Roberto Mallone

Summary

Country: France

Publications

  1. pmc Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks?
    Slobodan Culina
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Clin Dev Immunol 2011:286248. 2011
  2. pmc HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes
    Matthieu Scotto
    INSERM, U986, DeAR Lab Avenir, Cochin Saint Vincent de Paul Hospital, Paris, France
    Diabetes 61:2546-55. 2012
  3. pmc T cells recognizing a peptide contaminant undetectable by mass spectrometry
    Vedran Brezar
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, Paris, France
    PLoS ONE 6:e28866. 2011
  4. pmc Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients
    Speranza Masala
    Sezione di Microbiologia e Virologia, Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy
    PLoS ONE 6:e26931. 2011
  5. doi Biomarkers for immune intervention trials in type 1 diabetes
    Roberto Mallone
    Cochin Institute, Inserm U1016, DeAR Lab Avenir, Paris, France Paris Descartes University, Sorbonne Paris Cité, Faculte de Medecine, Paris, France Assistance Publique Hôpitaux de Paris, Hotel Dieu, Service de Diabetologie, Paris, France Electronic address
    Clin Immunol 149:286-96. 2013
  6. doi Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative
    R Mallone
    INSERM U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, and Paris Descartes University, Paris, France
    Diabetes Metab Res Rev 27:720-6. 2011
  7. pmc Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
    R Mallone
    INSERM U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, Paris Cedex 14, France
    Clin Exp Immunol 163:33-49. 2011
  8. ncbi Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice
    Emmanuelle Enée
    Institut National de la Sante et de la Recherche Medicale, Unité 580, Paris, France
    J Immunol 180:5430-8. 2008
  9. doi The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment
    Emanuela Martinuzzi
    INSERM U580, Paris, France
    Diabetes 57:1312-20. 2008
  10. pmc T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives
    Roberto Mallone
    INSERM, U986, Hopital St Vincent de Paul, 82 avenue Denfert Rochereau, 75014 Paris, France
    Clin Dev Immunol 2011:513210. 2011

Collaborators

Detail Information

Publications21

  1. pmc Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks?
    Slobodan Culina
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Clin Dev Immunol 2011:286248. 2011
    ..T1D staging through immune surrogate markers before and after treatment will be key in understanding therapeutic actions and to finally turn ordinary blanks into magic bullets...
  2. pmc HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes
    Matthieu Scotto
    INSERM, U986, DeAR Lab Avenir, Cochin Saint Vincent de Paul Hospital, Paris, France
    Diabetes 61:2546-55. 2012
    ..These features may explain the T1D-protective effect of HLA-B7. The novel epitopes identified should find valuable applications for immune staging of HLA-B7(+) individuals...
  3. pmc T cells recognizing a peptide contaminant undetectable by mass spectrometry
    Vedran Brezar
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, Paris, France
    PLoS ONE 6:e28866. 2011
    ..If left undetected, minute impurities in synthetic peptide preparations may thus give spurious results...
  4. pmc Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients
    Speranza Masala
    Sezione di Microbiologia e Virologia, Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy
    PLoS ONE 6:e26931. 2011
    ..These results demonstrate that Abs recognizing MAP3865c epitopes cross-react with ZnT8, possibly underlying a molecular mimicry mechanism, which may precipitate T1D in MAP-infected individuals...
  5. doi Biomarkers for immune intervention trials in type 1 diabetes
    Roberto Mallone
    Cochin Institute, Inserm U1016, DeAR Lab Avenir, Paris, France Paris Descartes University, Sorbonne Paris Cité, Faculte de Medecine, Paris, France Assistance Publique Hôpitaux de Paris, Hotel Dieu, Service de Diabetologie, Paris, France Electronic address
    Clin Immunol 149:286-96. 2013
    ..This review discusses the current state of the art, setting the stage for future efforts to monitor disease heterogeneity, progression and therapeutic intervention in T1D. ..
  6. doi Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative
    R Mallone
    INSERM U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, and Paris Descartes University, Paris, France
    Diabetes Metab Res Rev 27:720-6. 2011
    ..Identification of T-cell reactivity to β-cell antigen epitopes is an important goal for studying pathogenesis and for designing and monitoring of immunotherapeutic interventions in type 1 diabetes (T1D)...
  7. pmc Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
    R Mallone
    INSERM U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, Paris Cedex 14, France
    Clin Exp Immunol 163:33-49. 2011
    ..These recommendations may be relevant not only for the analysis of T cell responses in autoimmune disease, but also in cancer and infectious disease, particularly in the context of clinical trials...
  8. ncbi Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice
    Emmanuelle Enée
    Institut National de la Sante et de la Recherche Medicale, Unité 580, Paris, France
    J Immunol 180:5430-8. 2008
    ....
  9. doi The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment
    Emanuela Martinuzzi
    INSERM U580, Paris, France
    Diabetes 57:1312-20. 2008
    ..The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown...
  10. pmc T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives
    Roberto Mallone
    INSERM, U986, Hopital St Vincent de Paul, 82 avenue Denfert Rochereau, 75014 Paris, France
    Clin Dev Immunol 2011:513210. 2011
    ..This may prove instrumental in the discovery of immune correlates of efficacy in clinical trials...
  11. doi Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms
    Georgia Afonso
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Immunol Methods 359:28-36. 2010
    ..However, washes with > 10% human serum decreased multimer counts, with no additional improvement in PBMC yields. These findings may be relevant for optimizing and harmonizing PBMC processing procedures for T-cell assays...
  12. doi Beyond the hormone: insulin as an autoimmune target in type 1 diabetes
    Vedran Brezar
    Institut National de la Sante et de la Recherche Medicale, Unité 986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, and Paris Descartes University, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Endocr Rev 32:623-69. 2011
    ..We will argue about possible reasons why insulin remains the mainstay of metabolic control in type 1 diabetes but has so far failed to prevent or halt β-cell autoimmunity as an immune modulatory reagent...
  13. doi acDCs enhance human antigen-specific T-cell responses
    Emanuela Martinuzzi
    INSERM U986, Diabetes and Autoimmunity Research Laboratory, Paris, France
    Blood 118:2128-37. 2011
    ....
  14. doi Measurement of CD8 T cell responses in human type 1 diabetes
    Emanuela Martinuzzi
    INSERM, U561, Saint Vincent de Paul Hospital, 75014 Paris, France
    Ann N Y Acad Sci 1150:61-7. 2008
    ..Second, appropriate readouts and measurement techniques need to be selected. This review summarizes recent advances on both of these battlefronts, and discusses the potential clinical applications of T cell assays...
  15. doi Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice
    Vedran Brezar
    INSERM, U986, DeAR Lab Avenir, Cochin Saint Vincent de Paul Hospital, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Eur J Immunol 42:1553-61. 2012
    ..These findings have important implications for designing insulin-based prevention trials...
  16. pmc Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes
    Sandrine Luce
    INSERM, U986, Paris, France
    Diabetes 60:3289-99. 2011
    ....
  17. doi Insulin and type 1 diabetes: immune connections
    Sloboda Culina
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Eur J Endocrinol 168:R19-31. 2013
    ....
  18. doi Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection
    Emanuela Martinuzzi
    INSERM, U580, Necker Hospital, Paris, France
    J Immunol Methods 333:61-70. 2008
    ..Implementation of this ELISpot procedure should expedite development of "immune staging" protocols for autoimmune as well as tumor and infectious diseases...
  19. doi Pathogenic and regulatory T cells in type 1 diabetes: losing self-control, restoring it, and how to take the temperature
    Slobodan Culina
    INSERM U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 75674, Paris, Cedex 14, France
    Curr Diab Rep 11:426-33. 2011
    ..Continuous development of T-cell assays exploring both pathogenic and regulatory players will be critical to "take the temperature" of undergoing disease progression and reversal...
  20. doi Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 149:119-22. 2013
    ..These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope...