L Mandelbrot

Summary

Country: France

Publications

  1. ncbi request reprint Placental transfer of darunavir in an ex vivo human cotyledon perfusion model
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris, Hopital Louis Mourier, Service de Gynecologie Obstetrique, Département Hospitalier Universitaire Risque et Grossesse, Colombes, France Université Paris Diderot, Paris, France
    Antimicrob Agents Chemother 58:5617-20. 2014
  2. ncbi request reprint [HIV and pregnancy: 2013 guidelines from the French expert working group]
    L Mandelbrot
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, Universite Paris Diderot, 178, rue des Renouillers, 92700 Colombes, France Electronic address
    J Gynecol Obstet Biol Reprod (Paris) 43:534-48. 2014
  3. ncbi request reprint [Reproductive options for people living with HIV: 2013 guidelines from the French expert working group]
    L Mandelbrot
    Service de Gynecologie Obstetrique, CHU Louis Mourier, AP HP, Universite Denis Diderot, 178, rue des Renouillers, 92700 Colombes, France Electronic address
    Gynecol Obstet Fertil 42:543-50. 2014
  4. doi request reprint [Prevention of mother-to-child transmission of toxoplasmosis: perspectives]
    L Mandelbrot
    Pôle Femme Enfant, Service de Gynecologie Obstetrique, Universite Paris Diderot, Hopital Louis Mourier, AP HP, HUPNVS, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 40:591-8. 2012
  5. doi request reprint Fetal varicella - diagnosis, management, and outcome
    Laurent Mandelbrot
    Hopital Louis Mourier, Service de Gynecologie Obstetrique, hôpitaux universitaires Paris Nord Val de Seine, Assistance Publique Hopitaux de Paris, Universite Paris Diderot, 178 rue des Renouillers, 92701, Colombes Cedex, France
    Prenat Diagn 32:511-8. 2012
  6. doi request reprint [Reproduction and HIV: has the condom become irrelevant?]
    L Mandelbrot
    Service de Gynecologie Obstetrique, Universite Paris Diderot, AP HP, hôpitaux universitaires Paris Nord Val de Seine, Hopital Louis Mourier, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 40:58-61. 2012
  7. pmc Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome
    Constance Delaugerre
    EA 3620 MRT, Descartes University, Paris, France
    Retrovirology 6:85. 2009
  8. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
  9. doi request reprint Atazanavir in pregnancy: impact on neonatal hyperbilirubinemia
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris, Louis Mourier Hospital, Department of Obstetrics and Gynecology, Colombes, France
    Eur J Obstet Gynecol Reprod Biol 157:18-21. 2011
  10. doi request reprint [Screening for gestational diabetes mellitus: Is it time to revise the recommendations?]
    L Mandelbrot
    Hopital Louis Mourier, AP HP, Universite Paris, Colombes, France
    Gynecol Obstet Fertil 38:409-14. 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Placental transfer of darunavir in an ex vivo human cotyledon perfusion model
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris, Hopital Louis Mourier, Service de Gynecologie Obstetrique, Département Hospitalier Universitaire Risque et Grossesse, Colombes, France Université Paris Diderot, Paris, France
    Antimicrob Agents Chemother 58:5617-20. 2014
    ..0% ± 2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40.3% ± 5.8%. This shows that darunavir crosses the placenta at a relatively low rate, resulting in fetal exposure. ..
  2. ncbi request reprint [HIV and pregnancy: 2013 guidelines from the French expert working group]
    L Mandelbrot
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, Universite Paris Diderot, 178, rue des Renouillers, 92700 Colombes, France Electronic address
    J Gynecol Obstet Biol Reprod (Paris) 43:534-48. 2014
    ..Monitoring of the child is necessary to determine whether or not it is free of HIV infection and to monitor possible adverse effects of perinatal exposure to antiretroviral drugs. ..
  3. ncbi request reprint [Reproductive options for people living with HIV: 2013 guidelines from the French expert working group]
    L Mandelbrot
    Service de Gynecologie Obstetrique, CHU Louis Mourier, AP HP, Universite Denis Diderot, 178, rue des Renouillers, 92700 Colombes, France Electronic address
    Gynecol Obstet Fertil 42:543-50. 2014
    ..Assisted reproduction has two objectives in the context of HIV, to allow the couple to conceive without abandoning condom use and/or to treat infertility. ..
  4. doi request reprint [Prevention of mother-to-child transmission of toxoplasmosis: perspectives]
    L Mandelbrot
    Pôle Femme Enfant, Service de Gynecologie Obstetrique, Universite Paris Diderot, Hopital Louis Mourier, AP HP, HUPNVS, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 40:591-8. 2012
    ..It is not recommeded to start therapy before such expert consultation. The reference centers should provide counseling and access to prenatal diagnosis and therapy options...
  5. doi request reprint Fetal varicella - diagnosis, management, and outcome
    Laurent Mandelbrot
    Hopital Louis Mourier, Service de Gynecologie Obstetrique, hôpitaux universitaires Paris Nord Val de Seine, Assistance Publique Hopitaux de Paris, Universite Paris Diderot, 178 rue des Renouillers, 92701, Colombes Cedex, France
    Prenat Diagn 32:511-8. 2012
    ..Prevention strategies include vaccination and post-exposure prophylaxis with immune globulin and/or antivirals. Perspectives for treating infected fetuses in utero require further research...
  6. doi request reprint [Reproduction and HIV: has the condom become irrelevant?]
    L Mandelbrot
    Service de Gynecologie Obstetrique, Universite Paris Diderot, AP HP, hôpitaux universitaires Paris Nord Val de Seine, Hopital Louis Mourier, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 40:58-61. 2012
    ..On the other hand, we must strongly discourage unprotected sex in high-risk situations. The best prevention of risk behavior is to offer complete information and appropriate support to people with HIV who wish to conceive...
  7. pmc Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome
    Constance Delaugerre
    EA 3620 MRT, Descartes University, Paris, France
    Retrovirology 6:85. 2009
    ..Primary-HIV-1-infection in newborns that occurs under antiretroviral prophylaxis that is a high risk of drug-resistance acquisition. We examine the frequency and the mechanisms of resistance acquisition at the time of infection in newborns...
  8. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  9. doi request reprint Atazanavir in pregnancy: impact on neonatal hyperbilirubinemia
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris, Louis Mourier Hospital, Department of Obstetrics and Gynecology, Colombes, France
    Eur J Obstet Gynecol Reprod Biol 157:18-21. 2011
    ..To study the impact on the neonate of maternal antiretroviral therapy with atazanavir (ATV)...
  10. doi request reprint [Screening for gestational diabetes mellitus: Is it time to revise the recommendations?]
    L Mandelbrot
    Hopital Louis Mourier, AP HP, Universite Paris, Colombes, France
    Gynecol Obstet Fertil 38:409-14. 2010
    ..There are simple screening tests. However, it remains difficult to define threshold values because there is a strong, continuous association of maternal glucose levels with increased risks of adverse pregnancy outcomes...
  11. ncbi request reprint Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
    S Blanche
    Service d Immunologie Hématologie Pédiatrique and INSERM U429 Laboratory, Hopital Necker, Paris, France
    Lancet 354:1084-9. 1999
    ..Zidovudine is commonly administered during pregnancy to prevent mother-to-child HIV-1 transmission. We investigated mitochondrial toxic effects in children exposed to zidovudine in utero and after birth...
  12. ncbi request reprint Perinatal HIV-1 transmission: interaction between zidovudine prophylaxis and mode of delivery in the French Perinatal Cohort
    L Mandelbrot
    Service de Gynécologie Obstétrique I, Hôpital Cochin Port Royal and the Institut National de la Santé et de la Recherche Médicale U149, Paris, France
    JAMA 280:55-60. 1998
    ..It is unclear whether elective cesarean delivery may have a protective effect against the transmission of human immunodeficiency virus 1 (HIV-1)...
  13. ncbi request reprint Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
    L Mandelbrot
    Service de Gynecologie Obstetrique, Hopital Cochin, 123 Boulevard de Port Royal, 75014 Paris, France
    JAMA 285:2083-93. 2001
    ..Zidovudine reduces maternal-infant transmission of human immunodeficiency virus 1 (HIV-1) infection by two thirds. Combination antiretroviral therapies are potentially more effective prevention...
  14. doi request reprint [Screening of gestational diabetes mellitus: a new consensus?]
    H Legardeur
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, université Paris VII Diderot, 178 rue des Renouillers, Colombes, France
    Gynecol Obstet Fertil 39:174-9. 2011
    ..Whether this new consensus will be adopted by public health bodies and professionals remains to be seen...
  15. ncbi request reprint [Postpartum diabetes screening following gestational diabetes mellitus: practices in a university hospital and focus on the role of the general practitioner]
    C Clarke
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, hôpitaux universitaires Paris Nord Val de Seine, AP HP, Universite Paris Diderot, 178 rue des Renouillers, Colombes Cedex, France
    J Gynecol Obstet Biol Reprod (Paris) 41:476-84. 2012
    ....
  16. pmc Placental transfer of maraviroc in an ex vivo human cotyledon perfusion model and influence of ABC transporter expression
    C Vinot
    EA 3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 57:1415-20. 2013
    ..Nevertheless, these results would need to be supported by in vivo data obtained from paired maternal and cord blood samples...
  17. ncbi request reprint Vertical transmission of viral infections
    L Mandelbrot
    Hopital Cochin, Service de Gynécologie Obstétrique I, Paris, France
    Curr Opin Obstet Gynecol 10:123-8. 1998
    ..As demonstrated by hepatitis B research in the past and human immunodeficiency virus today, multicenter cohort studies and clinical trials are a key to developing effective interventions...
  18. doi request reprint [Pediatric aids, 30 years later]
    S Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, AP HP, 149, rue de Sevres, 75015 Paris, France
    Arch Pediatr 20:890-6. 2013
    ....
  19. doi request reprint Prenatal diagnosis of 18q-syndrome: a case of fetal mosaicism with a normal karyotype in chorionic villi
    O Anselem
    Hopital Louis Mourier, Paris, France
    Fetal Diagn Ther 28:180-5. 2010
    ..Cytogenetic tests were repeated because of a short corpus callosum on ultrasound examination. This 18q-syndrome has been reported to be associated with poor neurodevelopmental outcome...
  20. ncbi request reprint [Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs]
    P F Ceccaldi
    Service de Gynecologie Obstetrique, Hopital Beaujon, GHU Nord, AP HP, Universite Paris 7, 100, boulevard du General Leclerc, 92100 Clichy, France
    J Gynecol Obstet Biol Reprod (Paris) 39:601-5. 2010
    ..Limitations of this ex vivo model are detailed in this review, also its recent contributions in better understanding of placental passage of drugs...
  21. doi request reprint Prenatal and postnatal follow-up of a fetal interhemispheric arachnoid cyst with partial corpus callosum agenesis, asymmetric ventriculomegaly and localized polymicrogyria. Case report
    F Fuchs
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, Colombes, France
    Fetal Diagn Ther 24:385-8. 2008
    ..At 17 months, he had mild left-side hemiparesis but he could walk alone and had begun to speak. To date, the child never experienced seizures. We review other published cases and discuss the postnatal outcome of this rare association...
  22. ncbi request reprint Factors related to medical appointment attendance after childbirth among HIV-infected women in the Paris region
    D Lemly
    Assistance Publique Hopitaux de Paris, Hopital Louis Mourier, Service de Gynecologie Obstretrique, Colombes, France
    AIDS Care 19:346-54. 2007
    ..In addition, increased communication between the health care providers of the mother and child may increase appointment attendance following delivery...
  23. ncbi request reprint [Specific particularities of uterine scars and their impact on the risk of uterine rupture in case of trial of labor]
    G Kayem
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, Hôpitaux Universitaires Paris Nord, AP HP, Val de Seine HUPNVS, 178, rue des Renouillers, 92701 Colombes Cedex, France
    J Gynecol Obstet Biol Reprod (Paris) 41:753-71. 2012
    ..To assess the risk of uterine rupture in case of uterine scar in specific situations. To investigate whether ultrasonographic measurement of the lower uterine segment is predictive of the risk of uterine rupture...
  24. ncbi request reprint [Cervical disease in postmenopausal HIV-1-infected women]
    P F Ceccaldi
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, Universite Paris 7, 178, rue des Renouillers, 92700 Colombes, France
    J Gynecol Obstet Biol Reprod (Paris) 39:466-70. 2010
    ..This infection is associated with a higher incidence of cervical squamous intraepithelial lesions (low-grade or LSIL, high grade or HSIL). The aim of our study was to describe the cervical disease in these patients during menopause...
  25. ncbi request reprint [Emerging viral infectious diseases and pregnancy]
    P F Ceccaldi
    Service de Gynecologie Obstetrique, CHU Louis Mourier, APHP, Universite Paris VII, 178, rue des Renouillers, 92701 Colombes, France
    Gynecol Obstet Fertil 35:339-42. 2007
    ..We report a review of the literature concerning the most quoted emergent virus (H5N1, SARS Coronavirus, Chikungunya, West Nile virus), and relate the perinatal management...
  26. ncbi request reprint [Pheochromocytoma and pregnancy. Case report]
    P Oger
    Service de Gynecologie Obstetrique, Hôpital Louis Mourier AP HP, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 34:323-5. 2006
    ..This case illustrates the difficulty of diagnosing pheochromocytoma in pregnancy, and the benefits of laparoscopic treatment in the first trimester...
  27. ncbi request reprint [What use of progesterone to prevent preterm birth?]
    H Legardeur
    Service de Gynecologie Obstetrique, Universite Paris Diderot, Hopital Louis Mourier, Colombes, France
    Gynecol Obstet Fertil 41:459-64. 2013
    ..In women with asymptomatic midtrimester sonographic short cervix, randomized studies show conflicting results and new studies are necessary before its widespread utilisation...
  28. ncbi request reprint [Terminations of pregnancy for maternal indications in the Paris area: a retrospective multicenter study in the period between the 2001 French law on termination of pregnancy and the new bioethics law]
    B Piel
    HUPNVS, Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, 178, rue des Renouillers, 92700 Colombes, France Université Paris Diderot, 75018 Paris, France
    J Gynecol Obstet Biol Reprod (Paris) 42:342-50. 2013
    ....
  29. ncbi request reprint Intrapericardial teratoma with hydrops leading to in utero demise
    F Pachy
    Assistance Publique Hopitaux de Paris, Department of Obstetrics and Gynecology, and Paris 7 Denis Diderot University, France
    Prenat Diagn 27:970-2. 2007
    ..When prenatal diagnosis is performed before this stage, in utero interventions can obtain decompression, and the birth can be planned with rapid and appropriate management of the neonate...
  30. ncbi request reprint Increased risk of cervical disease among human immunodeficiency virus-infected women with severe immunosuppression and high human papillomavirus load(1)
    I Heard
    Service d obstétrique et de gynécologie, Hópita Cochin, INSERM SC4, Paris, France
    Obstet Gynecol 96:403-9. 2000
    ....
  31. ncbi request reprint [A comparison of maternal and fetal complications during operative vaginal delivery using Thierry's spatulas and the vacuum extractor]
    S Vanlieferinghen
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, Universite Paris Diderot, 92700 Colombes, France
    J Gynecol Obstet Biol Reprod (Paris) 38:648-54. 2009
    ..To compare short-term maternal and fetal morbidities between Thierry's spatules and the vacuum extractor...
  32. ncbi request reprint Factors predictive of macrosomia in pregnancies with a positive oral glucose challenge test: Importance of fasting plasma glucose
    H Legardeur
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, Hopitaux Universitaires, Paris Nord Val de Seine et université Paris Diderot, HUPNVS, AP HP, 178, rue des Renouillers, 92701 Colombes Cedex, France
    Diabetes Metab 40:43-8. 2014
    ..The study aimed to determine the factors associated with fetal macrosomia following a positive oral glucose challenge test (OGCT)...
  33. ncbi request reprint [Uterine necrosis after arterial embolization for postpartum hemorrhage]
    J Belghiti
    Hopital Louis Mourier, AP HP, 178, rue des Renouillers, 92701 Colombes, France
    Gynecol Obstet Fertil 42:126-8. 2014
    ..We report a case of a uterine necrosis after arterial embolization for severe postpartum hemorrhage due to uterine atony on a uterus with fibroids. This complication occurred despite the use of the recommended technique. ..
  34. ncbi request reprint [Use of sismotherapy during pregnancy for severe depression]
    P F Ceccaldi
    Service de Gynecologie Obstetrique, CHU Louis Mourier, Assistance Publique Hopitaux de Paris AP HP, Universite Paris VII, 178 rue des Renouillers, Colombes, France
    Gynecol Obstet Fertil 36:773-5. 2008
    ..The occurrence of any superimposed obstetrical pathology (preeclampsia, premature delivery) should revise this treatment. Given the possible complications, it requires strict supervision of the pregnancy in a hospital setting...
  35. ncbi request reprint First-trimester ultrasound diagnosis in a recurrent case of Walker-Warburg syndrome
    G Blin
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, Universite Paris 7, Colombes, France
    Ultrasound Obstet Gynecol 26:297-9. 2005
    ..In some cases, recurrence can be suspected as early as the first trimester, however the diagnosis cannot be excluded on the basis of normal ultrasound appearance until later in pregnancy...
  36. ncbi request reprint [HIV and pregnancy]
    C Rouzioux
    Laboratoire de Virologie, CHU Necker Enfants Malades, 156, rue de Vaugirard, 75015, Paris, France
    Pathol Biol (Paris) 50:576-9. 2002
    ..The knowledge of the mechanisms and the timing of HIV mother-to-child transmission need to be more developed in order to design adapted antiretroviral posology and to try to reduce infant's exposure to drug toxicity...
  37. ncbi request reprint Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model
    F Forestier
    , Paris, France
    Am J Obstet Gynecol 185:178-81. 2001
    ..CONCLUSION: The low rate of placental transfer of saquinavir suggests that use of this antiretroviral drug by pregnant women may not lead to significant exposure of the fetus...
  38. ncbi request reprint [Amniocentesis trainer: development of a cheap and reproducible new training model]
    M Tassin
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, hôpitaux universitaires Paris Nord Val de Seine, Colombes Cedex, France
    J Gynecol Obstet Biol Reprod (Paris) 41:679-83. 2012
    ..We present here a new, simple, and cost-effective amniotrainer model that reproduces real life conditions, using chicken breast and condoms filled with water...
  39. doi request reprint [Use of magnesium sulfate in obstetrics]
    G Kayem
    Service de Gynecologie Obstetrique, Hopital Louis Mourier, AP HP, HUPNVS, Universite Paris Diderot, 178, rue des Renouillers, 92700 Colombes, France
    Gynecol Obstet Fertil 40:605-13. 2012
    ..A protocol using low doses associated with a well-conducted maternal surveillance reduces of maternal hypermagnesemia and the risk of maternal toxicity...
  40. doi request reprint [Evaluation study of student satisfaction in the faculty of medicine Denis-Diderot-Paris-VII for their teaching in obstetric gynaecology]
    D Desroque
    Service de Gynecologie Obstetrique, Université Denis Diderot Paris VII, CHU Lariboisière Saint Louis, 2 rue Ambroise Pare, Paris, France
    Gynecol Obstet Fertil 38:735-9. 2010
    ..The aim is to improve the quality of teaching and learning tools mainly with a view to preparing for the national examination competition...