of phosphatidylcholine in plant cells in response to phosphate deprivation
    Juliette Jouhet
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5019 CNRS CEA Université Joseph Fourier, DRDC PCV, CEA Grenoble, 17 rue des Martyrs, France
    FEBS Lett 544:63-8. 2003
    ....
  10. ncbi request reprint Molecular modeling and site-directed mutagenesis of plant chloroplast monogalactosyldiacylglycerol synthase reveal critical residues for activity
    Cyrille Botté
    UMR 5168 CNRS Commissariat à l Energie Atomique Institut National de la Recherche Agronomique, Universite Joseph Fourier, Departement Reponse et Dynamique Cellulaires, 17 rue des Martyrs, Commissariat a l Energie Atomique, 38054 Grenoble Cedex 9, France
    J Biol Chem 280:34691-701. 2005
    ..Additionally, the monotopic insertion of MGD in one membrane leaflet of the plastid envelope occurs very likely at the level of hydrophobic amino acids of the N-terminal domain...
  11. doi request reprint Role of phosphatidic acid in plant galactolipid synthesis
    Emmanuelle Dubots
    Laboratoire de Physiologie Cellulaire et Végétale, UMR 5168, CNRS, CEA, INRA, Universite Joseph Fourier Grenoble I, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble, France
    Biochimie 94:86-93. 2012
    ..Some mechanisms are considered to explain how physicochemical properties of PA allow this lipid to act as a central internal sensor in plant physiology...
  12. doi request reprint Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana
    Cyrille Y Botté
    Commissariat a l Energie Atomique, Centre National de la Recherche Scientifique, Universite Joseph Fourier Grenoble I, Institut National de la Recherche Agronomique, Unité Mixte de Recherche 5168, Grenoble, France
    Nat Chem Biol 7:834-42. 2011
    ..The whole-genome transcriptional response of Arabidopsis points to the potential benefits of galvestine-1 as a unique tool to study lipid homeostasis in plants...
  13. pmc Phosphate deprivation induces transfer of DGDG galactolipid from chloroplast to mitochondria
    Juliette Jouhet
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168 CNRS CEA Université Jseph Fourier INRA, DRDC PCV, CEA Grenoble, Grenoble, France
    J Cell Biol 167:863-74. 2004
    ..Contacts sites are favored at early stages of phosphate deprivation when DGDG cell content is just starting to respond to phosphate deprivation...
  14. ncbi request reprint Glycerolipids in photosynthesis: composition, synthesis and trafficking
    Laurence Boudière
    Laboratoire de Physiologie Cellulaire, Végétale, CNRS UMR 5168, CEA iRTSV, Univ Grenoble Alpes, INRA USC 1359, CEA Grenoble, 17 rue des Martyrs, 38054, Grenoble Cedex 9, France
    Biochim Biophys Acta 1837:470-80. 2014
    ..This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. ..
  15. pmc Activation of the chloroplast monogalactosyldiacylglycerol synthase MGD1 by phosphatidic acid and phosphatidylglycerol
    Emmanuelle Dubots
    Laboratoire de Physiologie Cellulaire Végétale, CNRS CEA INRA Université Joseph Fourier, CEA Grenoble, F 38054 Grenoble, France
    J Biol Chem 285:6003-11. 2010
    ..Activation of MGD1 by PA and PG is proposed as an important mechanism coupling phospholipid and galactolipid syntheses in plants...
  16. ncbi request reprint Evolution of galactoglycerolipid biosynthetic pathways--from cyanobacteria to primary plastids and from primary to secondary plastids
    Dimitris Petroutsos
    Laboratoire de Physiologie Cellulaire et Végétale, CNRS, CEA, INRA, Univ Grenoble Alpes, UMR 5168, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, F 38054 Grenoble, France
    Prog Lipid Res 54:68-85. 2014
    ..Questions for future research are highlighted. ..
  17. ncbi request reprint Construction of non-symmetric substitution matrices derived from proteomes with biased amino acid distributions
    Olivier Bastien
    Laboratoire de Physiologie Cellulaire Végétale, Département Réponse et Dynamique Cellulaire, UMR 5019, CNRS CEA INRA Université Joseph Fourier, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble, France
    C R Biol 328:445-53. 2005
    ..falciparum and A. thaliana is given as an example. This paper further provides an analysis of the obtained matrices in the frame of the information theory, supporting the discrimination advantage they bring...
  18. ncbi request reprint The plant S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase is located in both envelope and thylakoid chloroplast membranes
    Maryse A Block
    Laboratoire de Physiologie Cellulaire Végétale, CNRS CEA Université Joseph Fourier, DBMS PCV, Grenoble, France
    Eur J Biochem 269:240-8. 2002
    ..The rationale for a dual localization of the protein in the chloroplast is discussed...
  19. pmc Synthesis of chloroplast galactolipids in apicomplexan parasites
    Eric Maréchal
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5019 CNRS CEA Université Joseph Fourier, Département Réponse et Dynamique Cellulaire, CEA Grenoble, 38054 Grenoble Cedex 9, France
    Eukaryot Cell 1:653-6. 2002
    ..Furthermore, DGDG is immunologically detected in apicomplexans...
  20. pmc A configuration space of homologous proteins conserving mutual information and allowing a phylogeny inference based on pair-wise Z-score probabilities
    Olivier Bastien
    UMR 5019 CNRS CEA INRA Université Joseph Fourier, Laboratoire de Physiologie Cellulaire Végétale, Département Réponse et Dynamique Cellulaire, CEA Grenoble, 17 rue des Martyrs, F 38054, Grenoble Cedex 09, France
    BMC Bioinformatics 6:49. 2005
    ....
  21. pmc The cyst-dividing bacterium Ramlibacter tataouinensis TTB310 genome reveals a well-stocked toolbox for adaptation to a desert environment
    Gilles De Luca
    CEA, Lab Ecol Microbienne Rhizosphere and Environm Extre, IBEB, DSV, Saint Paul lez Durance, France
    PLoS ONE 6:e23784. 2011
    ....
  22. pmc Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs
    Nadia Saïdani
    Commissariat a l Energie Atomique, Centre National de la Recherche Scientifique, Université Grenoble Alpes, Institut National de la Recherche Agronomique, Unité Mixte de Recherche 5168, Institut de Recherches en Technologies et Sciences pour le Vivant, Grenoble, France
    Antimicrob Agents Chemother 58:2586-97. 2014
    ..Here, we propose the use of structure-activity relationship (SAR) models, which will be useful for designing probes to identify the target compound(s) and optimizations for monotherapy or combined-therapy strategies. ..
  23. doi request reprint Potential and limits of in silico target discovery - Case study of the search for new antimalarial chemotherapeutic targets
    Nadia Saïdani
    UMR 5168 CNRS CEA INRA Université Joseph Fourier, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, France
    Infect Genet Evol 9:359-67. 2009
    ..In silico strategies to assess the feasibility of bringing a target to a therapeutic development pipeline, in terms of target "druggability", are introduced...
  24. doi request reprint Plant lipid-associated fibrillin proteins condition jasmonate production under photosynthetic stress
    Abir Youssef
    Laboratory Plastes et Différenciation Cellulaire, CNRS Université Joseph Fourier, Grenoble, France
    Plant J 61:436-45. 2010
    ..Consistent correlative data suggest that this FIB effect is mediated by plastoglobule (and triacylglycerol) accumulation as the potential site for initiating the chloroplast stress-related JA biosynthesis...
  25. ncbi request reprint Fundamentals of massive automatic pairwise alignments of protein sequences: theoretical significance of Z-value statistics
    Olivier Bastien
    Laboratoire de Physiologie Cellulaire Végétale, Département Réponse et Dynamique Cellulaire, UMR 5168 CNRS CEA INRA Université J Fourier, CEA Grenoble, 17 rue des Martyrs, F 38054, Grenoble Cedex 09, France
    Bioinformatics 20:534-7. 2004
    ....
  26. doi request reprint Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii
    Cyrille Botté
    Unité Mixte de Recherche 5168, Centre National de la Recherche Scientifique Commissariat à l Energie, Institut de Recherches en Technologies et Sciences pour le Vivant, 38058 Grenoble, France
    J Lipid Res 49:746-62. 2008
    ..DGLE was detected in other Apicomplexa (i.e., Neospora, Plasmodium, Babesia, and Cryptosporidium)...
  27. pmc Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine
    Djeneb Camara
    Laboratoire de Physiologie Cellulaire Végétale, Commissariat à l Energie Atomique CNRS UMR5168 INRA USC1200 Université Joseph Fourier Grenoble I, Institut de Recherches en Technologies et Sciences pour le Vivant, F 38054 Grenoble, France
    J Biol Chem 287:22367-76. 2012
    ....
  28. doi request reprint Screening for inhibitors of chloroplast galactolipid synthesis acting in membrano and in planta
    Laurence Boudière
    Laboratoire de Physiologie Cellulaire et Végétale, UMR 5168 CNRS CEA INRA Université J Fourier Grenoble 1, Institut de Recherches en Technologies et Sciences pour le Vivant, CEA Grenoble, Grenoble, France
    Methods Mol Biol 1056:79-93. 2014
    ..Major issues raised by the screening of inhibitors acting on membrane proteins are discussed and can be useful for similar targets. ..
  29. pmc Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment scores
    Olivier Bastien
    UMR 5168 CNRS CEA INRA Université J, Fourier, Laboratoire de Physiologie Cellulaire Végétale, Département Réponse et Dynamique Cellulaire, CEA Grenoble, 17 rue des Martyrs, F 38054, Grenoble Cedex 09, France
    BMC Bioinformatics 9:332. 2008
    ..Simulations of Z-value distribution is known to fit with a Gumbel law. This remarkable property was not demonstrated and had no obvious biological support...