Matteo Elia Mangoni
Torrente A, Mesirca P, Neco P, Rizzetto R, Dubel S, Barrere C, et al
. L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity. Cardiovasc Res. 2016;109:451-61 pubmed publisher
..Our study also provides an additional pathophysiological mechanism for congenital SAN dysfunction and heart block linked to Cav1.3 loss of function in humans. ..
Mesirca P, Bidaud I, Mangoni M. Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond. J Physiol. 2016;594:5869-5879 pubmed publisher
..3-/- mice. This new concept of 'compensatory' ion channel targeting shines new light on the principles underlying the pacemaker mechanism and may open the way to new therapies for SSS. ..
Mangoni M, Traboulsie A, Leoni A, Couette B, Marger L, Le Quang K, et al
. Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ Res. 2006;98:1422-30 pubmed
..Our results demonstrate that CaV3.1/T-type Ca2+ channels contribute to SAN pacemaker activity and atrioventricular conduction. ..