St MANDARD

Summary

Affiliation: Centre de Recherche INSERM U866
Location: DIJON, FRANCE
URL: http://mandard21.voila.net/
Summary:
Using different tools rising from genomics to biochemistry and physiology, we aim at characterizing a novel mouse mutant deficient for a peroxisomal enzyme, the 3-ketoacylCoA thiolase B.
Grants:
The EU peroxisome project (Project No. LSHG-CT2004-512018).
- The Regional Council of Burgundy,
- The GDR-CNRS no2583 on peroxisome
- The French Ministry of Research, National Education and Technology
Publications:
A role for the peroxisomal 3-ketoacyl-CoA thiolase B in the control of PPARalpha-mediated upregulation of SREBP-2 target genes in the liver, 2011, Biochimie, in press.

The peroxisomal 3-keto-acyl-CoA thiolase B gene expression is under the dual control of PPARalpha and HNF4alpha in the liver, 2010, PPAR Research, in press.

Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643, Biochimie, 91(11-12):1376-86

Glycogen Synthase 2 is a novel target gene of Peroxisome Proliferator-Activated Receptors, 2007, Cell. Mol. Life Sci. 64(9):1145-1157.

PPARalpha protects against obesity-induced hepatic inflammation, 2007, Endocrinology,148:2753-2763.

The Interleukin 1 receptor antagonist is a direct target gene of PPARalpha in liver, 2007, Journal of Hepatology 46(5): 869-877.

The G0/G1 switch gene 2 is a novel PPAR-target gene, 2005, Biochemical Journal, 392(Pt 2):313-324.

The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL-4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment, 2004, J. Biol. Chem. 279(33):34411-34420.

PPARalpha governs glycerol metabolism, 2004, J. Clin. Invest. 114(1):94-103

Peroxisome Proliferator-Activated Receptor alpha target genes, 2004, Cell. Mol. Life Sci. 61:393-416.

The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism, 2001, FASEB J. 15 (11):1971-1978

Characterization of the fasting induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene, 2000, J. Biol. Chem. 275(37):28488-28493




Publications

  1. ncbi request reprint Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000
  2. doi request reprint Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643
    Ségolène Arnauld
    Centre de recherche INSERM U866, Laboratoire de Biochimie Métabolique et Nutritionnelle, 6, Boulevard Gabriel, Dijon F 21000, France
    Biochimie 91:1376-86. 2009
  3. pmc Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors
    S Mandard
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Cell Mol Life Sci 64:1145-57. 2007
  4. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
  5. pmc The G0/G1 switch gene 2 is a novel PPAR target gene
    Fokko Zandbergen
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 EV, Wageningen, The Netherlands
    Biochem J 392:313-24. 2005
  6. pmc PPARalpha governs glycerol metabolism
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Clin Invest 114:94-103. 2004
  7. ncbi request reprint The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 279:34411-20. 2004
  8. ncbi request reprint Peroxisome proliferator-activated receptor alpha target genes
    S Mandard
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands
    Cell Mol Life Sci 61:393-416. 2004
  9. ncbi request reprint The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    FASEB J 15:1971-8. 2001
  10. pmc The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver
    J Chamouton
    Centre de Recherche, INSERM U866, LBMN 6, Boulevard Gabriel, 21000 Dijon, France
    PPAR Res 2010:352957. 2010

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000
    ..Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions...
  2. doi request reprint Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643
    Ségolène Arnauld
    Centre de recherche INSERM U866, Laboratoire de Biochimie Métabolique et Nutritionnelle, 6, Boulevard Gabriel, Dijon F 21000, France
    Biochimie 91:1376-86. 2009
    ..Ultimately, not only the amount but also the quality of the hepatic fatty acid pool is modulated upon the deletion of Thb...
  3. pmc Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors
    S Mandard
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Cell Mol Life Sci 64:1145-57. 2007
    ..Overall, we conclude that mouse Gys-2 is a novel PPAR target gene and that transactivation by PPARs and HNF4alpha is mediated by two distinct response elements...
  4. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
    ..The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver...
  5. pmc The G0/G1 switch gene 2 is a novel PPAR target gene
    Fokko Zandbergen
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 EV, Wageningen, The Netherlands
    Biochem J 392:313-24. 2005
    ..Together, these data indicate that G0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation...
  6. pmc PPARalpha governs glycerol metabolism
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Clin Invest 114:94-103. 2004
    ..Overall, these data indicate that PPARalpha directly governs glycerol metabolism in liver, whereas PPARgamma regulates glycerol metabolism in adipose tissue...
  7. ncbi request reprint The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 279:34411-20. 2004
    ..Together, these data suggest that FIAF, similar to other adipocytokines such as adiponectin, may partially exert its function via a truncated form...
  8. ncbi request reprint Peroxisome proliferator-activated receptor alpha target genes
    S Mandard
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands
    Cell Mol Life Sci 61:393-416. 2004
    ....
  9. ncbi request reprint The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    FASEB J 15:1971-8. 2001
    ..It is concluded that in addition to oxidation of fatty acids, PPARalpha also regulates metabolism of amino acids in liver, indicating that PPARalpha is a key controller of intermediary metabolism during fasting...
  10. pmc The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver
    J Chamouton
    Centre de Recherche, INSERM U866, LBMN 6, Boulevard Gabriel, 21000 Dijon, France
    PPAR Res 2010:352957. 2010
    ..Overall, we conclude that HNF4α enhances the PPARα-mediated activation of Thb gene expression in part through interaction with the obligate PPARα partner, RXRα...
  11. pmc Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors
    Stéphane Mandard
    Centre de Recherche Inserm UMR866 Lipides, Nutrition, Cancer Faculté de Médecine, Université de Bourgogne 7, boulevard Jeanne d Arc, 21079 Dijon Cedex, France
    PPAR Res 2013:613864. 2013
    ..In the light of the data available in the literature, there is no doubt that more studies concerning the impact of PPAR ligands in livestock should be undertaken because it may finally raise unconsidered health and sanitary benefits...